Chronic granulomatous disease

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

The catalytic decomposition of hydrogen peroxide by iron salts

1934 • 2,483 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Chronic Granulomatous Disease: Report on a National Registry of 368 Patients

2000 • 1,680 citations

The Biochemical Basis of Phagocytosis

1959 • 1,240 citations

Active Oxygen Species and the Functions of Phagocytic Leukocytes

1980 • 1,124 citations

Sex chromatin and gene action in the mammalian X-chromosome.

1962 • 1,003 citations

Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity

1972 • 966 citations

Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.

1983 • 938 citations

In Vitro Bactericidal Capacity of Human Polymorphonuclear Leukocytes: Diminished Activity in Chronic Granulomatous Disease of Childhood *

1967 • 932 citations

Quantitative Nitroblue Tetrazolium Test in Chronic Granulomatous Disease

1968 • 894 citations

Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex

1978 • 876 citations

Genetic, Biochemical, and Clinical Features of Chronic Granulomatous Disease

2000 • 869 citations

Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.

1984 • 849 citations

Myeloperoxidase-Halide-Hydrogen Peroxide Antibacterial System

1968 • 840 citations

Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal location

1986 • 839 citations

Chlorination of Taurine by Human Neutrophils

1982 • 794 citations

The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

2002 • 753 citations

Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection

1969 • 697 citations

Studies of the Metabolic Activity of Leukocytes from Patients with a Genetic Abnormality of Phagocytic Function*

1967 • 677 citations

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

2001 • 600 citations

H2O2 Release from Human Granulocytes during Phagocytosis

1977 • 586 citations

Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

2000 • 476 citations

Is Cytosolic Ionized Calcium Regulating Neutrophil Activation?

1983 • 471 citations

Mechanism of the disproportionation of superoxide radicals

1977 • 466 citations

Minor Xp21 chromosome deletion in a male associated with expression of Duchenne muscular dystrophy, chronic granulomatous disease, retinitis pigmentosa, and McLeod syndrome.

1985 • 456 citations

Biological reactivity of hypochlorous acid: implications for microbicidal mechanisms of leukocyte myeloperoxidase.

1981 • 443 citations

Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation.

1990 • 435 citations

Interferon-Gamma, the Activated Macrophage, and Host Defense Against Microbial Challenge

1988 • 428 citations

BIOCHEMICAL AND MORPHOLOGICAL CHARACTERIZATION OF AZUROPHIL AND SPECIFIC GRANULES OF HUMAN NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES

1974 • 427 citations

Leukocyte Oxidase: Defective Activity in Chronic Granulomatous Disease

1967 • 425 citations

FATAL GRANULOMATOUS DISEASE OF CHILDHOOD

1966 • 421 citations

Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin

1984 • 418 citations

Long-Lived Oxidants Generated by Human Neutrophils: Characterization and Bioactivity

1983 • 396 citations

Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 ^c-src

1990 • 393 citations

ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.

1984 • 389 citations

Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558.

1991 • 379 citations

Defective Superoxide Production by Granulocytes from Patients with Chronic Granulomatous Disease

1974 • 375 citations

Chemiluminescence and superoxide production by myeloperoxidase-deficient leukocytes.

1976 • 373 citations

Spin trapping of superoxide.

1979 • 364 citations

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.

1985 • 358 citations

Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate.

1985 • 356 citations

The mechanism of action of superoxide dismutase from pulse radiolysis and electron paramagnetic resonance. Evidence that only half the active sites function in catalysis

1974 • 350 citations

The particulate superoxide-forming system from human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst.

1976 • 350 citations

Lactoferrin enhances hydroxyl radical production by human neutrophils, neutrophil particulate fractions, and an enzymatic generating system.

1981 • 338 citations

Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages

1984 • 335 citations

Novel cytochrome b system in phagocytic vacuoles of human granulocytes

1978 • 335 citations

Activation of the respiratory burst enzyme from human neutrophils in a cell-free system. Evidence for a soluble cofactor.

1985 • 334 citations

Activation of human neutrophil nicotinamide adenine dinucleotide phosphate, reduced (triphosphopyridine nucleotide, reduced) oxidase by arachidonic acid in a cell-free system.

1985 • 315 citations

Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.

1989 • 310 citations

An Inherited Abnormality of Neutrophil Adhesion

1980 • 306 citations

Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme.

1985 • 300 citations

Absence of Cytochrome b_-245in Chronic Granulomatous Disease

1983 • 300 citations

A Fatal Granulomatous Disease of Childhood

1959 • 297 citations

Stimulated neutrophils from patients with autosomal recessive chronic granulomatous disease fail to phosphorylate a Mr-44,000 protein

1985 • 286 citations

The origin of the chemiluminescence of phagocytosing granulocytes.

1976 • 283 citations

Coupling of the guanine nucleotide regulatory protein to chemotactic peptide receptors in neutrophil membranes and its uncoupling by islet-activating protein, pertussis toxin. A possible role of the toxin substrate in Ca2+-mobilizing receptor-mediated signal transduction.

1985 • 281 citations

Generation of Hydroxyl Radical by Enzymes, Chemicals, and Human Phagocytes In Vitro

1979 • 280 citations

LYMPHOID MALIGNANCY

1974 • 278 citations

Abnormalities of polymorphonuclear leukocyte function associated with a heritable deficiency of high molecular weight surface glycoproteins (GP138): common relationship to diminished cell adherence.

1984 • 273 citations

Superoxide Dismutases in Polymorphonuclear Leukocytes

1974 • 271 citations

Subcellular localization of the superoxide-forming enzyme in human neutrophils.

1979 • 268 citations

Chronic Granulomatous Disease

1983 • 266 citations

Ca2+ homeostasis in permeabilized human neutrophils. Characterization of Ca2+-sequestering pools and the action of inositol 1,4,5-triphosphate.

1984 • 266 citations

Genetic Variants of Chronic Granulomatous Disease: Prevalence of Deficiencies of Two Cytosolic Components of the NADPH Oxidase System

1989 • 258 citations

NADPH oxidase deficiency in X-linked chronic granulomatous disease.

1975 • 251 citations

Myeloperoxidase, hydrogen peroxide, chloride antimicrobial system: nitrogen-chlorine derivatives of bacterial components in bactericidal action against Escherichia coli

1979 • 251 citations

Characteristics of the cofactor requirements for the superoxide-generating NADPH oxidase of human polymorphonuclear leukocytes

1981 • 251 citations

Association of a Ras-related protein with cytochrome b of human neutrophils

1989 • 248 citations

The enzymic reduction and kinetics of oxidation of cytochrome b.245 of neutrophils

1982 • 247 citations

Myeloperoxidase Deficiency

1981 • 246 citations

Recent Advances in Chronic Granulomatous Disease

1983 • 236 citations

SUPRASTRIATE HEMIANOPIA

1974 • 232 citations

Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin.

1984 • 230 citations

Oxidation-reduction properties of the cytochrome b found in the plasma-membrane fraction of human neutrophils. A possible oxidase in the respiratory burst

1981 • 229 citations

Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes

1985 • 229 citations

Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes.

1983 • 223 citations

Effect of phorbol 12-myristate 13-acetate and its analogue 4 alpha-phorbol 12,13-didecanoate on protein phosphorylation and lysosomal enzyme release in rabbit neutrophils.

1984 • 221 citations

Activation of a NADPH Oxidase From Horse Polymorphonuclear Leukocytes in a Cell- Free System

1984 • 221 citations

Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C.

1985 • 216 citations

Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor.

1986 • 215 citations

Complete Deficiency of Leukocyte Glucose-6-Phosphate Dehydrogenase with Defective Bactericidal Activity

1972 • 214 citations

The O2(-) -forming oxidase responsible for the respiratory burst in human neutrophils. Properties of the solubilized enzyme.

1979 • 210 citations

Chronic Granulomatous Disease

1977 • 209 citations

Glutathione and the Hexose Monophosphate Shunt in Phagocytizing and Hydrogen Peroxide-treated Rat Leukocytes

1969 • 207 citations

The roles of extracellular and intracellular calcium in lysosomal enzyme release and superoxide anion generation by human neutrophils

1981 • 205 citations

Use of lipophilic probes of membrane potential to assess human neutrophil activation. Abnormality in chronic granulomatous disease.

1980 • 203 citations

Deficiency of Reduced Nicotinamide-Adenine Dinucleotide Oxidase in Chronic Granulomatous Disease

1968 • 201 citations

Correlation between membrane potential changes and superoxide production in human granulocytes stimulated by phorbol myristate acetate. Evidence for defective activation in chronic granulomatous disease.

1980 • 198 citations

Evaluation of Opsonic and Leukocyte Function With a Spectrophotometric Test in Patients With Infection and With Phagocytic Disorders

1973 • 197 citations

ABSENCE OF A NEWLY DESCRIBED CYTOCHROME b FROM NEUTROPHILS OF PATIENTS WITH CHRONIC GRANULOMATOUS DISEASE

1978 • 197 citations

Increased levels of cyclic adenosine-3',5'-monophosphate in human polymorphonuclear leukocytes after surface stimulation.

1980 • 193 citations

Binding of protein kinase C to neutrophil membranes in the presence of Ca2+ and its activation by a Ca2+-requiring proteinase.

1985 • 193 citations

Deficiency of a surface membrane glycoprotein (Mo1) in man.

1984 • 192 citations

Human granulocyte generation of hydroxyl radical.

1978 • 191 citations

Subcellular localization of the human neutrophil NADPH oxidase. b-Cytochrome and associated flavoprotein.

1984 • 187 citations

Failure of Nitro Blue Tetrazolium reduction in the phagocytic vacuoles of leukocytes in chronic granulomatous disease

1969 • 187 citations

Effects of oxygen tension and pH on the respiratory burst of human neutrophils

1979 • 183 citations

Biochemical aspects of phagocytosis in poly-morphonuclear leucocytes. NADH and NADPH oxidation by the granules of resting and phagocytizing cells

1964 • 182 citations

Chemotactic peptide activation of human neutrophils and HL-60 cells. Pertussis toxin reveals correlation between inositol trisphosphate generation, calcium ion transients, and cellular activation.

1985 • 182 citations

Pertussis toxin inhibits the rise in the intracellular concentration of free calcium that is induced by chemotactic factors in rabbit neutrophils: Possible role of the “G proteins” in calcium mobilization

1984 • 180 citations

Enzymatic Basis of the Respiratory Stimulation During Phagocytosis

1964 • 176 citations

Degranulation of leukocytes in chronic granulomatous disease

1969 • 175 citations

Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: role of G proteins in excitation response coupling.

1985 • 175 citations

Superoxide-forming enzyme from human neutrophils: evidence for a flavin requirement

1977 • 174 citations

Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease.

1987 • 172 citations

Lactoferrin Deficiency Associated with Altered Granulocyte Function

1982 • 172 citations

Do human neutrophils make hydroxyl radical? Determination of free radicals generated by human neutrophils activated with a soluble or particulate stimulus using electron paramagnetic resonance spectrometry.

1986 • 171 citations

The NBT slide test: A simple screening method for detecting chronic granulomatous disease and female carriers

1973 • 171 citations

Fluoride-mediated activation of the respiratory burst in human neutrophils. A reversible process.

1979 • 170 citations

Myeloperoxidase-Hydrogen Peroxide-Chloride Antimicrobial System: Effect of Exogenous Amines on Antibacterial Action Against Escherichia coli

1979 • 168 citations

A possible role for protein phosphorylation in the activation of the respiratory burst in human neutrophils. Evidence from studies with cells from patients with chronic granulomatous disease.

1986 • 168 citations

NEUTROPHIL DYSFUNCTION, CHRONIC GRANULOMATOUS DISEASE, AND NON-SPHEROCYTIC HÆMOLYTIC ANÆMIA CAUSED BY COMPLETE DEFICIENCY OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE

1973 • 163 citations

Amyloid macroglossia; report of a case.

1947 • 162 citations

The production of hydroxyl and superoxide radicals by stimulated human neutrophils — measurements by EPR spectroscopy

1979 • 161 citations

Isolation and properties of human neutrophil myeloperoxidase

1981 • 156 citations

Hydroxyl radical generation by polymorphonuclear leukocytes measured by electron spin resonance spectroscopy.

1979 • 156 citations

Ethylene formation from methional

1978 • 156 citations

Prenatal Diagnosis of Chronic Granulomatous Disease

1979 • 153 citations

The O2–producing enzyme of human neutrophils. Further properties.

1981 • 153 citations

A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease.

1989 • 148 citations

Defect in Pyridine Nucleotide Dependent Superoxide Production by a Particulate Fraction from the Granulocytes of Patients with Chronic Granulomatous Disease

1975 • 148 citations

The subcellular distribution and some properties of the cytochrome b component of the microbicidal oxidase system of human neutrophils

1979 • 145 citations

Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate.

1984 • 145 citations

Endogenous protein phosphorylation by resting and activated human neutrophils

1983 • 143 citations

Phagocytosis in Chronic Granulomatous Disease and the Chediak–Higashi Syndrome

1972 • 141 citations

Defective Bactericidal Activity in Myeloperoxidase-deficient Human Neutrophils

1969 • 139 citations

A p47-phox pseudogene carries the most common mutation causing p47-phox- deficient chronic granulomatous disease.

1997 • 138 citations

Proton secretion by stimulated neutrophils. Significance of hexose monophosphate shunt activity as source of electrons and protons for the respiratory burst.

1984 • 135 citations

Leukocyte function in chronic granulomatous disease of childhood

1969 • 134 citations

Surface‐reactive stimuli selectively increase protein phosphorylation in human neutrophils

1981 • 134 citations

Arrangement of the respiratory burst oxidase in the plasma membrane of the neutrophil.

1981 • 133 citations

B cell lines as models for inherited phagocytic diseases: abnormal superoxide generation in chronic granulomatous disease and giant granules in Chediak-Higashi syndrome.

1984 • 132 citations

Clinical Implications of Guanine Nucleotide–Binding Proteins as Receptor–Effector Couplers

1985 • 132 citations

Leukotriene production and inactivation by normal, chronic granulomatous disease and myeloperoxidase-deficient neutrophils.

1983 • 128 citations

The superoxide-generating oxidase of leucocytes. NADPH-dependent reduction of flavin and cytochrome b in solubilized preparations

1984 • 128 citations

Mechanism of the superoxide-producing oxidase of neutrophils. O2 is necessary for the fast reduction of cytochrome b-245 by NADPH

1985 • 126 citations

NAD(P)H oxidase activity in human neutrophils stimulated by phorbol myristate acetate.

1980 • 122 citations

Ethylene formation by polymorphonuclear leukocytes. Role of myeloperoxidase.

1978 • 121 citations

The pattern of genetic transmission of the leukocyte defect in fatal granulomatous disease of childhood

1968 • 120 citations

Point mutations in the beta-subunit of cytochrome b558 leading to X- linked chronic granulomatous disease

1991 • 120 citations

DNA linkage analysis of X chromosome-linked chronic granulomatous disease.

1986 • 120 citations

Activation of mouse peritoneal macrophages by lipopolysaccharide alters the kinetic parameters of the superoxide-producing NADPH oxidase.

1983 • 120 citations

Autosomal recessive chronic granulomatous disease caused by deletion at a dinucleotide repeat.

1991 • 119 citations

Stopped flow spectrophotometric observation of superoxide dismutation in aqueous solution

1976 • 118 citations

Absence of cytochrome b reduction in stimulated neutrophils from both female and male patients with chronic granulomatous disease

1980 • 117 citations

Molecular Genetics of Chronic Granulomatous Disease

1989 • 114 citations

Recombination events between the p47-phoxgene and its highly homologous pseudogenes are the main cause of autosomal recessive chronic granulomatous disease

2000 • 113 citations

The association of FAD with the cytochrome b–245 of human neutrophils

1982 • 112 citations

Structural and catalytic properties of the solubilized superoxide-generating activity of human polymorphonuclear leukocytes. Solubilization, stabilization in solution, and partial characterization

1979 • 111 citations

Functional relationship of the cytochrome b to the superoxide-generating oxidase of human neutrophils.

1982 • 109 citations

Assembly and activation of the NADPH:O2 oxidoreductase in human neutrophils after stimulation with phorbol myristate acetate.

1990 • 108 citations

A Variant of Chronic Granulomatous Disease: Deficient Oxidative Metabolism Due to a Low-Affinity NADPH Oxidase

1981 • 106 citations

IMPAIRED LEUCOTACTIC RESPONSIVENESS IN A CHILD WITH RECURRENT INFECTIONS

1969 • 106 citations

The NADPH-dependent O-.2-generating oxidase from human neutrophils.

1983 • 105 citations

A new exon created by intronic insertion of a rearranged LINE-1 element as the cause of chronic granulomatous disease

2000 • 103 citations

NADPH AND NADH OXIDATION BY GUINEA PIG POLYMORPHONUCLEAR LEUCOCYTES

1963 • 103 citations

Cytochrome b-245 from human neutrophils is a glycoprotein

1985 • 103 citations

Changes in phosphatidylinositol and phosphatidic acid in stimulated human neutrophils

1983 • 101 citations

The role of the phagocyte in host-parasite interactions

1969 • 100 citations

Hereditary myeloperoxidase deficiency

1981 • 98 citations

Identification of ubiquinone-50 in human neutrophils and its role in microbicidal events.

1982 • 98 citations

Biochemical and Biological Characterization of a Human Rac2 GTPase Mutant Associated with Phagocytic Immunodeficiency

2001 • 98 citations

Manganese-dependent NADPH oxidation by granulocyte particles. The role of superoxide and the nonphysiological nature of the manganese requirement.

1976 • 97 citations

Superoxide-forming NADPH oxidase preparation of pig polymorphonuclear leucocyte

1982 • 97 citations

Purification and partial characterization of the b-type cytochrome from human polymorphonuclear leukocytes.

1985 • 97 citations

Comparative study of the metabolic and bactericidal characteristics of severely glucose-6-phosphate dehydrogenase-deficient polymorphonuclear leukocytes and leukocytes from children with chronic granulomatous disease.

1972 • 97 citations

Studies on the mechanism of metabolic stimulation in polymorphonuclear leucocytes during phagocytosis I. Evidence for superoxide anion involvement in the oxidation of NADPH2

1975 • 95 citations

Cytoplasmic pH regulation in normal and abnormal neutrophils. Role of superoxide generation and Na+/H+ exchange.

1986 • 93 citations

Oxidative Damage to Neutrophils in Glutathione Synthetase Deficiency

1979 • 91 citations

Chronic Granulomatous Disease and the Kell Blood Groups

1975 • 90 citations

Subcellular localization of cytochrome b and ubiquinone in a tertiary granule of resting human neutrophils and evidence for a proton pump ATPase.

1984 • 90 citations

Random X inactivation resulting in mosaic nullisomy of region Xp21.1→p21.3 associated with heterozygosity for ornithine transcarbamylase deficiency and for chronic granulomatous disease

1984 • 89 citations

Defective Initiation of Oxidative Metabolism in Polymorphonuclear Leukocytes

1979 • 89 citations

Cytochrome b deficiency in an autosomal form of chronic granulomatous disease. A third form of chronic granulomatous disease recognized by monocyte hybridization.

1985 • 88 citations

Reduction and subsequent oxidation of a cytochrome b of human neutrophils after stimulation with phorbol myristate acetate

1979 • 88 citations

Purification of cytochrome b-245 from human neutrophils

1984 • 88 citations

Activation of the guinea pig granulocyte NAD(P)H-dependent superoxide generating enzyme: localization in a plasma membrane enriched particle and kinetics of activation

1980 • 88 citations

Hematologically Important Mutations: X-Linked Chronic Granulomatous Disease (Second Update)

2001 • 87 citations

Solubilization of the O2(-)-forming activity responsible for the respiratory burst in human neutrophils.

1978 • 84 citations

Autosomal recessive chronic granulomatous disease caused by defects in NCF-1, the gene encoding the phagocyte p47-phox: mutations not arising in theNCF-1 pseudogenes

2001 • 84 citations

X-linked Inheritance in Females with Chronic Granulomatous Disease

1980 • 83 citations

Opsonized zymosan-stimulated granulocytes-activation and activity of the superoxide-generating system and membrane potential changes

1981 • 81 citations

Respiratory burst oxidase from human neutrophils: purification and some properties.

1985 • 81 citations

Complementation in monocyte hybrids revealing genetic heterogeneity in chronic granulomatous disease

1984 • 80 citations

Neutrophil oxygen reduction: The enzymes and the products

1985 • 80 citations

Comparative aspects of oxidative metabolism of neutrophils from human blood and guinea pig peritonea: Magnitude of the respiratory burst, dependence upon stimulating agents, and localization of the oxidases

1980 • 79 citations

Purification and properties of a superoxide-generating oxidase from bovine polymorphonuclear neutrophils

1985 • 79 citations

Genes for two autosomal recessive forms of chronic granulomatous disease assigned to 1q25 (NCF2) and 7q11.23 (NCF1).

1990 • 77 citations

Hydrogen Peroxide Production in Chronic Granulomatous Disease

1977 • 77 citations

Chronic granulomatous disease--pieces of a cellular and molecular puzzle.

1973 • 76 citations

PX domains: attracted by phosphoinositides

2001 • 75 citations

Cytochrome b558 from (bovine) granulocytes. Partial purification from Triton X-114 extracts and properties of the isolated cytochrome.

1984 • 75 citations

Calmodulin-dependents stimulation of the NADPH oxidase of human neutrophils

1982 • 75 citations

Discoid lupus erythematosus-like lesions and stomatitis in female carriers of X-linked chronic granulomatous disease

1981 • 74 citations

The kinetics of neutrophil activation. The response to chemotactic peptides depends upon whether ligand-receptor interaction is rate-limiting.

1981 • 74 citations

The respiratory burst of bovine neutrophilis

1985 • 73 citations

Interferon-gamma improves splicing efficiency of CYBB gene transcripts in an interferon-responsive variant of chronic granulomatous disease due to a splice site consensus region mutation

2000 • 73 citations

Protein kinase C phosphorylates a component of NADPH oxidase of neutrophils

1985 • 71 citations

Phosphorylation of cytosolic proteins by resting and activated human neutrophils

1984 • 69 citations

Illness Resembling Lupus Erythematosus in Mothers of Boys with Chronic Granulomatous Disease

1972 • 69 citations

Chronic granulomatous disease in three female siblings.

1968 • 67 citations

Severe-glucose-6-phosphate dehydrogenase (G6PD) deficiency associated with chronic hemolytic anemia, granulocyte dysfunction, and increased susceptibility to infections: description of a new molecular variant (G6PD Barcelona)

1982 • 67 citations

Deficient flavoprotein component of the NADPH-dependent O2-.-generating oxidase in the neutrophils from three male patients with chronic granulomatous disease.

1984 • 67 citations

KELL PHENOTYPES IN CHRONIC GRANULOMATOUS DISEASE: A POTENTIAL TRANSFUSION HAZARD

1971 • 66 citations

Gene-scan method for the recognition of carriers and patients with p47phox-deficient autosomal recessive chronic granulomatous disease

2001 • 64 citations

The cytochrome b and flavin content and properties of the O2−-forming NADPH oxidase solubilized from activated neutrophils

1983 • 63 citations

Adults with chronic granulomatous disease of “childhood”

1977 • 63 citations

Granulocytes without degranulation: neutrophil function in granule-depleted cytoplasts.

1983 • 62 citations

Cytochrome b, flavins, and ubiquinone-50 in enucleated human neutrophils (polymorphonuclear leukocyte cytoplasts).

1984 • 62 citations

Defective initiation of the metabolic stimulation in phagocytizing granulocytes: a new congenital defect.

1976 • 62 citations

Isolation of plasma membrane from human neutrophils and determination of cytochrome b and quinone content

1981 • 61 citations

Studies on neutrophil b-type cytochrome in situ by low temperature absorption spectroscopy.

1985 • 59 citations

Hematologically Important Mutations: The Autosomal Recessive Forms of Chronic Granulomatous Disease (First Update)

2000 • 58 citations

Myeloperoxidase inactivation in the course of catalysis of chlorination of taurine

1977 • 58 citations

Elevated Serum Creatine Phosphokinase in Subjects with McLeod Syndrome

1981 • 58 citations

Chronic granulomatous disease due to granulocytes with abnormal NADPH oxidase activity and deficient cytochrome-b

1983 • 58 citations

Enhancement by Ca2+ or Mg2+ of catalytic activity of the superoxide-producing NADPH oxidase in membrane fractions of human neutrophils and monocytes.

1985 • 57 citations

Leukocyte degranulation and vacuole formation in patients with chronic granulomatous disease of childhood

1968 • 56 citations

Pyridine and imidazole reversibly inhibit the respiratory burst in porcine and human neutrophils: Evidence for the involvement of cytochrome in the reaction

1985 • 55 citations

Allogeneic bone marrow transplantation for chronic granulomatous disease

1982 • 54 citations

Con-A-stimulated superoxide production by granulocytes: reversible activation of NADPH oxidase

1982 • 51 citations

NAD(P)H-dependent superoxide production by phagocytic vesicles from guinea pig and human granulocytes.

1980 • 51 citations

Identification of a novel NCF-1 (p47-phox) pseudogene not containing the signature GT deletion: significance for A47° chronic granulomatous disease carrier detection

2002 • 51 citations

Changes in protein phosphorylation in guinea pig polymorphonuclear leukocytes by treatment with membrane-perturbing agents which stimulate superoxide anion production

1984 • 50 citations

Somatic gene therapy. Current status and future prospects.

1986 • 49 citations

Examination of the oxidase function of the b-type cytochrome in human polymorphonuclear leucocytes

1984 • 49 citations

Composition of partially purified NADPH oxidase from pig neutrophils

1984 • 48 citations

Activation of the human neutrophil NADPH oxidase results in coupling of electron carrier function between ubiquinone-10 and cytochrome b559.

1985 • 48 citations

Granulocyte transfusion therapy in chronic granulomatous disease

1981 • 47 citations

ABNORMALITIES OF LEUKOCYTE CHEMOTAXIS IN HUMAN DISEASE*

1975 • 47 citations

A variant form of X‐linked chronic granulomatous disease with normal nitroblue tetrazolium slide test and cytochrome b

1983 • 47 citations

Ubiquinone content and respiratory burst activity of latex-filled phagolysosomes isolated from human neutrophils and evidence for the probable involvement of a third granule.

1983 • 46 citations

Unique characteristics of superoxide production by human eosinophils in eosinophilic states

1979 • 46 citations

The NADPH oxidase of guinea pig polymorphonuclear leucocytes

1983 • 46 citations

Chronic granulomatous disease

1978 • 45 citations

Isolation from neutrophil membranes of a complex containing active NADPH oxidase and cytochrome b-245

1984 • 44 citations

Improved superoxide-generating ability by interferon γ due to splicing pattern change of transcripts in neutrophils from patients with a splice site mutation inCYBB gene

2001 • 44 citations

The isolation from rat peritoneal leukocytes of plasma membrane enriched in alkaline phosphatase and a b-type cytochrome

1979 • 44 citations

CYTOCHROME b IS PRESENT IN NEUTROPHILS FROM PATIENTS WITH CHRONIC GRANULOMATOUS DISEASE

1979 • 43 citations

Quantitation of superoxide production in human polymorphonuclear leukocytes from normals and 3 types of chronic granulomatous disease

1979 • 40 citations

Mutational analysis of patients with p47-phox–deficient chronic granulomatous disease

2001 • 40 citations

Abnormal Kinetics of Degranulation in Chronic Granulomatous Disease

1974 • 38 citations

Kx Antigen, The McLeod Phenotype, and Chronic Granulomatous Disease: Further Studies

1976 • 38 citations

Molecular and functional characterization of a new X-linked chronic granulomatous disease variant (X91+) case with a double missense mutation in the cytosolic gp91phox C-terminal tail

2002 • 37 citations

Identification and quantitation of electron-transport components in human polymorphonuclear neutrophils

1982 • 36 citations

Chronic granulomatous disease, the McLeod syndrome, and the Kell blood groups.

1978 • 35 citations

Reduced Oxygen By-Products and White Blood Cells

1982 • 35 citations

Spectrum of function of neutrophils from carriers of sex-linked chronic granulomatous disease

1975 • 34 citations

Impaired granulocyte superoxide production and prolongation of the respiratory burst due to a low-affinity NADPH-dependent oxidase

1983 • 34 citations

Activity of Antibiotics in Chronic Granulomatous Disease Leukocytes

1983 • 34 citations

NADPH-dependent reduction of 2,6-dichlorophenol-indophenol by the phagocytic vesicles of pig polymorphonuclear leucocytes

1983 • 33 citations

Proton secretion by the sodium/hydrogen ion antiporter in the human neutrophil.

1986 • 33 citations

Disorders of neutrophil function. Defects in the early stages of the phagocytic process.

1973 • 32 citations

Failure to Detect Superoxide in Human Neutrophils Stimulated With Latex Particles(21)

1983 • 32 citations

The enzyme responsible for the respiratory burst in elicited guinea pig peritoneal macrophages

1982 • 31 citations

Studies of cytochrome b-245 translocation in the PMA stimulation of the human neutrophil NADPH-oxidase.

1985 • 30 citations

Neutrophil Dysfunction Associated with States of Chronic and Recurrent Infection

1980 • 28 citations

Cytosolic free calcium changes induced by chemotactic peptide in neutrophils from patients with chronic granulomatous disease

1984 • 28 citations

Selective enrichment of NADPH oxidase activity in phagosomes from guinea pig polymorphonuclear leukocytes

1982 • 28 citations

The subcellular particulate NADPH-dependent O2.(-)-generating oxidase from human blood monocytes: comparison to the neutrophil system

1982 • 27 citations

A novel and unusual case of chronic granulomatous disease in a child with a homozygous 36-bp deletion in the CYBA gene (A220) leading to the activation of a cryptic splice site in intron 4

2002 • 27 citations

Protein phosphorylation in intact pig leukocytes

1984 • 26 citations

Prenatal diagnosis in two families with autosomal, p47^phox‐deficient chronic granulomatous disease due to a novel point mutation in NCF1

2002 • 25 citations

Subcellular Localization of O2− Generating Enzyme in Guinea Pig Polymorphonuclear Leukocytes; Fractionation of Subcellular Particles by Using a Percoll Density Gradient

1982 • 24 citations

Molecular quality control machinery contributes to the leukocyte NADPH oxidase deficiency in chronic granulomatous disease

2002 • 23 citations

FIBROBLAST NITROBLUE TETRAZOLIUM TEST AND THE IN-UTERO DIAGNOSIS OF CHRONIC GRANULOMATOUS DISEASE

1980 • 22 citations

An unusual intronic mutation in the CYBB gene giving rise to chronic granulomatous disease

2001 • 22 citations

The O2− generating oxidoreductase of human neutrophils: Evidence of an obligatory requirement for calcium and magnesium for expression of catalytic activity

1983 • 20 citations

Monocyte function in patients with chronic granulomatous disease of childhood

1982 • 20 citations

Essential requirement of magnesium ion for optimal activity of the NADPH oxidase of guinea pig polymorphonuclear leukocytes

1983 • 20 citations

Normal leukocyte glutathione peroxidase activity in patients with chronic granulomatous disease

1976 • 20 citations

Identification of ubiquinone-50 as the major methylated nonpolar lipid in human monocytes. Regulation of its biosynthesis via methionine-dependent pathways and relationship to superoxide production.

1983 • 20 citations

Early changes in cyclic AMP and calcium efflux during phagocytosis by neutrophils from normals and patients with chronic granulomatous disease.

1983 • 20 citations

Utilization of Liposomes for Correction of the Metabolic and Bactericidal Deficiencies in Chronic Granulomatous Disease

1979 • 20 citations

Abnormal responses of granulocytes in chronic granulomatous disease

1981 • 19 citations

Heterogeneous Pathways of Oxidizing Radical Production in Human Neutrophils and the HL-60 Cell Line

1982 • 19 citations

Kx: its relationship to chronic granulomatous disease and genetic linkage with Xg

1981 • 19 citations

Electrophoretic isolation of a membrane-bound NADPH oxidase from guinea-pig polymorphonuclear leukocytes

1983 • 17 citations

Linkage of genes for chronic granulomatous disease and Xg

1980 • 17 citations

Leukotriene biosynthesis by polymorphonuclear leukocytes from two patients with chronic granulomatous disease.

1983 • 16 citations

Deficiency in C3b receptors on neutrophils of patients with chronic granulomatous disease and hyperimmunoglobulin-E recurrent infection (Job's) syndrome

1984 • 15 citations

Prenatal diagnosis of chronic granulomatous disease

1984 • 15 citations

Apparent Km of Leukocyte O 2 − and H2 O2 Forming Enzyme for Oxygen

1982 • 14 citations

Chronic Granulomatous Disease in Three Siblings

1978 • 12 citations

[Attempt to treat a case of chronic familial granulomatous disease by allogenic bone marrow transplantation].

1976 • 12 citations

Interrelationships of polymorphonuclear neutrophil membrane-bound calcium, membrane potential, and chemiluminescence: studies in single living cells

1984 • 12 citations

Human neutrophil dysfunction with giant granules and defective activation of the respiratory burst

1983 • 11 citations

Characterization of iodoproteins secreted by phagocytosing human polymorphonuclear leukocytes.

1979 • 10 citations

Somatic Triple Mosaicism in a Carrier of X-Linked Chronic Granulomatous Disease

1998 • 10 citations

Chronic granulomatous disease in two sisters

1984 • 10 citations

Purification of human granulocyte catalase in chronic myeloid leukemia

1977 • 10 citations

Structure and Regulation of NADPH Oxidase of Phagocytic Leukocytes

1999 • 9 citations

Prenatal Genetic Diagnosis: Current Status

1977 • 7 citations

Chronic Granulomatous Disease with Leukocytic Glucose-6-phosphate Dehydrogenase Deficiency in a 28-month-old Girl

1978 • 7 citations

A second case of somatic triple mosaicism in the CYBB gene causing chronic granulomatous disease

2001 • 6 citations

Regulation of macrophage oxidative metabolism and antiparasitic activity

1985 • 6 citations

Kell Phenotypes in 15 Japanese Patients with Chronic Granulomatous Disease

1979 • 5 citations

Arachidonic acid metabolism in polymorphonuclear leukocytes from patients with chronic granulomatous disease

1983 • 4 citations

NADPH-dependent oxygen reductase activity in pulmonary macrophages.

1981 • 4 citations

Acanthocytosis and Haemolytic Anaemia Due to the McLeod Blood Group

1981 • 4 citations

Antibacterial prophylaxis in chronic granulomatous disease. A case report.

1983 • 3 citations

Decreased neutrophil chemotaxis and chronic granulomatous disease

1984 • 2 citations