Effects of work and acidosis on pyruvate dehydrogenase activity in perfused rat hearts

[65] Assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods

1969 • 872 citations

Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids

1974 • 492 citations

Coenzyme A and carnitine distribution in normal and ischemic hearts.

1978 • 481 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, XI. COMPARATIVE STUDIES OF REGULATORY PROPERTIES OF THE PYRUVATE DEHYDROGENASE COMPLEXES FROM KIDNEY, HEART, AND LIVER MITOCHONDRIA

1969 • 355 citations

Control of maximum rates of glycolysis in rat cardiac muscle.

1979 • 311 citations

Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios

1975 • 303 citations

Regulation of mammalian pyruvate dehydrogenase

1975 • 299 citations

Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: Effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion

1971 • 231 citations

Regulation of heart muscle pyruvate dehydrogenase kinase

1974 • 227 citations

Active and Inactive Forms of Pyruvate Dehydrogenase in Rat Liver

1972 • 199 citations

Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication)

1973 • 174 citations

Pyruvate Dehydrogenase, Substrate Specificity and Product Inhibition

1969 • 161 citations

α-Keto Acid Dehydrogenase Complexes

1973 • 149 citations

Stimulation of phosphorylation and inactivation of pyruvate dehydrogenase by physiological inhibitors of the pyruvate dehydrogenase reaction

1975 • 141 citations

Interconversion of Phospho- and Dephospho- Forms of Pig Heart Pyruvate Dehydrogenase

1970 • 134 citations

Relative importance of pyruvate dehydrogenase interconversion and feed-back inhibition in the effect of fatty acids on pyruvate oxidation by rat heart mitochondria

1978 • 130 citations

Mechanism of pyruvate inhibition of kidney pyruvate dehydrogenasea kinase and synergistic inhibition by pyruvate and ADP.

1979 • 127 citations

Regulation of pyruvate dehydrogenase by fatty acid in isolated rat liver mitochondria.

1976 • 120 citations

Diabetes and the control of pyruvate dehydrogenase in rat heart mitochondria by concentration ratios of adenosine triphosphate/adenosine diphosphate, of reduced/oxidized nicotinamide-adenine dinucleotide and of acetyl-coenzyme A/coenzyme A.

1977 • 117 citations

Studies on the effects of coenzyme A-SH: acetyl coenzyme A, nicotinamide adenine dinucleotide: reduced nicotinamide adenine dinucleotide, and adenosine diphosphate: adenosine triphosphate ratios on the interconversion of active and inactive pyruvate dehydrogenase in isolated rat heart mitochondria.

1976 • 117 citations

Purification and Characterization of Pyruvate‐Dehydrogenase Phosphatase from Pig‐Heart Muscle

1972 • 110 citations

Regulation of Pyruvate Dehydrogenase in Rat Liver Mitochondria by Phosphorylation-Dephosphorylation

1974 • 104 citations

The regulation of pyruvate dehydrogenase in the isolated perfused rat heart.

1978 • 99 citations

Control of pyruvate dehydrogenase in the perfused rat heart by the intracellular concentration of acetyl-coenzyme A.

1964 • 99 citations

Coordination of citric acid cycle activity with electron transport flux.

1976 • 97 citations

EFFECTS OF ACIDOSIS ON MYOCARDIAL CONTRACTILITY AND METABOLISM*

1976 • 97 citations

A unifying mechanism for stimulation of mammalian pyruvate dehydrogenase(a) kinase by reduced nicotinamide adenine dinucleotide, dihydrolipoamide, acetyl coenzyme A, or pyruvate.

1978 • 96 citations

Factors in oxygen delivery to tissue

1974 • 74 citations

Energy-linked regulation of glucose and pyruvate oxidation in isolated perfused rat heart. Role of pyruvate dehydrogenase

1976 • 68 citations

Analysis of control of glycolysis in ischemic hearts having heterogeneous zones of anoxia

1978 • 50 citations

Respiratory acidosis and its reversibility in perfused rat heart: regulation of citric acid cycle activity

1978 • 37 citations

Regulation of myocardial energy metabolism.

1975 • 35 citations

Pyruvate Dehydrogenase Activation after an Increase in Cardiac Output

1976 • 25 citations

Control of energy production in cardiac muscle: effects of ischemia in acidosis.

1976 • 12 citations