Threonine 1336 of the human insulin receptor is a major target for phosphorylation by protein kinase C

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

Phosphorylation activates the insulin receptor tyrosine protein kinase.

1983 • 558 citations

A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.

1988 • 467 citations

Monoclonal antibodies to receptors for insulin and somatomedin-C.

1983 • 423 citations

Transforming potential of the c-fms proto-oncogene (CSF-1 receptor)

1987 • 357 citations

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

1986 • 325 citations

Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.

1988 • 315 citations

Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity.

1984 • 299 citations

Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C.

1983 • 291 citations

Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.

1986 • 275 citations

Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.

1984 • 260 citations

Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654.

1985 • 244 citations

Identification of insulin receptor tyrosine residues autophosphorylated in vitro.

1987 • 182 citations

Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity.

1988 • 161 citations

High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.

1987 • 151 citations

Predominance of tyrosine phosphorylation of insulin receptors during the initial response of intact cells to insulin.

1985 • 146 citations

Identification of the insulin receptor tyrosine residues undergoing insulin-stimulated phosphorylation in intact rat hepatoma cells.

1988 • 145 citations

Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects.

1988 • 144 citations

Kinetic parameters of the protein tyrosine kinase activity of EGF-receptor mutants with individually altered autophosphorylation sites.

1988 • 133 citations

Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites.

1988 • 132 citations

Alteration of epidermal growth factor receptor activity by mutation of its primary carboxyl-terminal site of tyrosine self-phosphorylation.

1988 • 120 citations

Distinct structural requirements of Ca²⁺/phospholipid‐dependent protein kinase (protein kinase C) and cAMP‐dependent protein kinase as evidenced by synthetic peptide substrates

1985 • 103 citations

Properties of a human insulin receptor with a COOH-terminal truncation. I. Insulin binding, autophosphorylation, and endocytosis.

1988 • 103 citations

Substrate specificity of phospholipid/Ca2+-dependent protein kinase as probed with synthetic peptide fragments of the bovine myelin basic protein.

1985 • 96 citations

Release of a phorbol ester-induced mitogenic block by mutation at Thr-654 of the epidermal growth factor receptor.

1988 • 83 citations

Identification of lymphocyte integral membrane proteins as substrates for protein kinase C. Phosphorylation of the interleukin-2 receptor, class I HLA antigens, and T200 glycoprotein.

1986 • 78 citations

Kinetic evidence for activating and non-activating components of autophosphorylation of the insulin receptor protein kinase

1986 • 65 citations

src kinase catalyzes the phosphorylation and activation of the insulin receptor kinase.

1985 • 64 citations

Kinetic properties of the insulin receptor tyrosine protein kinase: Activation through an insulin-stimulated tyrosine-specific, intramolecular autophosphorylation

1986 • 57 citations

Phosphorylation of the human interleukin-2 receptor and a synthetic peptide identical to its C-terminal, cytoplasmic domain.

1986 • 42 citations

Identification of a phosphorylation site of the rat insulin receptor catalyzed by protein kinase C in an intact cell

1989 • 41 citations

Phospholipid environment alters hormone-sensitivity of the purified insulin receptor kinase

1987 • 32 citations