The role of phospholipid-derived mediators including arachidonic acid, its metabolites, and inositol triphosphate and of intracellular Ca2+ in glucose-induced insulin secretion by pancretic islets

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

1967 • 2,783 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Prostaglandins and Thromboxanes

1978 • 1,310 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Intracellular ATP directly blocks K+ channels in pancreatic B-cells

1984 • 1,199 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells

1984 • 1,099 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Intracellular phospholipases A

1980 • 989 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

Calcium messenger system: an integrated view.

1984 • 916 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

Regulation of insulin release by calcium.

1981 • 866 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Production of diglyceride from phosphatidylinositol in activated human platelets.

1979 • 727 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

The Calcium Messenger System

1986 • 669 citations

Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices

1985 • 641 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.

1984 • 567 citations

The second messenger linking receptor activation to internal Ca release in liver

1984 • 557 citations

Regulation of insulin secretion studied with pieces of rabbit pancreas incubated in vitro

1964 • 540 citations

New Hypothesis of Insulin Secretion

1968 • 539 citations

Separation of phospholipids and individual molecular species of phospholipids by high-performance liquid chromatography.

1982 • 533 citations

The phorbol ester receptor: a phospholipid-regulated protein kinase

1985 • 522 citations

Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor

1984 • 520 citations

Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent swiss 3T3 cells stimulated to divide by platelet-derived growth factor.

1981 • 492 citations

Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.

1984 • 481 citations

New Perspectives on the Microvasculature of the Islets of Langerhans in the Rat

1982 • 476 citations

Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands

1985 • 450 citations

Hormonal effects on calcium homeostasis in isolated hepatocytes.

1980 • 441 citations

Effects of carbohydrates on secretion of insulin from isolated rat pancreas

1963 • 432 citations

5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown.

1985 • 429 citations

Mechanism of glucose-induced insulin secretion.

1980 • 425 citations

Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate

1984 • 410 citations

ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.

1984 • 389 citations

Acidic phospholipids, unsaturated fatty acids, and limited proteolysis mimic the effect of calmodulin on the purified erythrocyte Ca2+ - ATPase.

1981 • 388 citations

Cation Requirements for Insulin Secretion in the Isolated Perfused Pancreas

1966 • 386 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

Hormone-stimulated polyphosphoinositide breakdown in rat liver plasma membranes. Roles of guanine nucleotides and calcium.

1986 • 378 citations

Cooperative roles of various membrane phospholipids in the activation of calcium-activated, phospholipid-dependent protein kinase.

1981 • 367 citations

Single microtubules from squid axoplasm support bidirectional movement of organelles

1985 • 363 citations

Interplay of Nutrients and Hormones in the Regulation of Insulin Release*

1985 • 363 citations

Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.

1984 • 358 citations

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.

1985 • 358 citations

Protein kinase C phosphorylates human platelet inositol trisphosphate 5′-phosphomonoesterase, increasing the phosphatase activity

1986 • 354 citations

Insulin release: The fuel hypothesis

1979 • 351 citations

A New in Vitro Model for the Study of Pancreatic A and B Cells*

1985 • 345 citations

Catecholamine secretion from digitonin-treated adrenal medullary chromaffin cells.

1983 • 338 citations

The temporal integration of the aldosterone secretory response to angiotensin occurs via two intracellular pathways.

1984 • 332 citations

Regulation of Pancreatic Insulin and Glucagon Secretion

1976 • 329 citations

Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic B-cells

1984 • 324 citations

The Metabolic Derangements and Treatment of Diabetic Ketoacidosis

1983 • 320 citations

Lilly Lecture 1980: Insulin Resistance and Insulin Action: An In Vitro and In Vivo Perspective

1981 • 317 citations

Calcium-dependent exocytosis in bovine adrenal medullary cells with leaky plasma membranes

1978 • 315 citations

Identification of neutral active phospholipase C which hydrolyzes choline glycerophospholipids and plasmalogen selective phospholipase A2 in canine myocardium.

1985 • 315 citations

Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate.

1983 • 312 citations

Perifusion of Isolated Rat Islets in Vitro: Participation of the Microtubular System in the Biphasic Release of Insulin

1972 • 311 citations

Intracellular Ca2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets.

1986 • 310 citations

Stimulation of 1,2-diacylglycerol accumulation in hepatocytes by vasopressin, epinephrine, and angiotensin II.

1985 • 304 citations

Hormone-induced redistribution of calcium-activated phospholipid-dependent protein kinase in pituitary gonadotrophs.

1985 • 296 citations

Inositol trisphosphates in carbachol-stimulated rat parotid glands

1984 • 296 citations

A saturable receptor for 32P-inositol-l,4,5-trisphosphate in hepatocytes and neutrophils

1986 • 296 citations

Direct activation of purified protein kinase C by unsaturated fatty acids (oleate and arachidonate) in the absence of phospholipids and Ca²⁺

1985 • 293 citations

Mass changes in myoinositol trisphosphate in human platelets stimulated by thrombin. Inhibitory effects of phorbol ester.

1985 • 292 citations

Thyrotropin-releasing hormone rapidly activates the phosphodiester hydrolysis of polyphosphoinositides in GH3 pituitary cells. Evidence for the role of a polyphosphoinositide-specific phospholipase C in hormone action.

1983 • 292 citations

Role of a guanine nucleotide-binding regulatory protein in the hydrolysis of hepatocyte phosphatidylinositol 4,5-bisphosphate by calcium-mobilizing hormones and the control of cell calcium. Studies utilizing aluminum fluoride.

1985 • 290 citations

Glucagon and the a Cell

1981 • 290 citations

Calcium pools in saponin-permeabilized guinea pig hepatocytes.

1983 • 282 citations

Coupling of the guanine nucleotide regulatory protein to chemotactic peptide receptors in neutrophil membranes and its uncoupling by islet-activating protein, pertussis toxin. A possible role of the toxin substrate in Ca2+-mobilizing receptor-mediated signal transduction.

1985 • 281 citations

Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver.

1986 • 280 citations

Insulin-Dependent Diabetes Mellitus: The Initial Lesion

1981 • 273 citations

Inositol 1,4,5-trisphosphate releases Ca2+ from a Ca2+-transporting membrane vesicle fraction derived from human platelets.

1985 • 268 citations

Ca2+ homeostasis in permeabilized human neutrophils. Characterization of Ca2+-sequestering pools and the action of inositol 1,4,5-triphosphate.

1984 • 266 citations

Evidence for the participation of independent translocation for phosphate and glucose 6-phosphate in the microsomal glucose-6-phosphatase system. Interactions of the system with orthophosphate, inorganic pyrophosphate, and carbamyl phosphate.

1980 • 266 citations

A role for inositol triphosphate in intracellular Ca2+ mobilization and granule secretion in platelets.

1985 • 263 citations

Inositol 1,4,5-trisphosphate induces calcium release from sarcoplasmic reticulum of skeletal muscle

1985 • 258 citations

Altered cytosol/membrane enzyme redistribution on interleukin-3 activation of protein kinase C

1985 • 255 citations

Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates.

1982 • 251 citations

Insulin secretion: Combined effects of phorbol ester and A23187

1983 • 250 citations

Regulation of immunoreactive-insulin release from a rat cell line (RINm5F)

1983 • 240 citations

Guanine nucleotides decrease the free [Ca²⁺] required for secretion of serotonin from permeabilized blood platelets

1984 • 236 citations

Glucose metabolism in mouse pancreatic islets

1970 • 235 citations

Quantitation and early kinetics of inositol lipid changes induced by vasopressin in isolated and cultured hepatocytes.

1983 • 232 citations

Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid

1986 • 229 citations

Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes

1985 • 229 citations

First-Degree Relatives of Patients with Type I Diabetes Mellitus

1985 • 226 citations

Breakdown of polyphosphoinositides and not phosphatidylinositol accounts for muscarinic agonist-stimulated inositol phospholipid metabolism in rat parotid glands

1983 • 226 citations

The role of phosphoinositiees in signal transduction

1986 • 225 citations

Intracellular Free Calcium Localization in Neutrophils During Phagocytosis

1985 • 217 citations

Thyroliberin stimulates rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate by a phosphodiesterase in rat mammotropic pituitary cells. Evidence for an early Ca2+-independent action

1983 • 203 citations

Short Communication Inositol Tetrakis- And Pentakisphosphates In Gh4 Cells

1985 • 201 citations

Correlation between cytosolic free Ca2+ and insulin release in an insulin-secreting cell line.

1984 • 199 citations

Thyrotropin-releasing hormone activates a Ca2+-dependent polyphosphoinositide phosphodiesterase in permeable GH3 cells. GTP gamma S potentiation by a cholera and pertussis toxin-insensitive mechanism.

1986 • 197 citations

Inositol trisphosphate induces calcium release from nonmitochondrial stores i sea urchin egg homogenates.

1985 • 190 citations

The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase

1983 • 190 citations

Relationship between secretagogue-induced Ca2+ release and inositol polyphosphate production in permeabilized pancreatic acinar cells.

1985 • 184 citations

Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells

1984 • 184 citations

Thyrotropin-releasing hormone stimulates rapid loss of phosphatidylinositol and its conversion to 1,2-diacylglycerol and phosphatidic acid in rat mammotropic pituitary cells. Association with calcium mobilization and prolactin secretion.

1983 • 181 citations

Ca2+ regulates the inositol tris/tetrakisphosphate pathway in intact and broken preparations of insulin-secreting RINm5F cells.

1986 • 177 citations

Evidence suggesting that a novel guanine nucleotide regulatory protein couples receptors to phospholipase C in exocrine pancreas

1986 • 177 citations

Insulin secretion. Interrelationships of glucose, cyclic adenosine 3:5-monophosphate, and calcium.

1975 • 171 citations

Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate

1984 • 171 citations

Glucagon and the a Cell

1981 • 170 citations

Thyrotropin-releasing hormone and GTP activate inositol trisphosphate formation in membranes isolated from rat pituitary cells.

1986 • 169 citations

A guanine nucleotide-dependent phosphatidylinositol 4,5-diphosphate phospholipase C in cells transformed by the v-fms and v-fes oncogenes.

1986 • 168 citations

Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells.

1985 • 167 citations

The Glucose Receptor A DEFECTIVE MECHANISM IN DIABETES MELLITUS DISTINCT FROM THE BETA ADRENERGIC RECEPTOR

1973 • 166 citations

Arachidonic acid epoxides. Isolation and structure of two hydroxy epoxide intermediates in the formation of 8,11,12- and 10,11,12-trihydroxyeicosatrienoic acids.

1983 • 166 citations

Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets

1983 • 165 citations

Arachidonic acid metabolism in rabbit renal cortex. Formation of two novel dihydroxyeicosatrienoic acids.

1981 • 164 citations

Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes

1984 • 158 citations

Guanosine 5'-O-thiotriphosphate stimulates phospholipase C activity in plasma membranes of rat hepatocytes.

1985 • 154 citations

Second messenger function of inositol 1,4,5-trisphosphate. Early changes in inositol phosphates, cytosolic Ca2+, and insulin release in carbamylcholine-stimulated RINm5F cells.

1986 • 149 citations

A lipid requirement for the (Ca2+ + Mg2+)-activated ATPase of erythrocyte membranes

1977 • 149 citations

Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid

1982 • 147 citations

Phosphorylation of smooth muscle myosin light chain kinase by protein kinase C. Comparative study of the phosphorylated sites.

1985 • 145 citations

Inhibitors of Na+/H+ exchange block stimulus-provoked arachidonic acid release in human platelets. Selective effects on platelet activation by epinephrine, ADP, and lower concentrations of thrombin.

1985 • 144 citations

A Role for Prostaglandin E in Defective Insulin Secretion and Carbohydrate Intolerance in Diabetes Mellitus

1977 • 144 citations

Serotonin secretion from human platelets may be modified by Ca2+-activated, phospholipid-dependent myosin phosphorylation.

1984 • 143 citations

The effects of mepacrine and p-bromophenacyl bromide on arachidonic acid release in human platelets

1982 • 141 citations

NOVEL HYPOTHALAMIC ARACHIDONATE PRODUCTS STIMULATE SOMATOSTATIN RELEASE FROM THE MEDIAN EMINENCE¹

1983 • 141 citations

Thyrotropin-releasing hormone induces redistribution of protein kinase C in GH4C1 rat pituitary cells.

1985 • 140 citations

Molecular species of mono-, di-, and triphosphoinositides of bovine brain

1970 • 140 citations

Stimulus-secretion coupling of glucose-induced insulin release. X. Effect of glucose on 45 Ca efflux from perifused islets

1973 • 139 citations

Diacylglycerol metabolism in mast cells: a potential role in membrane fusion and arachidonic acid release.

1979 • 133 citations

Calcium pump activity of the renal plasma membrane and renal microsomes

1974 • 133 citations

The oxidative metabolism of arachidonic acid by purified cytochromes P-450

1981 • 133 citations

[16] A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of langerhans

1983 • 129 citations

Phosphorylation of smooth muscle myosin light chain kinase by Ca2+-activated, phospholipid-dependent protein kinase.

1985 • 128 citations

Lipoxygenase Pathway in Islet Endocrine Cells. OXIDATIVE METABOLISM OF ARACHIDONIC ACID PROMOTES INSULIN RELEASE

1983 • 125 citations

Guanine nucleotides stimulate production of inositol trisphosphate in rat cortical membranes

1985 • 125 citations

Protein kinase C in the human erythrocyte. Translocation to the plasma membrane and phosphorylation of bands 4.1 and 4.9 and other membrane proteins.

1985 • 123 citations

EFFECTS OF ACETYLCHOLINE ON PHOSPHOLIPIDES IN THE PANCREAS

1954 • 122 citations

Phospholipid-sensitive Ca2+-dependent protein kinase: a major protein phosphorylation system

1984 • 120 citations

Protein kinase C translocates from cytosol to membrane upon hormone activation: Effects of thyrotropin-releasing hormone in GH3 cells

1985 • 119 citations

The Roles of Intracellular and Extracellular Ca++ in Glucose-Stimulated Biphasic Insulin Release by Rat Islets

1978 • 119 citations

Dual effects of glucose on the cytosolic Ca²⁺ activity of mouse pancreatic β‐cells

1984 • 119 citations

Arachidonic acid epoxides. Demonstration through [18O]oxygen studies of an intramolecular transfer of the terminal hydroxyl group of (12S)-hydroperoxyeicosa-5,8,10,14-tetraenoic acid to form hydroxyepoxides.

1984 • 117 citations

Insulin Secretion Mechanisms and Glucose Metabolism in Isolated Islets

1972 • 114 citations

Mechanism of photoinactivation and re-activation in the bioluminescence system of the ctenophore Mnemiopsis

1984 • 111 citations

Preparation and characterization of plasma membrane-enriched fractions from rat pancreatic islets.

1976 • 110 citations

Ca2+-activated ATPase and ATP-dependent calmodulin-stimulated Ca2+ transport in islet cell plasma membrane

1980 • 110 citations

The role of calmodulin in the regulation of protein phosphorylation and insulin release in hamster insulinoma cells.

1980 • 109 citations

Early Phase of Insulin Release

1968 • 109 citations

Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. Paradoxical suppression of glucose utilization and lack of compensatory increase in glucose production, roles of insulin resistance, abnormal neuroendocrine responses, and islet paracrine interactions.

1984 • 108 citations

Calcium uptake into acini from rat pancreas: Evidence for intracellular ATP-dependent calcium sequestration

1982 • 107 citations

Insulinotropic effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in rat pancreatic islets.

1980 • 106 citations

Nutrient and Hormone-Neurotransmitter Stimuli Induce Hydrolysis of Polyphosphoinositides in Rat Pancreatic Islets*

1984 • 106 citations

Hormonal stimulation of arachidonic release from isolated perfused organs relationship to prostaglandin biosynthesis

1977 • 106 citations

Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts.

1986 • 105 citations

The effect of inositol trisphosphate on Ca2+ fluxes in insulin-secreting tumor cells.

1984 • 104 citations

Stimulation by d-Glucose of Cyclic Adenosine 3′ : 5′-Monophosphate Accumulation and Insulin Release in Isolated Pancreatic Islets of the Rat

1974 • 103 citations

Abnormal glucose metabolism accompanies failure of glucose to stimulate insulin release from a rat pancreatic cell line (RINm5F)

1983 • 103 citations

Calcium‐activated, phospholipid‐dependent protein kinase in rat pancreas islets of langerhans

1982 • 99 citations

Vanadate: A potent inhibitor of multifunctional glucose-6-phosphatase

1981 • 98 citations

Stimulus-secretion coupling of glucose-induced insulin release. Metabolism of alpha- and beta-D-glucose in isolated islets.

1976 • 98 citations

Identification and metabolism of polyphosphoinositides in isolated islets of Langerhans

1983 • 98 citations

Carbachol causes rapid phosphodiesteratic cleavage of phosphatidylinositol 4,5-bisphosphate and accumulation of inositol phosphates in rabbit iris smooth muscle; prazosin inhibits noradrenaline- and ionophore A23187-stimulated accumulation of inositol phosphates

1984 • 97 citations

The inositol phospholipids: a stereochemical view of biological activity

1986 • 96 citations

Guanine nucleotide regulation of agonist binding to muscarinic cholinergic receptors. Relation to efficacy of agonists for stimulation of phosphoinositide breakdown and Ca2+ mobilization

1985 • 96 citations

Cytosolic free Ca2+ in insulin secreting cells and its regulation by isolated organelles

1984 • 95 citations

A guanine nucleotide-dependent regulatory protein couples substance P receptors to phospholipase C in rat parotid gland

1986 • 95 citations

Myo-inositol Lipids

1976 • 94 citations

Inositol phosphates: Profusion and confusion

1986 • 93 citations

Glucoreceptor Mechanisms in Islets of Langerhans

1972 • 91 citations

Glucose-induced phospholipid hydrolysis in isolated pancreatic islets: quantitative effects on the phospholipid content of arachidonate and other fatty acids

1986 • 90 citations

Inositol 1,4,5-trisphosphate and the endoplasmic reticulum Ca2+ cycle of a rat insulinoma cell line.

1985 • 89 citations

Measurement of arachidonic acid liberation in thrombin-stimulated human platelets. Use of agents that inhibit both the cyclooxygenase and lipoxygenase enzymes

1985 • 88 citations

Regulation of insulin secretion from islets of Langerhans rendered permeable by electric discharge

1982 • 86 citations

Differentiation of Ca2+ pumps linked to plasma membrane and endoplasmic reticulum in the microsomal fraction from intestinal smooth muscle

1981 • 85 citations

Coupling of the thyrotropin-releasing hormone receptor to phospholipase C by a GTP-binding protein distinct from the inhibitory or stimulatory GTP-binding protein.

1986 • 85 citations

Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin

1986 • 85 citations

Phosphoinositide metabolism and insulin secretion from isolated rat pancreatic islets.

1976 • 84 citations

Insulin Secretion by Anomers of D-Glucose

1974 • 84 citations

The Dual Function of Glucose in Islets of Langerhans

1971 • 83 citations

Inter-Relations between the Phospholipids of Rat Pancreatic Islets during Glucose Stimulation and Their Response to Medium Inositol and Tetracaine

1975 • 83 citations

Calcium distribution in islets of langerhans: A study of calcium concentrations and of calcium accumulation in b cell organelles

1975 • 81 citations

5-Methyltryptamine stimulates phospholipase C-mediated breakdown of exogenous phosphoinositides by blowfly salivary gland membranes.

1985 • 81 citations

Phorbol Myristate Acetate: Effect of a Tumor Promoter on Insulin Release from Isolated Rat Islets of Langerhans*

1978 • 81 citations

Evidence for sequential signals in the induction of the arachidonic acid cascade in macrophages.

1986 • 80 citations

Inhibition of In Vivo Insulin Secretion by Prostaglandin E1

1974 • 78 citations

Protein phosphorylation in the pancreatic B-cell

1984 • 77 citations

Lymphocyte mechanical response triggered by cross-linking surface receptors.

1985 • 76 citations

Pancreatic islets synthesize phospholipids de novo from glucose via acyl-dihydroxyacetone phosphate

1985 • 76 citations

Pancreatic Insulin-, Glucagon-, and Somatostatin-Positive Islet Cell Populations during the Perinatal Development of the Rat

1980 • 76 citations

Insulin Secretion in Diabetes Mellitus

1968 • 75 citations

Secretagogue-induced formation of inositol phosphates in rat exocrine pancreas. Implications for a messenger role for inositol trisphosphate

1984 • 74 citations

Acute effect of thyrotropin on phosphatidylinositol degradation and transient accumulation of diacylglycerol in isolated thyroid follicles

1980 • 74 citations

Evidence for the presence in smooth muscle of two types of Ca2+-transport ATPase

1984 • 73 citations

Standardization of a Digestion-filtration Method for Isolation of Pancreatic Islets

1976 • 73 citations

Inhibition of Prostaglandin E Synthesis Augments Glucose-induced Insulin Secretion in Cultured Pancreas

1981 • 72 citations

Regulation of Ca²⁺ Efflux from Kidney and Liver Mitochondria by Unsaturated Fatty Acids and Na⁺ Ions

1979 • 72 citations

Arachidonic acid metabolism in isolated pancreatic islets

1984 • 72 citations

The regulation of extramitochondrial steady state free Ca2+ concentration by rat insulinoma mitochondria.

1983 • 71 citations

Possible Role of Phospholipase A₂Action and Arachidonic Acid Metabolism in Angiotensin II–Mediated Aldosterone Secretion*

1985 • 69 citations

A possible role for glucose metabolites in the regulation of inositol-1,4,5-trisphosphate 5-phosphomonoesterase activity in pancreatic islets.

1986 • 69 citations

Glucose-induced accumulation of inositol trisphosphates in isolated pancreatic islets. Predominance of the 1,3,4-isomer

1986 • 67 citations

Arachidonic acid epoxidation: Epoxyeicosatrienoic acids are endogenous constituents of rat liver

1984 • 66 citations

Adenosine Triphosphatases of Rat Pancreatic Islets

1978 • 66 citations

Effect of glucose on polyphosphoinositide metabolism in isolated rat islets of Langerhans

1985 • 65 citations

Arachidonic acid metabolism in isolated pancreatic islets

1984 • 65 citations

Role of Ca2+ in secretagogue-stimulated breakdown of phosphatidylinositol in rat pancreatic islets.

1983 • 65 citations

Size of the inositol 1,4,5-trisphosphate-sensitive calcium pool in guinea-pig hepatocytes

1985 • 65 citations

Calcium uptake by subcellular fractions of pancreatic islets. Effects of nucleotides and theophylline

1976 • 65 citations

The Role of Calcium/Phospholipid-Dependent Protein Kinase in Leydig Cell Steroidogenesis*

1985 • 64 citations

Anomeric Specificity of Glucose-Stimulated Insulin Release: Evidence for a Glucoreceptor?

1974 • 64 citations

Hemoglobin- and hemin-catalyzed transformation of 12l-hydroperoxy-5,8,10,14-eicosatetraenoic acid

1984 • 63 citations

Studies on the mechanism of inhibition of glucose-stimulated insulin secretion by noradrenaline in rat islets of Langerhans

1985 • 62 citations

An Improved Method for the Isolation of Islets from the Beef Pancreas

1982 • 62 citations

Effect of Cytochalasin B on the Biphasic Release of Insulin in Perifused Rat Islets

1973 • 62 citations

Studies on the role of inositol trisphosphate in the regulation of insulin secretion from isolated rat islets of Langerhans

1985 • 62 citations

Arachidonic acid metabolism in isolated pancreatic islets. III. Effects of exogenous lipoxygenase products and inhibitors on insulin secretion

1985 • 60 citations

Inositol 1,4,5‐trisphosphate may be a signal for f‐Met‐Leu‐Phe‐induced intracellular Ca mobilisation in human leucocytes (HL‐60 cells)

1984 • 60 citations

The formation of inositol 1,2-cyclic phosphate on agonist stimulation of phosphoinositide breakdown in mouse pancreatic minilobules. Evidence for direct phosphodiesteratic cleavage of phosphatidylinositol.

1985 • 60 citations

Evidence for tight coupling of thyrotropin-releasing hormone receptors to stimulated inositol trisphosphate formation in rat pituitary cells.

1985 • 60 citations

Ca-activated ATPase activity in subcellular fractions of mouse pancreatic islets

1976 • 59 citations

The identification of an epoxy-hydroxy acid as a product from the incubation of arachidonic acid with washed blood platelets

1979 • 59 citations

Correlation of Ca2+-and calmodulin-dependent protein kinase activity with secretion of insulin from islets of Langerhans

1983 • 59 citations

Prostaglandins as Modulators of Pancreatic Islet Function

1979 • 59 citations

Enhanced Release of Insulin by Prostaglandins in Isolated Pancreatic Islets

1973 • 59 citations

Activation of protein kinase C by a tumor‐promoting phorbol ester in pancreatic islets

1984 • 57 citations

Evidence for coupling of phospatidic acid formation and calcium influx in thrombin-activated human platelets

1982 • 57 citations

Nutrient metabolism in islet cells

1984 • 56 citations

A Threshold Distribution Hypothesis for Packet Storage of Insulin: II. Effect of Calcium

1972 • 56 citations

Phospholipids and islet function

1983 • 56 citations

Islet-cell metabolism during insulin release. Effects of glucose, citrate, octanoate, tolbutamide, glucagon and theophylline

1969 • 54 citations

Modulation of insulin secretion by lipoxygenase products of arachidonic acid. Relation to lipoxygenase activity of pancreatic islets.

1983 • 54 citations

Synergistic Effect of a Tumor-Promoting Phorbol Ester and a Hypoglycemic Sulfonylurea upon Insulin Release^*

1983 • 54 citations

Arachidonic Acid Metabolism and Prolactin Secretion in vitro: A Possible Role for the Lipoxygenase Products

1983 • 54 citations

Identification and characterization of Ca2+-phospholipid-dependent protein kinase in rat islets and hamster β-cells

1984 • 54 citations

Coupling factors in nutrient-induced insulin release

1984 • 53 citations

Prostaglandin synthesis and metabolism in isolated pancreatic islets of the rat

1981 • 53 citations

Presence, induction and possible role of glucose 6-phosphatase in mammalian pancreatic islets

1969 • 53 citations

Actin filament formation in pancreatic β‐cells during glucose stimulation of insulin secretion

1980 • 53 citations

Calmodulin-activated protein kinase activity in rat pancreatic islet cell membranes

1982 • 52 citations

Stimulation of protein kinase C and insulin release by 1-oleoyl-2-acetyl-glycerol

1985 • 52 citations

Use of a High Voltage Technique to Determine the Molecular Requirements for Exocytosis in Islet Cells

1980 • 52 citations

Endogenous release of hepoxilin A3 from isolated perifused pancreatic islets of Langerhans

1985 • 51 citations

Effects on Glucose-induced Insulin Secretion of Lipoxygenase-derived Metabolites of Arachidonic Acid

1984 • 51 citations

Calcium sequestration activity in rat liver microsomes. Evidence for a cooperation of calcium transport with glucose-6-phosphatase

1985 • 50 citations

LIPOXYGENATION OF ARACHIDONIC ACID: A PIVOTAL STEP IN STIMULUS-SECRETION COUPLING IN THE PANCREATIC BETA CELL

1982 • 50 citations

Accumulation of the inositol phosphates in thrombin-stimulated, washed rabbit platelets in the presence of lithium

1984 • 50 citations

Glucose 6-phosphate regulates Ca2+ steady state in endoplasmic reticulum of islets. A possible link in glucose-induced insulin secretion.

1986 • 49 citations

Effects of Epidermal Growth Factor, Phorbol Myristate Acetate, and Arachidonic Acid on Choriogonadotropin Secretion by Cultured Human Choriocarcinoma Cells*

1985 • 49 citations

Activity of endogenous phospholipase C and phospholipase A2 in glucose stimulated pancreatic islets

1984 • 49 citations

Regulation of Ca2+ transport by isolated organelles of a rat insulinoma. Studies with endoplasmic reticulum and secretory granules.

1984 • 48 citations

Evidence for glucose-responsive and -unresponsive pools of phospholipid in pancreatic islets.

1985 • 48 citations

Is phospholipase A2 a “glucose sensor” responsible for the phasic pattern of insulin release?

1984 • 48 citations

Involvement of 5-lipoxygenase metabolites in ACTH-stimulated corticosteroidogenesis in rat adrenal glands

1985 • 48 citations

Coordinate actions of arachidonic acid and protein kinase C in gonadotropin-releasing hormone-stimulated secretion of luteinizing hormone

1986 • 48 citations

Absolute configuration of epoxyeicosatrienoic acids (EETs) formed during catalytic oxygenation of arachidonic acid by purified rat liver microsomal cytochrome P-450

1984 • 48 citations

Evidence Supporting a Correlation between Arachidonic Acid Release and Prolactin Secretion from GH₃Cells*

1985 • 48 citations

Ether-Linked Lysophospholipids Initiate Insulin Secretion: Lysophospholipids May Mediate Effects of Phospholipase A2 Activation on Hormone Release

1986 • 48 citations

Differential mechanisms of translocation of protein kinase C to plasma membranes in activated human neutrophils

1986 • 46 citations

Possible Role of Endogenous Arachidonic Acid Metabolites in Stimulated Release of Insulin and Glucagon from the Isolated, Perfused Rat Pancreas

1984 • 46 citations

Protein phosphorylation in permeabilized pancreatic islet cells

1985 • 46 citations

Active calcium uptake by islet-cell endoplasmic reticulum.

1982 • 46 citations

Microdetermination of phosphoinositides in a single extract

1985 • 46 citations

Lipoxygenase Products of Arachidonic Acid Stimulate LHRH Release from Rat Median Eminence

1985 • 46 citations

Stimulation of insulin release after raising extracellular calcium

1976 • 45 citations

Cyclic AMP-dependent protein phosphorylation and insulin secretion in intact islets of Langerhans

1984 • 44 citations

Phorbol ester stimulation of insulin release and secretory-granule protein phosphorylation in a transplantable rat insulinoma

1984 • 44 citations

Confirmation of Impaired Early Insulin Response to Glycemic Stimulus in Nonobese Mild Diabetics

1975 • 44 citations

Thyrotropin releasing hormone rapidly enhances [32P]orthophosphate incorporation into phosphatidic acid in cloned GH3 cells

1981 • 44 citations

Glucose-6-phosphatase Activity of Mouse Pancreatic Islets

1968 • 43 citations

Alloxan inhibition of a Ca2+- and calmodulin-dependent protein kinase activity in pancreatic islets.

1983 • 43 citations

Effect of cytochalasin B on hexose transport and glucose metabolism in pancreatic islets

1974 • 42 citations

A role for the lipoxygenase pathway of arachidonic acid metabolism in glucose- and glucagon-induced insulin secretion

1983 • 42 citations

Nonspecific inhibition of enzymes by p-bromophenacyl bromide inhibition of human platelet phospholipase C and modification of sulfhydryl groups

1984 • 42 citations

Thyrotropin (TSH)-Releasing Hormone Decreases Phosphatidylinositol and Increases Unesterified Arachidonic Acid in Thyrotropic Cells: Possible Early Events in Stimulation of TSH Secretion*

1984 • 42 citations

On the mechanism by which hormones induce the release of Ca2+ from mitochondria in the liver cell

1982 • 42 citations

Metabolism of arachidonic acid by isolated rat hepatocytes, renal cells and by some rabbit tissues

1982 • 41 citations

Effects of inhibitors of arachidonic acid metabolism on calcium uptake and catecholamine release in cultured adrenal chromaffin cells

1984 • 40 citations

Alkaline phosphatase of the calf intestine hydrolyzes phospholipids

1985 • 40 citations

The role of calcium in phospholipid turnover following glucose stimulation in neonatal rat cultured islets.

1984 • 40 citations

Effects of Prostaglandin Ei and of Epinephrine on the Dynamics of Insulin Releasein Vitro¹

1974 • 40 citations

Endogenous substrate proteins for Ca2+-calmodulin-dependent, Ca2+-phospholipid-dependent and cyclic AMP-dependent protein kinases in mouse pancreatic islets

1984 • 39 citations

β-Cell cytoplasmic Ca2+ balance as a determinant for glucose-stimulated insulin release

1985 • 39 citations

Dynamics of calcium-induced insulin release

1977 • 38 citations

Oxygenation products of arachidonic acid: Third messengers for insulin release

1984 • 38 citations

The Effect of Glucose on the Acute Uptake and Efflux of Calcium-45 in Isolated Rat Islets

1977 • 38 citations

Cationic Environment and Dynamics of Insulin Secretion. I. Effect of Low Concentrations of Sodium¹

1974 • 37 citations

Arachidonic acid inhibits thyrotropin-releasing hormone-induced elevation of cytoplasmic free calcium in GH3 pituitary cells.

1985 • 37 citations

A comparison of the effects of glucose and acetylcholine on insulin release and intermediary metabolism in rat pancreatic islets.

1979 • 37 citations

Effect of D‐glucose on the incorporation of ³²P into phospholipids of mouse pancreatic islets

1972 • 35 citations

Phosphatidylinositol hydrolysis in isolated guinea-pig islets of Langerhans

1983 • 34 citations

Inhibition by mepacrine and p-bromophenacylbromide of phosphoinositide hydrolysis, glucose oxidation, calcium uptake and insulin release in rat pancreatic islets

1984 • 34 citations

THE EFFECT OF AGEING ON THE TOTAL VOLUMES OF THE A AND B CELLS IN THE ISLETS OF LANGERHANS OF THE RAT

1959 • 34 citations

Involvement of protein kinase C in the phosphorylation of an insulin-granule membrane protein

1984 • 34 citations

Transformation of arachidonic acid in the rat anterior pituitary

1982 • 33 citations

Enhanced de novo synthesis of phosphatidic acid and phosphatidylinositol in rat pancreatic islets exposed to nutrient or neurotransmitter stimuli

1984 • 33 citations

Effect of Alloxan on Permeability and Hexose Transport in Rat Pancreatic Islets

1975 • 33 citations

Lack of specificity of melittin as a probe for insulin release mediated by endogenous phospholipase A2 or lipoxygenase

1986 • 32 citations

Abnormal Glucose Modulation of Islet A- and B-Cell Responses to Arginine in Non-insulin-dependent Diabetes Mellitus

1985 • 32 citations

Specificity and Ultrastructural Localization of Pancreatic B Cell Glucose-6-Phosphatase

1965 • 32 citations

The effects of prostaglandins on secretion of glucagon and inselin by the perfused rat pancreas

1979 • 32 citations

Preparation of deuterated arachidonic acid

1981 • 32 citations

Insulin as a surface marker on isolated cells from rat pancreatic islets.

1983 • 31 citations

Effects of Hydroxyeicosatetraenoic Acids on Fatty Acid Esterification in Phospholipids and Insulin Secretion in Pancreatic Islets*

1985 • 31 citations

II. Biochemical mechanisms in the phosphatidylinositol effect

1983 • 30 citations

Regulation of pancreatic islet‐cell plasma membrane Ca²⁺ + Mg²⁺‐ATPase by Calmodulin

1982 • 29 citations

Regulation by nucleotides of ⁴⁵calcium uptake in homogenates of rat islets of langerhans

1975 • 29 citations

Subcellular Localization of the Alterations in Phosphatidylinositol Metabolism Following Glucose-induced Insulin Release from Rat Pancreatic Islets

1977 • 28 citations

Islet Transplantation in Treating Diabetes

1986 • 27 citations

Luteinizing Hormone-Releasing Hormone Stimulates Arachidonic Acid Release in Rat Granulosa Cells*

1985 • 27 citations

Resolution of DEAE-cellulose chromatography of the enzymatic steps in the transformation of arachidonic acid into 8,11,12- and 10,11,12-trihydroxy-eicosatrienoic acid by the rat lung

1983 • 27 citations

Inositol phospholipid arachidonic acid metabolism in GH3 pituitary cells

1986 • 26 citations

Conformational studies of myosin phosphorylated by protein kinase C.

1985 • 26 citations

Regulation of actin polymerizaton in rat islets of Langerhans

1980 • 26 citations

Insulin secretion: The effector system

1984 • 25 citations

The prostaglandin system and insulin release. Studies with the isolated perfused rat pancreas

1979 • 25 citations

Epoxygenation of arachidonic acid by rat anterior pituitary microsomal fractions

1984 • 25 citations

Effects of cytochalasins B and D on alloxan inhibition of insulin release

1975 • 25 citations

Novel approach to the study of the regulation of hormone‐sensitive lipase in rat adipocytes

1983 • 24 citations

Effect of Anomers of D-glucose on Alloxan Inhibition of Insulin Release in Isolated Perifused Pancreatic Islets

1976 • 24 citations

THE (Ca²⁺+ Mg²⁺)‐ATPase OF ADIPOCYTE PLASMA MEMBRANE: REGULATION BY CALMODULIN AND INSULIN*

1982 • 23 citations

Multiple Metabolic Functions of Glucose in Rat Pancreatic Islets

1975 • 23 citations

Effect of Exogenous Phospholipase A2 on Insulin Secretion from Perifused Rat Islets

1985 • 22 citations

The Effect of Prostacyclin and 6-Keto-Prostaglandin F1α on Insulin Secretion and Cyclic Adenosine 3′, 5′-Monophosphate Content in Isolated Rat Islets

1981 • 22 citations

Effects of Indomethacin on Acute Insulin Release in Man

1980 • 22 citations

Calmodulin and pancreatic B-cell function

1984 • 21 citations

Insulin response to glucose, tolbutamide, secretin, and isoprenaline in maturity-onset diabetes mellitus.

1972 • 21 citations

Modulation of insulin secretion by cyclic AMP and prostaglandin E: The effects of theophylline, sodium salicylate and tolbutamide

1982 • 20 citations

A role for endogenous prostaglandins in defective glucose potentiation of nonglucose insulin secretagogues in diabetics

1981 • 20 citations

Quantitative Vitreous Fluorophotometry in Insulin-treated Cystic Fibrosis Patients

1983 • 19 citations

Effects of lipoxygenase and cyclooxygenase inhibitors on glucose-stimulated insulin secretion from the isolated perfused rat pancreas

1984 • 19 citations

Studies on the mechanism by which melittin stimulates insulin secretion from isolated rat islets of Langerhans

1985 • 19 citations

Is Somatostatin a True Local Inhibitory Regulator of Insulin Secretion?

1984 • 18 citations

The Effect of Flurbiprofen, a Potent Inhibitor of Prostaglandin Synthesis, on Insulin and Glucagon Release from Isolated Rat Pancreas^*

1984 • 18 citations

Contrasting Patterns of Insulin Biosynthesis, Compartmental Storage, and Secretion: Rat Tumor Versus Islet Cells

1984 • 18 citations

Coordinated regulation of free Ca2+ by isolated organelles from a rat insulinoma.

1984 • 18 citations

Prostaglandins, Glucose Homeostasis, and Diabetes Mellitus

1981 • 18 citations

The priming effect of glucose on insulin secretion from isolated islets of Langerhans

1981 • 18 citations

Temporal changes in islet polymerized and depolymerized tubulin during biphasic insulin release

1980 • 18 citations

Calmodulin inhibits inositol trisphosphate-induced Ca2+ mobilization from the endoplasmic reticulum of islets

1986 • 17 citations

Phasic Glucose-stimulated Insulin Secretion by Neonatal Rat Pancreatic Islet Cells: Enhancement by Sodium Salicylate

1984 • 17 citations

The effect of phalloidin on insulin secretion from islets of langerhans isolated from rat pancreas

1984 • 16 citations

Effects of dehydrouramil on protein phosphorylation and insulin secretion in rat islets of Langerhans

1986 • 16 citations

Reversal by methysergide of inhibition of insulin secretion by prostaglandin E in the dog.

1978 • 15 citations

Glucose-induced, calcium-mediated protein phosphorylation in intact pancreatic islets

1984 • 15 citations

Identification and significance of glucokinase in transplantable insulinomas.

1983 • 14 citations

Quantitation ofmyo-inositol as its hexakis(trifluoroacetyl) derivative with negative ion chemical ionization mass spectrometry

1986 • 13 citations

Role of arachidonate lipoxygenase and cyclooxygenase products in insulin and glucagon secretion from rat pancreatic islets

1984 • 13 citations

Glucose dependent stimulation by prostaglandin D2 of glucagon and insulin in perfused rat pancreas

1983 • 12 citations

Effects of prostacyclin and its stable analog, iloprost, upon insulin secretion in isolated pancreatic islets

1984 • 12 citations

Phospholipase A2 inhibitors

1983 • 12 citations

Stimulus-secretion coupling in the pancreatic B-cell: introductory remarks.

1984 • 11 citations

Evidence for the involvement of lipoxygenase products in steroidogenesis

1985 • 11 citations

Effects of insulin secretagogues and inhibitors on phospholipid metabolism in Langerhans' islets of rat pancreas

1983 • 11 citations

Specificity of inhibition of calcium- and calmodulin-dependent protein kinase by alloxan

1984 • 10 citations

Activity of prostaglandin biosynthetic pathways in rat pancreatic islets

1984 • 9 citations

Stimulation of 6-keto-prostaglandin F1α release from isolated pancreatic islets by an insulinotropic concentration of glucose

1983 • 9 citations

Lipoxygenase inhibitors and cyclic AMP-mediated insulin secretion caused by forskolin, theophylline and dibutyryl cyclic AMP.

1985 • 9 citations