Neutrophil oxygen reduction: The enzymes and the products

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

The Metabolic Basis of Inherited Disease

1979 • 2,083 citations

The Biochemical Basis of Phagocytosis

1959 • 1,240 citations

Active Oxygen Species and the Functions of Phagocytic Leukocytes

1980 • 1,124 citations

Ciba Foundation Symposium

1957 • 1,100 citations

Principles of Biochemistry.

1937 • 1,033 citations

Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity

1972 • 966 citations

Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.

1983 • 938 citations

Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex

1978 • 876 citations

Spin trapping of superoxide and hydroxyl radical: Practical aspects

1980 • 861 citations

Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.

1984 • 849 citations

Myeloperoxidase-Halide-Hydrogen Peroxide Antibacterial System

1968 • 840 citations

Knowing and Being

1969 • 828 citations

Chlorination of Taurine by Human Neutrophils

1982 • 794 citations

Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.

1975 • 749 citations

Superoxide‐dependent formation of hydroxyl radicals in the presence of iron chelates

1978 • 748 citations

The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.

1975 • 705 citations

Studies of the Metabolic Activity of Leukocytes from Patients with a Genetic Abnormality of Phagocytic Function*

1967 • 677 citations

The neutrophil: Function and clinical disorders

1978 • 670 citations

A Mechanism for the Production of Ethylene from Methional

1970 • 668 citations

Evidence that Peroxidation of Lysosomal Membranes Is Initiated by Hydroxyl Free Radicals Produced during Flavin Enzyme Activity

1973 • 663 citations

The neutrophil: Function and clinical disorders

1979 • 628 citations

The Activation of Mononuclear Phagocytes: Fact, Fancy, and Future

1978 • 609 citations

H2O2 Release from Human Granulocytes during Phagocytosis

1977 • 586 citations

Localization of NADH oxidase on the surface of human polymorphonuclear leukocytes by a new cytochemical method.

1975 • 464 citations

Principles of biochemistry

1993 • 455 citations

Mechanism of the luminol-dependent chemiluminescence of human neutrophils.

1982 • 429 citations

Molecular and Cellular Mechanisms of Leukocyte Chemotaxis

1981 • 415 citations

Biochemical Criteria for Activated Macrophages

1978 • 406 citations

Long-Lived Oxidants Generated by Human Neutrophils: Characterization and Bioactivity

1983 • 396 citations

THE EXTRA RESPIRATION OF PHAGOCYTOSIS

1932 • 394 citations

Chemiluminescence and superoxide production by myeloperoxidase-deficient leukocytes.

1976 • 373 citations

Increased production of superoxide anion by macrophages exposed in vitro to muramyl dipeptide or lipopolysaccharide.

1980 • 356 citations

The particulate superoxide-forming system from human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst.

1976 • 350 citations

Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury.

1983 • 338 citations

The Mechanism of Action of Xanthine Oxidase

1974 • 337 citations

Novel cytochrome b system in phagocytic vacuoles of human granulocytes

1978 • 335 citations

Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages

1984 • 335 citations

Mechanisms of chlorine oxidation of hydrogen peroxide

1978 • 322 citations

Absence of Cytochrome b_-245in Chronic Granulomatous Disease

1983 • 300 citations

Assessment of chlorination by human neutrophils

1983 • 285 citations

The origin of the chemiluminescence of phagocytosing granulocytes.

1976 • 283 citations

Generation of Hydroxyl Radical by Enzymes, Chemicals, and Human Phagocytes In Vitro

1979 • 280 citations

Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical.

1981 • 280 citations

Subcellular localization of the superoxide-forming enzyme in human neutrophils.

1979 • 268 citations

Quantitative and temporal characterization of the extracellular H2O2 pool generated by human neutrophils.

1984 • 264 citations

Free radicals and inflammation. Protection of phagocytosine leukocytes by superoxide dismutase.

1975 • 264 citations

Formation of singlet oxygen by the myeloperoxidase-mediated antimicrobial system.

1977 • 262 citations

Evidence for hydroxyl radical production by human neutrophils.

1977 • 257 citations

Myeloperoxidase-dependent effect of amines on functions of isolated neutrophils.

1983 • 257 citations

Myeloperoxidase, hydrogen peroxide, chloride antimicrobial system: nitrogen-chlorine derivatives of bacterial components in bactericidal action against Escherichia coli

1979 • 251 citations

Characteristics of the cofactor requirements for the superoxide-generating NADPH oxidase of human polymorphonuclear leukocytes

1981 • 251 citations

Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion.

1984 • 249 citations

Comprehensive Inorganic Chemistry

1973 • 249 citations

The enzymic reduction and kinetics of oxidation of cytochrome b.245 of neutrophils

1982 • 247 citations

Myeloperoxidase Deficiency

1981 • 246 citations

Macrophage oxygen-dependent antimicrobial activity. II. The role of oxygen intermediates.

1979 • 236 citations

Oxidation-reduction properties of the cytochrome b found in the plasma-membrane fraction of human neutrophils. A possible oxidase in the respiratory burst

1981 • 229 citations

Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms.

1983 • 225 citations

Activation of a NADPH Oxidase From Horse Polymorphonuclear Leukocytes in a Cell- Free System

1984 • 221 citations

Complete Deficiency of Leukocyte Glucose-6-Phosphate Dehydrogenase with Defective Bactericidal Activity

1972 • 214 citations

The O2(-) -forming oxidase responsible for the respiratory burst in human neutrophils. Properties of the solubilized enzyme.

1979 • 210 citations

THE FORMATION OF FREE RADICALS AND THE CONSEQUENCES OF THEIR REACTIONS IN VIVO

1978 • 196 citations

Human granulocyte generation of hydroxyl radical.

1978 • 191 citations

Singlet Excited Oxygen as a Mediator of the Antibacterial Action of Leukocytes

1974 • 190 citations

Subcellular localization of the human neutrophil NADPH oxidase. b-Cytochrome and associated flavoprotein.

1984 • 187 citations

Effects of oxygen tension and pH on the respiratory burst of human neutrophils

1979 • 183 citations

Biochemical aspects of phagocytosis in poly-morphonuclear leucocytes. NADH and NADPH oxidation by the granules of resting and phagocytizing cells

1964 • 182 citations

Lipid Peroxidation by Human Blood Phagocytes

1974 • 177 citations

Superoxide-forming enzyme from human neutrophils: evidence for a flavin requirement

1977 • 174 citations

Lactoferrin Deficiency Associated with Altered Granulocyte Function

1982 • 172 citations

Fluoride-mediated activation of the respiratory burst in human neutrophils. A reversible process.

1979 • 170 citations

Termination of the Respiratory Burst in Human Neutrophils

1978 • 168 citations

Enhancement of Neutrophil Function as a Result of Prior Exposure to Chemotactic Factor

1980 • 162 citations

The production of hydroxyl and superoxide radicals by stimulated human neutrophils — measurements by EPR spectroscopy

1979 • 161 citations

Oxidation of arachidonic acid in micelles by superoxide and hydrogen peroxide.

1981 • 160 citations

Stimulation of human neutrophil leukocyte aerobic glucose metabolism by purified chemotactic factors.

1974 • 158 citations

Exposure of human neutrophils to chemotactic factors potentiates activation of the respiratory burst enzyme.

1983 • 157 citations

Hydroxyl radical generation by polymorphonuclear leukocytes measured by electron spin resonance spectroscopy.

1979 • 156 citations

Ethylene formation from methional

1978 • 156 citations

Generation of superoxide radicals by human peripheral neutrophils activated by chemotactic factor. Evidence for the role of calcium.

1979 • 156 citations

Role of the Superoxide Anion in the Myeloperoxidase-mediated Antimicrobial System

1974 • 153 citations

The O2–producing enzyme of human neutrophils. Further properties.

1981 • 153 citations

The Reaction of Cytochrome Oxidase with Cytochrome c

1965 • 148 citations

Chemiluminescence of phagocytic cells caused by N-formylmethionyl peptides

1978 • 148 citations

The subcellular distribution and some properties of the cytochrome b component of the microbicidal oxidase system of human neutrophils

1979 • 145 citations

Singlet oxygen production by lactoperoxidase.

1983 • 144 citations

Proton secretion by stimulated neutrophils. Significance of hexose monophosphate shunt activity as source of electrons and protons for the respiratory burst.

1984 • 135 citations

Arrangement of the respiratory burst oxidase in the plasma membrane of the neutrophil.

1981 • 133 citations

Reaction of peroxidase with reduced nicotinamide-adenine dinucleotide and reduced nicotinamide-adenine dinucleotide phosphate

1965 • 129 citations

Enzymatic basis of macrophage activation. Kinetic analysis of superoxide production in lysates of resident and activated mouse peritoneal macrophages and granulocytes.

1984 • 128 citations

Cytochrome b-245 of neutrophils is also present in human monocytes, macrophages and eosinophils

1981 • 127 citations

Chemiluminescence by Polymorphonuclear Leukocytes from Patients with Active Bacterial Infection

1980 • 127 citations

Role of cell surface contact in the kinetics of superoxide production by granulocytes.

1983 • 126 citations

NAD(P)H oxidase activity in human neutrophils stimulated by phorbol myristate acetate.

1980 • 122 citations

Ethylene formation by polymorphonuclear leukocytes. Role of myeloperoxidase.

1978 • 121 citations

Activation of mouse peritoneal macrophages by lipopolysaccharide alters the kinetic parameters of the superoxide-producing NADPH oxidase.

1983 • 120 citations

Isolation of cytochrome b560 from complex II (succinateùbiquinone oxidoreductase) and its reconstitution with succinate dehydrogenase.

1980 • 119 citations

Stopped flow spectrophotometric observation of superoxide dismutation in aqueous solution

1976 • 118 citations

Singlet oxygen production by chloroperoxidase-hydrogen peroxide-halide systems.

1984 • 117 citations

Flavonoid inhibition of the human neutrophil NADPH-oxidase

1984 • 116 citations

An attempt to demonstrate a reaction between superoxide and hydrogen peroxide

1976 • 116 citations

The origin of chemiluminescence produced by neutrophils stimulated by opsonized zymosan.

1983 • 115 citations

Stimulation of neutrophil oxygen-dependent metabolism by human leukocytic pyrogen.

1979 • 114 citations

Lymphokines Enhance the Capacity of Human Monocytes to Secrete Reactive Oxygen Intermediates

1982 • 113 citations

Biochemical requirements for singlet oxygen production by purified human myeloperoxidase.

1984 • 113 citations

The association of FAD with the cytochrome b–245 of human neutrophils

1982 • 112 citations

Structural and catalytic properties of the solubilized superoxide-generating activity of human polymorphonuclear leukocytes. Solubilization, stabilization in solution, and partial characterization

1979 • 111 citations

Functional relationship of the cytochrome b to the superoxide-generating oxidase of human neutrophils.

1982 • 109 citations

A kinetic analysis of the interaction of human myeloperoxidase with hydrogen peroxide, chloride ions, and protons.

1982 • 108 citations

The NADPH-dependent O-.2-generating oxidase from human neutrophils.

1983 • 105 citations

Respiratory burst enzyme in human neutrophils. Evidence for multiple mechanisms of activation.

1981 • 104 citations

Effects of a chemotactic factor, N-formylmethionyl peptide, on adherence, superoxide anion generation, phagocytosis, and microtubule assembly of human polymorphonuclear leukocytes.

1979 • 103 citations

NADPH AND NADH OXIDATION BY GUINEA PIG POLYMORPHONUCLEAR LEUCOCYTES

1963 • 103 citations

Regulation of human polymorphonuclear leukocyte superoxide release by cellular responses to chemotactic peptides.

1981 • 101 citations

Immune complex induced generation of oxygen metabolites by human neutrophils.

1982 • 101 citations

Hereditary myeloperoxidase deficiency

1981 • 98 citations

Identification of ubiquinone-50 in human neutrophils and its role in microbicidal events.

1982 • 98 citations

Manganese-dependent NADPH oxidation by granulocyte particles. The role of superoxide and the nonphysiological nature of the manganese requirement.

1976 • 97 citations

Superoxide-forming NADPH oxidase preparation of pig polymorphonuclear leucocyte

1982 • 97 citations

An attempt to evaluate the rate of the haber‐weiss reaction by using ·OH radical scavengers

1977 • 96 citations

Studies on the mechanism of metabolic stimulation in polymorphonuclear leucocytes during phagocytosis I. Evidence for superoxide anion involvement in the oxidation of NADPH2

1975 • 95 citations

Effects of anaerobiosis and inhibitors on O2-production by human granulocytes

1975 • 95 citations

The role of the superoxide anion in the xanthine oxidase-induced autoxidation of linoleic acid

1978 • 92 citations

Subcellular localization of cytochrome b and ubiquinone in a tertiary granule of resting human neutrophils and evidence for a proton pump ATPase.

1984 • 90 citations

Activation of the guinea pig granulocyte NAD(P)H-dependent superoxide generating enzyme: localization in a plasma membrane enriched particle and kinetics of activation

1980 • 88 citations

Purification of cytochrome b-245 from human neutrophils

1984 • 88 citations

The measurement of superoxide anion production by granulocytes in whole blood. A clinical test for the evaluation of phagocyte function and serum opsonic capacity

1983 • 88 citations

Extracellular proton release by stimulated neutrophils.

1981 • 86 citations

Solubilization of the O2(-)-forming activity responsible for the respiratory burst in human neutrophils.

1978 • 84 citations

Subcellular localization of H2O2 production in human neutrophils stimulated with particles and an effect of cytochalasin-B on the cells

1982 • 80 citations

In Vitro Responses of Human Neutrophils to N-Formyl-Methionyl-Leucyl-Phenylalanine: Correlation with Effects of Acute Bacterial Infection

1979 • 80 citations

Stimulus-response coupling in the human neutrophil Transmembrane potential and the role of extracellular Na+

1980 • 77 citations

Hydrogen Peroxide Production in Chronic Granulomatous Disease

1977 • 77 citations

Chemistry of superoxide ion. II. Reaction with hydroperoxides

1976 • 76 citations

The fenton reaction between ferrous‐diethylenetriaminepentaacetic acid and hydrogen peroxide

1982 • 75 citations

Cytochrome b558 from (bovine) granulocytes. Partial purification from Triton X-114 extracts and properties of the isolated cytochrome.

1984 • 75 citations

Calmodulin-dependents stimulation of the NADPH oxidase of human neutrophils

1982 • 75 citations

Myeloperoxidase and singlet oxygen: a reappraisal

1978 • 74 citations

Ambiguity associated with use of singlet oxygen trapping agents in myeloperoxidase-catalyzed oxidations

1978 • 70 citations

Chemotactic factor enhancement of superoxide release from fluoride and phorbol myristate acetate stimulated neutrophils

1981 • 70 citations

ATP-dependent acidification of membrane vesicles isolated from purified rat liver lysosomes. Acidification activity requires phosphate.

1983 • 69 citations

Deficient flavoprotein component of the NADPH-dependent O2-.-generating oxidase in the neutrophils from three male patients with chronic granulomatous disease.

1984 • 67 citations

Increased Superoxide Generation by Normal Granulocytes Incubated In Sera from Patients with Psoriasis

1981 • 65 citations

Granulocyte activation by endotoxin. II. Role of granulocyte adherence, aggregation, and effect of cytochalasin B, and comparison with formylated chemotactic peptide-induced stimulation.

1983 • 65 citations

The cytochrome b and flavin content and properties of the O2−-forming NADPH oxidase solubilized from activated neutrophils

1983 • 63 citations

Catalytic properties of the resolved flavoprotein and cytochrome B components of the NADPH dependent O2−• generating oxidase from human neutrophils

1984 • 62 citations

Oxygen metabolism in cloned macrophage cell lines: glucose dependence of superoxide production, metabolic and spectral analysis.

1984 • 62 citations

Cytochrome b, flavins, and ubiquinone-50 in enucleated human neutrophils (polymorphonuclear leukocyte cytoplasts).

1984 • 62 citations

The role of superoxide in xanthine oxidase-induced autooxidation of linoleic acid.

1982 • 62 citations

Isolation of plasma membrane from human neutrophils and determination of cytochrome b and quinone content

1981 • 61 citations

Generation of chemiluminescence by a particulate fraction isolated from human neutrophils. Analysis of molecular events.

1979 • 61 citations

Myeloperoxidase inactivation in the course of catalysis of chlorination of taurine

1977 • 58 citations

Chronic granulomatous disease due to granulocytes with abnormal NADPH oxidase activity and deficient cytochrome-b

1983 • 58 citations

Enhancement of Human Neutrophil Bactericidal Activity by Chemotactic Factors

1979 • 56 citations

Independent Stimulation of Motility and the Oxidative Metabolic Burst of Human Polymorphonuclear Leukocytes

1978 • 53 citations

NAD(P)H-dependent superoxide production by phagocytic vesicles from guinea pig and human granulocytes.

1980 • 51 citations

A reaction between the superoxide free radical and lipid hydroperoxide in sodium linoleate micelles

1982 • 50 citations

Examination of the oxidase function of the b-type cytochrome in human polymorphonuclear leucocytes

1984 • 49 citations

Chemiluminescence of Human and Canine Polymorphonuclear Leukocytes in the Absence of Phagocytosis

1978 • 47 citations

The NADPH oxidase of guinea pig polymorphonuclear leucocytes

1983 • 46 citations

Ubiquinone content and respiratory burst activity of latex-filled phagolysosomes isolated from human neutrophils and evidence for the probable involvement of a third granule.

1983 • 46 citations

Unique characteristics of superoxide production by human eosinophils in eosinophilic states

1979 • 46 citations

Reactions of oxygen radical species with methional: A pulse radiolysis study

1976 • 45 citations

Superoxide anions do not react with hydroperoxides

1979 • 45 citations

Isolation from neutrophil membranes of a complex containing active NADPH oxidase and cytochrome b-245

1984 • 44 citations

The isolation from rat peritoneal leukocytes of plasma membrane enriched in alkaline phosphatase and a b-type cytochrome

1979 • 44 citations

Biochemistry and Function of Phagocytes

1982 • 41 citations

Detection, Pathogenesis, and Prevention of Damage to Human Granulocytes Caused by Interaction with Nylon Wool Fiber

1977 • 41 citations

Dissociation of human neutrophil membrane depolarization, respiratory burst stimulation and phospholipid metabolism by quinacrine

1983 • 41 citations

Rapid incorporation of the human neutrophil plasma membrane cytochrome b into phagocytic vacuoles

1980 • 40 citations

Kx Antigen, The McLeod Phenotype, and Chronic Granulomatous Disease: Further Studies

1976 • 38 citations

Studies on the labile, stable Nadi oxidase and peroxidase staining reactions in the isolated particles of horse granulocyte.

1961 • 38 citations

Evidence for production of oxidizing radicals by the particulate O-2- forming system from human neutrophils

1979 • 37 citations

The effects of an ECF-A and formyl methionyl chemotactic peptides on oxidative metabolism of human eosinophils and neutrophils.

1981 • 36 citations

Identification and quantitation of electron-transport components in human polymorphonuclear neutrophils

1982 • 36 citations

Intrinsic dichlorophenolindophenol reductase activity associated with the superoxide-generating oxidoreductase of human granulocytes

1981 • 34 citations

NADPH-dependent reduction of 2,6-dichlorophenol-indophenol by the phagocytic vesicles of pig polymorphonuclear leucocytes

1983 • 33 citations

Failure to Detect Superoxide in Human Neutrophils Stimulated With Latex Particles(21)

1983 • 32 citations

THE RATE OF OXIDATION OF HYDROGEN PEROXIDE BY BROMINE AND ITS RELATION TO THE CATALYTIC DECOMPOSITION OF HYDROGEN PEROXIDE IN A BROMINE—BROMIDE SOLUTION

1928 • 31 citations

The enzyme responsible for the respiratory burst in elicited guinea pig peritoneal macrophages

1982 • 31 citations

Selective enrichment of NADPH oxidase activity in phagosomes from guinea pig polymorphonuclear leukocytes

1982 • 28 citations

The subcellular particulate NADPH-dependent O2.(-)-generating oxidase from human blood monocytes: comparison to the neutrophil system

1982 • 27 citations

Subcellular Localization of O2− Generating Enzyme in Guinea Pig Polymorphonuclear Leukocytes; Fractionation of Subcellular Particles by Using a Percoll Density Gradient

1982 • 24 citations

Arachidonic acid-induced chemiluminescence of human polymorphonuclear leukocytes

1982 • 23 citations

No or little production of singlet molecular oxygen in HOCl or HOClH2O2 a model system for myeloperoxidase/H2O2/Cl−

1980 • 21 citations

Subcellular localization of NAD(P)H oxidase(s) in human neutrophilic polymorphonuclear leucocytes

1978 • 21 citations

The O2− generating oxidoreductase of human neutrophils: Evidence of an obligatory requirement for calcium and magnesium for expression of catalytic activity

1983 • 20 citations

Essential requirement of magnesium ion for optimal activity of the NADPH oxidase of guinea pig polymorphonuclear leukocytes

1983 • 20 citations

Identification of ubiquinone-50 as the major methylated nonpolar lipid in human monocytes. Regulation of its biosynthesis via methionine-dependent pathways and relationship to superoxide production.

1983 • 20 citations

Heterogeneous Pathways of Oxidizing Radical Production in Human Neutrophils and the HL-60 Cell Line

1982 • 19 citations

Delineation of the catalytic components of the NADPH-dependent O2− generating oxidoreductase of human neutrophils

1983 • 17 citations

Electrophoretic isolation of a membrane-bound NADPH oxidase from guinea-pig polymorphonuclear leukocytes

1983 • 17 citations

SPIN TRAPPING OF THE SUPEROXIDE RADICAL BY 4‐(N‐METHYLPYRIDINIUM) t‐BUTYL NITRONE

1980 • 16 citations

Anomalous neutrophil granule distribution in a patient with lactoferrin deficiency: Pertinence to the respiratory burst

1985 • 16 citations

NADPH-dependent reduction of ubiquinone-1 associated with the superoxide-forming oxidase of pig polymorphonuclear leucocytes

1984 • 9 citations

Electron transport in xanthine oxidase. A model for other biological electron transport chains

1976 • 8 citations