Centrosome replication, genomic instability and cancer

Genetic instabilities in human cancers

1998 • 4,165 citations

Genetic instability in colorectal cancers

1997 • 1,989 citations

Control of apoptosis and mitotic spindle checkpoint by survivin

1998 • 1,881 citations

Catalog of chromosome aberrations in cancer

1985 • 1,522 citations

Mitotic kinases as regulators of cell division and its checkpoints

2001 • 1,503 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

Acute Myeloid Leukemia

1999 • 1,211 citations

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

1999 • 814 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Identification of a Vertebrate Sister-Chromatid Separation Inhibitor Involved in Transformation and Tumorigenesis

1999 • 801 citations

Zur Frage der Entstehung maligner Tumoren

1914 • 796 citations

Mutations in the APC tumour suppressor gene cause chromosomal instability

2001 • 722 citations

Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication

2000 • 704 citations

Deregulated cyclin E induces chromosome instability

1999 • 692 citations

Nucleophosmin/B23 Is a Target of CDK2/Cyclin E in Centrosome Duplication

2000 • 671 citations

Centrosome defects and genetic instability in malignant tumors.

1998 • 583 citations

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

2001 • 553 citations

Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation

1994 • 543 citations

Microtubule nucleation by γ-tubulin-containing rings in the centrosome

1995 • 530 citations

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1998 • 528 citations

Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity

1998 • 515 citations

Requirement of Cdk2-Cyclin E Activity for Repeated Centrosome Reproduction in Xenopus Egg Extracts

1999 • 505 citations

Centrosome-independent mitotic spindle formation in vertebrates

2000 • 502 citations

Pericentrin and γ-Tubulin Form a Protein Complex and Are Organized into a Novel Lattice at the Centrosome

1998 • 485 citations

The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

2000 • 483 citations

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin A

1999 • 476 citations

The Respective Contributions of the Mother and Daughter Centrioles to Centrosome Activity and Behavior in Vertebrate Cells

2000 • 462 citations

Evolution of neoplastic cell lineages in Barrett oesophagus

1999 • 448 citations

Cyclin-dependent kinase control of centrosome duplication

1999 • 423 citations

A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators

1998 • 419 citations

Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1

2001 • 413 citations

Microtubule Organizing Centers

1985 • 412 citations

Managing the centrosome numbers game: from chaos to stability in cancer cell division

2001 • 402 citations

Centrosome-Dependent Exit of Cytokinesis in Animal Cells

2001 • 396 citations

Re-evaluating centrosome function

2001 • 392 citations

Microtubule minus-end anchorage at centrosomal and non-centrosomal sites: the role of ninein

2000 • 388 citations

Genetic instability of cancer cells is proportional to their degree of aneuploidy

1998 • 378 citations

Centrioles in the cell cycle. I. Epithelial cells.

1982 • 362 citations

Centriole Disassembly In Vivo and Its Effect on Centrosome Structure and Function in Vertebrate Cells

1998 • 361 citations

THE CENTROSOME AND CELLULAR ORGANIZATION

1994 • 361 citations

Requirement of a Centrosomal Activity for Cell Cycle Progression Through G ₁ into S Phase

2001 • 336 citations

Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression.

2001 • 330 citations

Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

1999 • 329 citations

Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification

1999 • 315 citations

The C. elegans zyg-1 Gene Encodes a Regulator of Centrosome Duplication with Distinct Maternal and Paternal Roles in the Embryo

2001 • 309 citations

Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast.

1999 • 306 citations

Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells.

1995 • 301 citations

Zur Frage der Entstehung maligner Tumoren

1914 • 294 citations

DNA Content as a Prognostic Marker in Patients with Oral Leukoplakia

2001 • 289 citations

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas

1998 • 285 citations

Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression

1999 • 284 citations

Spindle Assembly in Animal Cells

2000 • 281 citations

Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations

2000 • 274 citations

Centriole cycle in Chinese hamster ovary cells as determined by whole-mount electron microscopy.

1981 • 271 citations

Ductal Carcinoma in Situ of the Breast

1997 • 242 citations

Aneuploidy and cancer

2000 • 240 citations

Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation

2000 • 234 citations

The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion

2000 • 232 citations

Zygotic development without functional mitotic centrosomes

2001 • 223 citations

The Mouse Mps1p-like Kinase Regulates Centrosome Duplication

2001 • 221 citations

Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation

1997 • 219 citations

Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle

1999 • 201 citations

Altered Centrosome Structure Is Associated with Abnormal Mitoses in Human Breast Tumors

1999 • 200 citations

The Mammalian γ-Tubulin Complex Contains Homologues of the Yeast Spindle Pole Body Components Spc97p and Spc98p

1998 • 197 citations

Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype.

2001 • 197 citations

Mode of centriole duplication and distribution.

1990 • 197 citations

Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells

1997 • 178 citations

Endomitosis of Human Megakaryocytes Are Due to Abortive Mitosis

1998 • 178 citations

Vaccinia virus infection disrupts microtubule organization and centrosome function

2000 • 166 citations

The Centrosome and Its Role in the Organization of Microtubules

1987 • 166 citations

Centriole number and the reproductive capacity of spindle poles.

1985 • 162 citations

Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway

2001 • 145 citations

Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression

2000 • 145 citations

Formation of the tetraploid intermediate is associated with the development of cells with more than four centrioles in the elastase-simian virus 40 tumor antigen transgenic mouse model of pancreatic cancer.

1991 • 133 citations

Centrosome abnormalities in pancreatic ductal carcinoma.

1999 • 129 citations

A Role for Cyclin D3 in the Endomitotic Cell Cycle

1997 • 121 citations

Centrosome Abnormalities and Genomic Instability by Episomal Expression of Human Papillomavirus Type 16 in Raft Cultures of Human Keratinocytes

2001 • 120 citations

p21cip-1/waf-1 Deficiency Causes Deformed Nuclear Architecture, Centriole Overduplication, Polyploidy, and Relaxed Microtubule Damage Checkpoints in Human Hematopoietic Cells

1999 • 116 citations

Centrosomes and cancer

1999 • 113 citations

Identification of a gamma-tubulin-binding domain in BRCA1.

2001 • 109 citations

Protein synthesis and the cell cycle: centrosome reproduction in sea urchin eggs is not under translational control.

1990 • 108 citations

p21cip-1/waf-1 Deficiency Causes Deformed Nuclear Architecture, Centriole Overduplication, Polyploidy, and Relaxed Microtubule Damage Checkpoints in Human Hematopoietic Cells

1999 • 100 citations

Multi-step control of spindle pole body duplication by cyclin-dependent kinase

2000 • 100 citations

Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients

2001 • 100 citations

Centrosomes as command centres for cellular control

2001 • 94 citations

Centrosome amplification as a possible mechanism for numerical chromosome aberrations in cerebral primitive neuroectodermal tumors with TP53 mutations

1998 • 91 citations

The SCF ubiquitin ligase protein Slimb regulates centrosome duplication in Drosophila

2000 • 88 citations

Structure and function of the centriole in animal cells: progress and questions

1996 • 85 citations

Embryonic Lethality and Tumorigenesis Caused by Segmental Aneuploidy on Mouse Chromosome 11

1998 • 84 citations

Reproductive capacity of sea urchin centrosomes without centrioles

1989 • 79 citations

Centrosomes and cancer

1999 • 76 citations

Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts

2000 • 76 citations

BRCA1-associated tumorigenesis: what have we learned from knockout mice?

2001 • 74 citations

Role of p21Cip1/Waf1 in cell-cycle exit of endomitotic megakaryocytes

2001 • 71 citations

Genomic Convergence and Suppression of Centrosome Hyperamplification in Primary p53−/− Cells in Prolonged Culture

2000 • 65 citations

A Role for Cyclin E/Cdk2 in the Timing of the Midblastula Transition inXenopusEmbryos

1997 • 65 citations

Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression

2003 • 61 citations

Endoreplication in megakaryoblastic cell lines is accompanied by sustained expression of G1/S cyclins and downregulation of cdc25C.

1996 • 60 citations

Centrosomes and the spatial distribution of microtubules in animal cells

1986 • 58 citations

Centrosome Hyperamplification in Head and Neck Squamous Cell Carcinoma: A Potential Phenotypic Marker of Tumor Aggressiveness

2000 • 57 citations

Centrosome structure and microtubule nucleation in animal cells.

1999 • 53 citations

Interphase cytogenetic analysis of cervical intraepithelial neoplasia.

1998 • 53 citations

Asymmetrical segregation of chromosomes with a normal metaphase/anaphase checkpoint in polyploid megakaryocytes

2001 • 50 citations

Ductal carcinoma in situ of the breast

1997 • 49 citations

The centrosome

1999 • 48 citations

Cytogenetic Analysis of Colorectal Adenomas

1998 • 48 citations

Anticentriolar autoantibodies in children with central nervous system manifestations of Mycoplasma pneumoniae infection.

1994 • 44 citations

DNA aneuploidy as a marker of premalignancy in surveillance of patients with ulcerative colitis

1999 • 43 citations

Stepwise Progression of Centrosome Defects Associated with Local Tumor Growth and Metastatic Process of Human Pancreatic Carcinoma Cells Transplanted Orthotopically into Nude Mice

2001 • 43 citations

Centrosome structure and microbubule nucleation in animal cells

1999 • 41 citations

DNA Aneuploidy by Flow Cytometry Is an Independent Prognostic Factor in Gastric Cancer

1998 • 40 citations

Constitutional genomic instability with inversions, duplications, and amplifications in 9p23-24 in BRCA2 mutation carriers.

2001 • 40 citations

Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer

1997 • 40 citations

Centrosome and microtubule instability in aging Drosophila cells

1999 • 33 citations

Integrating centrosome structure with protein composition and function in animal cells

2000 • 31 citations

Centrosome proteins: a major class of autoantigens in scleroderma.

1999 • 28 citations

Image analysis of papillary thyroid carcinoma fine-needle aspirates

1999 • 28 citations

Microtubule Nucleating Capacity of Centrosomes in Tissue Sections

1999 • 27 citations

Centrosome and microtubule instability in agingDrosophila cells

1999 • 26 citations

Multiple Centrosome Formation Induced by the Expression of Vpr Gene of Human Immunodeficiency Virus

1999 • 22 citations

Image analysis of papillary thyroid carcinoma fine-needle aspirates

1999 • 21 citations

DNA ploidy, Ki-67 and p53 as indicators of lymph node metastasis in early gastric carcinoma.

1999 • 20 citations

Nuclear DNA in histological and cytological specimens: measurement and prognostic significance.

1997 • 15 citations

The interphase microtubule damage checkpoint defines an S-phase commitment point and does not requirep21waf-1

2001 • 10 citations

Renal and Bladder Cancers

1997 • 5 citations

Human Cytogenetic Cancer Markers

1998 • 2 citations