The glucagon-induced activation of pyruvate dehydrogenase in hepatocytes is diminished by 4β-phorbol 12-myristate 13-acetate. A role for cytoplasmic Ca2+ in dehydrogenase regulation

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS

1969 • 4,428 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

1972 • 519 citations

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

1979 • 431 citations

Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones

1971 • 388 citations

On the role of the calcium transport cycle in heart and other mammalian mitochondria

1980 • 375 citations

Changes in free cytosolic Ca2+ in hepatocytes following alpha 1-adrenergic stimulation. Studies on Quin-2-loaded hepatocytes.

1983 • 375 citations

Relation between mitochondrial calcium transport and control of energy metabolism

1985 • 362 citations

Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues

1978 • 359 citations

Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.

1984 • 358 citations

The mammalian pyruvate dehydrogenase complex: Structure and regulation

1983 • 336 citations

Regulation of Hepatic Metabolism

1976 • 314 citations

Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios

1975 • 303 citations

Metabolic Compartmentation

1983 • 303 citations

Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria

1980 • 292 citations

α-Keto acid dehydrogenase complexes

1972 • 244 citations

Effect of glucagon on metabolite compartmentation in isolated rat liver cells during gluconeogenesis from lactate

1977 • 234 citations

Inhibition of hepatic alpha 1-adrenergic effects and binding by phorbol myristate acetate.

1985 • 218 citations

Differential effects of phorbol ester on phenylephrine and vasopressin-induced Ca2+ mobilization in isolated hepatocytes.

1985 • 199 citations

Recently discovered systems of enzyme regulation by reversible phosphorylation

1980 • 156 citations

Regulation of Mammalian Pyruvate Dehydrogenase Complex by a Phosphorylation–Dephosphorylation Cycle

1981 • 153 citations

Stimulation of phosphorylation and inactivation of pyruvate dehydrogenase by physiological inhibitors of the pyruvate dehydrogenase reaction

1975 • 141 citations

Characterization of the effects of Ca2+ on the intramitochondrial Ca2+-sensitive enzymes from rat liver and within intact rat liver mitochondria

1985 • 139 citations

Relative importance of pyruvate dehydrogenase interconversion and feed-back inhibition in the effect of fatty acids on pyruvate oxidation by rat heart mitochondria

1978 • 130 citations

The phorbol ester, TPA inhibits glucagon‐stimulated adenylate cyclase activity

1984 • 128 citations

Sensitivity of the response of cytosolic calcium in Quin-2-loaded rat hepatocytes to glucagon, adenine nucleosides, and adenine nucleotides.

1985 • 119 citations

Control of respiration in isolated mitochondria: Quantitative evaluation of the dependence of respiratory rates on [ATP], [ADP], and [Pi]

1977 • 116 citations

Cytosolic free Ca²⁺ in isolated rat hepatocytes as measured by quin2

1984 • 111 citations

Mitogen-induced changes in Ca2+ permeability are not mediated by voltage-gated K+ channels.

1986 • 88 citations

Studies on the activation of rat liver pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase by adrenaline and glucagon. Role of increases in intramitochondrial Ca2+ concentration

1985 • 84 citations

Hormone-induced changes in NADH fluorescence and O2 consumption of rat hepatocytes

1982 • 75 citations

Effect of micromolar concentrations of free Ca2+ ions on pyruvate dehydrogenase interconversion in intact rat heart mitochondria

1981 • 69 citations

Effect of phenylephrine on pyruvate dehydrogenase activity in rat hepatocytes and its interaction with insulin and glucagon

1983 • 57 citations

Regulation of pyruvate dehydrogenase interconversion in isolated hepatocytes by the mitochondrial ATP/ADP ratio

1975 • 56 citations

4 β-Phorbol 12-myristate 13-acetate attenuates the glucagon-induced increase in cytoplasmic free Ca2+ concentration in isolated rat hepatocytes

1986 • 56 citations

Effects of phorbol esters on α1-adrenergic-mediated and glucagon-mediated actions in isolated rat hepatocytes

1985 • 55 citations

Activation of pyruvate dehydrogenase in the perfused rat liver by vasopressin

1978 • 54 citations

Early Kinetics of Glucagon Action in Isolated Hepatocytes at the Mitochondrial Level

1980 • 46 citations

Distinct effects of glucagon and vasopressin on proline metabolism in isolated hepatocytes. The role of oxoglutarate dehydrogenase

1984 • 39 citations

Decreased flux through pyruvate dehydrogenase during calcium ion movements induced by vasopressin, α-adrenergic agonists and the ionophore A23187 in perfused rat liver

1983 • 37 citations

Hormonal control of pyruvate dehydrogenase activity in rat liver

1984 • 34 citations

Effects of Calcium Ions on the Activation of Gluconeogenesis by Norepinephrine in Perfused Rat Liver

1980 • 34 citations

The effects of alpha-adrenergic stimulation on the regulation of the pyruvate dehydrogenase complex in the perfused rat liver.

1985 • 15 citations