Centrosome structure and microtubule nucleation in animal cells.

MICROTUBULE POLYMERIZATION DYNAMICS

1997 • 2,442 citations

Nucleation of microtubule assembly by a γ-tubulin-containing ring complex

1995 • 851 citations

Microtubule assembly nucleated by isolated centrosomes

1984 • 775 citations

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

1996 • 685 citations

Identification of a Protein That Interacts with Tubulin Dimers and Increases the Catastrophe Rate of Microtubules

1996 • 651 citations

Identification of γ-tubulin, a new member of the tubulin superfamily encoded by mipA gene of Aspergillus nidulans

1989 • 613 citations

Pericentrin, a highly conserved centrosome protein involved in microtubule organization

1994 • 579 citations

γ-Tubulin is a highly conserved component of the centrosome

1991 • 566 citations

γ-tubulin is a component of the spindle pole body that is essential for microtubule function in Aspergillus nidulans

1990 • 558 citations

Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles

1988 • 546 citations

Microtubule nucleation by γ-tubulin-containing rings in the centrosome

1995 • 530 citations

Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

1996 • 506 citations

Pericentrin and γ-Tubulin Form a Protein Complex and Are Organized into a Novel Lattice at the Centrosome

1998 • 485 citations

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.

1995 • 471 citations

Actomyosin-based Retrograde Flow of Microtubules in the Lamella of Migrating Epithelial Cells Influences Microtubule Dynamic Instability and Turnover and Is Associated with Microtubule Breakage and Treadmilling

1997 • 470 citations

In vitro reconstitution of centrosome assembly and function: The central role of γ-tubulin

1994 • 457 citations

γ-Tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation

1992 • 447 citations

C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2

1998 • 438 citations

γ-Tubulin is present in Drosophila melanogaster and homo sapiens and is associated with the centrosome

1991 • 405 citations

polo encodes a protein kinase homolog required for mitosis in Drosophila.

1991 • 403 citations

p34cdc2 is located in both nucleus and cytoplasm; part is centrosomally associated at G2/M and enters vesicles at anaphase.

1989 • 376 citations

Centrosome organization and centriole architecture: Their sensitivity to divalent cations

1992 • 365 citations

Centriole Disassembly In Vivo and Its Effect on Centrosome Structure and Function in Vertebrate Cells

1998 • 361 citations

Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles

1996 • 351 citations

Fate of microtubule-organizing centers during myogenesis in vitro.

1985 • 331 citations

Characterization of Two Related Drosophila γ-tubulin Complexes that Differ in Their Ability to Nucleate Microtubules

1999 • 309 citations

The fission yeast γ-tubulin is essential for mitosis and is localized at microtubule organizing centers

1991 • 294 citations

Structural and chemical characterization of isolated centrosomes

1987 • 292 citations

Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends.

1994 • 271 citations

γ-Tubulin in mammalian cells: the centrosomal and the cytosolic forms

1996 • 256 citations

Progress in Cell Cycle Research

1997 • 243 citations

Spc98p and Spc97p of the yeast gamma -tubulin complex mediate binding to the spindle pole body via their interaction with Spc110p

1997 • 239 citations

Centrosome assembly in vitro: role of gamma-tubulin recruitment in Xenopus sperm aster formation

1994 • 228 citations

Initiation and growth of microtubules from mitotic centers in lysed mammalian cells.

1975 • 219 citations

Three-dimensional structural characterization of centrosomes from early Drosophila embryos.

1995 • 212 citations

TheUNI3Gene Is Required for Assembly of Basal Bodies ofChlamydomonasand Encodes δ-Tubulin, a New Member of the Tubulin Superfamily

1998 • 203 citations

A molecular marker for centriole maturation in the mammalian cell cycle.

1995 • 197 citations

The Mammalian γ-Tubulin Complex Contains Homologues of the Yeast Spindle Pole Body Components Spc97p and Spc98p

1998 • 197 citations

Microsurgical removal of centrosomes blocks cell reproduction and centriole generation in BSC-1 cells

1991 • 195 citations

Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450

1999 • 193 citations

The spindle pole body component Spc97p interacts with the gamma -tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication

1997 • 193 citations

Microtubule-nucleating activity of centrosomes in Chinese hamster ovary cells is independent of the centriole cycle but coupled to the mitotic cycle.

1981 • 191 citations

Polyglutamylation of Tubulin as a Progressive Regulator of in Vitro Interactions between the Microtubule-Associated Protein Tau and Tubulin

1994 • 189 citations

When Overexpressed, a Novel Centrosomal Protein, RanBPM, Causes Ectopic Microtubule Nucleation Similar to γ-Tubulin

1998 • 188 citations

The spindle pole body component Spc98p interacts with the gamma-tubulin-like Tub4p of Saccharomyces cerevisiae at the sites of microtubule attachment.

1996 • 183 citations

Protofilaments and rings, two conformations of the tubulin family conserved from bacterial FtsZ to alpha/beta and gamma tubulin.

1996 • 179 citations

Gamma-tubulin is required for the structure and function of the microtubule organizing centre in Drosophila neuroblasts.

1995 • 179 citations

Cloning of a cdna encoding human centrin, an ef-hand protein of centrosomes and mitotic spindle poles

1994 • 177 citations

The calcium-binding protein cell division cycle 31 of Saccharomyces cerevisiae is a component of the half bridge of the spindle pole body.

1993 • 176 citations

Receptors determine the cellular localization of a γ-tubulin complex and thereby the site of microtubule formation

1998 • 168 citations

Abnormal Spindle Protein, Asp, and the Integrity of Mitotic Centrosomal Microtubule Organizing Centers

1999 • 167 citations

Centriole number and the reproductive capacity of spindle poles.

1985 • 162 citations

Interaction of Kinesin Motor Domains with α- and β-Tubulin Subunits at a Tau-independent Binding Site

1996 • 162 citations

GMAP-210, A Cis-Golgi Network-associated Protein, Is a Minus End Microtubule-binding Protein

1999 • 159 citations

Microtubule Treadmilling in Vivo

1997 • 159 citations

A highly divergent gamma-tubulin gene is essential for cell growth and proper microtubule organization in Saccharomyces cerevisiae.

1995 • 157 citations

Analysis of Tub4p, a yeast gamma-tubulin-like protein: implications for microtubule-organizing center function.

1996 • 156 citations

Glutamylation of centriole and cytoplasmic tubulin in proliferating non-neuronal cells

1998 • 151 citations

gamma-Tubulin-like Tub4p of Saccharomyces cerevisiae is associated with the spindle pole body substructures that organize microtubules and is required for mitotic spindle formation.

1996 • 150 citations

The Drosophila Gene abnormal spindle Encodes a Novel Microtubule-associated Protein That Associates with the Polar Regions of the Mitotic Spindle

1997 • 144 citations

Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome

1999 • 144 citations

Centrosomal control of microtubule dynamics

1999 • 143 citations

Microtubule organizing centers and γ-tubulin

1994 • 140 citations

AKAP350, a Multiply Spliced Protein Kinase A-anchoring Protein Associated with Centrosomes

1999 • 139 citations

Microtubule-organizing centers in higher plants

1993 • 138 citations

The Cdc31p-binding protein Kar1p is a component of the half bridge of the yeast spindle pole body.

1995 • 137 citations

Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene

1997 • 136 citations

Katanin, the microtubule-severing ATPase, is concentrated at centrosomes

1996 • 135 citations

Molecular cloning and centrosomal localization of human caltractin.

1993 • 128 citations

Basal body duplication in Paramecium requires γ-tubulin

1999 • 127 citations

Reconstruction of the Centrosome Cycle from Cryoelectron Micrographs

1997 • 125 citations

Characterization of the Human Homologue of the Yeast Spc98p and Its Association with γ-Tubulin

1998 • 123 citations

Drosophila gamma-tubulin is part of a complex containing two previously identified centrosomal MAPs.

1993 • 119 citations

Xgrip109: A γ Tubulin–Associated Protein with an Essential Role in γ Tubulin Ring Complex (γTuRC) Assembly and Centrosome Function

1998 • 112 citations

Gamma-tubulin can both nucleate microtubule assembly and self-assemble into novel tubular structures in mammalian cells.

1995 • 110 citations

Microtubule structure and dynamics

1997 • 108 citations

Nucleation of microtubules from mitotic centrosomes is modulated by a phosphorylated epitope

1990 • 108 citations

The Yeast Spindle Pole Body Component Spc72p Interacts with Stu2p and Is Required for Proper Microtubule Assembly

1998 • 104 citations

Microtubule dynamics: Treadmilling comes around again

1997 • 103 citations

Evidence for tektins in centrioles and axonemal microtubules.

1988 • 101 citations

Centrosome inheritance in starfish zygotes: Selective loss of the maternal centrosome after fertilization

1989 • 101 citations

Centrosome-microtubule nucleation

1997 • 100 citations

Reproductive capacity of sea urchin centrosomes without centrioles

1989 • 79 citations

Identification of centrosomal proteins in a human lymphoblastic cell line.

1986 • 77 citations

A High-Affinity Binding Protein for the Regulatory Subunit of cAMP-Dependent Protein Kinase II in the Centrosome of Human Cells

1993 • 73 citations

Mass isolation of calf thymus centrosomes: identification of a specific configuration.

1989 • 69 citations

Microtubule nucleating activity of centrosomes in cell-free extracts from Xenopus eggs: involvement of phosphorylation and accumulation of pericentriolar material

1993 • 64 citations

Centrosomal deployment of γ-tubulin and pericentrin: Evidence for a microtubule-nucleating domain and a minus-end docking domain in certain mouse epithelial cells

1997 • 63 citations

Microtubule release and capture in epithelial cells

1999 • 61 citations

Pulse treatment of interphasic HeLa cells with nanomolar doses of docetaxel affects centrosome organization and leads to catastrophic exit of mitosis

1997 • 54 citations

225‐Kilodalton phosphoprotein associated with mitotic centrosomes in sea urchin eggs

1989 • 52 citations

Protein complexes containing gamma-tubulin are present in mammalian brain microtubule protein preparations

1997 • 49 citations

[20] Rapid isolation of centrosomes

1998 • 48 citations

Parthenogenesis in Xenopus eggs injected with centrosomes from synchronized human lymphoid cells

1989 • 45 citations

Mammalian Sperm Tubulin: An Exceptionally Large Number of Variants Based on Several Posttranslational Modifications

1997 • 38 citations

cDNA sequence for mouse caltractin

1993 • 38 citations

Microtubule organization by the budding yeast spindle pole body

1999 • 37 citations

Centrosome Inheritance in Starfish Zygotes II: Selective Suppression of the Maternal Centrosome during Meiosis

1993 • 35 citations

A nice ring to the centrosome

1995 • 35 citations

Organisation and functional regulation of the centrosome in animal cells

1997 • 33 citations

Role of γ-tubulin in mitosis-specific microtubule nucleation from the schizosaccharomyces pombe spindle pole body

1996 • 33 citations

Tektins as structural determinants in basal bodies

1998 • 32 citations

Partial purification of centrosomes from Chinese hamster ovary cells

1978 • 26 citations

Identification of MINUS, a small polypeptide that functions as a microtubule nucleation suppressor

1999 • 20 citations

In isolated human centrosomes, the associated kinases phosphorylate a specific subset of centrosomal proteins

1995 • 14 citations

Cytoskeleton: Microtubule nucleation takes shape

1996 • 13 citations

Aster-Forming Abilities of the Egg, Polar Body, and Sperm Centrosomes in Early Starfish Development

1998 • 13 citations

Demonstration and Analysis of Tubulin Binding Sites on Centrosomes

1997 • 6 citations