Studies on the activation of rat liver pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase by adrenaline and glucagon. Role of increases in intramitochondrial Ca2+ concentration

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

The Respiratory Chain and Oxidative Phosphorylation

1956 • 2,073 citations

Calcium messenger system: an integrated view.

1984 • 916 citations

Specific inhibition of mitochondrial Ca++ transport by ruthenium red

1971 • 616 citations

myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.

1984 • 567 citations

The second messenger linking receptor activation to internal Ca release in liver

1984 • 557 citations

Changes in free cytosolic Ca2+ in hepatocytes following alpha 1-adrenergic stimulation. Studies on Quin-2-loaded hepatocytes.

1983 • 375 citations

Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues

1978 • 359 citations

Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.

1984 • 358 citations

Calcium content of mitochondria and endoplasmic reticulum in liver frozen rapidly in vivo

1985 • 356 citations

The effect of ruthenium red on Ca2+ transport and respiration in rat liver mitochondria

1972 • 321 citations

Role of calcium in the hormonal regulation of liver metabolism

1981 • 317 citations

Mitochondrial calcium transport

1980 • 304 citations

Regulation of mammalian pyruvate dehydrogenase

1975 • 299 citations

Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria

1980 • 292 citations

Molecular mechanisms involved in α-adrenergic responses

1981 • 246 citations

Studies on alpha-adrenergic activation of hepatic glucose output. The role of mitochondrial calcium release in alpha-adrenergic activation of phosphorylase in perfused rat liver.

1979 • 201 citations

The calcium cycle of mitochondria

1979 • 197 citations

Inositol(1,4,5)trisphosphate-promoted Ca2+ release from microsomal fractions of rat liver

1984 • 193 citations

Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat heart. Evidence from studies with isolated mitochondria that adrenaline activates the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes by increasing the intramitochondrial concentration of Ca2+

1984 • 151 citations

Selective inhibition of Na+-induced Ca2+ release from heart mitochondria by diltiazem and certain other Ca2+ antagonist drugs.

1982 • 150 citations

Determination of the matrix free Ca2+ concentration and kinetics of Ca2+ efflux in liver and heart mitochondria.

1982 • 144 citations

Calcium ion fluxes induced by the action of α-adrenergic agonists in perfused rat liver

1982 • 144 citations

Characterization of the effects of Ca2+ on the intramitochondrial Ca2+-sensitive enzymes from rat liver and within intact rat liver mitochondria

1985 • 139 citations

Evidence for mitochondrial localization of the hormone-responsive pool of Ca2+ in isolated hepatocytes.

1979 • 128 citations

Reversible phosphorylation of pyruvate dehydrogenase in rat skeletal-muscle mitochondria. Effects of starvation and diabetes

1984 • 120 citations

Cytosolic free Ca²⁺ in isolated rat hepatocytes as measured by quin2

1984 • 111 citations

Calcium metabolism in rat hepatocytes

1978 • 111 citations

The origin, quantitation, and kinetics of intracellular calcium mobilization by vasopressin and phenylephrine in hepatocytes.

1983 • 97 citations

Stable changes to calcium fluxes in mitochondria isolated from rat livers perfused with α-adrenergic agonists and with glucagon

1980 • 93 citations

A comparative study of the regulation of Ca2+ of the activities of the 2-oxoglutarate dehydrogenase complex and NAD+-isocitrate dehydrogenase from a variety of sources

1981 • 91 citations

Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes

1985 • 89 citations

Modulation of the alpha 1-adrenergic control of hepatocyte calcium redistribution by increases in cyclic AMP.

1983 • 78 citations

Hormone-induced changes in NADH fluorescence and O2 consumption of rat hepatocytes

1982 • 75 citations

Na⁺ releases Ca²⁺ from liver, kidney and lung mitochondria

1980 • 74 citations

Studies on alpha-adrenergic-induced respiration and glycogenolysis in perfused rat liver.

1982 • 70 citations

Calcium movements in in situ mitochondria following activation of α‐adrenergic receptors in rat liver cells

1980 • 70 citations

Effect of micromolar concentrations of free Ca2+ ions on pyruvate dehydrogenase interconversion in intact rat heart mitochondria

1981 • 69 citations

Effect of micromolar concentrations of free calcium ions on the reduction of heart mitochondrial NAD(P) by 2-oxoglutarate

1981 • 68 citations

Stimulation by α-adrenergic agonists of Ca2+ fluxes, mitochondrial oxidation and gluconeogenesis in perfused rat liver

1983 • 65 citations

Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat epididymal adipose tissue. Evidence against a role for Ca2+ in the activation of pyruvate dehydrogenase by insulin

1984 • 60 citations

Effect of fatty acids and ketones on the activity of pyruvate dehydrogenase in skeletal-muscle mitochondria

1983 • 59 citations

Effect of phenylephrine on pyruvate dehydrogenase activity in rat hepatocytes and its interaction with insulin and glucagon

1983 • 57 citations

Mitochondrial-reticular cytostructure in liver cells

1983 • 56 citations

Activation of pyruvate dehydrogenase in the perfused rat liver by vasopressin

1978 • 54 citations

Mitochondrial and extramitochondrial Ca2+ pools in the perfused rat liver. Mitochondria are not the origin of calcium mobilized by vasopressin.

1985 • 51 citations

Glucagon-induced stimulation of 2-oxoglutarate metabolism in mitochondria from rat liver

1978 • 49 citations

Calcium Ions, Hormones and Mitochondrial Metabolism

1981 • 47 citations

Regulation of hepatic glycogenolysis by glucagon in male and female rats. Role of cAMP and Ca2+ and interactions between epinephrine and glucagon.

1984 • 46 citations

Time course of alpha1-adrenergic and vasopressin actions on phosphorylase activation, calcium efflux, pyridine nucleotide reduction, and respiration in hepatocytes.

1983 • 46 citations

Evidence for β-adrenergic activation of Na+-dependent efflux of Ca2+ from isolated liver mitochondria

1982 • 44 citations

On the mechanism by which hormones induce the release of Ca2+ from mitochondria in the liver cell

1982 • 42 citations

Effect of phenylephrine on glutamate and glutamine metabolism in isolated perfused rat liver

1984 • 41 citations

Effect of the α-agonist noradrenaline on total and 45Ca2+ movements in mitochondria of rat liver cells

1981 • 41 citations

Distinct effects of glucagon and vasopressin on proline metabolism in isolated hepatocytes. The role of oxoglutarate dehydrogenase

1984 • 39 citations

The α-adrenergic-mediated activation of Ca2+ influx into cardiac mitochondria. A possible mechanism for the regulation of intramitochondrial free CA2+

1981 • 39 citations

The activation of Na+-dependent efflux of Ca2+ from liver mitochondria by glucagon and β-adrenergic agonists

1983 • 38 citations

Determination of mitochondrial calcium content in hepatocytes by a rapid cellular fractionation technique. Vasopressin stimulates mitochondrial Ca2+ uptake

1984 • 37 citations

Rapid action of glucagon on hepatic mitochondrial calcium metabolism and respiratory rates

1980 • 37 citations

Decreased flux through pyruvate dehydrogenase during calcium ion movements induced by vasopressin, α-adrenergic agonists and the ionophore A23187 in perfused rat liver

1983 • 37 citations

Studies on the interactions of Ca2+ and pyruvate in the regulation of rat heart pyruvate dehydrogenase activity. Effects of starvation and diabetes

1982 • 36 citations

Stimulation of calcium-ion efflux from liver mitochondria by sodium ions and its response to ADP and energy state

1981 • 35 citations

Glutamine metabolism of isolated rat hepatocytes. Evidence for catecholamine activation of alpha-ketoglutarate dehydrogenase.

1984 • 34 citations

Hormonal control of pyruvate dehydrogenase activity in rat liver

1984 • 34 citations

Effects of Calcium Ions on the Activation of Gluconeogenesis by Norepinephrine in Perfused Rat Liver

1980 • 34 citations

Evidence that adrenaline activates key oxidative enzymes in rat liver by increasing intramitochondrial [Ca²⁺]

1985 • 33 citations

Mechanism of activation of pyruvate dehydrogenase by mitogens in pig lymphocytes

1983 • 33 citations

α-adrenergic stimulation of respiration in isolated rat hepatocytes

1983 • 31 citations

Sex difference in cellular calcium metabolism of rat hepatocytes and in α-adrenergic activation of glycogen phosphorylase

1983 • 31 citations

Na⁺‐dependent regulation of extramitochondrial Ca²⁺ by rat‐liver mitochondria

1984 • 28 citations

The role of calcium in the stimulation of gluconeogenesis by catecholamines

1981 • 25 citations

Hormonal regulation of gluconeogenesis

1983 • 22 citations

Ca2+ -dependent activation of oxoglutarate dehydrogenase by vasopressin in isolated hepatocytes

1985 • 21 citations

Evidence that glucagon acts on the liver to decrease mitochondrial calcium stores

1983 • 18 citations

Herbicides and fungicides stimulate Ca²⁺ efflux from rat liver mitochondria

1981 • 17 citations

Rapid efflux of Ca2+ from heart mitochondria in the presence of inorganic pyrophosphate

1984 • 14 citations

A second site of vasopressin action on [1-14C]oleate metabolism in isolated rat hepatocytes: Increased formation of 14CO2

1980 • 11 citations

Properties of a new calcium ion antagonist on cellular uptake and mitochondrial efflux of calcium ions

1984 • 7 citations

Can isolated spans of the tricarboxylic acid cycle operate independently? L-proline, oleate and butyrate metabolism in rat hepatocytes.

1983 • 4 citations