Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation by an Akt/Phosphatidylinositol 3-Kinase Pathway

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1998 • 1,136 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

1996 • 631 citations

A Molecular Basis for Insulin Resistance

1997 • 550 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1998 • 487 citations

Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.

1997 • 428 citations

Tumor Necrosis Factor α-induced Phosphorylation of Insulin Receptor Substrate-1 (IRS-1)

1995 • 426 citations

The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action

1998 • 369 citations

Requirement for Activation of the Serine-Threonine Kinase Akt (Protein Kinase B) in Insulin Stimulation of Protein Synthesis but Not of Glucose Transport

1998 • 336 citations

Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt

1998 • 318 citations

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

1997 • 316 citations

Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.

1994 • 305 citations

Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation and Function by Mitogen-activated Protein Kinase

1997 • 300 citations

Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts

1994 • 278 citations

Protein Kinase C Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation Requires Serine 612

1997 • 245 citations

The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin.

1994 • 234 citations

Toso, a Cell Surface, Specific Regulator of Fas-Induced Apoptosis in T Cells

1998 • 224 citations

Regulation of Phosphatidylinositol 3′-Kinase by Tyrosyl Phosphoproteins

1995 • 222 citations

Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling

1998 • 198 citations

Oncostatin M is a proinflammatory mediator. In vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules.

1997 • 197 citations

The Mammalian Target of Rapamycin Phosphorylates Sites Having a (Ser/Thr)-Pro Motif and Is Activated by Antibodies to a Region near Its COOH Terminus

1997 • 165 citations

Insulin resistance and non-insulin-dependent diabetes mellitus: cellular and molecular mechanisms

1995 • 125 citations

Circulating endothelin-1 levels in obese patients with the metabolic syndrome

2009 • 100 citations

Insulin Stimulates the Degradation of IRS-1 in 3T3-L1 Adipocytes

1993 • 94 citations

Dexamethasone down-regulation of insulin receptor substrate-1 in 3T3-L1 adipocytes.

1994 • 86 citations

Platelet-derived Growth Factor Inhibits Insulin Stimulation of Insulin Receptor Substrate-1-associated Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes without Affecting Glucose Transport

1998 • 85 citations

Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II.

1993 • 80 citations

Endothelin-1 Induces Insulin Resistance in Conscious Rats

1996 • 59 citations

Cross-talk between the Platelet-derived Growth Factor and the Insulin Signaling Pathways in 3T3-L1 Adipocytes

1997 • 51 citations

Role of endothelin-1 in diabetes mellitus

1998 • 48 citations

Endothelin-1 Inhibits Insulin-Stimulation Glucose Uptake in Isolated Rat Adipocytes

1994 • 46 citations

Insulin and Interleukin-4 Induce Desensitization to the Mitogenic Effects of Insulin-like Growth Factor-I

1997 • 22 citations

Differential Regulation of Insulin-Stimulated Tyrosine Phosphorylation of IRS-1 and SHC by Wortmannin in Intact Cells

1996 • 15 citations