Diabetes induces selective alterations in the expression of protein kinase C isoforms in hepatocytes

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS

1969 • 4,428 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

1992 • 743 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.

1989 • 508 citations

Expression cloning and signaling properties of the rat glucagon receptor

1993 • 393 citations

Activation of two signal-transduction systems in hepatocytes by glucagon

1986 • 383 citations

‘Crosstalk’: a pivotal role for protein kinase C in modulating relationships between signal transduction pathways

1991 • 328 citations

Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.

1988 • 315 citations

Protein kinase C activation by cis-fatty acid in the absence of Ca2+ and phospholipids.

1986 • 309 citations

Stimulation of 1,2-diacylglycerol accumulation in hepatocytes by vasopressin, epinephrine, and angiotensin II.

1985 • 304 citations

Alfred P. Sloan Jr. prize. Studies and prospectives of the protein kinase C family for cellular regulation

1989 • 298 citations

Effect of phorbol esters on protein kinase C-zeta.

1992 • 282 citations

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

1987 • 232 citations

Unique substrate specificity and regulatory properties of PKC‐ε: a rationale for diversity

1989 • 226 citations

Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate.

1986 • 198 citations

Purification and characterisation of bovine brain protein kinase C isotypes α, β and γ

1989 • 169 citations

Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins.

1988 • 156 citations

A role for Gi in control of thrombin receptor-phospholipase C coupling in human platelets.

1988 • 138 citations

Lipopolysaccharide response is linked to the GTP binding protein, Gi2, in the promonocytic cell line U937

1989 • 119 citations

Hormonal regulation of Gi2 α-subunit phosphorylation in intact hepatocytes

1990 • 117 citations

Studies on the phosphorylation of protein kinase C-α

1992 • 103 citations

Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Withdrawal of GTP-dependent inhibition.

1986 • 102 citations

A monoclonal antibody recognising the site of limited proteolysis of protein kinase C

1988 • 96 citations

Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein Gi-2 in hepatocytes

1990 • 95 citations

Threonine 1336 of the human insulin receptor is a major target for phosphorylation by protein kinase C

1990 • 87 citations

Challenge of hepatocytes by glucagon triggers a rapid modulation of adenylate cyclase activity in isolated membranes

1983 • 81 citations

The rapid desensitization of glucagon-stimulated adenylate cyclase is a cyclic AMP-independent process that can be mimicked by hormones which stimulate inositol phospholipid metabolism

1987 • 81 citations

The design and biological properties of potent and selective inhibitors of protein kinase C

1992 • 71 citations

Vasopressin in Rats With Genetic and Streptozocin-Induced Diabetes

1989 • 66 citations

Protein kinase C

1992 • 53 citations

Effects of thrombin, phorbol myristate acetate and prostaglandin D₂ on 40–41 kDa protein that is ADP ribosylated by pertussis toxin in platelets

1986 • 52 citations

Role of cofactors in protein kinase C activation

1992 • 48 citations

Altered G-protein expression and adenylate cyclase activity in platelets of non-insulin-dependent diabetic (NIDDM) male subjects

1991 • 45 citations

Stimulated phosphatidylcholine hydrolysis as a signal transduction pathway in mitogenesis

1991 • 43 citations

Phosphorylation of the inhibitory guanine‐nucleotide‐binding protein as a possible mechanism of inhibition by protein kinase C of agonist‐induced Ca²⁺ mobilization in human platelet

1992 • 41 citations

Identification of a phosphorylation site of the rat insulin receptor catalyzed by protein kinase C in an intact cell

1989 • 41 citations

Biochemical properties of rat protein kinase C‐η expressed in COS cells

1992 • 41 citations

Glucagon, vasopressin and angiotensin all elicit a rapid, transient increase in hepatocyte protein kinase C activity

1992 • 39 citations

Do multiple species of protein kinase C transduce different signals?

1987 • 34 citations

Gi-2 at the centre of an active phosphorylation/dephosphorylation cycle in hepatocytes: The fine-tuning of stimulatory and inhibitory inputs into adenylate cyclase in normal and diabetic states

1991 • 30 citations

Activation of membrane protein kinase C by glucagon and Ca2+-mobilizing hormones in cultured rat hepatocytes. Role of phosphatidylinositol and phosphatidylcholine hydrolysis

1991 • 30 citations

Multiple modes of protein kinase C regulation and their significance in signalling

1988 • 24 citations

Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein Gi, which is inactivated upon challenge of hepatocytes with glucagon

1989 • 21 citations

Inositol phosphate metabolism: Further problems and some solutions

1989 • 14 citations

Distinct functional domains on the insulin receptor β-subunit Do they provide a molecular basis for “selective” insulin resistance?

1989 • 8 citations