In L6 Skeletal Muscle Cells, Glucose Induces Cytosolic Translocation of Protein Kinase C-α and Trans-activates the Insulin Receptor Kinase

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose

1968 • 1,213 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Regulation of protein kinase C

1997 • 919 citations

The insulin signalling system and the IRS proteins

1997 • 582 citations

Lysophosphatidic acid: G-protein signalling and cellular responses

1997 • 492 citations

Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells.

1981 • 440 citations

A synthetic peptide substrate for selective assay of protein kinase C

1990 • 292 citations

Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.

1986 • 275 citations

Kinetics of glucose disposal in whole body and across the forearm in man.

1987 • 268 citations

Ceramide Inactivates Cellular Protein Kinase Cα

1996 • 251 citations

Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides.

1994 • 242 citations

Tumor necrosis factor-alpha- and hyperglycemia-induced insulin resistance. Evidence for different mechanisms and different effects on insulin signaling.

1996 • 222 citations

Glucose metabolism in perfused skeletal muscle. Interaction of insulin and exercise on glucose uptake

1975 • 211 citations

Ceramide-induced Translocation of Protein Kinase C-δ and -ϵ to the Cytosol

1997 • 178 citations

Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling.

1993 • 162 citations

Differential expression of the GLUT1 and GLUT4 glucose transporters during differentiation of L6 muscle cells

1991 • 148 citations

Exercise-Induced Increase in Glucose Transporters in Plasma Membranes of Rat Skeletal Muscle*

1989 • 134 citations

Hypoxia Stimulates Glucose Transport in Insulin-Resistant Human Skeletal Muscle

1995 • 118 citations

Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase.

1994 • 117 citations

Influence of hyperglycemia on insulin's in vivo effects in type II diabetes.

1984 • 117 citations

Insulin and Glucose-dependent Regulation of the Glucose Transport System in the Rat L6 Skeletal Muscle Cell Line

1989 • 110 citations

Acute and chronic effects of hyperglycaemia on glucose metabolism

1990 • 104 citations

Prevention by Protein Kinase C Inhibitors of Glucose-Induced Insulin-Receptor Tyrosine Kinase Resistance in Rat Fat Cells

1991 • 94 citations

Protein kinase C isoforms β 1 and β 2 inhibit the tyrosine kinase activity of the insulin receptor

1997 • 94 citations

Activation of protein kinase C alpha inhibits insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1.

1994 • 87 citations

Acute Hyperglycemia Provides an Insulin-Independent Inducer for GLUT4 Translocation in C2C12 Myotubes and Rat Skeletal Muscle

1995 • 79 citations

Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites.

1996 • 77 citations

Activation of Protein Kinase Cα Inhibits Signaling by Members of the Insulin Receptor Family

1995 • 74 citations

Glucose and a-ketoisocaproate induce transient inward currents in rat pancreatic beta cells

1997 • 54 citations

Streptavidin blotting: a sensitive technique to study cell surface proteins; application to investigate autophosphorylation and endocytosis of biotin-labeled insulin receptors.

1993 • 54 citations

The role of protein kinase C in insulin action

1992 • 53 citations

Cellular and molecular pathogenesis

1996 • 52 citations

High Glucose Condition Activates Protein Tyrosine Phosphatases and Deactivates Insulin Receptor Function in Insulin-Sensitive Rat 1 Fibroblasts

1994 • 51 citations

Hyperglycemia Activates Glucose Transport in Rat Skeletal Muscle Via a Ca2+-Dependent Mechanism

1995 • 49 citations

The biological activity of the human epidermal growth factor receptor is positively regulated by its C-terminal tyrosines.

1991 • 45 citations

In NIH-3T3 Fibroblasts, Insulin Receptor Interaction with Specific Protein Kinase C Isoforms Controls Receptor Intracellular Routing

1998 • 45 citations

Differential Role of Insulin Receptor Substrate (IRS)-1 and IRS-2 in L6 Skeletal Muscle Cells Expressing the Arg1152 → Gln Insulin Receptor

1999 • 44 citations

Mutation in a conserved motif next to the insulin receptor key autophosphorylation sites de-regulates kinase activity and impairs insulin action.

1993 • 41 citations

Molecular and cellular biology of diabetes mellitus

1990 • 39 citations

In Skeletal Muscle, Glucose Storage and Oxidation Are Differentially Impaired by the IR1152 Mutant Receptor

1997 • 28 citations

Use of electroblotting to detect and analyze phosphotyrosine containing peptides separated by two-dimensional gel electrophoresis

1987 • 27 citations

The glucoregulatory response to intravenous glucose infusion in normal man: Roles of insulin and glucose

1981 • 16 citations

Regulation of glycogen synthetase and phosphorylase phosphatase activities in rat adipose tissue

1977 • 12 citations