The mammalian pyruvate dehydrogenase complex: Structure and regulation

Methoden der enzymatischen Analyse

1962 • 3,983 citations

ENZYMATIC PROPERTIES OF THE INNER AND OUTER MEMBRANES OF RAT LIVER MITOCHONDRIA

1968 • 1,398 citations

Regulation of Metabolic Processes in Mitochondria

1967 • 1,182 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY PHOSPHORYLATION AND DEPHOSPHORYLATION

1969 • 669 citations

Multienzyme complexes

1974 • 655 citations

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

1972 • 519 citations

Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids

1974 • 492 citations

Regulation of Glucose Uptake by Muscle

1962 • 484 citations

Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide

1976 • 399 citations

Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones

1971 • 388 citations

Generation by Insulin of a Chemical Mediator That Controls Protein Phosphorylation and Dephosphorylation

1979 • 373 citations

Studies on Rat Adipose Tissue in Vitro

1958 • 371 citations

Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats

1976 • 357 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, XI. COMPARATIVE STUDIES OF REGULATORY PROPERTIES OF THE PYRUVATE DEHYDROGENASE COMPLEXES FROM KIDNEY, HEART, AND LIVER MITOCHONDRIA

1969 • 355 citations

Regulation of Hepatic Metabolism

1976 • 314 citations

Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios

1975 • 303 citations

Regulation of mammalian pyruvate dehydrogenase

1975 • 299 citations

Sites of phosphorylation on pyruvate dehydrogenase from bovine kidney and heart

1978 • 283 citations

α-Keto acid dehydrogenase complexes

1972 • 282 citations

α-Keto acid dehydrogenase complexes

1972 • 278 citations

STUDIES ON THE NATURE AND REACTIONS OF PROTEIN-BOUND LIPOIC ACID

1958 • 273 citations

Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilization in rat heart

1970 • 270 citations

Interactions of Metabolism and the Physiological Role of Insulin

1966 • 256 citations

α-Keto acid dehydrogenase complexes

1972 • 244 citations

Insulin-stimulated intracellular hydrogen peroxide production in rat epididymal fat cells

1979 • 239 citations

Effect of glucagon on metabolite compartmentation in isolated rat liver cells during gluconeogenesis from lactate

1977 • 234 citations

Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: Effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion

1971 • 231 citations

Metabolic Interconversion of Enzymes

1972 • 228 citations

Regulation of heart muscle pyruvate dehydrogenase kinase

1974 • 227 citations

Pyruvate Dehydrogenase Activation in Adipocyte Mitochondria by an Insulin-Generated Mediator from Muscle

1979 • 222 citations

A partial view of the mechanism of insulin action

1981 • 215 citations

THE ENZYMATIC ACETYLATION OF AMINES

1953 • 209 citations

Active and Inactive Forms of Pyruvate Dehydrogenase in Rat Liver

1972 • 199 citations

Regulation of glucose uptake by muscle. 7. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, on the concentrations of hexose phosphates, nucleotides and inorganic phosphate in perfused rat heart

1964 • 199 citations

The insulin-like effect of hydrogen peroxide on pathways of lipid synthesis in rat adipocytes.

1979 • 196 citations

Studies on Rat Adipose Tissue in Vitro

1962 • 190 citations

Evidence that insulin activates an intrinsic plasma membrane protease in generating a secondary chemical mediator.

1980 • 175 citations

Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication)

1973 • 174 citations

Superiority of interconvertible enzyme cascades in metabolic regulation: Analysis of multicyclic systems

1977 • 173 citations

Activation of pyruvate dehydrogenase by direct addition of insulin to an isolated plasma membrane/mitochondria mixture: Evidence for generation of insulin's second messenger in a subcellular system

1980 • 172 citations

THE EFFECT OF INSULIN AND PITUITARY HORMONES ON GLUCOSE UPTAKE IN MUSCLE

1951 • 170 citations

Regulation of pyruvate metabolism in mammalian tissues.

1979 • 166 citations

Studies on the Mechanism of Activation of Adipose Tissue Pyruvate Dehydrogenase by Insulin

1973 • 162 citations

Pyruvate Dehydrogenase, Substrate Specificity and Product Inhibition

1969 • 161 citations

Function of calcium ions in pyruvate dehydrogenase phosphatase activity

1972 • 157 citations

Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase

1974 • 157 citations

Regulation of Mammalian Pyruvate Dehydrogenase Complex by a Phosphorylation–Dephosphorylation Cycle

1981 • 153 citations

[50] Purification and resolution of the pyruvate dehydrogenase complex (Escherichia coli)

1966 • 152 citations

α-Keto Acid Dehydrogenase Complexes

1973 • 149 citations

Pyruvate Dehydrogenase Complex Activity in Normal and Deficient Fibroblasts

1981 • 148 citations

The regulation of triglyceride synthesis and fatty acid synthesis in rat epididymal adipose tissue. Effects of insulin, adrenaline and some metabolites in vitro

1970 • 145 citations

Stimulation of phosphorylation and inactivation of pyruvate dehydrogenase by physiological inhibitors of the pyruvate dehydrogenase reaction

1975 • 141 citations

An NADH-linked spectrophotometric assay for pyruvate dehydrogenase complex in crude tissue homogenates.

1981 • 139 citations

Superiority of interconvertible enzyme cascades in metabolic regulation: analysis of monocyclic systems.

1977 • 136 citations

Interconversion of Phospho- and Dephospho- Forms of Pig Heart Pyruvate Dehydrogenase

1970 • 134 citations

Phosphorylation state of cytosolic and mitochondrial adenine nucleotides and of pyruvate dehydrogenase in isolated rat liver cells

1976 • 133 citations

Relative importance of pyruvate dehydrogenase interconversion and feed-back inhibition in the effect of fatty acids on pyruvate oxidation by rat heart mitochondria

1978 • 130 citations

Metabolic Interconversion of Enzymes 1973

1974 • 128 citations

Reduced nicotinamide adenine dinucleotide phosphate oxidase in adipocyte plasma membrane and its activation by insulin

1977 • 127 citations

Mechanism of pyruvate inhibition of kidney pyruvate dehydrogenasea kinase and synergistic inhibition by pyruvate and ADP.

1979 • 127 citations

Hormonal regulation of pyruvate dehydrogenase

1971 • 127 citations

Interconversion and Kinetic Properties of Pyruvate Dehydrogenase from Brain

1971 • 127 citations

Subunit structure of dihydrolipoyl transacetylase component of pyruvate dehydrogenase complex from Escherichia coli

1979 • 122 citations

Distribution of Metabolites Between the Cytosolic and Mitochondrial Compartments of Hepatocytes Isolated from Fed Rats

1978 • 120 citations

Interconversion of pyruvate dehydrogenase in rat heart muscle upon perfusion with fatty acids or ketone bodies

1971 • 120 citations

Diabetes and the control of pyruvate dehydrogenase in rat heart mitochondria by concentration ratios of adenosine triphosphate/adenosine diphosphate, of reduced/oxidized nicotinamide-adenine dinucleotide and of acetyl-coenzyme A/coenzyme A.

1977 • 117 citations

Studies on the effects of coenzyme A-SH: acetyl coenzyme A, nicotinamide adenine dinucleotide: reduced nicotinamide adenine dinucleotide, and adenosine diphosphate: adenosine triphosphate ratios on the interconversion of active and inactive pyruvate dehydrogenase in isolated rat heart mitochondria.

1976 • 117 citations

Purification of porcine liver pyruvate dehydrogenase complex and characterization of its catalytic and regulatory properties

1977 • 113 citations

Endogenous hydrogen peroxide and peroxidative metabolism in adipocytes in response to insulin and sulfhydryl reagents

1978 • 113 citations

Purification and Characterization of Pyruvate‐Dehydrogenase Phosphatase from Pig‐Heart Muscle

1972 • 110 citations

Metabolic Interconversion of Enzymes 1980

1981 • 109 citations

Kinetic and Regulatory Properties of Heart Muscle Pyruvate Dehydrogenase

1969 • 107 citations

Regulation of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads. Effects of starvation, alloxan-diabetes and high-fat diet

1976 • 105 citations

Hormonal regulation of adipose-tissue acetyl-coenzyme A carboxylase by changes in the polymeric state of the enzyme. The role of long-chain fatty acyl-coenzyme A thioesters and citrate

1974 • 104 citations

Regulation of Pyruvate Dehydrogenase in Rat Liver Mitochondria by Phosphorylation-Dephosphorylation

1974 • 104 citations

Glucose metabolism in perfused skeletal muscle. Pyruvate dehydrogenase activity in starvation, diabetes and exercise

1976 • 104 citations

Mechanisms regulating adipose-tissue pyruvate dehydrogenase

1972 • 103 citations

Subunit structure of dihydrolipoyl transacetylase component of pyruvate dehydrogenase complex from bovine heart.

1981 • 100 citations

Partial purification from rat adipocyte plasma membranes of a chemical mediator which simulates the action of insulin on pyruvate dehydrogenase.

1981 • 100 citations

Control of pyruvate dehydrogenase interconversion in adipose tissue by insulin

1971 • 99 citations

The regulation of pyruvate dehydrogenase in the isolated perfused rat heart.

1978 • 99 citations

Characterization of a pyruvate dehydrogenase activator released by adipocyte plasma membranes in response to insulin.

1981 • 99 citations

Mammalian α-Keto Acid Dehydrogenase Complexes

1969 • 98 citations

A unifying mechanism for stimulation of mammalian pyruvate dehydrogenase(a) kinase by reduced nicotinamide adenine dinucleotide, dihydrolipoamide, acetyl coenzyme A, or pyruvate.

1978 • 96 citations

Insulin stimulation of pyruvate dehydrogenase in an isolated plasma membrane-mitochondrial mixture occurs by activation of pyruvate dehydrogenase phosphatase.

1980 • 95 citations

Interconversion of Pyruvate Dehydrogenase in the Isolated Perfused Rat Liver

1973 • 94 citations

Regulation of pig heart pyruvate dehydrogenase by phosphorylation. Studies on the subunit and phosphorylation stoicheiometries

1978 • 93 citations

ATP‐dependent inactivation of heart muscle pyruvate dehydrogenase and reactivation by Mg⁺⁺

1969 • 93 citations

Regulation of Pyruvate Dehydrogenase in Mitochondria of Rat Liver

1972 • 93 citations

Function of the nonidentical subunits of mammalian pyruvate dehydrogenase

1972 • 93 citations

THE EFFECT OF INSULIN AND PITUITARY HORMONES ON GLUCOSE UPTAKE IN MUSCLE

1951 • 92 citations

Insulin, chemistry, structure, and function of insulin and related hormones

1980 • 92 citations

Amino acid sequences around the sites of phosphorylation in the pig heart pyruvate dehydrogenase complex

1979 • 90 citations

Phosphorylation of additional sites on pyruvate dehydrogenase inhibits its re-activation by pyruvate dehydrogenase phosphate phosphatase

1978 • 89 citations

The control of fatty acid and triglyceride synthesis in rat epididymal adipose tissue. Roles of coenzyme A derivatives, citrate and <scp>l</scp>-glycerol 3-phosphate

1968 • 88 citations

The activity of pyruvate dehydrogenase in rat brain during postnatal development

1974 • 88 citations

The elementary reactions of the pig heart pyruvate dehydrogenase complex. A study of the inhibition by phosphorylation

1976 • 88 citations

ATP content of isolated fat cells effects of insulin, ouabain, and lipolytic agents

1970 • 87 citations

The Effect of Fatty Acids on the Regulation of Pyruvate Dehydrogenase in Perfused Rat Liver

1978 • 86 citations

Activation of Pyruvate Dehydrogenase during Metabolism of Ammonium Ions in Hemoglobin‐Free Perfused Rat Liver

1975 • 85 citations

Enhanced activity of pyruvate dehydrogenase kinase in rat heart mitochondria in alloxan‐diabetes or starvation

1978 • 85 citations

On the reaction mechanism of lipoyl dehydrogenase

1960 • 84 citations

Pyruvate Dehydrogenase Complex from Baker's Yeast. 1. Purification and Some Kinetic and Regulatory Properites

1981 • 83 citations

Effect of Insulin on Fatty Acid Synthesis from Pyuvate, Lactate, or Endogenous Sources in Adipose Tissue: Evidence for the Hormonal Regulation of Pyruvate Dehydrogenase¹

1970 • 82 citations

Metabolism of Isolated Kidney Tubules

1972 • 80 citations

Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio.

1975 • 80 citations

The mode of regulation of pyruvate dehydrogenase of lactating rat mammary gland. Effects of starvation and insulin

1978 • 77 citations

Structure and symmetry of B. stearothermophilus pyruvate dehydrogenase multienzyme complex and implications for eucaryote evolution

1979 • 77 citations

Pyruvate dehydrogenase and the hormonal regulation of fat synthesis in mammalian tissues

1978 • 76 citations

PYRUVATE OXIDATION SYSTEM OF HEART MUSCLE

1952 • 75 citations

Monovalent cation requirement for ADP inhibition of pyruvate dehydrogenase kinase

1974 • 75 citations

Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio.

1975 • 75 citations

Rapid intersite transfer of acetyl groups and movement of pyruvate dehydrogenase component in the kidney pyruvate dehydrogenase complex.

1980 • 75 citations

Regulation of pyruvate oxidation and the conservation of glucose.

1978 • 74 citations

Insulin stimulates the release from liver plasma membranes of a chemical modulator of pyruvate dehydrogenase

1981 • 74 citations

Function of phosphorylation sites on pyruvate dehydrogenase

1979 • 73 citations

Regulation of kinase reactions in pig heart pyruvate dehydrogenase complex

1979 • 72 citations

The Pyruvate‐Dehydrogenase Complex from Azotobacter vinelandii

1975 • 72 citations

Active and inactive forms of pyruvatedehydrogenase in skeletal muscle as related to the metabolic and functional state of the muscle cell

1975 • 71 citations

Insulin activates Pyruvate Dehydrogenase in Rat Epididymal Adipose Tissue

1971 • 70 citations

Short-Term Regulation of Liver Metabolism

1982 • 70 citations

Regulation of Pyruvate Dehydrogenase in Muscle

1973 • 70 citations

Regulation of Pyruvate-Dehydrogenase Interconversion in Rat-Liver Mitochondria as Related to the Phosphorylation State of Intramitochondrial Adenine Nucleotides

1974 • 69 citations

Effect of micromolar concentrations of free Ca2+ ions on pyruvate dehydrogenase interconversion in intact rat heart mitochondria

1981 • 69 citations

Short‐term regulation of liver metabolism

1982 • 68 citations

Brain Pyruvate Dehydrogenase: Phosphorylation and Enzyme Activity Altered by a Training Experience

1981 • 68 citations

Energy-linked regulation of glucose and pyruvate oxidation in isolated perfused rat heart. Role of pyruvate dehydrogenase

1976 • 68 citations

Glycogen phosphorylase, glucose output and vasoconstriction in the perfused rat liver. Concentration-dependence of actions of adrenaline, vasopressin and angiotensin II

1976 • 67 citations

Mammalian α-Keto Acid Dehydrogenase Complexes

1969 • 67 citations

Relationshiop between phosphorylation and activity of pyruvate dehydrogenase in rat liver mitochondria and the absence of such a relationship for pyruvate carboxylase.

1978 • 67 citations

Metabolic Interconversion of Enzymes

1972 • 66 citations

Incorporation of 32Pi into pyruvate dehydrogenase phosphate in mitochondria from control and insulin-treated adipose tissue

1976 • 63 citations

The pyruvate dehydrogenase complex from the mitochondrial fraction of Neurospora crassa

1970 • 62 citations

Activation of pyruvate dehydrogenase in adipose tissue by insulin. Evidence for an effect of insulin on pyruvate dehydrogenase phosphate phosphatase

1975 • 62 citations

Isolation from Rat Adipocytes of a Chemical Mediator for Insulin Activation of Pyruvate Dehydrogenase

1980 • 61 citations

Control of pyruvate dehydrogenase activity in intact cardiac mitochondria. Regulation of the inactivation and activation of the dehydrogenase.

1975 • 59 citations

Plant pyruvate dehydrogenase complex purification, characterization and regulation by metabolites and phosphorylation

1977 • 59 citations

Effects of insulin, epinephrine, and cyclic adenosine monophosphate on pyruvate dehydrogenase of adipose tissue

1973 • 58 citations

Studies on the Action of Insulin in Isolated Adipose Tissue Cells

1968 • 57 citations

Regulation by Insulin of Adipose Tissue Pyruvate Dehydrogenase. A Mechanism Controlling Fatty Acid Synthesis from Carbohydrates

1974 • 56 citations

Regulation of pyruvate dehydrogenase interconversion in isolated hepatocytes by the mitochondrial ATP/ADP ratio

1975 • 56 citations

Peptides derived from pyruvate dehydrogenase as substrates for pyruvate dehydrogenase kinase and phosphatase

1977 • 55 citations

Studies of the effects of beta-adrenergic agonists on the regulation of pyruvate dehydrogenase in the perfused rat heart.

1980 • 55 citations

Kinetic properties of the partially purified pyruvate dehydrogenase complex of ox brain

1973 • 54 citations

Alpha-Keto acid dehydrogenase complexes, V. Macromolecular organization of pyruvate and alpha-ketoglutarate dehydrogenase complexes isolated from beef kidney mitochondria.

1966 • 54 citations

Activation of pyruvate dehydrogenase in the perfused rat liver by vasopressin

1978 • 54 citations

Function and regulation of mammalian pyruvate dehydrogenase complex. Acetylation, interlipoyl acetyl transfer, and migration of the pyruvate dehydrogenase component.

1979 • 54 citations

Studies on the relationship between ketogenesis and pyruvate oxidation in isolated rat liver mitochondria.

1978 • 52 citations

Calcium ions and the regulation of pyruvate dehydrogenase.

1974 • 52 citations

Lipoic acid content of dihydrolipoyl transacylases determined by isotope dilution analysis

1980 • 50 citations

A kinetic study of dihydrolipoyl transacetylase from bovine kidney.

1975 • 50 citations

Purification and characterization of pyruvate dehydrogenase complex from broccoli floral buds

1977 • 49 citations

The inhibitory effects of acyl-coenzyme a esters on the pyruvate and α-oxoglutarate dehydrogenase complexes

1969 • 49 citations

Analysis of Site Occupancies in [³²P] Phosphorylated Pyruvate Dehydrogenase Complexes by Aspartyl‐Prolyl Cleavage of Tryptic Phosphopeptides

1981 • 47 citations

Studies on the regulation of pyruvate dehydrogenase in the isolated perfused rat heart.

1979 • 47 citations

Determination of pyruvate dehydrogenase and acetyl-CoA synthetase activities using citrate synthase

1981 • 47 citations

Evidence for lipoic acid mediated NADH and acetyl-CoA stimulation of liver and kidney pyruvate dehydrogenase kinase

1976 • 46 citations

Conversion of inactive (phosphorylated) pyruvate dehydrogenase complex into active complex by the phosphate reaction in heart mitochondria is inhibited by alloxan-diabetes or starvation in the rat

1978 • 46 citations

Chemistry, structure and function of insulin and related hormones

1980 • 46 citations

Enzyme Localization in Beef‐Heart Mitochondria

1972 • 46 citations

Role of Free Oxaloacetate in Ketogenesis. Derivation from the Direct Measurement of Mitochondrial [3-Hydroxybutyrate]/[Acetoacetate] Ratio in Hepatocytes

1982 • 45 citations

Studies on inactivation of pyruvate dehydrogenase by palmitoylcarnitine oxidation in isolated rat heart mitochondria.

1977 • 44 citations

α-Keto Acid Dehydrogenase Complexes

1970 • 44 citations

Effect of dichloroacetate and glucagon on the incorporation of labeled substrates into glucose and on pyruvate dehydrogenase in hepatocytes from fed and starved rats

1977 • 44 citations

Thermolabile factor accelerates pyruvate dehydrogenase kinase reaction in heart mitochondria of starved or alloxan‐diabetic rats

1981 • 44 citations

Neurospora crassa pyruvate dehydrogenase: Interconversion by phosphorylation and dephosphorylation

1972 • 43 citations

A comparison of the regulation of pyruvate dehydrogenase in mitochondria from rat brain and liver

1975 • 42 citations

Plant pyruvate dehydrogenase complex: Inactivation and reactivation by phosphorylation and dephosphorylation

1980 • 40 citations

Interconversion of inactive to active pyruvate dehydrogenase in rat liver after fructose application in vivo

1971 • 40 citations

Regulation of lipogenesis in adipose tissue: The significance of the activation of pyruvate dehydrogenase by insulin

1974 • 38 citations

The regulatory function of potato pyruvate dehydrogenase

1971 • 38 citations

Properties and Subunit Structure of Pig Heart Pyruvate Dehydrogenase1

1976 • 38 citations

On the mechanism of irreversible pyruvate dehydrogenase inactivation in liver mitochondrial extracts

1975 • 37 citations

Properties of pyruvate dehydrogenase of rat mammary tissue and its changes during pregnancy, lactation and weaning

1974 • 36 citations

RÔLE OF COENZYME A AND DIPHOSPHOPYRIDINE NUCLEOTIDE IN THE OXIDATION OF PYRUVATE

1952 • 35 citations

Regulation of the Mammalian Pyruvate Dehydrogenase Multienzyme Complex by Mg²⁺ and the Adenine Nucleotide Pool

1974 • 35 citations

Metabolism of Isolated Kidney Tubules

1974 • 34 citations

Purification and properties of the Ascaris pyruvate dehydrogenase complex

1979 • 33 citations

Inactivation and Disassembly of the Pyruvate Dehydrogenase Multienzyme Complex from Bovine Kidney by Limited Proteolysis with an Enzyme from Rat Liver

1979 • 33 citations

The Pyruvate‐Dehydrogenase Complex from Azotobacter vinelandii

1975 • 31 citations

Lipogenesis in man

1980 • 30 citations

Hormones and Cell Regulation, Vol. 7

1983 • 28 citations

Regulation of the Human Pyruvate Dehydrogenase Complex

1976 • 28 citations

Effects of work and acidosis on pyruvate dehydrogenase activity in perfused rat hearts

1980 • 27 citations

Role of multi‐site phosphorylation in regulation of pig heart pyruvate dehydrogenase phosphatase

1979 • 27 citations

Pyruvate dehydrogenase complex of ascites tumour. Activation by AMP and other properties of potential significance in metabolic regulation

1980 • 27 citations

Bovine Kidney Pyruvate Dehydrogenase Complex

1980 • 26 citations

Antitrachoma Activity of Rifamycin B and 8-O-Acetylrifamycin S

1971 • 26 citations

Absent pyruvate inhibition of pyruvate dehydrogenase kinase in lactating rat mammary gland following various treatments

1979 • 25 citations

Pyruvate Dehydrogenase Activation after an Increase in Cardiac Output

1976 • 25 citations

Isolation and Characterisation of Pyruvate Dehydrogenase Complex from Brewer’s Yeast

1973 • 25 citations

Activity of the pyruvate dehydrogenase complex in the mammary gland of normal and diabetic rats

1976 • 25 citations

The regulation of pyruvate dehydrogenase by fatty acids in isolated rabbit heart mitochondria

1978 • 25 citations

Effects of Fasting on the Control of Fatty-Acid Synthesis in Hepatoma 7777 and Host Liver. Role of Long-Chain Fatty Acyl-CoA, the Mitochondrial Citrate Transporter and Pyruvate Dehydrogenase Activity

1975 • 25 citations

Pyruvate dehydrogenase complex — meticulous regulator of glucose disposal in animals

1978 • 24 citations

Occupancy of sites of phosphorylation in inactive rat heart pyruvate dehydrogenase phosphate in vivo

1981 • 24 citations

Insulin activates pyruvate dehydrogenase by lowering the mitochondrial acetyl‐CoA/CoA ratio as evidenced by digitonin fraction of isolated fat cells

1978 • 23 citations

Effect of phenylpyruvate on pyruvate dehydrogenase activity in rat brain mitochondria

1973 • 23 citations

Activation of pyruvate dehydrogenase in rat adipocytes by concanavalin a: Evidence for insulin-like effect mediated by hydrogen peroxide

1980 • 22 citations

Activation of the pyruvate dehydrogenase complex in isolated fat cell mitochondria by hydrogen peroxide and t‐butyl hydroperoxide

1980 • 22 citations

Partial purification and characterization of a pyruvate dehydrogenase-complex-inactivating enzyme from rat liver

1978 • 22 citations

Incorporation of [32P]phosphate into the pyruvate dehydrogenase complex in rat heart mitochondria

1980 • 22 citations

Role of multisite phosphorylation in the regulation of ox kidney pyruvate dehydrogenase complex

1980 • 22 citations

Control of Fatty Acid Synthesis in White Adipose Tissue by Insulin: Coordination Between the Mitochondrial Citrate Transporter and Pyruvate Dehydrogenase

1974 • 21 citations

The effects of fatty acids on oxidative decarboxylation of pyruvate in rat small intestine

1974 • 20 citations

Subunit Structure of Dihydrolipoamide Acetyltransferase Component of Pyruvate Dehydrogenase Complex from Bovine Kidney

1980 • 20 citations

Purification, Properties, and Subunit Composition of Pig Heart Lipoate Acetyltransferase&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;

1975 • 20 citations

An improved procedure for the assay of pyruvate dehydrogenase

1979 • 20 citations

Metabolic interconversion of enzymes 1975

1977 • 20 citations

The effect of acetate on the regulation of the branched chain α-keto acid and the pyruvate dehydrogenase complexes in the perfused rat liver

1981 • 20 citations

Regulation by Insulin and Free Fatty Acids of Pyruvate Dehydrogenase Activity in Perfused Rat Liver

1977 • 19 citations

Inhibition by acetaldehyde of the pyruvate dehydrogenase complex from ox brain and ox kidney (Short Communication)

1973 • 19 citations

The effect of insulin on pyruvate dehydrogenase interconversion in heart muscle of alloxan-diabetic rats

1978 • 19 citations

Kinetic and regulatory properties of pyruvate dehydrogenase from Ehrlich ascites tumor cells.

1976 • 18 citations

Effects of Growth Hormone on the Oxidation of [1-¹⁴C]-Pyruvate in Adipose Tissue of Hypophysectomized Rats

1981 • 18 citations

Mammalian lipoate acetyltransferase: molecular weight determination by gel filtration in the presence of guanidinium chloride

1980 • 17 citations

Structure, Function and Regulation of the Mammalian Pyruvate Dehydrogenase Complex

1974 • 16 citations

Effect of hypoxia, ischemia and barbiturate anesthesia on interconversion of pyruvate dehydrogenase in guinea pig brain

1976 • 16 citations

Dephosphorylation of pig heart pyruvate dehydrogenase phosphate complexes by pig heart pyruvate dehydrogenase phosphate phosphatase

1981 • 16 citations

Regulation of Pyruvate Dehydrogenase in Heart Mitochondria

1977 • 15 citations

Pyruvate dehydrogenase and the regulation of glucose metabolism in ruminant tissues

1980 • 14 citations

Reduction of mitochondrial pyruvate dehydrogenase phosphatase activity in lactating rat mammary gland following starvation or insulin deprivation

1979 • 14 citations

Control of pyruvate dehydrogenase interconversion by palmitoyl‐coenzyme A as related to adenine nucleotide translocation in isolated fat cell mitochondria

1975 • 14 citations

Enhanced dissociation of pyruvate dehydrogenase from the pyruvate dehydrogenase complex following phosphorylation and regulatory implications

1979 • 13 citations

Effect of insulin on pyruvate metabolism in epididymal adipose tissue of the rat. Correlation of intracellular pyruvate contents and pyruvate dehydrogenase activity

1973 • 13 citations

Studies on the Influence of Fatty Acids on Pyruvate Dehydrogenase Interconversion in Rat‐Liver Mitochondria

1976 • 12 citations

Eine vereinfachte Fettgewebsmethode zur Insulinbestimmung im Serum

1966 • 11 citations

Molecular Aspects of the Regulation of the Mammalian Pyruvate Dehydrogenase Complex

1972 • 11 citations

Pyruvate dehydrogenase activity in liver and brown fat of the developing rat

1976 • 10 citations

Effects of Fructose Concentration on Adenine Nucleotide Concentrations and Pyruvate Dehydrogenase Activity of Perfused Rat Liver

1977 • 10 citations

[77] Coenzyme A-linked pyruvic oxidase (bacterial)

1955 • 10 citations

Regulation of the Mammalian Pyruvate Dehydrogenase Complex: Physiological Aspects and Characterization of PDH-Phosphatase from Pig Heart

1972 • 10 citations

PYRUVATE DEHYDROGENASE COMPLEX: STRUCTURE, FUNCTION, AND REGULATION

1972 • 10 citations

Ultrastructural localization of pyruvate dehydrogenase in rat heart muscle

1973 • 9 citations

The effect of pyruvate transport inhibitors on the regulation of pyruvate dehydrogenase in the perfused rat heart

1979 • 9 citations

Activation of pyruvate dehydrogenase by insulin in isolated brown fat cells.

1979 • 9 citations

Stimulation of pyruvate dehydrogenase activity by insulin-dextran complex in mouse adipose tissue

1979 • 9 citations

Inactivation of pig heart pyruvate dehydrogenase complex by adenosine‐5′‐O(3‐thiotriphosphate)

1980 • 8 citations

Pyruvate dehydrogenase activity in hamster small intestine during development

1977 • 8 citations

Pyruvate dehydrogenase activity in several tissues of genetically obese hyperglycemic mice

1978 • 8 citations

α-keto acid dehydrogenases and acyl-CoA synthetases from pigeon breast muscle

1977 • 8 citations

Influence of phenylpyruvate on the interconversion of pyruvate dehydrogenase complex from mammalian brain and kidney

1974 • 8 citations

Evidence for two‐domain subunit structure of kidney lipoate acetyltransferase

1980 • 7 citations

Cellular distribution of pyruvate dehydrogenase phosphatase. Activity in normal, hyperinsulinized and diabetic rats

1976 • 7 citations

Pyruvate Dehydrogenase and ATP Citrate (pro-3S)-LyaseActivities in Adipose Tissue and Liver of the Young Lean and the Older Obese Rat

1979 • 7 citations

Effect of Glutamate on the Control of Fatty-Acid Synthesis in White Adipose Tissue of the Rat. Inhibition of Pyruvate Dehydrogenase

1975 • 6 citations

Evidence for Multi-Site Phosphorylation of Pyruvate Dehydrogenase within Intact Mitochondria

1978 • 6 citations

Effects of dibutyryl cyclic adenosine 3', 5'-monophosphate on pyruvate metabolism in rat adipose tissue

1972 • 6 citations

On the Mechanism of Insulin Action on Pyruvate Dehydrogenase Interconversion in Adipose Tissue

1974 • 5 citations

ACUTE HORMONAL REGULATION OF FATTY ACID SYNTHESIS IN MAMMALIAN TISSUES

1978 • 5 citations

Structure, Function, and Regulation of Mammalian Pyruvate Dehydrogenase Complex

1981 • 4 citations

Pyruvate Dehydrogenase Activity in the Normal and Cryptorchid Rat Testis

1974 • 4 citations

METABOLISM OF PYRUVATE IN ANIMALS

1978 • 4 citations

Activation of Pyruvate Dehydrogenase in Adipose Tissue: Role of Insulin and Pyruvate

1973 • 4 citations

Pyruvate dehydrogenase in rat kidney metabolism.

1975 • 4 citations

Stimulation of Intracellular H2 02 Production in Rat Epididymal Adipocytes by Insulin, Insulin Fragments, and Other Hormones and Growth Factors with Insulin-Like Activities

1980 • 4 citations

Gewinnung von a-Hydroxyäthyl-2-thiaminpyrophosphat mit Pyruvatoxydase aus Schweineherzmuskel

1961 • 3 citations

Regulation of Adipose Tissue Pyruvate Dehydrogenase by Insulin: Possible Messenger Role of Peroxide(s)

1981 • 3 citations

Effect of insulin on pyruvate and glucose metabolism of beating mouse heart cells

1972 • 2 citations

Metabolic Interconversion of the Pyruvate Dehydrogenase Complex as Related to the Mitochondrial Energy State

1976 • 1 citations