Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat heart. Evidence from studies with isolated mitochondria that adrenaline activates the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes by increasing the intramitochondrial concentration of Ca2+

The Respiratory Chain and Oxidative Phosphorylation

1956 • 2,073 citations

Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth Muscle

1977 • 1,745 citations

Use of the liquid scintillation spectrometer for determining adenosine triphosphate by the luciferase enzyme

1969 • 898 citations

Relationships between calcium and cyclic nucleotides in cell activation.

1977 • 849 citations

Specific inhibition of mitochondrial Ca++ transport by ruthenium red

1971 • 616 citations

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

1972 • 519 citations

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

1979 • 431 citations

The Interrelations between the Transport of Sodium and Calcium in Mitochondria of Various Mammalian Tissues

1978 • 402 citations

Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide

1976 • 399 citations

On the role of the calcium transport cycle in heart and other mammalian mitochondria

1980 • 375 citations

Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues

1978 • 359 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, XI. COMPARATIVE STUDIES OF REGULATORY PROPERTIES OF THE PYRUVATE DEHYDROGENASE COMPLEXES FROM KIDNEY, HEART, AND LIVER MITOCHONDRIA

1969 • 355 citations

The Role of Cyclic-AMP-Dependent Protein Kinase in the Regulation of Glycogen Metabolism in Mammalian Skeletal Muscle

1978 • 352 citations

The effect of ruthenium red on Ca2+ transport and respiration in rat liver mitochondria

1972 • 321 citations

Mitochondrial calcium transport

1980 • 304 citations

Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria

1980 • 292 citations

Free calcium in heart muscle at rest and during contraction measured with Ca2+-sensitive microelectrodes

1980 • 272 citations

The Calcium‐Induced and Sodium‐Induced Effluxes of Calcium from Heart Mitochondria

1977 • 265 citations

Regulation of heart muscle pyruvate dehydrogenase kinase

1974 • 227 citations

The calcium cycle of mitochondria

1979 • 197 citations

Regulation of the citric acid cycle in mammalian systems

1980 • 171 citations

Role of calcium ions in the regulation of intramitochondrial metabolism. Properties of the Ca2+-sensitive dehydrogenases within intact uncoupled mitochondria from the white and brown adipose tissue of the rat

1980 • 157 citations

Selective inhibition of Na+-induced Ca2+ release from heart mitochondria by diltiazem and certain other Ca2+ antagonist drugs.

1982 • 150 citations

Determination of the matrix free Ca2+ concentration and kinetics of Ca2+ efflux in liver and heart mitochondria.

1982 • 144 citations

The informational role of calcium in the cytosol.

1979 • 144 citations

Relative importance of pyruvate dehydrogenase interconversion and feed-back inhibition in the effect of fatty acids on pyruvate oxidation by rat heart mitochondria

1978 • 130 citations

Properties and functions of the calcium-dependent regulator protein.

1979 • 119 citations

Ruthenium Red inhibits the activation of pyruvate dehydrogenase caused by positive inotropic agents in the perfused rat heart

1983 • 119 citations

Mechanisms involved in alpha-adrenergic phenomena: role of calcium ions in actions of catecholamines in liver and other tissues

1980 • 118 citations

Mechanisms underlying calcium homeostasis in isolated hepatocytes.

1983 • 118 citations

Properties and functions of the calcium-dependent regulator protein.

1979 • 78 citations

Exchangeable and total calcium pools in mitochondria of rat epididymal fat-pads and isolated fat-cells. Role in the regulation of pyruvate dehydrogenase activity

1976 • 74 citations

Effect of micromolar concentrations of free Ca2+ ions on pyruvate dehydrogenase interconversion in intact rat heart mitochondria

1981 • 69 citations

The α-adrenergic-mediated activation of the cardiac mitochondrial Ca2+ uniporter and its role in the control of intramitochondrial Ca2+in vivo

1983 • 68 citations

Effect of micromolar concentrations of free calcium ions on the reduction of heart mitochondrial NAD(P) by 2-oxoglutarate

1981 • 68 citations

The activation of pyruvate dehydrogenase in the perfused rat heart by adrenaline and other inotropic agents

1981 • 68 citations

Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat epididymal adipose tissue. Evidence against a role for Ca2+ in the activation of pyruvate dehydrogenase by insulin

1984 • 60 citations

Studies of the effects of beta-adrenergic agonists on the regulation of pyruvate dehydrogenase in the perfused rat heart.

1980 • 55 citations

Occupancy of phosphorylation sites in pyruvate dehydrogenase phosphate complex in rat heart in vivo. Relation to proportion of inactive complex and rate of re-activation by phosphatase

1982 • 54 citations

Calcium Ions, Hormones and Mitochondrial Metabolism

1981 • 47 citations

Penetration of the mitochondrial membrane by tricarboxylic acid anions.

1968 • 44 citations

Studies on the interactions of Ca2+ and pyruvate in the regulation of rat heart pyruvate dehydrogenase activity. Effects of starvation and diabetes

1982 • 36 citations

Incorporation of [32P]phosphate into the pyruvate dehydrogenase complex in rat heart mitochondria

1980 • 22 citations