Transcriptional Regulation of Transforming Growth Factor β1 by Glucose: Investigation into the Role of the Hexosamine Biosynthesis Pathway

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Transforming growth factor-beta in disease: the dark side of tissue repair.

1992 • 1,126 citations

Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.

1991 • 980 citations

Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy.

1993 • 819 citations

Glucose Toxicity

1990 • 742 citations

Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta.

1994 • 593 citations

Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator

1995 • 560 citations

Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.

1993 • 525 citations

TGF-β: Regulation of extracellular matrix

1992 • 485 citations

Reduced O Glycosylation of Sp1 Is Associated with Increased Proteasome Susceptibility

1997 • 429 citations

High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells.

1998 • 418 citations

Characterization of the Promoter Region of the Human Transforming Growth Factor-β1 Gene

1989 • 400 citations

High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β

1992 • 353 citations

Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance.

1996 • 330 citations

Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule

1992 • 264 citations

In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats.

1995 • 259 citations

High glucose causes an increase in extracellular matrix proteins in cultured mesangial cells.

1990 • 228 citations

Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells.

1992 • 184 citations

Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation

1991 • 143 citations

Localization of the carbohydrate response element of the rat L-type pyruvate kinase gene

1991 • 143 citations

Carbohydrate regulation of the rat L-type pyruvate kinase gene requires two nuclear factors: LF-A1 and a member of the c-myc family

1993 • 138 citations

Mechanisms of Glucose-Enhanced Extracellular Matrix Accumulation in Rat Glomerular Mesangial Cells

1994 • 127 citations

Effect of High Glucose on Type IV Collagen Production by Cultured Glomerular Epithelial, Endothelial, and Mesangial Cells

1993 • 120 citations

Renal tubular basement membrane and collagen type IV in diabetes mellitus

1993 • 98 citations

Transforming growth factor-beta and the glomerular extracellular matrix in renal pathology.

1994 • 96 citations

Glucose regulation of transforming growth factor-alpha expression is mediated by products of the hexosamine biosynthesis pathway.

1993 • 80 citations

Diabetic Glomerulopathy: Structural Characteristics of the Early and Advanced Stages

1983 • 75 citations

Regulation of Insulin-Stimulated Glycogen Synthase Activity by Overexpression of Glutamine: Fructose-6-Phosphate Amidotransferase in Rat-1 Fibroblasts

1993 • 66 citations

Effect of glycated proteins on the matrix of glomerular epithelial cells.

1998 • 62 citations

Regulation of Glycogen Synthase by Glucose, Glucosamine, and Glutamine:Fructose-6-Phosphate Amidotransferase

1995 • 53 citations

Evidence for cAMP-dependent Protein Kinase in Mediating the Parathyroid Hormone-stimulated Rise in Cytosolic Free Calcium in Rabbit Connecting Tubules

1989 • 43 citations

Regulation of Glycogen Synthase and Protein Phosphatase-1 by Hexosamines

1996 • 30 citations