Signalling aspects of insulin resistance in skeletal muscle

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

The extended protein kinase C superfamily

1998 • 1,544 citations

Mechanism of free fatty acid-induced insulin resistance in humans.

1996 • 1,507 citations

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307

2000 • 1,423 citations

Protein kinase C activation and the development of diabetic complications.

1998 • 1,328 citations

Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link

1994 • 1,302 citations

Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

1999 • 1,300 citations

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

1999 • 1,256 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

1998 • 1,142 citations

Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle

2000 • 1,119 citations

Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

1999 • 1,084 citations

Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.

1991 • 980 citations

Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

1999 • 867 citations

Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years

1998 • 856 citations

REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS

1998 • 804 citations

Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes

1998 • 765 citations

Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

1999 • 762 citations

Multiple pathways control protein kinase C phosphorylation

2000 • 598 citations

Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate

1999 • 590 citations

A Molecular Basis for Insulin Resistance

1997 • 550 citations

Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.

1993 • 543 citations

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.

1995 • 524 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

Effects of fat on insulin-stimulated carbohydrate metabolism in normal men.

1991 • 506 citations

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors.

1996 • 490 citations

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

1999 • 483 citations

An update of the enzymology and regulation of sphingomyelin metabolism

1990 • 460 citations

Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide

1998 • 447 citations

Reduced O Glycosylation of Sp1 Is Associated with Increased Proteasome Susceptibility

1997 • 429 citations

Tumor Necrosis Factor α-induced Phosphorylation of Insulin Receptor Substrate-1 (IRS-1)

1995 • 426 citations

Tumor Necrosis Factor (TNF)-α Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase

1996 • 404 citations

Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients.

2000 • 374 citations

Insulin Receptor Substrate-1 Phosphorylation and Phosphatidylinositol 3-Kinase Activity in Skeletal Muscle From NIDDM Subjects After In Vivo Insulin Stimulation

1997 • 347 citations

Inhibition of Akt Kinase by Cell-permeable Ceramide and Its Implications for Ceramide-induced Apoptosis

1998 • 344 citations

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

2000 • 344 citations

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

1997 • 316 citations

Alterations in the Expression and Cellular Localization of Protein Kinase C Isozymes ε and θ Are Associated With Insulin Resistance in Skeletal Muscle of the High-Fat–Fed Rat

1997 • 315 citations

Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.

1988 • 315 citations

Role of the glucosamine pathway in fat-induced insulin resistance.

1997 • 315 citations

Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.

1994 • 305 citations

Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation and Function by Mitogen-activated Protein Kinase

1997 • 300 citations

New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin

1997 • 293 citations

Insulin-Stimulated Akt Kinase Activity Is Reduced in Skeletal Muscle From NIDDM Subjects

1998 • 293 citations

Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.

1986 • 275 citations

Protein kinase C binding partners

2000 • 264 citations

Phosphorylation of Insulin Receptor Substrate-1 on Multiple Serine Residues, 612, 632, 662, and 731, Modulates Insulin Action

1996 • 255 citations

Novel Roles of Specific Isoforms of Protein Kinase C in Activation of the c-fos Serum Response Element

1999 • 255 citations

Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.

1999 • 253 citations

Protein Kinase C Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation Requires Serine 612

1997 • 245 citations

High-Fat Feeding Impairs Insulin-Stimulated GLUT4 Recruitment via an Early Insulin-Signaling Defect

1997 • 228 citations

Akt Protein Kinase Inhibits Rac1-GTP Binding through Phosphorylation at Serine 71 of Rac1

2000 • 217 citations

A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat

1994 • 217 citations

Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation by an Akt/Phosphatidylinositol 3-Kinase Pathway

1999 • 207 citations

Diacylglycerol and Phosphatidate Generated by Phospholipases C and D, Respectively, Have Distinct Fatty Acid Compositions and Functions

1997 • 200 citations

Inhibition of PKB/Akt1 by C2-Ceramide Involves Activation of Ceramide-Activated Protein Phosphatase in PC12 Cells

2000 • 197 citations

Phosphorylation of Insulin Receptor Substrate-1 (IRS-1) by Protein Kinase B Positively Regulates IRS-1 Function

1999 • 195 citations

BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1

1998 • 186 citations

Insulin Signalling

1999 • 183 citations

Protein kinase C isotypes and signaling in neutrophils. Differential substrate specificities of a translocatable calcium- and phospholipid-dependent beta-protein kinase C and a phospholipid-dependent protein kinase which is inhibited by long chain fatty acyl coenzyme A

1991 • 163 citations

Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling.

1993 • 162 citations

PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus

1998 • 160 citations

Sphingomyelinase and Ceramide Suppress Insulin-induced Tyrosine Phosphorylation of the Insulin Receptor Substrate-1

1996 • 153 citations

Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus.

1996 • 152 citations

A High Fat Diet Impairs Stimulation of Glucose Transport in Muscle

1998 • 146 citations

Glucosamine-induced Insulin Resistance in 3T3-L1 Adipocytes Is Caused by Depletion of Intracellular ATP

1998 • 144 citations

Chronic Activation of Protein Kinase C in Soleus Muscles and Other Tissues of Insulin-Resistant Type II diabetic Goto-Kakizaki (GK), Obese/Aged, and Obese/Zucker Rats: A Mechanism For Inhibiting Glycogen Synthesis

1996 • 140 citations

Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia.

1995 • 140 citations

Translocation of Protein Kinase Cε and Protein Kinase Cδ to Membrane Is Required for Ultraviolet B-induced Activation of Mitogen-activated Protein Kinases and Apoptosis

1999 • 137 citations

Atypical PKC ζ is activated by ceramide, resulting in coactivation of NF-κb/JNK kinase and cell survival

1999 • 135 citations

The Tissue Concentration of UDP-N-acetylglucosamine Modulates the Stimulatory Effect of Insulin on Skeletal Muscle Glucose Uptake

1997 • 128 citations

Phosphorylation of glycogen synthase by the Ca2+- and phospholipid-activated protein kinase (protein kinase C).

1984 • 127 citations

Protein Kinase Cζ Is a Negative Regulator of Protein Kinase B Activity

1999 • 127 citations

Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells.

1999 • 120 citations

Selective Ceramide Binding to Protein Kinase C-α and -δ Isoenzymes in Renal Mesangial Cells

1998 • 116 citations

Effects of Cell-Permeable Ceramides and Tumor Necrosis Factor-α on Insulin Signaling and Glucose Uptake in 3T3-L1 Adipocytes

1998 • 112 citations

Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats - effects of feeding

1999 • 112 citations

Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle.

1999 • 104 citations

Mechanism of Hexosamine-Induced Insulin Resistance in Transgenic Mice Overexpressing Glutamine:Fructose-6-Phosphate Amidotransferase: Decreased Glucose Transporter GLUT4 Translocation and Reversal by Treatment with Thiazolidinedione*

1999 • 104 citations

Protein kinase C isoforms α, δ and θ require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells)

1998 • 103 citations

Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity.

1994 • 102 citations

Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats.

1999 • 102 citations

Tyrosine phosphorylation of specific protein kinase C isoenzymes participates in insulin stimulation of glucose transport in primary cultures of rat skeletal muscle.

1999 • 97 citations

Cross‐talk mechanisms in the development of insulin resistance of skeletal muscle cells

1999 • 97 citations

A Novel Phosphoprotein Inhibitor of Protein Type-1 Phosphatase Holoenzymes

1999 • 96 citations

Potential Role of TNFα and Lipoprotein Lipase as Candidate Genes for Obesity ,

1997 • 92 citations

Membrane-targeted Phosphatidylinositol 3-Kinase Mimics Insulin Actions and Induces a State of Cellular Insulin Resistance

1999 • 91 citations

Enhanced Stimulation of Diacylglycerol and Lipid Synthesis by Insulin in Denervated Muscle: Altered Protein Kinase C Activity and Possible Link to Insulin Resistance

1991 • 90 citations

Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

1999 • 89 citations

Protein Kinase Cδ Mediates Insulin-Induced Glucose Transport in Primary Cultures of Rat Skeletal Muscle

1999 • 88 citations

Pioglitazone time-dependently reduces tumour necrosis factor-α level in muscle and improves metabolic abnormalities in Wistar fatty rats

1998 • 88 citations

Activation of protein kinase C alpha inhibits insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1.

1994 • 87 citations

Threonine 1336 of the human insulin receptor is a major target for phosphorylation by protein kinase C

1990 • 87 citations

Expression of the major isoenzyme of protein kinase-C in skeletal muscle, nPKC theta, varies with muscle type and in response to fructose-induced insulin resistance.

1994 • 80 citations

Modulation of intracellular calcium transients and dopamine release by neuropeptide Y in PC-12 cells

1994 • 80 citations

Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II.

1993 • 80 citations

Purification and Characterization of Ceramide-Activated Protein Phosphatases

1998 • 72 citations

Thiazolidinedione Treatment Enhances Insulin Effects on Protein Kinase C-ζ/λ Activation and Glucose Transport in Adipocytes of Nondiabetic and Goto-Kakizaki Type II Diabetic Rats

2000 • 68 citations

Rapid and Long Term Effects of Protein Kinase C on Receptor Tyrosine Kinase Phosphorylation and Degradation

1995 • 67 citations

Increased flux through the hexosamine biosynthesis pathway inhibits glucose transport acutely by activation of protein kinase C

1997 • 65 citations

Effects of insulin on the translocation of protein kinase C-θ and other protein kinase C isoforms in rat skeletal muscles

1995 • 64 citations

Diabetes induces selective alterations in the expression of protein kinase C isoforms in hepatocytes

1993 • 61 citations

Expression of four protein kinase C isoforms in rat fibroblasts. Differential alterations in ras-, src-, and fos-transformed cells.

1992 • 58 citations

Transcriptional Regulation of Transforming Growth Factor β1 by Glucose: Investigation into the Role of the Hexosamine Biosynthesis Pathway

2020 • 58 citations

Cellular Mechanism of Nutritionally Induced Insulin Resistance: The Desert Rodent Psammomys obesus and Other Animals in which Insulin Resistance leads to Detrimental Outcome

1998 • 56 citations

Palmitoyl‐CoA and the acyl‐CoA thioester of the carcinogenic peroxisome‐proliferator ciprofibrate potentiate diacylglycerol‐activated protein kinase C by decreasing the phosphatidylserine requirement of the enzyme

1990 • 53 citations

Characterization of free and glyceride-esterified long chain fatty acids in different skeletal muscle types of the rat.

1998 • 53 citations

Protein Kinase C Modulates the Insulin-Stimulated Increase in Akt1 and Akt3 Activity in 3T3-L1 Adipocytes

1998 • 52 citations

Insulin stimulates phospholipase D-dependent phosphatidylcholine hydrolysis, Rho translocation, de novo phospholipid synthesis, and diacylglycerol/protein kinase C signaling in L6 myotubes.

1996 • 44 citations

Insulin increases mRNA levels of protein kinase C-α and -β in rat adipocytes and protein kinase C-α, -β and -θ in rat skeletal muscle

1995 • 43 citations

Effect of Tumor Necrosis Factor‐α on Insulin‐Stimulated Mitogen‐Activated Protein Kinase Cascade in Cultured Rat Skeletal Muscle Cells

1996 • 43 citations

Discordant Effects of Glucosamine on Insulin-stimulated Glucose Metabolism and Phosphatidylinositol 3-Kinase Activity

1999 • 42 citations

Identification of a phosphorylation site of the rat insulin receptor catalyzed by protein kinase C in an intact cell

1989 • 41 citations

Molecular mechanisms of insulin action in normal and insulin-resistant states

2009 • 40 citations

Phorbol ester-mediated protein kinase C interaction with wild-type and COOH-terminal truncated insulin receptors.

1991 • 40 citations

Glucosamine induces translocation of Protein kinase C isoenzymes in mesangial cells

2009 • 39 citations

Transcriptional Regulation of Insulin Receptor Substrate 1 by Protein Kinase C

1996 • 36 citations

Acute and Chronic Exposure to Tumor Necrosis Factor-α Fails to Affect Insulin-Stimulated Glucose Metabolism of Isolated Rat Soleus Muscle*

1997 • 35 citations

In L6 Skeletal Muscle Cells, Glucose Induces Cytosolic Translocation of Protein Kinase C-α and Trans-activates the Insulin Receptor Kinase

1999 • 35 citations

Distinct Effects of Saturated Fatty Acids on Protein Kinase C Subspecies1

1995 • 34 citations

Identification of serines‐1035/1037 in the kinase domain of the insulin receptor as protein kinase Cα mediated phosphorylation sites

1994 • 34 citations

Extracellular matrix induced by TGFβ impairs insulin signal transduction in 3T3-L1 preadipose cells

1998 • 33 citations

Effect of fatty acids and their acyl-CoA esters on protein kinase C activity in fibroblasts: Possible implications in fatty acid oxidation defects

1994 • 31 citations

Long chain fatty acids as modulators of gene transcription in preadipose cells

1999 • 28 citations

Interaction of the human insulin receptor tyrosine kinase from the baculovirus expression system with protein kinase C in a cell-free system.

1993 • 27 citations

Ectopic Expression of Protein Kinase CβII, -δ, and -ϵ, but Not -βI or -ζ, Provide for Insulin Stimulation of Glucose Uptake in NIH-3T3 Cells

1999 • 26 citations

Induction of Insulin Resistance in Primary Cultured Adult Cardiac Myocytes*

1991 • 26 citations

Differential recovery of protein kinase C-α and -ɛ isozymes after long-term phorbol ester treatment in rat renal mesangial cells

1991 • 25 citations

Role of JTT-501, a new insulin sensitiser, in restoring impaired GLUT4 translocation in adipocytes of rats fed a high fat diet

1998 • 24 citations

The role of phosphatidylinositide‐3‐kinase in basal mitogen‐activated protein kinase activity and cell survival

1999 • 24 citations

Effect of tumor necrosis factor-α on insulin signal transduction in rat adipocytes: relation to PKCβ and ζ translocation

1999 • 22 citations

Phorbol Esters Induce Insulin Receptor Phosphorylation in Transfected Fibroblasts without Affecting Tyrosine Kinase Activity

1993 • 21 citations

Untitled

1999 • 20 citations

Tissue- and isoform-specific effects of aging in rats on protein kinase C in insulin-sensitive tissues

1999 • 18 citations

Effects of insulin on protein kinase-C (PKC) in HIRC-B cells: specific activation of PKC epsilon and its resistance to phorbol ester-induced down-regulation.

1994 • 18 citations

Human insulin receptor mutated at threonine 1336 functions normally in Chinese hamster ovary cells

1993 • 8 citations

Endocrine and nutritional modulation of glucose disposal and storage in muscle

1997 • 7 citations

The Effect of Acute (60 minute) Insulin Stimulation upon Human Skeletal Muscle Glycogen Synthase and Protein Phosphatase‐1 in Non‐insulin‐dependent Diabetic Patients and Control Subjects

1995 • 5 citations