Clinical Implications of Guanine Nucleotide–Binding Proteins as Receptor–Effector Couplers

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.

1982 • 808 citations

Actions of cholera toxin and the prevention and treatment of cholera

1981 • 532 citations

Homologies Between Signal Transducing G Proteins and ras Gene Products

1984 • 500 citations

ADENYLATE CYCLASE-COUPLED BETA-ADRENERGIC RECEPTORS: Structure and Mechanisms of Activation and Desensitization

1983 • 486 citations

Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors

1983 • 473 citations

Adrenergic Receptors in Man

1982 • 401 citations

The Influence of Hyperthyroidism and Hypothyroidism on α and β-Adrenergic Receptor Systems and Adrenergic Responsiveness*

1983 • 350 citations

Guanine nucleotide-binding regulatory proteins and dual control of adenylate cyclase.

1984 • 342 citations

The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins.

1983 • 304 citations

Opiate-dependent modulation of adenylate cyclase.

1977 • 265 citations

Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium.

1983 • 237 citations

Cyclic GMP Accumulation Causes Degeneration of Photoreceptor Cells: Simulation of an Inherited Disease

1977 • 232 citations

A role of the B-oligomer moiety of islet-activating protein, pertussis toxin, in development of the biological effects on intact cells.

1983 • 227 citations

Identification of a gamma subunit associated with the adenylyl cyclase regulatory proteins Ns and Ni.

1984 • 214 citations

ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding.

1984 • 189 citations

Multiple symmetric lipomatosis: a defect in adrenergic-stimulated lipolysis.

1977 • 122 citations

Different mechanisms of desensitization of adenylate cyclase by isoproterenol and prostaglandin E1 in human fibroblasts. Role of regulatory components in desensitization.

1982 • 115 citations

Coupling of Dopamine D ₁ Recognition Sites with Adenylate Cyclase in Nuclei Accumbens and Caudatus of Schizophrenics

1983 • 99 citations

Pseudohypoparathyroidism: inheritance of deficient receptor-cyclase coupling activity.

1981 • 97 citations

CATALYTIC UNIT OF ADENYLATE CYCLASE: REDUCED ACTIVITY IN AGED-HUMAN LYMPHOCYTES

1982 • 94 citations

Are guanine nucleotide binding proteins a distinct class of regulatory proteins?

1983 • 88 citations

Age-Related Elevation of Plasma Catecholamine Concentration and Reduced Responsiveness of Lymphocyte Adenylate Cyclase*

1981 • 88 citations

Deficient guanine nucleotide regulatory unit activity in cultured fibroblast membranes from patients with pseudohypoparathyroidism type I. A cause of impaired synthesis of 3',5'-cyclic AMP by intact and broken cells

1983 • 86 citations

Transducin: an amplifier protein in vision

1981 • 79 citations

PROLONGED SOMATOSTATIN PRETREATMENT DESENSITIZES SOMATOSTATIN'S INHIBITION OF RECEPTOR-MEDIATED RELEASE OF ADRENOCORTICOTROPIN HORMONE AND SENSITIZES ADENYLATE CYCLASE

1983 • 75 citations

Perfusion of the Pancreas Isolated from Pertussis-Sensitized Rats: Potentiation of Insulin Secretory Responses Due to β-Adrenergic Stimulation

1977 • 62 citations

The syndromes of primary hormone resistance

1979 • 60 citations

Hypothyroidism modulates beta adrenergic receptor adenylate cyclase interactions in rat reticulocytes.

1981 • 58 citations

Hormone-sensitive fat cell adenylate cyclase in the rat. Influences of growth, cell size, and aging.

1976 • 57 citations

Predictive value of the analogy between hormone‐sensitive adenylate cyclase and light‐sensitive photoreceptor cyclic GMP Phosphodiesterase: A specific role for a light‐sensitive GTPase as a component in the activation sequence

1979 • 56 citations

Human Chorionic Gonadotropin-Induced Heterologous Desensitization of Adenylyl Cyclase from Highly Luteinized Rat Ovaries: Attenuation of Regulatory N Component Activity^*

1983 • 49 citations

Functional modification of the guanine nucleotide regulatory protein after desensitization of turkey erythrocytes by catecholamines

1983 • 47 citations

MYOCARDIAL BETA-ADRENERGIC RECEPTORS FROM ADRENALECTOMIZED RATS:IMPAIRED FORMATION OF HIGH-AFFINITY AGONIST-RECEPTOR COMPLEXES

1981 • 44 citations

Promotion of lipolysis in rat adipocytes by pertussis toxin: reversal of endogenous inhibition.

1983 • 43 citations

Fat cell beta-adrenergic receptor in the hypothyroid rat. Impaired interaction with the stimulatory regulatory component of adenylate cyclase.

1984 • 42 citations

Epinephrine-Induced Alterations in Urinary Cyclic AMP in Hyper- and Hypothyroidism

1975 • 41 citations

Thyrotropin stimulation of the ADP-ribosyltransferase activity of bovine thyroid membranes.

1982 • 40 citations

Novel S49 lymphoma variants with aberrant cyclic AMP metabolism.

1981 • 40 citations

Platelets of pseudohypoparathyroid patients: Evidence that distinct receptor-cyclase coupling proteins mediate stimulation and inhibition of adenylate cyclase

1982 • 37 citations

REDUCTION OF FLUID-LOSS IN CHOLERA BY NICOTINIC ACID:

1983 • 28 citations

PSEUDOHYPOPARATHYROIDISM: INHERITANCE AND EXPRESSION OF DEFICIENT RECEPTOR‐CYCLASE COUPLING PROTEIN ACTIVITY

1983 • 24 citations

High skeletal muscle adenylate cyclase in malignant hyperthermia.

1981 • 22 citations

Mechanism of action of glycopeptide hormones and cholera toxin: what is the role of ADP-ribosylation?

1983 • 21 citations

Effects of Estradiol Treatment on Rabbit Luteal Adenylyl Cyclase: Loss of Luteinizing Hormone Receptors andAttenuation of the Regulatory N Component Activity^*

1983 • 17 citations

Plasma Adenosine 3′:5′-Cyclic Monophosphate Response to Glucagon in Thyroid Disease

1975 • 16 citations

Chapter 8 Cyclic-GMP Phosphodiesterase and Calmodulin in Early-Onset Inherited Retinal Degenerations

1981 • 13 citations

Choleragen, adenylate cyclase, and ADP-ribosylation.

1981 • 9 citations

THE RELATIONSHIP BETWEEN THYROID FUNCTION AND THE RENAL RESPONSE TO PARATHYROID HORMONE

1977 • 8 citations

Receptor-Cyclase Coupling Protein in Erythrocytes of Patients with Essential Hypertension

1984 • 3 citations

A conjugate of the A1 peptide of chloera toxin and the lectin of Wisteria floribunda that activates the adenylate cyclase of intact cells

1983 • 2 citations