Biochemical and Biological Characterization of a Human Rac2 GTPase Mutant Associated with Phagocytic Immunodeficiency

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

The biochemical basis of the NADPH oxidase of phagocytes

1993 • 631 citations

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1989 • 585 citations

Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

1996 • 571 citations

Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense

1999 • 568 citations

Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells

1996 • 565 citations

Rho GTPases

1998 • 534 citations

Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

2000 • 476 citations

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

1997 • 445 citations

Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages

1997 • 415 citations

Rho effectors and reorganization of actin cytoskeleton

1997 • 379 citations

rac1 Regulates a Cytokine-Stimulated, Redox-Dependent Pathway Necessary for NF-κB Activation

1996 • 337 citations

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.

2000 • 335 citations

Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245.

1992 • 265 citations

Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.

1994 • 260 citations

Characterization of RAC3, a Novel Member of the Rho Family

1997 • 240 citations

NEW EMBO MEMBERS' REVIEW: Signaling from Ras to Rac and beyond: not just a matter of GEFs

2000 • 219 citations

Optimization of Fibronectin-Assisted Retroviral Gene Transfer into Human CD34⁺Hematopoietic Cells

1997 • 215 citations

Emerging concepts in the Ras superfamily of GTP‐binding proteins

1993 • 208 citations

Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase.

1992 • 176 citations

Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity of white spotting and steel mutant mice.

1994 • 170 citations

Role of the Guanosine Triphosphatase Rac2 in T Helper 1 Cell Differentiation

2000 • 170 citations

Rac2 Stimulates Akt Activation Affecting BAD/Bcl-XL Expression while Mediating Survival and Actin Function in Primary Mast Cells

2000 • 168 citations

Retroviral-Mediated Gene Transfer of gp91phox Into Bone Marrow Cells Rescues Defect in Host Defense Against Aspergillus fumigatus in Murine X-Linked Chronic Granulomatous Disease

1997 • 124 citations

The Rac Target NADPH Oxidase p67 Interacts Preferentially with Rac2 Rather Than Rac1

1996 • 110 citations

A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells.

1990 • 108 citations

Retroviral-Mediated Gene Transfer of gp91phox Into Bone Marrow Cells Rescues Defect in Host Defense Against Aspergillus fumigatus in Murine X-Linked Chronic Granulomatous Disease

1997 • 103 citations

Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac.

1994 • 93 citations

Participation of the small molecular weight GTP-binding protein Rac1 in cell-free activation and assembly of the respiratory burst oxidase. Inhibition by a carboxyl-terminal Rac peptide.

1994 • 90 citations

The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments.

1991 • 87 citations

Involvement of GTP-binding proteins in actin polymerization in human neutrophils.

1990 • 84 citations

Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth

1999 • 66 citations

SmgGDS stabilizes nucleotide-bound and -free forms of the Rac1 GTP-binding protein and stimulates GTP/GDP exchange through a substituted enzyme mechanism

1994 • 54 citations

Identification of Rho GTPase-dependent Sites in the Dbl Homology Domain of Oncogenic Dbl That Are Required for Transformation

2000 • 53 citations

Rac1, a low‐molecular‐mass GTP‐binding‐protein with high intrinsic GTPase activity and distinct biochemical properties

1992 • 50 citations

A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation

1991 • 50 citations

Two types of RAS mutants that dominantly interfere with activators of RAS.

1994 • 49 citations

Progress in the Use of Gene Transfer Methods to Treat Genetic Blood Diseases

2000 • 45 citations

Guanine Nucleotide Binding Properties of Rac2 Mutant Proteins and Analysis of the Responsiveness to Guanine Nucleotide Dissociation Stimulator^,

1997 • 30 citations

Deleted Work

1955 • 0 citations