The role of ras gene expression and transforming growth factor α production in the etiology and progression of rodent and human breast cancer

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

1984 • 4,180 citations

ras GENES

1987 • 3,818 citations

Angiogenic Factors

1987 • 3,702 citations

A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2

1973 • 2,431 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Growth Factors and Cancer

1991 • 2,044 citations

Transforming growth factor beta

2011 • 1,990 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

Cellular Oncogenes and Multistep Carcinogenesis

1983 • 1,154 citations

Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping

1988 • 1,107 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Breast Tumor Cell Lines From Pleural Effusions2

1974 • 973 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

EPIDERMAL-GROWTH-FACTOR RECEPTOR STATUS AS PREDICTOR OF EARLY RECURRENCE OF AND DEATH FROM BREAST CANCER

1987 • 881 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Expression of Cellular Oncogenes in Human Malignancies

1984 • 840 citations

Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1982 • 836 citations

Peptide growth factors are multifunctional

1988 • 835 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

A gene activated by growth factors is related to the oncogene v-jun.

1988 • 771 citations

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

1983 • 719 citations

The Action of Oncogenes in the Cytoplasm and Nucleus

1985 • 708 citations

Transforming growth factor α

1988 • 707 citations

Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor

1987 • 703 citations

Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse Embryos

1988 • 688 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

Signal Transduction by the Platelet-Derived Growth Factor Receptor

1989 • 653 citations

Fos-Associated Protein p39 Is the Product of the jun Proto-Oncogene

1988 • 643 citations

ras GTPase activating protein: Signal transmitter and signal terminator

1989 • 621 citations

Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers

1988 • 608 citations

Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells.

1988 • 604 citations

Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

1982 • 599 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

Structure and Function of Human Amphiregulin: A Member of the Epidermal Growth Factor Family

1989 • 586 citations

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.

1986 • 541 citations

The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

1984 • 539 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism.

1989 • 528 citations

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction

1989 • 516 citations

EPIDERMAL-GROWTH-FACTOR RECEPTORS AND OESTROGEN RECEPTORS IN HUMAN BREAST CANCER

1985 • 496 citations

Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells.

1983 • 484 citations

Inhibition of protein kinase C by tamoxifen.

1985 • 464 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

1983 • 446 citations

Expression of Transforming Growth Factor α and its Messenger Ribonucleic Acid in Human Breast Cancer: Its Regulation by Estrogen and its Possible Functional Significance

1988 • 440 citations

Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract.

1984 • 435 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

Structural Rearrangement of the Retinoblastoma Gene in Human Breast Carcinoma

1988 • 423 citations

Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene.

1985 • 416 citations

Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas.

1986 • 413 citations

Reversible Inhibition of Mammary Gland Growth by Transforming Growth Factor-β

1987 • 408 citations

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

1986 • 406 citations

Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor.

1983 • 403 citations

Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.

1989 • 402 citations

Microinjection of the oncogene form of the human H-ras (t-24) protein results in rapid proliferation of quiescent cells

1984 • 401 citations

Cellular transformation by coordinated action of three peptide growth factors from human platelets

1984 • 383 citations

Alterations of myc , myb , and ras ^Ha Proto-Oncogenes In Cancers Are Frequent and Show Clinical Correlation

1986 • 379 citations

Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein

1984 • 379 citations

Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells

1976 • 374 citations

Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ

1989 • 360 citations

Induction of transforming growth factor-α in activated human alveolar macrophages

1988 • 359 citations

<italic>N</italic>-Nitrosomethylurea as Mammary Gland Carcinogen in Rats

1975 • 354 citations

Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines.

1988 • 354 citations

Expression in rat fibroblasts of a human transforming growth factor-α cDNA results in transformation

1986 • 346 citations

MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF

1985 • 332 citations

Absence of TGF-β Receptors and Growth Inhibitory Responses in Retinoblastoma Cells

1988 • 331 citations

Role of epidermal growth factor in carcinogenesis.

1986 • 330 citations

Characterization of estrogen responsive transforming activity in human breast cancer cell lines.

1986 • 330 citations

Antiphosphotyrosine Recovery of Phospholipase C Activity After EGF Treatment of A-431 Cells

1988 • 324 citations

Breast Cancer Epidemiology

2012 • 324 citations

Two Syngeneic Cell Lines from Human Breast Tissue: The Aneuploid Mammary Epithelial (Hs578T) and the Diploid Myoepithelial (Hs578Bst) Cell Lines 2

1977 • 299 citations

Epidermal growth factor stimulates transcription of the c-jun proto-oncogene in rat fibroblasts

1988 • 289 citations

Epidermal growth factor binding by breast tumor biopsies and relationship to estrogen receptor and progestin receptor levels.

1984 • 279 citations

Epidermal Growth Factor Receptor Gene Expression in Estrogen Receptor-Positive and Negative Human Breast Cancer Cell Lines

1987 • 274 citations

Estrogen-Induced Factors of Breast Cancer Cells Partially Replace Estrogen to Promote Tumor Growth

1986 • 273 citations

Developmental expression of transforming growth factors alpha and beta in mouse fetus.

1988 • 272 citations

Epidermal growth factor-like transforming growth factor. I. Isolation, chemical characterization, and potentiation by other transforming factors from feline sarcoma virus-transformed rat cells.

1983 • 266 citations

Different transforming growth factor-α species are derived from a glycosylated and palmitoylated transmembrane precursor

1987 • 264 citations

The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein.

1989 • 260 citations

Transforming Growth Factor β: Biochemistry and Roles in Embryogenesis, Tissue Repair and Remodeling, and Carcinogenesis

1988 • 255 citations

Proliferative index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical and pathological variables

1987 • 253 citations

Molecular characterization of a gene of the ‘EGF family’ expressed in undifferentiated human NTERA2 teratocarcinoma cells.

1989 • 251 citations

Oncogenes in development

1987 • 250 citations

Growth fractions in breast cancers determined in situ with monoclonal antibody Ki-67.

1986 • 249 citations

Related functional domains in virus DNA polymerases.

1987 • 243 citations

Purification and characterization of vaccinia virus growth factor

1985 • 238 citations

Possible positive autocrine feedback in the prereplicative phase of human fibroblasts

1987 • 234 citations

Production of platelet-derived growth factor-like molecules and reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents.

1984 • 233 citations

Ductal morphogenesis in the mouse mammary gland: Evidence supporting a role for epidermal growth factor

1988 • 232 citations

Presence of epidermal growth factor receptor as an indicator of poor prognosis in patients with breast cancer.

1985 • 230 citations

Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle.

1987 • 230 citations

Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice.

1987 • 228 citations

Monoclonal antibodies of predefined specificity detect activated ras gene expression in human mammary and colon carcinomas.

1984 • 223 citations

Transforming growth factor(s) production enables cells to grow in the absence of serum: an autocrine system.

1982 • 219 citations

Loss of a c-H-ras-1 allele and aggressive human primary breast carcinomas.

1986 • 214 citations

When the products of oncogenes and anti-oncogenes meet

1989 • 213 citations

Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation.

1989 • 213 citations

Estrogen‐induced lysosomal proteases secreted by breast cancer cells: A role in carcinogenesis?

1987 • 209 citations

Receptors for epidermal growth factor and insulin-like growth factor I and their relation to steroid receptors in human breast cancer.

1988 • 208 citations

A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient.

1984 • 207 citations

Epidermal growth factor stimulates guanine nucleotide binding activity and phosphorylation of ras oncogene proteins

1984 • 203 citations

Characterization of epidermal growth factor receptor and action on human breast cancer cells in culture.

1984 • 201 citations

Epidermal growth factor receptors and effect of epidermal growth factor on growth of human breast cancer cells in long-term tissue culture.

1982 • 200 citations

Activation of growth factor secretion in tumorigenic states of breast cancer induced by 17 beta-estradiol or v-Ha-ras oncogene.

1987 • 199 citations

Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription.

1988 • 196 citations

Progress in Cancer Research and Therapy.

1978 • 195 citations

Epidermal growth factor receptors in human breast cancer

1984 • 190 citations

A Harvey-ras responsive transcription element is also responsive to a tumour-promoter and to serum

1988 • 187 citations

Transfection of v- ras ^H DNA into MCF-7 Human Breast Cancer Cells Bypasses Dependence on Estrogen for Tumorigenicity

1985 • 185 citations

Cell Culture Methods for Molecular and Cell Biology

1985 • 184 citations

Breast Cancer: Cellular and Molecular Biology

1988 • 182 citations

Expression of p21ras in fresh primary and metastatic human colorectal tumors.

1985 • 181 citations

Regulation of Cathepsin-D and pS2 Gene Expression by Growth Factors in MCF7 Human Breast Cancer Cells

1989 • 180 citations

Transforming Growth Factor-α Gene Expression and Action in the Seminiferous Tubule: Peritubular Cell-Sertoli Cell Interactions*

1989 • 172 citations

Pertussis Toxin-Sensitive Pathway in the Stimulation of c- myc Expression and DNA Synthesis by Bombesin

1986 • 171 citations

Differential response to growth factor by rat mammary epithelium plated on different collagen substrata in serum-free medium.

1981 • 167 citations

Epidermal growth factor requirement for development of cultured mammary gland

1980 • 165 citations

Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor

1987 • 162 citations

Growth factor expression in normal, benign, and malignant breast tissue

1988 • 161 citations

Differential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor.

1986 • 159 citations

Expression of p21ras in normal and malignant human tissues: lack of association with proliferation and malignancy.

1987 • 159 citations

Local effects of EGF, α‐TGF, and EGF‐like growth factors on lobuloalveolar development of the mouse mammary gland in vivo

1987 • 147 citations

Methods for preparation of media, supplements, and substrata for serum-free animal cell culture

1984 • 146 citations

Proto-oncogene abnormalities in human breast cancer: correlations with anatomic features and clinical course of disease.

1987 • 143 citations

Detection of genes with a potential for suppressing the transformed phenotype associated with activated ras genes.

1989 • 141 citations

Expression of the 21,000 molecular weight ras protein in a spectrum of benign and malignant human mammary tissues.

1986 • 140 citations

Growth regulation of human breast carcinoma occurs through regulated growth factor secretion

1987 • 139 citations

Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblasts.

1988 • 139 citations

Suppression of tropomyosin synthesis, a common biochemical feature of oncogenesis by structurally diverse retroviral oncogenes.

1985 • 138 citations

Stimulation by insulin-like growth factors is required for cellular transformation by type beta transforming growth factor.

1985 • 137 citations

Transforming Growth Factor α Production and Epidermal Growth Factor Receptor Expression in Normal and Oncogene Transformed Human Mammary Epithelial Cells

1989 • 135 citations

Steroid Hormone Receptors in Breast Cancer Treatment Strategy

1980 • 135 citations

Increased secretion of type beta transforming growth factor accompanies viral transformation of cells.

1985 • 132 citations

The Effects of a Constitutive Expression of Transforming Growth Factor-α on the Growth of MCF-7 Human Breast Cancer Cellsin Vitroandin Vivo

1989 • 132 citations

Induction of Transforming Growth Factor-α Expression in Human Keratinocytes by Phorbol Esters

1989 • 131 citations

The human c-Kirstenrasgene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231

1987 • 130 citations

Prognostic significance of the expression of a ras protein with a molecular weight of 21,000 by human breast cancer.

1987 • 130 citations

Variables controlling somatomedin production by cultured human fibroblasts

1983 • 129 citations

Opposing effects of a ras oncogene on growth factor-stimulated phosphoinositide hydrolysis: desensitization to platelet-derived growth factor and enhanced sensitivity to bradykinin.

1987 • 125 citations

Expression of Transforming Growth Factor α (TGFα) in Differentiated Rat Mammary Tumors: Estrogen Induction of TGFα Production

1987 • 124 citations

Growth factors, oncogenes, and multistage carcinogenesis

1987 • 121 citations

Epidermal growth factor receptor (EGFr) status associated with failure of primary endocrine therapy in elderly postmenopausal patients with breast cancer

1988 • 117 citations

Loss of epidermal growth factor requirement and malignant transformation

1979 • 117 citations

Expression of growth factors and oncogenes in normal and tumor-derived human mammary epithelial cells.

1988 • 116 citations

Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors.

1986 • 116 citations

Tumor suppressors: Recessive mutations that lead to cancer

1988 • 115 citations

The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a growth factor gene with sequence similarity to those encoding epidermal growth factor and transforming growth factor alpha.

1987 • 115 citations

EPIDERMAL-GROWTH-FACTOR RECEPTORS AND ESTROGEN-RECEPTORS IN HUMAN-BREAST CANCER

1985 • 114 citations

Epidermal growth factor receptor gene-amplified MDA-468 breast cancer cell line and its nonamplified variants.

1987 • 114 citations

Immunological detection and quantitation of alpha transforming growth factors in human breast carcinoma cells

1986 • 114 citations

Augmentation of the response of normal mammary epithelial cells to estradiol by mammary stroma.

1983 • 110 citations

Phorbol Ester or Epidermal Growth Factor (EGF) Stimulates the Concurrent Accumulation of mRNA for the EGF Receptor and Its Ligand Transforming Growth Factor-α in a Breast Cancer Cell Line

1989 • 110 citations

The cellular response to induction of the p21 c-Ha-ras oncoprotein includes stimulation of jun gene expression.

1989 • 108 citations

Transformation Induced by Abelson Murine Leukemia Virus Involves Production of a Polypeptide Growth Factor

1982 • 108 citations

Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha‐transforming growth factors in ras‐transformed mouse mammary epithelial cells

1987 • 108 citations

ras gene alterations and enhanced levels of ras p21 expression in a spectrum of benign and malignant human mammary tissues.

1986 • 104 citations

Human malignant tumours of the breast, as compared to their respective normal tissue, have elevated expression of the Harvey ras oncogene.

1984 • 103 citations

Transformation of human mammary epithelial cells by oncogenic retroviruses.

1988 • 103 citations

Transformation of an established mouse mammary epithelial cell line following transfection with a human transforming growth factor alpha cDNA

1989 • 102 citations

Mapping and sequencing of a gene from myxoma virus that is related to those encoding epidermal growth factor and transforming growth factor alpha

1987 • 102 citations

Cellular responsiveness to growth factors correlates with a cell's ability to express the transformed phenotype

1983 • 100 citations

Transformation of normal rat kidney (NRK) cells by an infectious retrovirus carrying a synthetic rat type alpha transforming growth factor gene.

1987 • 100 citations

Epidermal growth factor (EGF) stimulates inositol trisphosphate formation in cells which overexpress the EGF receptor

1987 • 99 citations

Transgenic mice carrying the mouse mammary tumor virus ras fusion gene: distinct effects in various tissues.

1989 • 99 citations

Genes and proteins in oncogenesis

1983 • 96 citations

High Frequency of Rare Alleles of the Human c-Ha-ras-1 Proto-oncogene in Breast Cancer Patients2

1986 • 96 citations

Amplified expression of p21 ras protein in hormone-dependent mammary carcinomas of humans and rodents

1985 • 94 citations

Transforming growth factor-α in the mammalian brain

1989 • 94 citations

Expression of growth factor and epidermal growth factor receptor encoded transcripts in human gastric tissues.

1989 • 94 citations

The significance of oncogene amplification in primary breast cancer

1989 • 94 citations

Alpha-transforming growth factor secreted by untransformed bovine anterior pituitary cells in culture. II. Identification using a sequence-specific monoclonal antibody.

1986 • 86 citations

Partial purification of transforming growth factors from human milk.

1986 • 84 citations

Transforming growth factor-α messenger RNA localization in the developing adult rat and human mammary gland by in situ hybridization

1990 • 83 citations

Oncogenes and Transcriptional Control

1987 • 82 citations

Transient induction of c-fos and c-myc in an immediate consequence of growth factor stimulation.

1985 • 81 citations

Purification of a mammary-derived growth factor from human milk and human mammary tumors.

1985 • 79 citations

Epidermal growth factor-like proteins in breast fluid and human milk

1988 • 77 citations

The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence.

1988 • 74 citations

Independent Molecular Pathways in Initiation and Loss of Hormone Responsiveness of Breast Carcinomas

1988 • 74 citations

Members of the src and ras oncogene families supplant the epidermal growth factor requirement of BALB/MK-2 keratinocytes and induce distinct alterations in their terminal differentiation program.

1985 • 74 citations

Functions of diacylglycerol in glycerolipid metabolism, signal transduction and cellular transformation.

1988 • 73 citations

Epidermal growth factor receptor status of histological sub-types of breast cancer

1988 • 72 citations

Ha-ras hypervariable alleles in myelodysplasia

1986 • 71 citations

Oncogenes and Growth Control

1986 • 71 citations

G-protein-mediated epidermal growth factor signal transduction in a human breast cancer cell line. Evidence for two intracellular pathways distinguishable by pertussis toxin.

1988 • 71 citations

TGFα stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression

1988 • 70 citations

Regulation of epithelial cell proliferation by transforming growth factors

1989 • 70 citations

Induction and modulation of anchorage-independent growth by platelet-derived growth factor, fibroblast growth factor, and transforming growth factor-beta.

1986 • 68 citations

Transmembrane signalling at epidermal growth factor receptors overexpressed in NIH 3T3 cells. Phosphoinositide hydrolysis, cytosolic Ca2+ increase and alkalinization correlate with epidermal-growth-factor-induced cell proliferation

1988 • 66 citations

Structural properties of a soluble bioactive precursor for transforming growth factor-alpha.

1988 • 65 citations

Reversal of transformed phenotype by monoclonal antibodies against Ha-ras p21 proteins

1986 • 65 citations

Loss of platelet-derived growth factor-stimulated phospholipase activity in NIH-3T3 cells expressing the EJ-ras oncogene.

1987 • 63 citations

Prognostic significance of the receptor for epidermal growth factor in human mammary carcinomas.

1987 • 63 citations

New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line.

1985 • 62 citations

Different growth factors stimulate cell division of rat mammary epithelial, myoepithelial, and stromal cell lines in culture

1984 • 61 citations

Receptors for epidermal growth factor and estrogen as predictors of relapse in patients with mammary carcinoma.

1988 • 60 citations

Varying degrees of amplification of the N-ras oncogene in the human breast cancer cell line MCF-7.

1985 • 60 citations

Epidermal and transforming growth factor α in patients with breast tumours

1989 • 59 citations

Mechanism of carcinogenesis: the role of oncogenes, transcriptional enhancers and growth factors.

1985 • 58 citations

The transformation of primary and established mouse mammary epithelial cells by p21-ras is concentration dependent.

1988 • 57 citations

Retroviruses expressing different levels of the normal epidermal growth factor receptor: Biological properties and new bioassay

1989 • 57 citations

Receptor‐phosphoinositidase C coupling Multiple G‐proteins?

1987 • 54 citations

Mutant but not normal p21 ras elevates inositol phospholipid breakdown in two different cell systems.

1988 • 53 citations

Coupling of TGF-β-induced mitogenesis to G-protein activation in AKR-2B cells

1988 • 52 citations

Importance of extended growth potential and growth factor independence on in vivo neoplastic potential of primary rat mammary carcinoma cells.

1987 • 51 citations

Induction of Transforming Growth Factor α Expression in Mouse Mammary Epithelial Cells after Transformation with a Point-Mutated c-Ha-rasProtooncogene

1988 • 51 citations

Expression of epidermal growth factor receptors (EGFR) on breast carcinomas in relation to growth fractions, estrogen receptor status and morphological criteria. An immunohistochemical study.

1988 • 51 citations

The preneoplastic state in mouse mammary tumorigenesis

1988 • 50 citations

Sequential expression and cooperative interaction of c-Ha-ras and c-erbB genes in in vivo chemical carcinogenesis.

1989 • 50 citations

Anchorage-independent growth-conferring factor production by rat mammary tumor cells.

1982 • 50 citations

Growth of mammary epithelial cells in breast‐cancer biopsies correlates with egf binding

1987 • 49 citations

4 Paracrine regulation of mammary gland growth

1986 • 47 citations

Increased expression of growth factor mRNAs accompanies viral transformation of rodent cells.

1988 • 42 citations

Growth factors and oncogenes in breast cancer

1990 • 42 citations

DNA flow cytometry of human breast carcinomas and its relationship to transferrin and epidermal growth factor receptors

1986 • 42 citations

mRNA Expression of Transforming Growth Factor Alpha in Human Breast Carcinomas and Its Activity in Effusions of Breast Cancer Patients

1989 • 42 citations

Suppression of synthesis and utilization of tropomyosin in mouse and rat fibroblasts by transforming growth factor alpha: a pathway in oncogene action.

1987 • 42 citations

Modulation of transforming growth factor type beta action by activated ras and c-myc.

1987 • 40 citations

Activated H-ras transforms rat intestinal epithelial cells with expression of α-TGF

1987 • 40 citations

Immunohistochemical study of the ras oncogene expression in human breast lesions.

1986 • 39 citations

A structure and some function

1988 • 39 citations

Emergence of hamster fibroblast tumors in nude mice—evidence for in vivo selection leading to loss of growth factor requirement

1981 • 39 citations

A mammary‐derived growth inhibitor (MDGI) related 70 kDa antigen identified in nuclei of mammary epithelial cells

1989 • 38 citations

Modulation by Estrogen and Growth Factors of Transforming Growth Factor-Alpha and Epidermal Growth Factor Receptor Expression in Normal and Malignant Human Mammary Epithelial Cells

1989 • 38 citations

Identification of a polypeptide secreted by human breast cancer cells (MCF-7) as the human estrogen-responsive gene (pS2) product

1988 • 37 citations

Comparative Study of Harvey-<i>RAS</i> Oncogene Expression with Conventional Clinicopathologic Parameters of Breast Cancer

1986 • 37 citations

Epidermal Growth Factor Activates Phosphoinositide Turnover and Protein Kinase C in BALB/MK Keratinocytes

1988 • 36 citations

Effect of v-rasH oncogene transfection on estrogen-independent tumorigenicity of estrogen-dependent human breast cancer cells.

1987 • 36 citations

Receptors for EGF and oestradiol and thymidinekinase activity in different histological subgroups of human mammary carcinomas

1986 • 35 citations

Rapid and Selective Alterations in the Expression of Cellular Genes Accompany Conditional Transcription of Ha-v-ras in NIH 3T3 Cells

1987 • 34 citations

Normal human mesothelial cells and fibroblasts transfected with the EJras oncogene become EGF-independent, but are not malignantly transformed.

1987 • 33 citations

Validity of the Dmba-Induced Mammary Cancer Model for the Study of Human Breast Cancer

1987 • 33 citations

Endocrine responsive cancers of man.

1981 • 32 citations

Interaction between Transforming Growth Factor-Alpha and c-Ha-ras p21 in Progression of Human Gastric Carcinoma

1988 • 32 citations

Tumor-associated growth factors in malignant rodent and human mammary epithelial cells

1988 • 30 citations

Transforming growth factors: sources, properties and possible roles in normal and malignant cell growth control

1984 • 30 citations

Identification of transforming growth factor alpha in human primary breast carcinomas.

1987 • 29 citations

Epidermal growth factor receptors in human breast cancer

1988 • 27 citations

Insulin stimulates the phosphorylation level of V-Ha-ras protein in membrane fraction

1987 • 26 citations

c-H-ras-1 expression in 7,12-dimethyl benzanthracene-induced Balb/c mouse mammary hyperplasias and their tumors.

1988 • 26 citations

Receptors for epidermal growth factor in human mammary carcinomas and their metastases.

1986 • 25 citations

Differential growth factor expression in transformed mouse NIH‐3T3 cells

1990 • 25 citations

c-Ha-ras-1 polymorphism in human breast carcinomas: evidence for a normal distribution of alleles.

1988 • 24 citations

The role of epidermal growth factor in normal and neoplastic growth of mouse mammary epithelial cells

1988 • 24 citations

Immunocytochemical demonstration and significance of p21 ras family oncogene product in benign and malignant breast disease

1986 • 24 citations

Expression of p21ras gene products in breast cancer relates to histological types and to receptor and nodal status

1988 • 23 citations

p21 ras protein expression in benign and malignant

1988 • 21 citations

EGF binding is quantitatively related to growth in node-positive breast cancer

1988 • 20 citations

Increased frequency of specific alleles of the c-Ha-ras gene in Japanese cancer patients

1988 • 19 citations

Rapid and selective alterations in the expression of cellular genes accompany conditional transcription of Ha-v-ras in NIH 3T3 cells.

1987 • 18 citations

Molecular associations and conceptual connections

1988 • 17 citations

Flat revertants derived from kirsten murine sarcoma virus‐transformed cells produce transforming growth factors

1984 • 17 citations

Distribution of Ha-RAS-1 proto-oncogene alleles in breast cancer patients and in a control population

1988 • 17 citations

Heterogeneity of genetic alterations in primary human breast tumors

1988 • 17 citations

Needle aspiration of palpable breast lesions: a new application of the membrane filter technique and its results.

1975 • 16 citations

Relationships Between Drug Regime and Histology of Rectal Mucosa in Crohn's Disease

1988 • 16 citations

Isolation of Two Syngeneic Cell Lines From a Rat Mammary Carcinoma: Growth Factor Production by Neoplastic Epithelial Cells<xref ref-type="fn" rid="FN2">2</xref>

1985 • 16 citations

Transforming Growth Factors Produced by Viral-Transformed and Human Tumor Cells

1984 • 15 citations

Growth Factors and Oncogenes in Breast Cancer

1988 • 14 citations

Cancer: Functions of ras oncogenes

1984 • 13 citations

Laboratory models of hormone-dependent cancer

1982 • 13 citations

Platelet‐derived growth factor or basic fibroblast growth factor induce anchorage‐independent growth of human fibroblasts

1988 • 11 citations

Hormones and cancer 3

1988 • 6 citations

Evidence that the viral Ki-RAS protein, but not the pp60v-src protein of ASV, stimulates proliferation through the PDGF receptor

1987 • 5 citations

Interactions between estrogens, prolactin, and growth hormone on the growth of N-nitrosomethylurea-induced rat mammary tumors.

1985 • 5 citations

Chapter 16. Oncological Aspects of Growth Factors

1986 • 4 citations