Interaction between free radicals and excitatory amino acids in the formation of ischemic brain edema in rats.

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

1986 • 2,584 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury

1987 • 1,821 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

Excitotoxity and the NMDA receptor

1987 • 1,053 citations

Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death

1984 • 893 citations

Ischemia-Induced Shift of Inhibitory and Excitatory Amino Acids from Intra- to Extracellular Compartments

1985 • 663 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

Central nervous systems trauma and strokeI. Biochemical considerations for oxygen radical formation and lipid peroxidation

1989 • 626 citations

NMDA receptors activate the arachidonic acid cascade system in striatal neurons

1988 • 600 citations

The glutamate antagonist MK‐801 reduces focal ischemic brain damage in the rat

1988 • 547 citations

Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage

1990 • 510 citations

Non-competitive antagonists of excitatory amino acid receptors

1987 • 502 citations

Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger.

1988 • 377 citations

Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat

1988 • 370 citations

Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury

1989 • 368 citations

The molecular basis of brain injury and brain edema

1990 • 355 citations

Dynamics of Extracellular Metabolites in the Striatum after Middle Cerebral Artery Occlusion in the Rat Monitored by Intracerebral Microdialysis

1989 • 350 citations

Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue Injury

1987 • 334 citations

Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea.

1984 • 322 citations

The Molecular Basis of Brain Injury and Brain Edema: The Role of Oxygen Free Radicals

1990 • 321 citations

21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils.

1988 • 266 citations

MK-801 protects the neonatal brain from hypoxic-ischemic damage

1987 • 261 citations

Free radicals in central nervous system ischemia.

1990 • 251 citations

Ischemic Damage in Hippocampal CA1 is Dependent on Glutamate Release and Intact Innervation from CA3

1989 • 249 citations

21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures

1990 • 248 citations

Glutamate Antagonist Therapy Reduces Neurologic Deficits Produced by Focal Central Nervous System Ischemia

1988 • 245 citations

Excitatory Amino Acid Release from Rat Hippocampal Slices as a Consequence of Free‐Radical Formation

1988 • 210 citations

Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains.

1988 • 208 citations

MK-801 reduced cerebral ischemic injury by inducing hypothermia

1990 • 205 citations

Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia

1988 • 192 citations

Protection by NMDA Antagonists against Selective Cell Loss following Transient Ischaemia

1990 • 162 citations

Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats.

1989 • 162 citations

MK-801 prevents hypobaric-ischemic neuronal degeneration in infant rat brain

1989 • 161 citations

The Neuroprotective Action of Ketamine and MK-801 after Transient Cerebral Ischemia in Rats

1988 • 143 citations

Effect of steroids on edema and sodium uptake of the brain during focal ischemia in rats.

1990 • 142 citations

21-Aminosteroid reduces ion shifts and edema in the rat middle cerebral artery occlusion model of regional ischemia.

1988 • 135 citations

Blockade of excitatory amino acid receptors protects anoxic hippocampal slices

1987 • 128 citations

Effects of Anoxia on the Stimulated Release of Amino Acid Neurotransmitters in the Cerebellum In Vitro

1983 • 127 citations

Dextromethorphan protects against cerebral injury following transient focal ischemia in rabbits.

1988 • 115 citations

Interactions of Phencyclidine Receptor Agonist MK‐801 with Dopaminergic System: Regional Studies in the Rat

1990 • 112 citations

Differences in results from in vivo and in vitro studies on the use-dependency of N-methylaspartate antagonism by MK-801 and other phencyclidine receptor ligands

1988 • 99 citations

Prevention of thiourea-induced pulmonary edema by hydroxyl-radical scavengers

1983 • 81 citations

Dimethylthiourea Reduces Ischemic Brain Edema without Affecting Cerebral Blood Flow

1990 • 63 citations

Xanthine oxidase is not a major source of free radicals in focal cerebral ischemia

1991 • 62 citations

Neurotransmitter amino acids in the CNS. II. Some changes in amino acid levels in rat brain synaptosomes during and after in vitro anoxia and simulated ischemia

1984 • 62 citations

Reduction of activities of superoxide dismutase but not of glutathione peroxidase in rat brain regions following decapitation ischemia

1988 • 52 citations

Amelioration of ischaemic cerebral oedema by a free radical scavenger, AVS: 1,2-bis(nicotinamido)-propane. An experimental study using a regional ischaemia model in cats

1984 • 44 citations

A mask for delivery of inhalation gases to small laboratory animals.

1980 • 21 citations