Transforming Growth Factor β: Biochemistry and Roles in Embryogenesis, Tissue Repair and Remodeling, and Carcinogenesis

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

1983 • 1,613 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Some recent advances in the chemistry and biology of transforming growth factor-beta.

1987 • 1,308 citations

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

1987 • 1,287 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Transforming Growth Factor-β: Biological Function and Chemical Structure

1986 • 1,198 citations

Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid

1986 • 1,148 citations

Type beta transforming growth factor: a bifunctional regulator of cellular growth.

1985 • 1,107 citations

Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin

1986 • 1,071 citations

A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication

1987 • 1,050 citations

Cell biology of extracellular matrix

1992 • 1,042 citations

Isolation of the bovine and human genes for müllerian inhibiting substance and expression of the human gene in animal cells

1986 • 997 citations

Expression and secretion of type beta transforming growth factor by activated human macrophages.

1987 • 981 citations

Mesoderm induction in early Xenopus embryos by heparin-binding growth factors

1987 • 953 citations

Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-β

1987 • 938 citations

New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.

1981 • 925 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo

1987 • 883 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin

1986 • 854 citations

Cell Surface Receptors for Extracellular Matrix Molecules

1987 • 793 citations

Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta.

1987 • 791 citations

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

1986 • 786 citations

Growth Inhibitor from BSC-1 Cells Closely Related to Platelet Type β Transforming Growth Factor

1984 • 779 citations

Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

1986 • 777 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family

1987 • 756 citations

A maternal mRNA localized to the vegetal hemisphere in xenopus eggs codes for a growth factor related to TGF-β

1987 • 747 citations

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta.

1987 • 736 citations

Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-β

1985 • 722 citations

The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

1987 • 710 citations

Regulation of wound-healing angiogenesis-effect of oxygen gradients and inspired oxygen concentration.

1981 • 644 citations

A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β

1988 • 620 citations

Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.

1987 • 619 citations

Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells.

1988 • 604 citations

Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

1986 • 579 citations

Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix.

1988 • 571 citations

Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells.

1986 • 570 citations

Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro.

1987 • 561 citations

Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium.

1986 • 559 citations

Type beta transforming growth factor is an inhibitor of myogenic differentiation.

1986 • 559 citations

Distribution and modulation of the cellular receptor for transforming growth factor-beta.

1987 • 556 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells.

1986 • 542 citations

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.

1986 • 541 citations

Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta.

1986 • 533 citations

Transforming growth factor production by chemically transformed cells.

1981 • 506 citations

Purification and characterization of two cartilage-inducing factors from bovine demineralized bone.

1985 • 503 citations

Cell adhesion protein receptors as targets for transforming growth factor-$beta; action

1987 • 498 citations

The murine transforming growth factor-beta precursor.

1986 • 492 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in Vivo

1983 • 451 citations

Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta.

1986 • 443 citations

Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones.

1987 • 434 citations

Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

1987 • 434 citations

Isolation and partial characterization of a Mr 32,000 protein with inhibin activity from porcine follicular fluid.

1985 • 434 citations

Fibronectin in early avian embryos: Synthesis and distribution along the migration pathways of neural crest cells

1980 • 417 citations

Purification and initial characterization of a type beta transforming growth factor from human placenta.

1983 • 409 citations

Regulation of myogenic differentiation by type beta transforming growth factor.

1986 • 408 citations

Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation.

1988 • 392 citations

Neural crest cell migration: requirements for exogenous fibronectin and high cell density.

1983 • 388 citations

Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.

1987 • 387 citations

Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors.

1983 • 381 citations

Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions

1985 • 366 citations

Type beta transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts.

1985 • 364 citations

Peptide growth factors and inflammation, tissue repair, and cancer.

1986 • 360 citations

Purification and properties of a type .beta. transforming growth factor from bovine kidney

1983 • 355 citations

Adenovirus DNA replication in vitro: identification of a host factor that stimulates synthesis of the preterminal protein-dCMP complex.

1982 • 350 citations

Translocation of a localized maternal mRNA to the vegetal pole of Xenopus oocytes

1987 • 346 citations

Molecular Characterization of Fibroblast Growth Factor: Distribution and Biological Activities in Various Tissues

1986 • 340 citations

Mechanisms of neovascularization. Vascular sprouting can occur without proliferation of endothelial cells.

1984 • 339 citations

Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts.

1986 • 339 citations

T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta.

1987 • 337 citations

Cartilage-inducing factor-B is a unique protein structurally and functionally related to transforming growth factor-beta.

1987 • 336 citations

Normal embryo fibroblasts release transforming growth factors in a latent form

1984 • 336 citations

Purification of nuclear factor I by DNA recognition site affinity chromatography.

1986 • 331 citations

Inhibitory action of transforming growth factor beta on endothelial cells.

1987 • 324 citations

Specific binding of a cellular DNA replication protein to the origin of replication of adenovirus DNA.

1983 • 318 citations

Transforming growth factor-beta inhibits endothelial cell proliferation

1986 • 313 citations

Inhibition of endothelial cell proliferation by type β-transforming growth factor: Interactions with acidic and basic fibroblast growth factors

1986 • 312 citations

Histology : cell and tissue biology

1983 • 296 citations

Transforming Growth Factor β

1988 • 295 citations

Cloning and sequence analysis of cDNA species coding for the two subunits of inhibin from bovine follicular fluid.

1986 • 273 citations

Antibodies to the N-terminal portion of cartilage-inducing factor A and transforming growth factor beta. Immunohistochemical localization and association with differentiating cells.

1986 • 271 citations

Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells.

1982 • 263 citations

Purification and properties of porcine platelet-derived growth factor.

1984 • 260 citations

Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts.

1987 • 247 citations

Transforming growth factor-beta. A very potent inhibitor of myoblast differentiation, identical to the differentiation inhibitor secreted by Buffalo rat liver cells.

1986 • 247 citations

β-Transforming Growth Factor is stored in human blood platelets as a latent high molecular weight complex

1986 • 241 citations

Possible positive autocrine feedback in the prereplicative phase of human fibroblasts

1987 • 234 citations

Respiratory gas tensions and pH in healing wounds

1967 • 234 citations

Production of platelet-derived growth factor-like molecules and reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents.

1984 • 233 citations

Differential effects of transforming growth factor-beta on proliferation of normal and malignant rat liver epithelial cells in culture.

1986 • 224 citations

Transforming growth factor‐beta modulates the expression of osteoblast and chondroblast phenotypes in vitro

1988 • 216 citations

Human transforming growth factor type .beta.2: production by a prostatic adenocarcinoma cell line, purification, and initial characterization

1987 • 204 citations

Transforming growth factor type beta specifically stimulates synthesis of proteoglycan in human adult arterial smooth muscle cells.

1987 • 198 citations

The Reversal of an Adriamycin® Induced Healing Impairment with Chemoattractants and Growth Factors

1986 • 175 citations

Purification of kidney epithelial cell growth inhibitors.

1980 • 174 citations

Transforming growth factors.

1985 • 168 citations

Transforming growth factor β levels in rat wound chambers

1987 • 161 citations

Intron-exon structure of the human transforming growth factor-β precursor gene

1987 • 159 citations

Transforming growth factor-beta inhibits the in vitro generation of lymphokine-activated killer cells and cytotoxic T cells

1988 • 155 citations

Stimulation of normal human fibroblast collagen production and processing by transforming growth factor-β

1986 • 145 citations

Transforming Growth Factor-Beta: Selective Increase in Glycosaminoglycan Synthesis by Cultures of Fibroblasts From Patients With Progressive Systemic Sclerosis

1987 • 145 citations

Molecular Repair, Wound Healing, And Carcinogenesis: Tumor Production A Possible Overhealing?

1973 • 139 citations

Complete amino acid sequence of human transforming growth factor type beta 2.

1987 • 139 citations

Stimulation by insulin-like growth factors is required for cellular transformation by type beta transforming growth factor.

1985 • 137 citations

Amino acid sequence of the BSC-1 cell growth inhibitor (polyergin) deduced from the nucleotide sequence of the cDNA.

1988 • 134 citations

Increased secretion of type beta transforming growth factor accompanies viral transformation of cells.

1985 • 132 citations

Bi‐functional action of transforming growth factor‐β on DNA synthesis in early passage human fetal fibroblasts

1986 • 121 citations

Membrane binding characteristics of two forms of transforming growth factor-beta.

1987 • 118 citations

Transforming growth factor type β regulation of actin mRNA

1986 • 116 citations

Latent beta-transforming growth factor in nontransformed and Kirsten sarcoma virus-transformed normal rat kidney cells, clone 49F.

1984 • 112 citations

Mouse embryos contain polypeptide growth factor(s) capable of inducing a reversible neoplastic phenotype in nontransformed cells in culture

1982 • 110 citations

Separate binding sites for nuclear factor 1 and a CCAAT DNA binding factor in the mouse alpha 2(I) collagen promoter.

1987 • 109 citations

Type beta transforming growth factor (TGF-β) is a potent stimulator of the basal secretion of follicle stimulating hormone (FSH) in a pituitary monolayer system

1986 • 107 citations

Antibodies to peptide determinants in transforming growth factor .beta. and their applications

1988 • 102 citations

Differential control by platelet factors of squamous differentiation in normal and malignant human bronchial epithelial cells.

1983 • 99 citations

Cloning and Sequence Analysis of Simian Transforming Growth Factor-β cDNA

1987 • 95 citations

05. Control of cell growth and proliferation

2005 • 95 citations

High-affinity binding site for a specific nuclear protein in the human IgM gene

1985 • 89 citations

Opposite and selective effects of epidermal growth factor and human platelet transforming growth factor-beta on the production of secreted proteins by murine 3T3 cells and human fibroblasts.

1986 • 84 citations

Complementary Deoxyribonucleic Acid Cloning of Bovine Transforming Growth Factor-β1

1987 • 75 citations

The effects of platelet‐derived transforming growth factor β on normal human diploid gingival fibroblasts

1986 • 75 citations

Origin of adenovirus DNA replication

1985 • 75 citations

Purification to homogeneity and amino acid sequence analysis of two anionic species of human interleukin 1.

1986 • 73 citations

Sequence of the porcine transforming growth factor-beta precursor

1987 • 66 citations

An indirect immunofluorescence study of the distribution of fibronectin during the formation of the cushion tissue mesenchyme in the embryonic heart

1984 • 49 citations

Epstein-Barr virus induction by a serum factor. Purification of a high molecular weight protein that is responsible for induction.

1982 • 31 citations

Epstein-Barr virus induction by a serum factor. Characterization of the purified factor and the mechanism of its activation.

1982 • 20 citations

EBV-inducing factor from platelets exhibits growth-promoting activity for NIH 3T3 cells.

1985 • 12 citations