Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation

Current protocols in molecular biology

1988 • 7,584 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

1995 • 2,548 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1995 • 2,028 citations

Genetic instability in colorectal cancers

1997 • 1,989 citations

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Notch Signaling

1995 • 1,282 citations

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

1997 • 1,259 citations

Formation and Activation of a Cyclin E-cdk2 Complex During the G ₁ Phase of the Human Cell Cycle

1992 • 1,046 citations

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

1996 • 1,013 citations

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

1996 • 956 citations

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

1997 • 953 citations

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

1992 • 941 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

1984 • 889 citations

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1994 • 866 citations

A Familial Alzheimer's Disease Locus on Chromosome 1

1995 • 810 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

1995 • 741 citations

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1995 • 705 citations

Apolipoprotein E and Alzheimer disease.

1995 • 697 citations

Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells

1996 • 549 citations

Interfering with Apoptosis: Ca ²⁺ -Binding Protein ALG-2 and Alzheimer's Disease Gene ALG-3

1996 • 481 citations

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1996 • 481 citations

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.

1994 • 445 citations

Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation

1996 • 424 citations

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.

1994 • 407 citations

Mitotic mechanisms in Alzheimer's disease?

1996 • 384 citations

Protein Topology of Presenilin 1

1996 • 374 citations

A4POE*4-associated Alzheimer's disease risk is modified by α1–antichymotrypsin polymorphism

1995 • 337 citations

Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome

1996 • 328 citations

Kinetochore structure, duplication, and distribution in mammalian cells: analysis by human autoantibodies from scleroderma patients.

1981 • 312 citations

Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated Presenilins

1997 • 291 citations

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.

1995 • 280 citations

SPXX, a frequent sequence motif in gene regulatory proteins

1989 • 276 citations

Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope.

1994 • 257 citations

Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane

1994 • 240 citations

The Alzheimer’s Disease-Associated Presenilins Are Differentially Phosphorylated Proteins Located Predominantly within the Endoplasmic Reticulum

1996 • 229 citations

Membrane Topology of the C. elegans SEL-12 Presenilin

1996 • 204 citations

Genetic dissection of Alzheimer disease, a heterogeneous disorder.

1995 • 179 citations

Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1

1995 • 166 citations

Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis

1995 • 156 citations

NDC1: a nuclear periphery component required for yeast spindle pole body duplication

1993 • 151 citations

Distribution of kinetochore (centromere) antigen in mammalian cell nuclei.

1981 • 147 citations

Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders.

1991 • 143 citations

Genes and the Biology of Cancer

1995 • 142 citations

Autoimmune response directed against conserved determinants of nuclear envelope proteins in a patient with linear scleroderma.

1983 • 133 citations

Anticentromere and Anticentriole Antibodies in the Scleroderma Spectrum

1983 • 133 citations

The lamin B receptor of the inner nuclear membrane undergoes mitosis-specific phosphorylation and is a substrate for p34cdc2-type protein kinase.

1992 • 133 citations

Requirement of the Familial Alzheimer's Disease Gene PS2 for Apoptosis

1996 • 132 citations

Alzheimer‐associated presenilin‐2 confers increased sensitivity to poptosis in PC12 cells

1996 • 132 citations

Sex chromosome aneuploidy and aging

1995 • 128 citations

Characterization of human presenilin 1 using N‐terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing

1996 • 122 citations

Alzheimer Aβ neurotoxicity: Promotion by antichymotrypsin, ApoE4; inhibition by Aβ-related peptides

1996 • 109 citations

Role of the β-amyloid precursor protein in Alzheimer's disease

1994 • 95 citations

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

1996 • 91 citations

The intracellular distribution of the transformation-associated protein p53 in adenovirus-transformed rodent cells.

1988 • 59 citations

Immunohistochemical analysis of presenilin‐1 expression in the mouse brain

1996 • 58 citations

Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3.

1995 • 57 citations

High levels of amyloid-β protein from S182 (Glu246) familial Alzheimerʼs cells

1995 • 54 citations

Review and Hypothesis

1998 • 53 citations

Presenile because of presenilin

1996 • 50 citations

Genetic Clues to Alzheimer's Disease

1996 • 46 citations

A Possible Unitary Genetic Hypothesis for Alzheimer's Disease and Down Syndromea

1985 • 46 citations

Localization of Alzheimer-Associated Presenilin 1 in Transfected COS-7 Cells

1996 • 46 citations

The mammalian centromere: Its molecular architecture

1996 • 25 citations

Deleted Work

1955 • 0 citations