Free Radicals and the Pathogenesis of Neuronal Death: Cooperative Role of Excitatory Amino Acids

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Reactive Oxygen Species and the Central Nervous System

1992 • 2,931 citations

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Temporal profile of neuronal damage in a model of transient forebrain ischemia

1982 • 2,695 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Glutamate: A Neurotransmitter in Mammalian Brain

1984 • 1,981 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Free Radicals as Mediators of Tissue Injury and Disease

1993 • 1,480 citations

Excitatory amino acid receptors in the vertebrate central nervous system.

1989 • 1,316 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia

1990 • 1,125 citations

The release and uptake of excitatory amino acids

1990 • 1,090 citations

Excitotoxity and the NMDA receptor

1987 • 1,053 citations

Role of oxygen free radicals in carcinogenesis and brain ischemia

1990 • 885 citations

Guam Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Linked to a Plant Excitant Neurotoxin

1987 • 881 citations

Metabotropic glutamate receptors in brain function and pathology

1993 • 799 citations

Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.

1990 • 787 citations

A radical hypothesis for neurodegeneration

1993 • 727 citations

Cerebral hypoxia: some new approaches and unanswered questions

1990 • 674 citations

The free radical pathology and the microcirculation in the major central nervous system disorders.

1980 • 660 citations

Oxygen radical mechanisms of brain injury following ischemia and reperfusion

1991 • 657 citations

Central nervous systems trauma and strokeI. Biochemical considerations for oxygen radical formation and lipid peroxidation

1989 • 626 citations

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.

1993 • 623 citations

NMDA receptors activate the arachidonic acid cascade system in striatal neurons

1988 • 600 citations

Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase.

1991 • 591 citations

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

1991 • 554 citations

Advances in Our Understanding of the Mechanisms of the Neurotoxicity of MPTP and Related Compounds

1993 • 541 citations

Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage

1990 • 510 citations

Excitotoxicity and the NMDA receptor -- still lethal after eight years

1995 • 504 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

1992 • 457 citations

Molecular Neurobiology of Glutamate Receptors

1992 • 436 citations

Glutamate receptor channels: novel properties and new clones

1992 • 427 citations

Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats.

1992 • 399 citations

Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells

1989 • 375 citations

Calcium Accumulation and Neuronal Damage in the Rat Hippocampus following Cerebral Ischemia

1987 • 374 citations

Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue Injury

1987 • 334 citations

Pathophysiology of acute ischaemic stroke

1992 • 292 citations

21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils.

1988 • 266 citations

Liposome-entrapped superoxide dismutase reduces cerebral infarction in cerebral ischemia in rats.

1990 • 266 citations

The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine‐depleted rats and MPTP‐treated monkeys

1991 • 258 citations

21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures

1990 • 248 citations

The N-methyl-D-aspartate antagonist, MK-801, fails to protect against neuronal damage caused by transient, severe forebrain ischemia in adult rats

1991 • 239 citations

Oxygen Radicals and Neuropsychiatric Illness

1991 • 230 citations

Contributory mechanisms in the causation of neurodegenerative disorders

1993 • 228 citations

Oxygen radicals in CNS damage

1989 • 226 citations

Relationship between free radical production and lipid peroxidation during ischemia-reperfusion injury in the rat brain

1991 • 216 citations

Excitatory Amino Acid Release from Rat Hippocampal Slices as a Consequence of Free‐Radical Formation

1988 • 210 citations

Oxidative stress as a cause of Parkinson's disease

1991 • 203 citations

High Sensitivity of Glutamate Uptake to Extracellular Free Arachidonic Acid Levels in Rat Cortical Synaptosomes and Astrocytes

1992 • 188 citations

The relationship between excitotoxicity and oxidative stress in the central nervous system

1993 • 167 citations

Excitotoxins: An Overview

1983 • 142 citations

Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats

1993 • 104 citations

Metabotropic excitatory amino acid receptors reveal their true colors

1991 • 92 citations

Interaction between free radicals and excitatory amino acids in the formation of ischemic brain edema in rats.

1991 • 91 citations

Biochemical mechanisms of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

1991 • 90 citations

The Free Radical Trapping Agent N-Tert.-Butyl-α-Phenylnitrone (PBN) Attenuates Cerebral Ischaemic Injury in Gerbils

1991 • 76 citations

Mechanisms of drug actions against neuronal damage caused by ischemia — An overview

1993 • 70 citations

A novel treatment of global cerebral ischaemia with a glycine partial agonist

1992 • 65 citations

A study of the dose dependency of a glycine receptor antagonist in focal ischemia.

1993 • 54 citations

Thiokynurenates: a new group of antagonists of the glycine moduiatory site of the NMBA receptor

1991 • 37 citations

Thiokynurenates prevent excitotoxic neuronal death in vitro and in vivo by acting as glycine antagonists and as inhibitors of lipid peroxidation

1992 • 33 citations

Amelioration of brain damage after focal ischemia in the rat by a novel inhibitor of lipid peroxidation

1991 • 28 citations