Excitotoxins: An Overview

Kainic acid as a tool in neurobiology

1978 • 1,314 citations

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1976 • 1,247 citations

THE EXCITATION AND DEPRESSION OF SPINAL NEURONES BY STRUCTURALLY RELATED AMINO ACIDS

1960 • 853 citations

Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system

1971 • 808 citations

Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNS

1981 • 728 citations

Ibotenic acid-induced neuronal degeneration: A morphological and neurochemical study

1979 • 467 citations

GLUTAMATE-INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS

1971 • 409 citations

BINDING OF [³H]KAINIC ACID, AN ANALOGUE OF <scp>l</scp>‐GLUTAMATE, TO BRAIN MEMBRANES

1976 • 308 citations

Acute dendrotoxic changes in the hippocampus of kainate treated rats

1979 • 306 citations

Glutamate as a Neurotransmitter

2018 • 271 citations

Evidence suggesting secondary epileptogenic lesions after kainic acid: pretreatment with diazepam reduces distant but not local brain damage

1979 • 249 citations

Abnormal Glutamate Metabolism in an Adult-Onset Degenerative Neurological Disorder

1982 • 227 citations

Activation of dopamine receptors inhibits calcium-dependent glutamate release from cotico-striatal terminals in vitro

1980 • 189 citations

Structure-activity relations for the neurotoxicity of kainic acid derivatives and glutamate analogues

1978 • 182 citations

Sustained electrical stimulation of the perforant path duplicates kainate-induced electrophysiological effects and hippocampal damage in rats

1981 • 179 citations

ANTAGONISM OF EXCITATORY AMINO ACID‐INDUCED RESPONSES AND OF SYNAPTIC EXCITATION IN THE ISOLATED SPINAL CORD OF THE FROG

1979 • 152 citations

Fine structural changes in the rat striatum after local injections of kainic acid

1977 • 142 citations

Acute Elevations of Serum Luteinizing Hormone Induced by Kainic Acid, N-Methyl Aspartic Acid or Homocysteic Acid

1978 • 116 citations

Kainate-like neurotoxicity of folates

1981 • 108 citations

Kainic acid and the glutamate receptor

1978 • 102 citations

Methyltetrahydrofolate is a potent and selective agonist for kainic acid receptors

1980 • 93 citations

Evidence supporting the indirect depolarization of primary afferent terminals in the frog by excitatory amino acids

1980 • 86 citations

Depression of synaptic excitation and of amino acid induced excitatory responses of spinal neurones by D-α-aminoadipate, α,ϵ-diaminopimelic acid and HA-966

1977 • 76 citations

Stereospecificity of the gliotoxic and anti-neurotoxic actions of alpha-aminoadipate

1980 • 74 citations

Phylogenetic distribution of [3H]kainic acid receptor binding sites in neuronal tissue

1980 • 72 citations

Alteration in Neuronal‐Glial Metabolism of Glutamate by the Neurotoxin Kainic Acid

1982 • 72 citations

Kainic acid neurotoxicity; effect of systemic injection on neurotransmitter markers in different brain regions

1981 • 71 citations

The fate of synaptic receptors in the kainate-lesioned striatum

1978 • 68 citations

D-aminaphosphonovalerate is 100-fold more powerful than D-alpha-aminoadipate in blocking N-methylaspartate neurotoxicity

1981 • 61 citations

The action of D-α-aminoadipate on excitatory amino acid receptors of rat thalamic neurones

1978 • 56 citations

Intrastriatal folic acid mimics the distant but not local brain damaging properties of kainic acid

1981 • 52 citations

Cooperative interactions at [3H]kainic acid binding sites in rat and human cerebellum

1979 • 51 citations

A microiontophoretic study of the action of kainic acid and putative neurotransmitters in the rat mesencephalic trigeminal nucleus

1980 • 50 citations

Activity of the enantiomers of 2-amino-5-phosphono-valeric acid as stereospecific antagonists of excitatory aminoacids

1981 • 43 citations

α-Aminoadipate blocks the neurotoxic action of N-methyl aspartate

1979 • 42 citations

Selective resistance of sensory cells of the mesencephalic trigeminal nucleus to kainic acid-induced lesions

1979 • 42 citations

Systemic dipiperidinoethane mimics the convulsant and neurotoxic actions of kainic acid

1980 • 28 citations

123 ULTRASTRUCTURAL ANALYSIS OF HIPPOCAMPAL DAMAGE PRODUCED BY SUSTAINED PERFORANT PATH STIMULATION IN THE RAT

1981 • 4 citations