Mannose 6-phosphate-independent targeting of lysosomal enzymes in I-cell disease B lymphoblasts.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

Protein Oligomerization in the Endoplasmic Reticulum

1989 • 993 citations

Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight.

1980 • 809 citations

The Structure and Function of the Aspartic Proteinases

1990 • 637 citations

Biosynthesis of lysosomal enzymes in fibroblasts. Phosphorylation of mannose residues.

1980 • 404 citations

Fibroblasts from patients with I-cell disease and pseudo-Hurler polydystrophy are deficient in uridine 5'-diphosphate-N-acetylglucosamine: glycoprotein N-acetylglucosaminylphosphotransferase activity.

1981 • 323 citations

Cloning and sequence analysis of cDNA for human cathepsin D.

1985 • 318 citations

Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protease

1987 • 312 citations

Enzymatic phosphorylation of lysosomal enzymes in the presence of UDP-N-acetylglucosamine. Absence of the activity in l-cell fibroblasts

1981 • 299 citations

Intracellular sorting and processing of a yeast vacuolar hydrolase: proteinase A propeptide contains vacuolar targeting information.

1988 • 287 citations

Cathepsin D is membrane-associated in macrophage endosomes.

1988 • 259 citations

The spectrum of anionic oligosaccharides released by endo-beta-N-acetylglucosaminidase H from glycoproteins. Structural studies and interactions with the phosphomannosyl receptor.

1983 • 244 citations

Structural studies of phosphorylated high mannose-type oligosaccharides.

1980 • 236 citations

Biosynthesis and transport of cathepsin D in cultured human fibroblasts.

1983 • 235 citations

Is there a mechanism for introducing acid hydrolases into liver lysosomes that is independent of mannose 6-phosphate recognition? evidence from I-cell disease

1982 • 169 citations

Epstein-Barr virus shuttle vector for stable episomal replication of cDNA expression libraries in human cells.

1988 • 154 citations

Yeast carboxypeptidase Y vacuolar targeting signal is defined by four propeptide amino acids.

1990 • 147 citations

Deficiency of UDP-N-acetylglucosamine: Lysosomal enzyme N-acetylglucosamine-1-phosphotransferase in organs of I-cell patients

1982 • 147 citations

Generation of a lysosomal enzyme targeting signal in the secretory protein pepsinogen

1990 • 144 citations

Intracellular Sorting and Processing of a Yeast Vacuolar Hydrolase: Proteinase A Propeptide Contains Vacuolar Targeting Information

1988 • 121 citations

Mannose 6-phosphate-independent targeting of cathepsin D to lysosomes in HepG2 cells.

1991 • 106 citations

Identification of subcellular compartments involved in biosynthetic processing of cathepsin D.

1992 • 90 citations

Procathepsins L and D are membrane-bound in acidic microsomal vesicles

1991 • 87 citations

Mapping and molecular modeling of a recognition domain for lysosomal enzyme targeting.

1991 • 79 citations

Mechanism of intramolecular activation of pepsinogen. Evidence for an intermediate delta and the involvement of the active site of pepsin in the intramolecular activation of pepsinogen.

1976 • 76 citations

Expression of human cathepsin D in Xenopus oocytes: phosphorylation and intracellular targeting.

1987 • 73 citations

Cathepsin D precursors in clathrin-coated organelles from human fibroblasts.

1985 • 55 citations

Lysosomal enzyme phosphorylation. I. Protein recognition determinants in both lobes of procathepsin D mediate its interaction with UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase

1992 • 54 citations

Epstein-Barr Virus Shuttle Vector for Stable Episomal Replication of cDNA Expression Libraries in Human Cells

1988 • 45 citations

Phosphorylation of Asn-linked oligosaccharides located at novel sites on the lysosomal enzyme cathepsin D

1992 • 37 citations

Regulated secretion

1990 • 28 citations

Properties of N-acetylglucosamine 1-phosphotransferase from human lymphoblasts

1987 • 24 citations

I-cell disease: evidence for a mannose 6-phosphate independent pathway for translocation of lysosomal enzymes in lymphoblastoid cells

1988 • 18 citations

Low Temperature Blocks Transport and Sorting of Cathepsin D in Fibroblasts

1988 • 15 citations

Biosynthesis, processing, and secretion of α-L-fucosidase in lymphoid cells from patients with I-cell disease and pseudo-Hurler polydystrophy

1991 • 8 citations

Biochemical studies on lymphoblastoid cells with inherited N-acetyl-glucosamine 1-phosphotransferase deficiency (I-cell disease).

1988 • 3 citations