Interferon-Gamma, the Activated Macrophage, and Host Defense Against Microbial Challenge

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

1983 • 1,918 citations

Mechanism of a Reaction in Vitro Associated with Delayed-Type Hypersensitivity

1966 • 1,604 citations

CELLULAR RESISTANCE TO INFECTION

1962 • 1,422 citations

Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.

1966 • 1,274 citations

EXACERBATIONS OF MULTIPLE SCLEROSIS IN PATIENTS TREATED WITH GAMMA INTERFERON

1987 • 1,062 citations

THE INFLUENCE OF IMMUNOLOGICALLY COMMITTED LYMPHOID CELLS ON MACROPHAGE ACTIVITY IN VIVO

1969 • 932 citations

Immune Interferon in the Circulation of Patients with Autoimmune Disease

1979 • 907 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

1984 • 847 citations

Treatment of multiple sclerosis with gamma interferon

1987 • 739 citations

Qualitative Analysis of Immune Function in Patients with the Acquired Immunodeficiency Syndrome

1985 • 737 citations

Interferon-Like Virus-Inhibitor Induced in Human Leukocytes by Phytohemagglutinin

1965 • 710 citations

Expression of human immune interferon cDNA in E. coli and monkey cells

1982 • 703 citations

Interleukin l and T Cell Activation

1982 • 622 citations

Response of resting human peripheral blood natural killer cells to interleukin 2.

1984 • 616 citations

Recombinant interferon-gamma increases HLA-DR synthesis and expression.

1983 • 577 citations

“Lymphokines”: Non-Antibody Mediators of Cellular Immunity generated by Lymphocyte Activation

1969 • 575 citations

Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection.

1985 • 555 citations

Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.

1986 • 532 citations

Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes.

1986 • 527 citations

Impaired Production of Lymphokines and Immune (Gamma) Interferon in the Acquired Immunodeficiency Syndrome

1984 • 513 citations

ALTERATIONS OF MACROPHAGE FUNCTIONS BY MEDIATORS FROM LYMPHOCYTES

1971 • 507 citations

Interleukin 2-mediated immune interferon (IFN-gamma) production by human T cells and T cell subsets.

1983 • 483 citations

Regulation of the production of immune interferon and cytotoxic T lymphocytes by interleukin 2.

1981 • 477 citations

Gamma interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosis.

1985 • 462 citations

Cloning and expression of murine immune interferon cDNA.

1983 • 455 citations

Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-gamma is the activating lymphokine.

1983 • 404 citations

Widespread and selective induction of major histocompatibility complex-determined antigens in vivo by gamma interferon.

1985 • 397 citations

Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells

1986 • 389 citations

Preferential effect of γ interferon on the synthesis of HLA antigens and their mRNAs in human cells

1982 • 386 citations

Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA.

1987 • 365 citations

Activation of human macrophages. Comparison of other cytokines with interferon-gamma.

1984 • 362 citations

Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma.

1985 • 356 citations

REQUIREMENT OF THYMUS (T) LYMPHOCYTES FOR RESISTANCE TO LISTERIOSIS

1972 • 352 citations

Interleukin 2 Regulates Expression of Its Receptor and Synthesis of Gamma Interferon by Human T Lymphocytes

1984 • 350 citations

Local and Systemic Effects of Intradermal Recombinant Interferon-γ in Patients with Lepromatous Leprosy

1986 • 328 citations

THE RELATIVE IMPORTANCE OF BLOOD MONOCYTES AND FIXED MACROPHAGES TO THE EXPRESSION OF CELL-MEDIATED IMMUNITY TO INFECTION

1970 • 326 citations

1 alpha,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes.

1987 • 323 citations

Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.

1985 • 321 citations

Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria

1985 • 315 citations

Inhibition of Development of Exoerythrocytic Forms of Malaria Parasites by γ-Interferon

1986 • 315 citations

Effects of natural and recombinant IL 2 on regulation of IFN gamma production and natural killer activity: lack of involvement of the Tac antigen for these immunoregulatory effects.

1984 • 310 citations

Mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis.

1987 • 310 citations

Immune Specific Induction of Interferon Production in Cultures of Human Blood Lymphocytes

1969 • 307 citations

Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor.

1986 • 302 citations

Growth inhibition of Candida albicans by human polymorphonuclear neutrophils: activation by interferon-gamma and tumor necrosis factor.

1986 • 293 citations

Natural killer (NK) cells as a responder to interleukin 2 (IL 2). II. IL 2-induced interferon gamma production.

1983 • 288 citations

Evolution of recurrent herpes simplex lesions. An immunohistologic study.

1985 • 238 citations

Macrophage-activating factor produced by a T cell hybridoma: physiochemical and biosynthetic resemblance to gamma-interferon.

1983 • 236 citations

Protection of mice against the intracellular bacterium Listeria monocytogenes by recombinant immune interferon

1984 • 228 citations

Stimulation by Granulocyte-Macrophage Colony-Stimulating Factor of Leishmania Tropica Killing by Macrophages

1979 • 227 citations

CELLULAR MEDIATORS OF ANTI-LISTERIA IMMUNITY AS AN ENLARGED POPULATION OF SHORT-LIVED, REPLICATING T CELLS

1973 • 225 citations

Macrophage oxygen-dependent antimicrobial activity. III. Enhanced oxidative metabolism as an expression of macrophage activation.

1980 • 223 citations

Activation of human monocyte cytotoxicity by natural and recombinant immune interferon.

1983 • 220 citations

THE ENHANCEMENT OF MACROPHAGE BACTERIOSTASIS BY PRODUCTS OF ACTIVATED LYMPHOCYTES

1973 • 215 citations

Interferons with Special Emphasis on the Immune System

1983 • 211 citations

Functional identity between murine γ Interferon and macrophage activating factor

1983 • 206 citations

Experimental visceral leishmaniasis: production of interleukin 2 and interferon-gamma, tissue immune reaction, and response to treatment with interleukin 2 and interferon-gamma.

1987 • 199 citations

Patients at Risk for AIDS-Related Opportunistic Infections

1985 • 197 citations

Recombinant human granulocyte/macrophage colony-stimulating factor activates intracellular killing of Leishmania donovani by human monocyte-derived macrophages.

1987 • 194 citations

Cellular Immunity and Herpesvirus Infections in Cardiac-Transplant Patients

1977 • 189 citations

Opioid-mediated suppression of interferon-gamma production by cultured peripheral blood mononuclear cells.

1987 • 186 citations

Pharmacokinetics, single-dose tolerance, and biological activity of recombinant gamma-interferon in cancer patients.

1985 • 185 citations

Induction of crisis forms in the human malaria parasite Plasmodium falciparum by gamma-interferon-activated, monocyte-derived macrophages.

1984 • 184 citations

Killing of intracellular Leishmania donovani by human mononuclear phagocytes. Evidence for oxygen-dependent and -independent leishmanicidal activity.

1983 • 183 citations

Migration Inhibitory Factor and Interferon in the Circulation of Mice with Delayed Hypersensitivity

1973 • 180 citations

Interferon: Immunobiology and Clinical Significance

1982 • 177 citations

Macrophage activation: priming activity from a T-cell hybridoma is attributable to interferon-gamma.

1983 • 177 citations

Expression of functional IL 2 receptors by lipopolysaccharide and interferon-gamma stimulated human monocytes.

1987 • 176 citations

Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis.

1986 • 172 citations

Impaired production of gamma-interferon by newborn cells in vitro is due to a functionally immature macrophage.

1985 • 172 citations

Gamma interferon is able to enhance the oxidative metabolism of human neutrophils

1986 • 166 citations

Differential expression of Ia and Ia-associated invariant chain in mouse tissues after in vivo treatment with IFN-gamma.

1986 • 164 citations

The interaction in vitro of Pneumocystis carinii with macrophages and L-cells.

1978 • 164 citations

Demonstration in Tissue Culture of Lymphocyte-Mediated Immunity to Tuberculosis

1970 • 160 citations

Human mononuclear phagocyte antiprotozoal mechanisms: oxygen-dependent vs oxygen-independent activity against intracellular Toxoplasma gondii.

1985 • 160 citations

Interferon-gamma inhibits the intrahepatocytic development of malaria parasites in vitro.

1987 • 157 citations

Synthesis in vitro of 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 by interferon-gamma-stimulated normal human bone marrow and alveolar macrophages.

1987 • 152 citations

The interaction of human macrophages and lymphocytes in the phytohemagglutinin-stimulated production of interferon

1971 • 148 citations

Cellular origin of interleukin 2 (IL 2) in man: evidence for stimulus-restricted IL 2 production by T4+ and T8+ T lymphocytes.

1982 • 147 citations

Mechanisms of macrophage antimicrobial activity

1983 • 146 citations

Chronic infection due to Mycobacterium intracellulare in mice: association with macrophage release of prostaglandin E2 and reversal by injection of indomethacin, muramyl dipeptide, or interferon-gamma.

1986 • 145 citations

Activity of recombinant tumor necrosis factor on Toxoplasma gondii and Trypanosoma cruzi.

1986 • 143 citations

Gamma-interferon is the factor in lymphokine that activates human macrophages to inhibit intracellular Chlamydia psittaci replication.

1983 • 139 citations

In vitro cultivation of Toxoplasma gondii cysts in astrocytes in the presence of gamma interferon

1986 • 133 citations

Cellular and Humoral Immunity in the Pathogenesis of Recurrent Herpes Viral Infections in Patients with Lymphoma

1980 • 132 citations

Interferon γ and lymphotoxin or tumor necrosis factor act synergistically to induce macrophage killing of tumor cells and schistosomula of schistosoma mansoni

1987 • 132 citations

Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2.

1983 • 131 citations

Thymic deficiency in Down's syndrome.

1979 • 130 citations

Bacterial lipopolysaccharide-induced interferon-gamma production: roles of interleukin 1 and interleukin 2.

1986 • 130 citations

Cellular origin and interactions involved in gamma-interferon production induced by OKt3 monoclonal antibody.

1982 • 129 citations

Activation of tissue macrophages from AIDS patients: in vitro response of AIDS alveolar macrophages to lymphokines and interferon-gamma.

1985 • 129 citations

Transfer of Adoptive Immunity to Tuberculosis in Mice

1975 • 128 citations

Recombinant interferon-gamma induces interleukin 2 receptors on human peripheral blood monocytes.

1986 • 126 citations

Parasite-specific anergy in human filariasis. Insights after analysis of parasite antigen-driven lymphokine production.

1987 • 126 citations

Activity of Interferons Alpha, Beta, and Gamma Against Human Immunodeficiency Virus Replication In Vitro

1987 • 125 citations

Phase I trial of recombinant interferon gamma in cancer patients.

1986 • 121 citations

Reduced interferon-gamma mRNA levels in human neonates. Evidence for an intrinsic T cell deficiency independent of other genes involved in T cell activation.

1986 • 118 citations

Enhancement of macrophage bactericidal capacity by antigenically stimulated immune lymphocytes

1972 • 118 citations

Nude Mice in Immunology

2015 • 114 citations

On the mechanism of T cell-independent anti-Listeria resistance in nude mice.

1980 • 113 citations

Lymphokines Enhance the Capacity of Human Monocytes to Secrete Reactive Oxygen Intermediates

1982 • 113 citations

The roles of interleukin 2 and interferon‐γ in human B cell activation, growth and differentiation

1986 • 111 citations

Administration of recombinant interferon gamma to cancer patients enhances monocyte secretion of hydrogen peroxide.

1985 • 110 citations

Impaired Cellular Immunity to Cytomegalovirus in Congenitally Infected Children and Their Mothers

1979 • 107 citations

Defective IFN-gamma production in the human neonate. I. Dysregulation rather than intrinsic abnormality.

1985 • 104 citations

Leukocytes and Interferon in the Host Response to Viral Infections II. Enhanced Interferon Response of Leukocytes from Immune Animals

1966 • 104 citations

Some Properties of Virus and Immune-Induced Human Lymphocyte Interferons

1972 • 103 citations

Characterization of the gamma-interferon-mediated induction of antigen-presenting ability in P388D1 cells.

1983 • 101 citations

Selective Impairment of Lymphocyte Reactivity to Varicella-Zoster Virus Antigen among Untreated Patients with Lymphoma

1978 • 100 citations

The role of a gamma interferon-like lymphokine in the activation of T cells for expression of interleukin 2 receptors

1983 • 100 citations

Activation of Normal Rabbit Macrophage Monolayers by Supernatants of Antigen-Stimulated Lymphocytes

1970 • 99 citations

Role of protein kinase C and intracellular calcium mobilization in the induction of macrophage tumoricidal activity by interferon-gamma.

1986 • 98 citations

B cell growth factor activity of interferon-gamma. Recombinant human interferon-gamma promotes proliferation of anti-mu-activated human B lymphocytes.

1986 • 97 citations

The actions of interferon and antiinflammatory agents on induction of indoleamine 2,3-dioxygenase in human peripheral blood monocytes

1987 • 97 citations

In vivo and in vitro activation of alveolar macrophages by recombinant interferon-gamma.

1987 • 97 citations

Demonstration and partial characterization of the interferon-gamma receptor on human mononuclear phagocytes.

1985 • 97 citations

Immunohistochemical studies of interleukin‐2 and γ‐interferon in rheumatoid arthritis

1985 • 96 citations

Lymphocytes from multiple sclerosis patients produce elevated levels of gamma interferonin vitro

1985 • 94 citations

Cell-Mediated Immunity to Cytomegalovirus Infection in Normal Subjects and Cardiac Transplant Patients

1978 • 94 citations

Role for Endogenous and Acquired Peroxidase in the Toxoplasmacidal Activity of Murine and Human Mononuclear Phagocytes

1982 • 93 citations

Enhanced production of murine interferon gamma by T cells generated in response to bacterial infection.

1982 • 93 citations

Evidence for the Identity of Murine Gamma Interferon and Macrophage Activating Factor

1982 • 92 citations

Intracellular fate of Mycobacterium leprae in normal and activated mouse macrophages

1987 • 92 citations

Interferon blocks interleukin 1-induced prostaglandin release from human peripheral monocytes.

1987 • 91 citations

Recombinant gamma interferon is a potent adjuvant for a malaria vaccine in mice.

1987 • 89 citations

Interferon in suction blister fluid from psoriatic lesions

1983 • 89 citations

Phase I study of multiple dose intramuscularly administered recombinant gamma interferon.

1986 • 88 citations

Effects of Antifungal Agents and Interferon on Macrophage Cytotoxicity for Fungi and Tumor Cells

1987 • 87 citations

Activation or suppression of the tumoricidal properties of monocytes from cancer patients following treatment with human recombinant gamma-interferon.

1986 • 86 citations

An analysis of in vitro T cell responsiveness in lepromatous leprosy.

1985 • 86 citations

Purified human interleukin-2 enhances induction of immune interferon

1983 • 85 citations

Localization of interferons and interleukin 2 in polymyositis and muscular dystrophy.

1986 • 85 citations

Toxoplasmosis in Nude Mice

1977 • 84 citations

Macrophage cytotoxicity factor. A product of in vitro sensitized thymus‐dependent cells

1973 • 83 citations

Recombinant human gamma interferon inhibits simian malaria

1986 • 83 citations

Internalization and degradation of receptor-bound interferon-gamma by murine macrophages. Demonstration of receptor recycling.

1987 • 82 citations

Lymphokine enhances oxygen-independent activity against intracellular pathogens.

1983 • 81 citations

Immune interferon in serum and synovial fluid in rheumatoid arthritis and related disorders.

1983 • 79 citations

Recombinant gamma interferon induces hypertriglyceridemia and inhibits post-heparin lipase activity in cancer patients.

1986 • 78 citations

The respiratory burst is not required for killing of intracellular and extracellular parasites by a lymphokine‐activated macrophage cell line

1985 • 78 citations

All human monocytes have the capability of expressing HLA-DQ and HLA-DP molecules upon stimulation with interferon-gamma.

1986 • 75 citations

Production of and in vitro response to interleukin 2 in the acquired immunodeficiency syndrome.

1985 • 74 citations

Gamma interferon as a crucial host defense against Rickettsia conorii in vivo

1987 • 72 citations

Interferonlike factors from antigen- and mitogen-stimulated human leukocytes with antirickettsial and cytolytic actions on Rickettsia prowazekii. Infected human endothelial cells, fibroblasts, and macrophages.

1983 • 71 citations

Mycobacterium leprae-burdened macrophages are refractory to activation by gamma interferon

1987 • 70 citations

Significance of Local Interferon in Recurrent Herpes Simplex Infection

1986 • 68 citations

Natural and recombinant interferons inhibit epithelial cell invasion by Shigella spp

1986 • 68 citations

Cellular responses to the intradermal injection of recombinant human gamma-interferon in lepromatous leprosy patients.

1987 • 68 citations

Release of lymphokines after Epstein Barr virus infection in vitro. I. Sources of and kinetics of production of interferons and interleukins in normal humans.

1986 • 67 citations

Induction of interferon-γ in human leukocyte cultures stimulated by Zn2+

1987 • 66 citations

Deficient immune interferon production in tuberculosis.

1985 • 62 citations

Leu-3+ T cells produce gamma-interferon in patients with recurrent herpes labialis.

1984 • 62 citations

Differential expression of Ia molecules by human monocytes.

1984 • 62 citations

Identification of the T cell subset that produces human gamma interferon.

1982 • 62 citations

Interferon inhibits the suppressor T cell response of delayed-type hypersensitivity

1982 • 61 citations

Defective gamma-interferon production in peripheral blood leukocytes of patients with acute tuberculosis

1986 • 61 citations

Evaluation of T Lymphocyte Effector Function in Immunodeficiency Diseases: Abnormality in Mitogen-Stimulated Interferon in Patients with Selective IgA Deficiency

1974 • 59 citations

The Immunology of Mycobacterial Infections

1982 • 59 citations

MIF-like activity of natural and recombinant human interferon-gamma and their neutralization by monoclonal antibody.

1985 • 59 citations

Activation of neonatal and adult human macrophages by alpha, beta, and gamma interferons

1985 • 58 citations

Gamma-interferon-induced inhibition of the growth of Rickettsia prowazekii in fibroblasts cannot be explained by the degradation of tryptophan or other amino acids

1986 • 58 citations

Interferon production of vitro by leucocytes from patients with systemic lupus erythematosus and rheumatoid arthritis.

1981 • 56 citations

Induction of MHC-determined antigens in the lung by interferon-gamma.

1986 • 55 citations

Oxygen-independent inhibition of intracellular Chlamydia psittaci growth by human monocytes and interferon-gamma-activated macrophages.

1986 • 54 citations

The Interferon Compartment of the Immune Response in Human Malaria: II. Presence of Serum-Interferon Gamma Following the Acute Attack

1985 • 54 citations

Impaired Cell-Mediated Immune Response in Patients with Congenital Rubella: Correlation with Gestational Age at Time of Infection

1979 • 52 citations

Serum lysozyme: an index of macrophage function.

1979 • 52 citations

Antigen-induced human interferon-gamma production. Differential dependence on interleukin 2 and its receptor.

1987 • 51 citations

Subcutaneous recombinant gamma interferon in cancer patients: toxicity, pharmacokinetics, and immunomodulatory effects

1987 • 50 citations

Enhancing effect of IFN-gamma on helper T cell activity and IL 2 production.

1985 • 49 citations

A lymphokine distinct from interferon-gamma that activates human monocytes to kill Leishmania donovani in vitro.

1986 • 47 citations

The anticellular and protein-inducing activities of human gamma interferon preparations are mediated by the interferon.

1983 • 47 citations

In vivo synergism of roxithromycin (RU 965) and interferon against Toxoplasma gondii

1987 • 47 citations

Patients with condyloma acuminatum exhibit decreased interleukin-2 and interferon gamma production and depressed natural killer activity

1987 • 46 citations

Interleukin 2 induction of interferon-gamma mRNA synthesis.

1986 • 46 citations

Nonoxidative microbicidal activity in normal human alveolar and peritoneal macrophages

1987 • 45 citations

In Vitro Activation of the Antibacterial Activity of Human Pulmonary Macrophages by Recombinant Interferon

1987 • 45 citations

Response of Congenitally Athymic (Nude) Mice to Infection With Mycobacterium boyis (Strain BCG)

1975 • 45 citations

Human monocyte activation for cytotoxicity against intracellular Leishmania donovani amastigotes: Induction of microbicidal activity by Interferon-γ

1985 • 44 citations

Crossprotection against nontuberculous mycobacterial infections by Mycobacterium tuberculosis memory immune T lymphocytes.

1986 • 44 citations

Detection of lymphokines and lymphokine receptors in pulmonary sarcoidosis. Immunohistologic evidence that inflammatory macrophages express IL-2 receptors.

1986 • 43 citations

Secretion of a macrophage‐activating factor distinct from interferon‐γ by human T cell clones

1984 • 43 citations

The significance of alpha/beta interferons and gamma interferon produced in mice infected with Listeria monocytogenes

1984 • 43 citations

PRODUCTION OF INTERFERON FOLLOWING AN IMMUNE RESPONSE

1970 • 42 citations

Chronic lymphocytic leukaemia. Studies on mitogen-stimulated lymphocyte interferon as a new technique for assessing T lymphocyte effector function.

1974 • 42 citations

In vivo induction of H‐2K/D antigens by recombinant interferon‐γ

1986 • 41 citations

Liver macrophages (Kupffer cells) as cytotoxic effector cells in extracellular and intracellular cytotoxicity

1985 • 41 citations

Gamma interferon production in response to homologous and heterologous strain antigens in mice chronically infected with Rickettsia tsutsugamushi

1984 • 38 citations

Macrophage activation for antileishmanial defense by an apparently novel mechanism.

1987 • 38 citations

Presence of a macrophage-mediated suppressor cell mechanism during cell-mediated immune response in experimental visceral leishmaniasis

1986 • 36 citations

Angiotensin II Regulates Interferon-γ Production

1987 • 36 citations

Release of Virus Inhibitor from Tuberculin-Sensitized Peritoneal Cells Stimulated by Antigen

1970 • 35 citations

Determination of the T‐Cell Subset Producing γ‐Interferon in Tuberculous Pleural Effusion

1986 • 34 citations

Interleukin-1 secretion by human alveolar macrophages stimulated with endotoxin is augmented by recombinant immune (gamma) interferon.

1986 • 34 citations

Phase I trial of recombinant interferon gamma by 1-hour i.v. infusion.

1986 • 33 citations

Interferon Deficiency Syndrome

1988 • 33 citations

Recombinant human interferon gamma suppresses HTLV‐III replication in vitro

1986 • 32 citations

The Effect of Hydrocortisone on the Production of γ-Interferon and Other Lymphokines by Human Peripheral Blood Mononuclear Cells

1986 • 28 citations

Phenotypic characterization of gamma interferon-induced human monocyte polykaryons

1985 • 27 citations

Effect of Treatment with Interferon-γ and Concanavalin A on the Course of Infection of Mice withSalmonella typhimuriumStrain LT-2

1987 • 26 citations

Human T-lymphocyte subset production of immune (?) interferon

1981 • 26 citations

Reversible defect in antigen-induced lymphokine and gamma-interferon generation in cutaneous leishmaniasis.

1984 • 25 citations

Phase I study of i.v. administered recombinant gamma interferon in cancer patients.

1986 • 25 citations

Stimulated human alveolar macrophages secrete interferon.

1985 • 23 citations

Retinitis Pigmentosa Associated with a Defect in the Production of Interferon-Gamma

1983 • 23 citations

Immunespecific interferon production by peripheral blood mononuclear leukocytes from patients with primary and recurrent orolabial herpes simplex virus infections

1985 • 22 citations

Interleukin 2 receptor blockade by anti-Tac antibody inhibits IFN-γ induction

1985 • 20 citations

Production of lymphokines by circulating human T lymphocytes that express or lack receptors for interleukin 2.

1984 • 20 citations

Interferon production in primary immunodeficiencies

1984 • 20 citations

The regulation of γ-interferon production by interleukins 1 and 2

1986 • 19 citations

Activation of rat and human alveolar macrophage intracellular microbicidal activity by a preformed LGL cytokine.

1985 • 19 citations

Effects of Interferons-α, -β, and -γ on Human Interleukin-2 Production

1986 • 18 citations

Immunologic profile in patients with Hodgkin's disease in complete remission

1987 • 18 citations

Natural cytotoxic activity in multiple sclerosis patients: defects in IL-2/interferon gamma-regulatory circuit.

1986 • 18 citations

Activation of protein kinase C down-regulates IFN-gamma receptors

1987 • 18 citations

Activation by synergism between endotoxin and lymphokines of the mouse macrophage cell line J774 against infection by Trypanosoma cruzi

1987 • 18 citations

Immunoreactive IFN-gamma in CSF in neurological disorders.

1987 • 17 citations

Effect of antineoplastic agents on gamma-interferon production in human peripheral blood mononuclear cells.

1984 • 16 citations

Effect of Intravenous Recombinant -Interferon on the Respiratory Burst of Blood Monocytes from Patients with AIDS

1986 • 15 citations

Concurrent enhancement of monocyte immunoregulatory properties and effector functions by recombinant interferon-γ

1986 • 15 citations

How Protozoa Evade Intracellular Killing

1983 • 15 citations

Relation of Cytosolic Calcium to the Microbicidal Activation of Blood Monocytes by Recombinant Interferon

1986 • 13 citations

Structure and function of human interferon-gamma.

1984 • 13 citations

SUBACUTE THYROIDITIS: ACTIVATED HLA-DR AND INTERFERON-γ EXPRESSING T CYTOTOXIC/SUPPRESSOR CELLS IN THYROID TISSUE AND PERIPHERAL BLOOD

1986 • 12 citations

Immunosuppressive effect of cyclosporin A on Mycobacterium bovis BCG infections in mice

1987 • 12 citations

Lymphokine stimulation of human macrophage C2 production is partially due to interferon-gamma.

1986 • 11 citations

In vitro correction of the interleukin-2 and interferon-gamma defect in multiple sclerosis.

1985 • 11 citations

Interferon responses of peripheral blood mononuclear cells from normal and leukaemic children

1986 • 10 citations

Cytokine activity after human bone marrow transplantation. Production of interferons by peripheral blood mononuclear cells from recipients of HLA-identical sibling bone marrow transplants.

1987 • 10 citations

Interferon Production and Lymphocyte Transformation in Lymphocytes of Leukemic Patients

1981 • 7 citations

Pharmacodynamic assays of the immunosuppressive action of cyclosporine therapy in transplant recipients.

1987 • 7 citations

Differences in interferon-gamma response of psoriatic lymphocytes to stimulation with various mitogens.

1986 • 6 citations

Effect of immunosuppressives on gamma-interferon production, lymphocyte proliferation, and cytotoxic function of activated T lymphocytes.

1987 • 1 citations