Centrosome and microtubule instability in agingDrosophila cells

THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY

1963 • 24,942 citations

A low-viscosity epoxy resin embedding medium for electron microscopy

1969 • 12,996 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Nucleation of microtubule assembly by a γ-tubulin-containing ring complex

1995 • 851 citations

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

1998 • 815 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Mitosis and the Physiology of Cell Division

1961 • 549 citations

Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation

1998 • 547 citations

Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity

1998 • 515 citations

Behavior of centrosomes during fertilization and cell division in mouse oocytes and in sea urchin eggs.

1986 • 330 citations

Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material

1983 • 323 citations

Spaceflight alters microtubules and increases apoptosis in human lymphocytes (Jurkat)

1998 • 268 citations

Phosphoproteins are components of mitotic microtubule organizing centers.

1984 • 246 citations

Cell aging in vivo and in vitro

1997 • 232 citations

Centrosomes and mitotic poles

1984 • 229 citations

Three-dimensional structural characterization of centrosomes from early Drosophila embryos.

1995 • 212 citations

Myocyte degeneration and cell death in hibernating human myocardium

1996 • 147 citations

Demonstration of cellular aging and senescence in serially passaged long-term cultures of human trabecular osteoblasts

1997 • 129 citations

From genes to structural morphogenesis: The genesis and epigenesis of a red blood cell

1987 • 124 citations

Studies in aging of the brain

1979 • 120 citations

Cytoplasmic microtubule-based motor proteins

1993 • 106 citations

Aging mechanisms in fruit flies

1996 • 106 citations

The microtubular cytoskeleton and chromosomes of unfertilized human oocytes aged in vitro

1988 • 97 citations

Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease

1992 • 96 citations

The CBA mouse as a model for age-related aneuploidy in man: studies of oocyte maturation, spindle formation and chromosome alignment during meiosis

1988 • 85 citations

Cytoskeletal alteration in aged porcine oocytes and parthenogenesis

1996 • 83 citations

Increased Calcium Buffering in Basal Forebrain Neurons During Aging

1998 • 80 citations

Telomerase and the Aging Cell

1998 • 79 citations

Centrosome detection in sea urchin eggs with a monoclonal antibody against Drosophila intermediate filament proteins: characterization of stages of the division cycle of centrosomes.

1987 • 77 citations

Identification and immunolocalization of cytoplasmic dynein in dictyostelium

1990 • 75 citations

MDCK cell cultures as an epithelial in vitro model: cytoskeleton and tight junctions as indicators for the definition of age-related stages by confocal microscopy.

1998 • 64 citations

Microtubules are required for centrosome expansion and positioning while microfilaments are required for centrosome separation in sea urchin eggs during fertilization and mitosis

1988 • 53 citations

Activation of maternal centrosomes in unfertilized sea urchin eggs

1992 • 51 citations

The Drosophila Cytoskeleton

1990 • 50 citations

Microgravity effects on Drosophila melanogaster behavior and aging. Implications of the IML-2 experiment

1996 • 49 citations

Stress-induced fractal rearrangement of the endothelial cell cytoskeleton causes apoptosis

1998 • 47 citations

Structural alterations of the mitotic apparatus induced by the heat shock response in Drosophila cells

1997 • 47 citations

The Cytoskeleton: Cellular architecture and choreography

1984 • 39 citations

Deregulation of Collagen Phagocytosis in Aging Human Fibroblasts: Effects of Integrin Expression and Cell Cycle

1997 • 39 citations

Regulation of transcription factor activity during cellular aging

1996 • 38 citations

Regulation of gene expression is preserved in aging Drosophila melanogaster

1998 • 34 citations

Cold-treated centrosome: Isolation of centrosomes from mitotic sea urchin eggs, production of an anticentrosomal antibody, and novel ultrastructural imaging

1996 • 32 citations

Changes in the Expression of Genes Involved in Protein Synthesis during <i>Drosophil</i><i>a</i> Aging

1996 • 29 citations

The centrosomal cycle: Visualization in PtK cells by a monoclonal antibody to a centrosomal 32 kd protein

1990 • 25 citations

Dithiothreitol prevents membrane fusion but not centrosome or microtubule organization during the first cell cycles in sea urchins

1994 • 25 citations

Accelerated Aging of Dermal Fibroblast-like Cells From the Senescence-Accelerated Mouse (SAM): Acceleration of Changes in DNA Ploidy Associated With In Vitro Cellular Aging

1998 • 23 citations

Decreased mitochondrial RNA levels without accumulation of mitochondrial DNA deletions in aging Drosophila melanogaster

1998 • 23 citations

Age-Related Changes in the mRNA Expression of Actin Isoforms in <i>Drosophila melanogaste</i><i>r</i>

1997 • 22 citations

Centrosome structure and function is altered by chloral hydrate and diazepam during the first reproductive cell cycles in sea urchin eggs

1998 • 17 citations

Effect of age and apoptosis on the mouse homologue of the huWRN gene

1998 • 16 citations

Effect of age on the growth and response of a Drosophila cell line to moulting hormone

1997 • 13 citations

Cytoskeletal alterations in the aged human neurohypophysis

1997 • 9 citations

Phenotypic Changes in Vascular Smooth Muscle Cells during Aging: Insulin Effect on Migration

1998 • 8 citations

Development of an In Vivo Perfusion System for Bovine Fetal Small Intestine

1992 • 3 citations