Dense core lysosomes can fuse with late endosomes and are re-formed from the resultant hybrid organelles

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1963 • 24,942 citations

Functions of Lysosomes

1966 • 2,942 citations

Mechanisms of intracellular protein transport

1994 • 2,280 citations

Ciba foundation symposium

1964 • 2,217 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

A new method of preparing gold probes for multiple-labeling cytochemistry.

1985 • 1,417 citations

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1988 • 846 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Fine Structure Immunocytochemistry

1993 • 707 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro.

1989 • 588 citations

Sizing of protein A-colloidal gold probes for immunoelectron microscopy.

1981 • 573 citations

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes.

1996 • 531 citations

The Lysosome Concept

2008 • 485 citations

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1990 • 452 citations

Low temperature selectively inhibits fusion between pinocytic vesicles and lysosomes during heterophagy of 125I-asialofetuin by the perfused rat liver.

1980 • 451 citations

Trafficking of lysosomal enzymes in normal and disease states.

1986 • 445 citations

Movement of internalized ligand–receptor complexes along a continuous endosomal reticulum

1990 • 428 citations

Lysosomes revisited

1983 • 427 citations

Penetration of semliki forest virus from acidic prelysosomal vacuoles

1983 • 411 citations

Cytoplasmic dynein-dependent vesicular transport from early to late endosomes [published erratum appears in J Cell Biol 1994 Feb;124(3):397]

1993 • 408 citations

A novel class of clathrin-coated vesicles budding from endosomes.

1996 • 369 citations

An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes.

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A study of positive staining of ultrathin frozen sections

1978 • 329 citations

Late endosomes derive from early endosomes by maturation

1991 • 311 citations

Cytoplasmic coat proteins involved in endosome function

1995 • 290 citations

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1996 • 258 citations

Sorting of mannose 6-phosphate receptors and lysosomal membrane proteins in endocytic vesicles.

1988 • 241 citations

Meeting of the apical and basolateral endocytic pathways of the Madin-Darby canine kidney cell in late endosomes.

1989 • 226 citations

THE UPTAKE, STORAGE, AND INTRACELLULAR HYDROLYSIS OF CARBOHYDRATES BY MACROPHAGES

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The tyrosine-based lysosomal targeting signal in lamp-1 mediates sorting into Golgi-derived clathrin-coated vesicles.

1996 • 188 citations

The effect of wortmannin on the localisation of lysosomal type I integral membrane glycoproteins suggests a role for phosphoinositide 3-kinase activity in regulating membrane traffic late in the endocytic pathway

1996 • 175 citations

Maturation models for endosome and lysosome biogenesis

1991 • 172 citations

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1996 • 170 citations

Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells.

1991 • 164 citations

Characterization of the cation-independent mannose 6-phosphate receptor-enriched prelysosomal compartment in NRK cells

1990 • 161 citations

The arguments for pre-existing early and late endosomes

1991 • 156 citations

Multivesicular bodies in HEp-2 cells are maturing endosomes.

1993 • 154 citations

Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cells.

1986 • 148 citations

Lysosomes

1989 • 147 citations

The biogenesis of lysosomes: Is it a kiss and run, continuous fusion and fission process?

1996 • 144 citations

Immunolabelling for electron microscopy

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AP-2-containing clathrin coats assemble on mature lysosomes.

1996 • 132 citations

Autophagic vacuoles rapidly fuse with pre-existing lysosomes in cultured hepatocytes

1992 • 124 citations

Phosphoinositide 3-kinases and membrane traffic

1996 • 124 citations

Delivery to lysosomes in the human carcinoma cell line HEp-2 involves an actin filament-facilitated fusion between mature endosomes and preexisting lysosomes.

1995 • 122 citations

Evidence for retrograde traffic between terminal lysosomes and the prelysosomal/late endosome compartment

1994 • 117 citations

Secretory lysosomes — a special mechanism of regulated secretion in haemopoietic cells

1996 • 107 citations

On vesicles and membrane compartments

1996 • 94 citations

Targeting and mistargeting of plasma membrane adaptors in vitro.

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Physiological functions of endosomal proteolysis

1995 • 91 citations

Reconstitution of an endosome-lysosome interaction in a cell-free system.

1989 • 74 citations

Lysosomes can fuse with a late endosomal compartment in a cell-free system from rat liver.

1994 • 73 citations

The endosomal concentration of a mannose 6-phosphate receptor is unchanged in the absence of ligand synthesis.

1987 • 59 citations

Animal cell lysosomes rapidly exchange membrane proteins.

1988 • 59 citations

Accumulation of indigestible substances reduces fusion competence of macrophage lysosomes.

1991 • 51 citations

Osmotic swelling of endocytic compartments induced by internalized sucrose is restricted to mature lysosomes in cultured mammalian cells

1991 • 49 citations

3-Methyladenine inhibits transport from late endosomes to lysosomes in cultured rat and mouse fibroblasts.

1994 • 46 citations

Immunohistochemistry

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Comparative behavior of lysosomes and the pre-lysosome compartment (PLC) in in vivo cell fusion experiments

1991 • 35 citations

Proteolysis and the evolutionary origin of polypeptide hormones

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Phosphatidylinositol 3-kinase is not required for recycling of mannose 6-phosphate receptors from late endosomes to the trans-Golgi network.

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Encyclopaedia of Molecular Biology

1994 • 5 citations