Control of Mitochondrial Substrate Oxidation

Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism

1961 • 4,416 citations

CHEMIOSMOTIC COUPLING IN OXIDATIVE AND PHOTOSYNTHETIC PHOSPHORYLATION

1966 • 3,631 citations

The Enzymes of Biological Membranes

1985 • 1,362 citations

Regulation of Metabolic Processes in Mitochondria

1967 • 1,182 citations

The Influence of Respiration and ATP Hydrolysis on the Proton‐Electrochemical Gradient across the Inner Membrane of Rat‐Liver Mitochondria as Determined by Ion Distribution

1974 • 707 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY PHOSPHORYLATION AND DEPHOSPHORYLATION

1969 • 669 citations

Estimation of Membrane Potential and pH Difference across the Cristae Membrane of Rat Liver Mitochondria

1969 • 589 citations

On cytochrome, a respiratory pigment, common to animals, yeast, and higher plants

1925 • 533 citations

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

1972 • 519 citations

Myocardial utilization of carbohydrate and lipids

1972 • 505 citations

Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids

1974 • 492 citations

SYSTEMS USED FOR THE TRANSPORT OF SUBSTRATES INTO MITOCHONDRIA

1968 • 449 citations

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

1979 • 431 citations

Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide

1976 • 399 citations

The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria

1978 • 380 citations

Molecular and physiological aspects of adenine nucleotide trasport in mitochondria

1976 • 373 citations

Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues

1978 • 359 citations

Reversible Inhibition of Mitochondrial Adenosine Diphosphate Phosphorylation by Long Chain Acyl Coenzyme A Esters

1971 • 357 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, XI. COMPARATIVE STUDIES OF REGULATORY PROPERTIES OF THE PYRUVATE DEHYDROGENASE COMPLEXES FROM KIDNEY, HEART, AND LIVER MITOCHONDRIA

1969 • 355 citations

Compartmentation and Communication in Living Systems. Ligand Conduction: a General Catalytic Principle in Chemical, Osmotic and Chemiosmotic Reaction Systems

1979 • 349 citations

The Interaction of Energy and Electron Transfer Reactions in Mitochondria

1961 • 347 citations

The kinetic properties of citrate synthase from rat liver mitochondria

1969 • 346 citations

Rapid separation of particulate components and soluble cytoplasm of isolated rat-liver cells

1974 • 324 citations

Mitochondrial structure and compartmentation

1967 • 322 citations

Bioenergetics of membranes

1978 • 314 citations

Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios

1975 • 303 citations

Regulation of mammalian pyruvate dehydrogenase

1975 • 299 citations

Sites of phosphorylation on pyruvate dehydrogenase from bovine kidney and heart

1978 • 283 citations

Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilization in rat heart

1970 • 270 citations

The effects of increased heart work on the tricarboxylate cycle and its interactions with glycolysis in the perfused rat heart

1972 • 258 citations

Electron transfer Chains and oxidative phosphorylation

1976 • 248 citations

α-Keto acid dehydrogenase complexes

1972 • 244 citations

Inhibitors Tools in Cell Research

1969 • 239 citations

Control of Citric Acid Cycle Activity in Rat Heart Mitochondria

1970 • 229 citations

Metabolite transport in mitochondria: an example for intracellular membrane function.

1970 • 229 citations

Respiratory Control and the Proton Electrochemical Gradient in Mitochondria

1973 • 228 citations

Stoichiometry of H+ ejection and Ca2+ uptake coupled to electron transport in rat heart mitochondria.

1978 • 228 citations

Regulation of heart muscle pyruvate dehydrogenase kinase

1974 • 227 citations

The metabolic significance of anion transport in mitochondria

1974 • 225 citations

Adenine Nucleotide Translocation of Mitochondria. Kinetics of the Adenine Nucleotide Exchange

1969 • 223 citations

Activation and Inhibition of DPN-linked Isocitrate Dehydrogenase of Heart by Certain Nucleotides^*

1963 • 223 citations

Hamster Brown‐Adipose‐Tissue Mitochondria

1974 • 214 citations

The phosphorylation potential generated by respiring mitochondria

1973 • 212 citations

Relation between the Gradient of the ATP/ADP Ratio and the Membrane Potential across the Mitochondrial Membrane

1977 • 210 citations

Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats

1977 • 208 citations

Kinetic Study of the Tricarboxylate Carrier in Rat Liver Mitochondria

1972 • 208 citations

Inhibition of citrate-synthase by palmityl-coenzyme A

1963 • 199 citations

Phosphate Transport in Rat Liver Mitochondria

1974 • 192 citations

The inhibition of adenine nucleotide translocase activity by oleoyl CoA and its reversal in rat liver mitochondria

1971 • 185 citations

A Scrutiny of Mitchell's Chemiosmotic Hypothesis of Respiratory Chain and Photosynthetic Phosphorylation

1969 • 185 citations

Subcellular Metabolite Concentrations

1978 • 182 citations

Feedback Interactions in the Control of Citric Acid Cycle Activity in Rat Heart Mitochondria

1972 • 179 citations

A Theoretical Background to the Use of Measured Concentrations of Intermediates in Study of the Control of Intermediary Metabolism

1972 • 178 citations

Differences between the ATP/ADP Ratios in the Mitochondrial Matrix and in the Extramitochondrial Space

1972 • 177 citations

Intramitochondrial and Extramitochondrial Concentrations of Adenine Nucleotides and Inorganic Phosphate in Isolated Hepatocytes from Fasted Rats

1978 • 176 citations

Reversible Inhibition of Adenine Nucleotide Translocation by Long Chain Fatty Acyl Coenzyme A Esters in Liver Mitochondria of Diabetic and Hibernating Animals

1972 • 172 citations

Effect of long-chain fatty acids and acyl-CoA on mitochondrial permeability, transport, and energy-coupling processes

1976 • 162 citations

Quantitative Correlation between the Distribution of Anions and the pH Difference across the Mitochondrial Membrane

1970 • 161 citations

Pyruvate Dehydrogenase, Substrate Specificity and Product Inhibition

1969 • 161 citations

Regulation of Glutamate Metabolism and Interactions with the Citric Acid Cycle in Rat Heart Mitochondria

1973 • 158 citations

Function of calcium ions in pyruvate dehydrogenase phosphatase activity

1972 • 157 citations

Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase

1974 • 157 citations

The effect of Ca2+ on the oxidation of glycerol phosphate by blowfly flight-muscle mitochondria

1967 • 154 citations

Control of mitochondrial respiration: A quantitative evaluation of the roles of cytochrome c and oxygen

1977 • 150 citations

α-Keto Acid Dehydrogenase Complexes

1973 • 149 citations

The respiratory activity and permeability of housefly sarcosomes

1962 • 146 citations

Effect of nicotinamide adenine dinucleotide on the membrane-associated reduced nicotinamide adenine dinucleotide oxidase of Mycobacterium phlei.

1975 • 145 citations

Stimulation of phosphorylation and inactivation of pyruvate dehydrogenase by physiological inhibitors of the pyruvate dehydrogenase reaction

1975 • 141 citations

Re-evaluation of the H+/site ratio of mitochondrial electron transport with the oxygen pulse technique.

1976 • 140 citations

Mitochondrial-Cytosolic Interactions in Perfused Rat Heart

1973 • 134 citations

Phosphorylation state of cytosolic and mitochondrial adenine nucleotides and of pyruvate dehydrogenase in isolated rat liver cells

1976 • 133 citations

Relative importance of pyruvate dehydrogenase interconversion and feed-back inhibition in the effect of fatty acids on pyruvate oxidation by rat heart mitochondria

1978 • 130 citations

Energy relationships between cytosolic metabolism and mitochondrial respiration in rat heart

1978 • 127 citations

Thermodynamic relationships between the oxidation-reduction reactions and the ATP synthesis in suspensions of isolated pigeon heart mitochondria

1974 • 126 citations

A QUANTITATIVE STUDY OF THE PRODUCTS OF FATTY ACID OXIDATION IN LIVER SUSPENSIONS

1946 • 126 citations

Regulation of Mitochondrial α-Ketoglutarate Metabolism by Product Inhibition at α-Ketoglutarate Dehydrogenase

1974 • 123 citations

Regulation of pyruvate dehydrogenase by fatty acid in isolated rat liver mitochondria.

1976 • 120 citations

Respiratory control in isolated perfused rat heart. Role of the equilibrium relations between the mitochondrial electron carriers and the adenylate system

1975 • 118 citations

Diabetes and the control of pyruvate dehydrogenase in rat heart mitochondria by concentration ratios of adenosine triphosphate/adenosine diphosphate, of reduced/oxidized nicotinamide-adenine dinucleotide and of acetyl-coenzyme A/coenzyme A.

1977 • 117 citations

Some Kinetic Properties of Pig-Heart Oxoglutarate Dehydrogenase that Provide a Basis for Metabolic Control of the Enzyme Activity and also a Stoicheiometric Assay for Coenzyme A in Tissue Extracts

1964 • 117 citations

Studies on the effects of coenzyme A-SH: acetyl coenzyme A, nicotinamide adenine dinucleotide: reduced nicotinamide adenine dinucleotide, and adenosine diphosphate: adenosine triphosphate ratios on the interconversion of active and inactive pyruvate dehydrogenase in isolated rat heart mitochondria.

1976 • 117 citations

Evidence for electrogenic aspartate transport in rat liver mitochondria

1974 • 116 citations

Control of respiration in isolated mitochondria: Quantitative evaluation of the dependence of respiratory rates on [ATP], [ADP], and [Pi]

1977 • 116 citations

Evaluation of the H+/site ratio of mitochondrial electron transport from rate measurements.

1976 • 115 citations

Mitochondrial Function in the Heart

1979 • 114 citations

Homeostatic regulation of cellular energy metabolism: experimental characterization in vivo and fit to a model

1978 • 110 citations

Inter-Relationships between Proton Electrochemical Gradient, Adenine-Nucleotide Phosphorylation Potential and Respiration, during Substrate-Level and Oxidative Phosphorylation by Mitochondria from Brown Adipose Tissue of Cold-Adapted Guinea-Pigs

1977 • 105 citations

Purification and Properties of Diphosphopyridine Nucleotide-linked Isocitrate Dehydrogenase of Mammalian Liver

1968 • 105 citations

Oxidative phosphorylation as a function of temperature

1969 • 105 citations

Regulation of Pyruvate Dehydrogenase in Rat Liver Mitochondria by Phosphorylation-Dephosphorylation

1974 • 104 citations

Thermodynamic relations between the mitochondrial oxidation-reduction reactions and cellular ATP levels in ascites tumor cells and perfused rat liver

1974 • 103 citations

Mammalian α-Keto Acid Dehydrogenase Complexes

1967 • 103 citations

Proton electrochemical gradient and rate of controlled respiration in mitochondria

1978 • 102 citations

Phosphate dependence and atractyloside inhibition of mitochondrial oxidative phosphorylation. The ADP-ATP carrier is rate-limiting.

1979 • 101 citations

Regulation of Metabolism in Working Muscle in Vivo

1966 • 100 citations

The regulation of pyruvate dehydrogenase in the isolated perfused rat heart.

1978 • 99 citations

Inhibition of citrate synthase by succinyl‐CoA and other metabolites

1971 • 99 citations

Stoichiometry of Adenosine Triphosphate-driven Proton Translocation in Bovine Heart Submitochondrial Particles

1973 • 98 citations

Stimulation of Mitochondrial Respiration and Phosphorylation by Transport-Inducing Antibiotics^*

1967 • 98 citations

Control of respiration by the mitochondrial phosphorylation state

1974 • 98 citations

Control of succinate dehydrogenase in mitochondria

1971 • 96 citations

Anion translocators in rat‐heart mitochondria

1971 • 95 citations

The Oxygen Consumption of Flies During Flight

1940 • 95 citations

Proton electrochemical gradient and phosphate potential in mitochondria

1978 • 94 citations

Interconversion of Pyruvate Dehydrogenase in the Isolated Perfused Rat Liver

1973 • 94 citations

Regulation of Pyruvate Dehydrogenase in Mitochondria of Rat Liver

1972 • 93 citations

Control of oxidative phosphorylation by the extramitochondrial ATP/ADP ratio

1976 • 92 citations

Control of mitochondrial metabolism by the ATPADP ratio

1978 • 90 citations

The steady state concentrations of coenzyme A-SH and coenzyme A thioester, citrate, and isocitrate during tricarboxylate cycle oxidations in rabbit heart mitochondria.

1975 • 86 citations

Electrical imbalance of adenine nucleotide transport across the mitochondrial membrane.

1978 • 85 citations

Relationship between Oxygen Uptake of Perifused Rat-Liver Cells and the Cytosolic Phosphorylation State Calculated from Indicator Metabolites and a Redetermined Equilibrium Constant

1978 • 81 citations

Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio.

1975 • 80 citations

Differences between the Reactivity of Endogenous and Exogenous Adenine Nucleotides in Mitochondria as Studied at Low Temperature

1968 • 80 citations

DPN-Linked Isocitrate Dehydrogenase of Animal Tissues* *The unpublished experimental work from this laboratory presented here and the preparation of this article have been assisted by a grant from the National Institute of Arthritis and Metabolic Diseases (AM 10501), United States Public Health Service.

1970 • 76 citations

Pyruvate dehydrogenase and the hormonal regulation of fat synthesis in mammalian tissues

1978 • 76 citations

Unequal charge separation by different coupling spans of the mitochondrial electron transport chain

1978 • 76 citations

Succinate dehydrogenase. XVIII. Regulation of succinate dehydrogenase activity by reduced coenzyme Q10

1971 • 75 citations

Effect of Divalent Metal Ions on Nucleotide Inhibition of Pig Heart Citrate Synthase

1966 • 75 citations

Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio.

1975 • 75 citations

Exchangeable and total calcium pools in mitochondria of rat epididymal fat-pads and isolated fat-cells. Role in the regulation of pyruvate dehydrogenase activity

1976 • 74 citations

Permeability of isolated mitochondria to oxaloacetate

1973 • 72 citations

Ketogenesis in isolated rat liver mitochondria I. Relationships with the citric acid cycle and with the mitochondrial energy state

1972 • 71 citations

A continuous recording technique for the measurement of carbon dioxide, and its application to mitochondrial oxidation and decarboxylation reactions

1967 • 71 citations

Regulation of Pyruvate Dehydrogenase in Muscle

1973 • 70 citations

Regulation of Pyruvate-Dehydrogenase Interconversion in Rat-Liver Mitochondria as Related to the Phosphorylation State of Intramitochondrial Adenine Nucleotides

1974 • 69 citations

Energy-linked regulation of glucose and pyruvate oxidation in isolated perfused rat heart. Role of pyruvate dehydrogenase

1976 • 68 citations

The K+/site and H+/site stoichiometry of mitochondrial electron transport.

1978 • 68 citations

The inhibition of succinate dehydrogenase by oxaloacetate

1969 • 68 citations

Relationshiop between phosphorylation and activity of pyruvate dehydrogenase in rat liver mitochondria and the absence of such a relationship for pyruvate carboxylase.

1978 • 67 citations

Functional relationship between the ADP/ATP-carrier and the F1-ATPase in mitochondria

1975 • 64 citations

Changes in the contents of adenine nucleotides and intermediates of glycolysis and citric acid cycle in flight muscle of the locust upon flight and their relationship to the control of the cycle

1979 • 64 citations

Incorporation of 32Pi into pyruvate dehydrogenase phosphate in mitochondria from control and insulin-treated adipose tissue

1976 • 63 citations

Control of ATP transport across the mitochondrial membrane in isolated rat‐liver cells

1977 • 63 citations

Modulation of mitochondrial succinate dehydrogenase activity, mechanism and function

1978 • 62 citations

Is the adenine nucleotide translocator rate-limiting for oxidative phosphorylation?

1978 • 61 citations

The Effects of Temperature and Some Inhibitors an the Carnitine Exchange System of Heart Mitochondria

1976 • 60 citations

Control of pyruvate dehydrogenase activity in intact cardiac mitochondria. Regulation of the inactivation and activation of the dehydrogenase.

1975 • 59 citations

Some properties of pyruvate and 2-oxoglutarate oxidation by blowfly flight-muscle mitochondria

1972 • 58 citations

Effect of cations and protons on the kinetics of substrate uptake in rat liver mitochondria

1972 • 56 citations

Effects of increased mechanical work by isolated perfused rat heart during production or uptake of ketone bodies. Assessment of mitochondrial oxidized to reduced free nicotinamide-adenine dinucleotide ratios and oxaloacetate concentrations

1975 • 56 citations

Controls of citrate synthase activity

1974 • 55 citations

Succinic Thiokinase

1964 • 53 citations

The Relationship between the Rates of Conversion of Palmitate into Citrate or Acetoacetate and the Acetyl-Coenzyme A Content of Rat-Liver Mitochondria

1965 • 51 citations

Studies on the regulation of pyruvate dehydrogenase in the isolated perfused rat heart.

1979 • 47 citations

The permeability of rat heart mitochondria to citrate

1969 • 45 citations

Microcompartmentation of aspartate in rat liver mitochondria.

1978 • 44 citations

Studies on inactivation of pyruvate dehydrogenase by palmitoylcarnitine oxidation in isolated rat heart mitochondria.

1977 • 44 citations

The control of isocitrate oxidation by rat liver mitochondria

1969 • 43 citations

Adenine Nucleotide Translocation in Mitochondria. Quantitative Evaluation of the Correlation between the Phosphorylation of Endogenous and Exogenous ADP in Mitochondria

1969 • 37 citations

Energy dependent changes in the cytochromes of the mitochondrial respiratory chain

1973 • 36 citations

Regulation of the Mammalian Pyruvate Dehydrogenase Multienzyme Complex by Mg²⁺ and the Adenine Nucleotide Pool

1974 • 35 citations

The inactivation of pyruvate dehydrogenase by fatty acid in isolated rat liver mitochondria

1975 • 34 citations

The control of tricarboxylate-cycle oxidations in blowfly flight muscle. The steady-state concentrations of citrate, isocitrate 2-oxoglutarate and malate in flight muscle and isolated mitochondria

1975 • 33 citations

Haemoglobin in the Australian anostracan Parartemia zietziana: Evolutionary strategies of conformity vs regulation

1978 • 32 citations

Regulation of Citrate Synthesis in Isolated Rat Liver Mitochondria

1971 • 29 citations

The nature of controlled respiration and its relationship to protonmotive force and proton conductance in blowfly flight-muscle mitochondria

1977 • 28 citations

The effects of coenzyme a and carnitine on steady-state ATP/ADP ratios and the rate of long-chain free fatty acid oxidation in liver mitochondria

1978 • 26 citations

The control of tricarboxylate-cycle oxidations in blowfly flight muscle. The steady-state concentrations of coenzyme A, acetyl-coenzyme A and succinyl-coenzyme A in flight muscle and isolated mitochondria

1974 • 26 citations

The regulation of pyruvate dehydrogenase by fatty acids in isolated rabbit heart mitochondria

1978 • 25 citations

Pyruvate Dehydrogenase Activation after an Increase in Cardiac Output

1976 • 25 citations

The control of tricarboxylate-cycle xidations in blowfly flight muscle. The oxidized and reduced nicotinamide-adenine dinucleotide content of flight muscle and isolated mitochondria, the adenosine triphosphate and adenosine diphosphate content of mitochondria, and the energy status of the mitochondria during controlled respiration

1975 • 23 citations

The Inhibition of Isocitrate Oxidation by Palmitoyl‐<scp>l</scp>‐carnitine and Palmitoyl‐CoA in Rat Liver Mitochondria

1976 • 21 citations

The effect of adenine nucleotides upon the 2‐oxoglutarate dehydrogenase of blowfly flight muscle

1972 • 21 citations

Effect of increased aortic perfusion pressure on fluorescent emission of the isolated rat heart

1974 • 20 citations

On the control of enzyme pathways

1976 • 20 citations

The transport of oxaloacetate in rat heart mitochondria

1978 • 19 citations

Studies on the regulation of pyruvate dehydrogenase in isolated beef heart mitochondria

1975 • 15 citations

Inhibition of uptake and oxidation of succinate in rat-liver mitochondria

1967 • 15 citations

The steady state activity of succinate dehydrogenase in the presence of opposing effectors

1975 • 15 citations

Regulation of Pyruvate Dehydrogenase in Heart Mitochondria

1977 • 15 citations

Kinetics of ADP, ATP transport in mitochondria as studied by the quench-flow method

1978 • 14 citations

Control of pyruvate dehydrogenase interconversion by palmitoyl‐coenzyme A as related to adenine nucleotide translocation in isolated fat cell mitochondria

1975 • 14 citations

Energy-linked regulation of the citric acid cycle and the pool size of the cycle intermediates in the isolated perfused rat heart

1977 • 14 citations

The new atractyloside type compound as a high affinity ligand to the adenine nucleotide carrier

1973 • 12 citations

Distribution of malate across the mitochondrial membrane as a significant factor in respiratory control

1968 • 11 citations

Proton Movements in Energy-Conserving Membranes

1977 • 9 citations

Fatty acid synthesis and Krebs' cycle activity in heart mitochondria

1973 • 8 citations

A comparison of energy-yielding reactions in the flight muscle of young adult and senescent blowflies

1978 • 8 citations

Cellular metabolite distribution and the control of gluconeogenesis in the perfused isolated rat liver

1976 • 7 citations