Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

1990 • 1,226 citations

Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.

1985 • 1,147 citations

The Relation between Insulin Sensitivity and the Fatty-Acid Composition of Skeletal-Muscle Phospholipids

1993 • 839 citations

REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS

1998 • 804 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

The IRS-signalling system: A network of docking proteins that mediate insulin action

1998 • 693 citations

What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes

1992 • 664 citations

Fish Oil Prevents Insulin Resistance Induced by High-Fat Feeding in Rats

1987 • 658 citations

Development of Muscle Insulin Resistance After Liver Insulin Resistance in High-Fat–Fed Rats

1991 • 586 citations

The insulin signalling system and the IRS proteins

1997 • 582 citations

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.

1995 • 524 citations

Untitled

1998 • 523 citations

An update of the enzymology and regulation of sphingomyelin metabolism

1990 • 460 citations

Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide

1998 • 447 citations

Insulin Receptor Substrate-1 Phosphorylation and Phosphatidylinositol 3-Kinase Activity in Skeletal Muscle From NIDDM Subjects After In Vivo Insulin Stimulation

1997 • 347 citations

Inhibition of Akt Kinase by Cell-permeable Ceramide and Its Implications for Ceramide-induced Apoptosis

1998 • 344 citations

A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat

1985 • 337 citations

Alterations in the Expression and Cellular Localization of Protein Kinase C Isozymes ε and θ Are Associated With Insulin Resistance in Skeletal Muscle of the High-Fat–Fed Rat

1997 • 315 citations

New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin

1997 • 293 citations

Insulin Signalling and Insulin Actions in the Muscles and Livers of Insulin-Resistant, Insulin Receptor Substrate 1-Deficient Mice

1996 • 289 citations

1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.

1990 • 273 citations

Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.

1992 • 263 citations

Free–Fatty Acid Inhibition of Insulin Binding, Degradation, and Action in Isolated Rat Hepatocytes

1990 • 252 citations

Mechanisms decreasing glucose oxidation in diabetes and starvation: Role of lipid fuels and hormones

1988 • 241 citations

Leptin stimulates glucose transport and glycogen synthesis in C 2 C 12 myotubes: evidence for a PI3-kinase mediated effect

1997 • 207 citations

BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1

1998 • 186 citations

Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha ) promoted by hyperosmotic stress

1998 • 175 citations

Saturated fatty Acid–Induced Insulin Resistance in Rat Adipocytes

1994 • 137 citations

Overexpression of Rad Inhibits Glucose Uptake in Cultured Muscle and Fat Cells

1996 • 122 citations

Effects of Cell-Permeable Ceramides and Tumor Necrosis Factor-α on Insulin Signaling and Glucose Uptake in 3T3-L1 Adipocytes

1998 • 112 citations

jun N-terminal Kinase Mediates Activation of Skeletal Muscle Glycogen Synthase by Insulin in Vivo

1996 • 109 citations

Phosphorylation of Sites 3a and 3b (Ser640 and Ser644) in the Control of Rabbit Muscle Glycogen Synthase

1995 • 94 citations

Fatty Acid-Induced Insulin Resistance in Adipocytes*

1997 • 91 citations

Insulin Receptor Substrate (IRS)-2 Is Dephosphorylated More Rapidly than IRS-1 via Its Association with Phosphatidylinositol 3-Kinase in Skeletal Muscle Cells

1997 • 83 citations

Protein Phosphatase-1 and insulin action

1998 • 70 citations

Increased concentrations of phosphatidate, diacylglycerol and ceramide in ras- and tyrosine kinase (fps)-transformed fibroblasts

1997 • 58 citations

Untitled

1998 • 54 citations

Characterization of free and glyceride-esterified long chain fatty acids in different skeletal muscle types of the rat.

1998 • 53 citations

Insulin action on glucose transport in isolated cardiac myocytes: signalling pathways and diabetes-induced alterations

1990 • 52 citations

Conditional, Tissue-specific Expression of Q205L Gαi2 in Vivo Mimics Insulin Activation of c-Jun N-terminal Kinase and p38 Kinase

1998 • 36 citations

Impaired skeletal muscle glycogen synthase activation by insulin in the Goto-Kakizaki (G/K) rat

1994 • 35 citations

Fatty acid induced insulin resistance in rat-1 fibroblasts overexpressing human insulin receptors: impaired insulin-stimulated mitogen-activated protein kinase activity

1997 • 31 citations

Induction of Insulin Resistance in Primary Cultured Adult Cardiac Myocytes*

1991 • 26 citations

Exogenous Triacylglycerol Inhibits Insulin-Stimulated Glucose Transport in L6 Muscle Cells in Vitro

1995 • 16 citations

Endocrine and nutritional modulation of glucose disposal and storage in muscle

1997 • 7 citations