Role of JTT-501, a new insulin sensitiser, in restoring impaired GLUT4 translocation in adipocytes of rats fed a high fat diet

Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease

1991 • 4,548 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.

1980 • 1,066 citations

Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.

1980 • 1,042 citations

Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes

1996 • 1,004 citations

Potential mechanism of insulin action on glucose transport in the isolated rat diaphragm. Apparent translocation of intracellular transport units to the plasma membrane.

1981 • 852 citations

Predictors of Progression From Impaired Glucose Tolerance to NIDDM: An Analysis of Six Prospective Studies

1997 • 611 citations

Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats

1986 • 465 citations

Characterization of New Oral Antidiabetic Agent CS-045: Studies in KK and ob/ob Mice and Zucker Fatty Rats

1988 • 459 citations

PREPARATION AND CHARACTERIZATION OF A PLASMA MEMBRANE FRACTION FROM ISOLATED FAT CELLS

1970 • 402 citations

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

1994 • 362 citations

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.

1992 • 328 citations

cAMP-dependent protein kinase and lipolysis in rat adipocytes. I. Cell preparation, manipulation, and predictability in behavior.

1985 • 302 citations

Thiazolidinediones in the treatment of insulin resistance and type II diabetes

1996 • 302 citations

An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects.

1988 • 292 citations

Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus

1982 • 276 citations

Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes.

1975 • 275 citations

In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus.

1983 • 249 citations

Glucose Transport: Pivotal Step in Insulin Action

1996 • 249 citations

Activated Phosphatidylinositol 3-Kinase Is Sufficient to Mediate Actin Rearrangement and GLUT4 Translocation in 3T3-L1 Adipocytes

1996 • 239 citations

Glucose tolerance in young and older athletes and sedentary men

1984 • 229 citations

A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat

1994 • 217 citations

A Human Peroxisome‐Proliferator‐Activated Receptor‐γ is Activated by Inducers of Adipogenesis, Including Thiazolidinedione Drugs

1996 • 202 citations

Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies

1997 • 200 citations

Overexpression of Catalytic Subunit p110α of Phosphatidylinositol 3-Kinase Increases Glucose Transport Activity with Translocation of Glucose Transporters in 3T3-L1 Adipocytes

1996 • 194 citations

Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation.

1992 • 180 citations

Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor-alpha on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3-L1 cells.

1995 • 170 citations

Insulin Induces the Translocation of GLUT4 From a Unique Intracellular Organelle to Transverse Tubules in Rat Skeletal Muscle

1992 • 164 citations

p85α Gene Generates Three Isoforms of Regulatory Subunit for Phosphatidylinositol 3-Kinase (PI 3-Kinase), p50α, p55α, and p85α, with Different PI 3-Kinase Activity Elevating Responses to Insulin

1997 • 161 citations

Decreased Insulin Binding, Glucose Transport, and Glucose Metabolism in Soleus Muscle of Rats Fed a High Fat Diet

1982 • 155 citations

Studies with antipeptide antibody suggest the presence of at least two types of glucose transporter in rat brain and adipocyte.

1988 • 152 citations

Roles of 1-Phosphatidylinositol 3-Kinase and ras in Regulating Translocation of GLUT4 in Transfected Rat Adipose Cells

1995 • 149 citations

Requirement for Phosphoinositide 3-Kinase in Insulin-Stimulated GLUT4 Translocation in 3T3-L1 Adipocytes

1995 • 143 citations

Repeat Treatment of Obese Mice With BRL 49653, a New Potent Insulin Sensitizer, Enhances Insulin Action in White Adipocytes: Association With Increased Insulin Binding and Cell-Surface GLUT4 as Measured by Photoaffinity Labeling

1995 • 139 citations

Glucose Transport Deficiency in Diabetic Animals Is Corrected by Treatment with the Oral Antihyperglycemic Agent Pioglitazone*

1991 • 135 citations

Role of Phosphatidylinositol-3-Kinase in Insulin Receptor Signaling: Studies with Inhibitor, LY294002

1994 • 135 citations

Insulin action rapidly modulates the apparent affinity of the insulin-like growth factor II receptor.

1983 • 132 citations

Pioglitazone Increases Insulin Sensitivity by Activating Insulin Receptor Kinase

1992 • 122 citations

Antidiabetic agent pioglitazone enhances adipocyte differentiation of 3T3-F442A cells

1993 • 113 citations

High Fat Feeding Causes Insulin Resistance and a Marked Decrease in the Expression of Glucose Transporters (Glut 4) in Fat Cells of Rats*

1991 • 112 citations

Diabetes and diabetes risk factors in second- and third-generation Japanese Americans in Seattle, Washington

1994 • 111 citations

EPIDEMIOLOGY, OBESITY, AND NON-INSULIN-DEPENDENT DIABETES MELLITUS

1989 • 107 citations

Role of Glucose Transport in the Postreceptor Defect of Non-insulin-dependent Diabetes Mellitus

1982 • 106 citations

Lower Prevalence of Diabetes in Female Former College Athletes Compared With Nonathletes

1986 • 87 citations

Troglitazone Prevents Glucose-Induced Insulin Resistance of Insulin Receptor in Rat-1 Fibroblasts

1994 • 84 citations

The antidiabetic agent pioglitazone increases expression of glucose transporters in 3T3-F442A cells by increasing messenger ribonucleic acid transcript stability.

1993 • 84 citations

Domains responsible for the differential targeting of glucose transporter isoforms.

1992 • 82 citations

In-vitro and In-vivo Responsiveness of Muscle and Adipose Tissue to Insulin in Rats Rendered Obese by a High-fat Diet

1978 • 77 citations

Glucose transport: locus of muscle insulin resistance in obese Zucker rats

1988 • 74 citations

Regulation of glucose transport in cultured muscle cells by novel hypoglycemic agents

1995 • 72 citations

Lilly lecture 1995. Glucose transport: pivotal step in insulin action

1996 • 68 citations

Level of skeletal muscle glucose transporter protein correlates with insulin-stimulated whole body glucose disposal in man

1991 • 60 citations

Potentiation of insulin stimulation of phosphatidylinositol 3-kinase by thiazolidinedione-derived antidiabetic agents in Chinese hamster ovary cells expressing human insulin receptors and L6 myotubes.

1994 • 57 citations

Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT4 glucose transporter expression in rat skeletal muscle

1993 • 57 citations

Insulin Treatment Reverses the Postreceptor Defect in Adipocyte 3-O-Methylglucose Transport in Type II Diabetes Mellitus*

1983 • 56 citations

Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor-alpha on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3-L1 cells

1995 • 56 citations

Failure of insulin-regulated recruitment of the glucose transporter GLUT4 in cardiac muscle of obese Zucker rats is associated with alterations of small-molecular-mass GTP-binding proteins

1995 • 55 citations

Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in Fao hepatoma cells.

1995 • 49 citations

Decreased insulin binding, glucose transport, and glucose metabolism in soleus muscle of rats fed a high fat diet

1982 • 49 citations

Effect of troglitazone (CS-045) and bezafibrate on glucose tolerance, Liver Glycogen synthase activity, and β-oxidation in fructose-fed rats

1995 • 48 citations

High-fat feeding induces tissue-specific alteration in proportion of activated insulin receptors in rats

1990 • 38 citations

Insulin induces the translocation of GLUT4 from a unique intracellular organelle to transverse tubules in rat skeletal muscle

1992 • 37 citations

VLDL Triglyceride Kinetics in Wistar Fatty Rats, An Animal Model of NIDDM: Effects of Dietary Fructose Alone or in Combination With Pioglitazone

1996 • 37 citations

Aetiology of non-insulin dependent diabetes

1989 • 32 citations

Lower prevalence of diabetes in female former college athletes compared with nonathletes

1986 • 30 citations

Glucose Tolerance and Physical Activity in a Health Survey of Middle‐aged Subjects

1985 • 26 citations

Gene expression of insulin signal-transduction pathway intermediates is lower in rats fed a beef tallow diet than in rats fed a safflower oil diet

1996 • 26 citations

Pioglitazone Treatment for 7 Days Failed to Correct the Defect in Glucose Transport and Glucose Transporter Translocation in Obese Zucker Rat (fa/fa) Skeletal Muscle Plasma Membranes

1995 • 24 citations

The Antihyperglycemic Agent Englitazone Prevents the Defect in Glucose Transport in Rats Fed a High-Fat Diet

1996 • 19 citations

Pioglitazone Ameliorates High Glucose Induced Desensitization of Insulin Receptor Kinase in Rat 1 Fibroblasts in Culture

1993 • 18 citations

The oxazolidinedione CP-92,768-2 partially protects insulin receptor substrate-1 from dexamethasone down-regulation in 3T3-L1 adipocytes.

1995 • 15 citations

Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in Fao hepatoma cells

1995 • 12 citations

The antihyperglycemic agent englitazone prevents the defect in glucose transport in rats fed a high-fat diet

1996 • 9 citations