Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha‐transforming growth factors in ras‐transformed mouse mammary epithelial cells

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Growth Factors and Cancer

1991 • 2,044 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

1982 • 928 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium.

1986 • 559 citations

Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells.

1983 • 484 citations

Cloning and sequence analysis of a cDNA for rat transforming growth factor-α

1985 • 388 citations

GROWTH FACTORS AND CANCER

1985 • 352 citations

Epidermal growth factor receptors

1981 • 352 citations

Expression in rat fibroblasts of a human transforming growth factor-α cDNA results in transformation

1986 • 346 citations

Characterization of estrogen responsive transforming activity in human breast cancer cell lines.

1986 • 330 citations

Role of epidermal growth factor in carcinogenesis.

1986 • 330 citations

Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells.

1982 • 263 citations

Purification and characterization of vaccinia virus growth factor

1985 • 238 citations

Production of platelet-derived growth factor-like molecules and reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents.

1984 • 233 citations

Transforming growth factor-β controls receptor levels for epidermal growth factor in NRK fibroblasts

1984 • 232 citations

Monoclonal antibodies of predefined specificity detect activated ras gene expression in human mammary and colon carcinomas.

1984 • 223 citations

Presence of transforming growth factors in human breast cancer cells.

1984 • 222 citations

ras gene Amplification and malignant transformation.

1985 • 204 citations

Epidermal growth factor stimulates guanine nucleotide binding activity and phosphorylation of ras oncogene proteins

1984 • 203 citations

Differential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor.

1986 • 159 citations

Stimulation by insulin-like growth factors is required for cellular transformation by type beta transforming growth factor.

1985 • 137 citations

Increased secretion of type beta transforming growth factor accompanies viral transformation of cells.

1985 • 132 citations

Growth factors and transformation.

1986 • 128 citations

Loss of epidermal growth factor requirement and malignant transformation

1979 • 117 citations

Immunological detection and quantitation of alpha transforming growth factors in human breast carcinoma cells

1986 • 114 citations

Human malignant tumours of the breast, as compared to their respective normal tissue, have elevated expression of the Harvey ras oncogene.

1984 • 103 citations

Synthesis of biologically active rat transforming growth factor I

1984 • 102 citations

Cellular responsiveness to growth factors correlates with a cell's ability to express the transformed phenotype

1983 • 100 citations

Amplified expression of p21 ras protein in hormone-dependent mammary carcinomas of humans and rodents

1985 • 94 citations

Detection of larger polypeptides structurally and functionally related to type I transforming growth factor.

1985 • 87 citations

Members of the src and ras oncogene families supplant the epidermal growth factor requirement of BALB/MK-2 keratinocytes and induce distinct alterations in their terminal differentiation program.

1985 • 74 citations

Polyoma virus-transformed cells produce transforming growth factor(s) and grow in serum-free medium

1982 • 64 citations

New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line.

1985 • 62 citations

Anchorage-independent growth-conferring factor production by rat mammary tumor cells.

1982 • 50 citations

Basic Science Review: Growth Factors in Cancer and Their Relationship to Oncogenes

1986 • 49 citations

Efficient synthesis of human type alpha transforming growth factor: its physical and biological characterization.

1986 • 46 citations

Emergence of hamster fibroblast tumors in nude mice—evidence for in vivo selection leading to loss of growth factor requirement

1981 • 39 citations

Epidermal growth factor receptor metabolism and protein kinase activity in human A431 cells infected with Snyder-Theilen feline sarcoma virus or harvey or Kirsten murine sarcoma virus

1983 • 35 citations

Heparin-treated, v-myc-transformed chicken heart mesenchymal cells assume a normal morphology but are hypersensitive to epidermal growth factor (EGF) and brain fibroblast growth factor (bFGF); cells transformed by the v-Ha-ras oncogene are refractory to EGF and bFGF but are hypersensitive to insulin-like growth factors.

1985 • 31 citations

Transforming growth factors: sources, properties and possible roles in normal and malignant cell growth control

1984 • 30 citations

Anchorage-independent growth of normal human mesothelial cells: A sensitive bioassay for EGF which discloses the absence of this factor in fetal calf serum

1985 • 25 citations

Selection of transfored cells in serum-free media

1985 • 23 citations

Epidermal growth factor (EGF) binding to membranes immobilized in microtiter wells and estimation of EGF-related transforming growth factor activity

1984 • 21 citations

Flat revertants derived from kirsten murine sarcoma virus‐transformed cells produce transforming growth factors

1984 • 17 citations

Transforming Growth Factors Produced by Viral-Transformed and Human Tumor Cells

1984 • 15 citations

Cancer: Functions of ras oncogenes

1984 • 13 citations

Effect of growth factors and methionine on glycolysis and methionine transport in rat fibroblasts and fibroblasts transfected with myc and ras genes.

1986 • 11 citations

The characteristics of an anchorage‐independent clonal agar assay for primary explanted bovine granulosa cells

1982 • 11 citations

Polyoma Virus Transformation of Rat Kidney Fibroblasts Results in Loss of Requirement For Insulin and Retinoic Acid

1983 • 7 citations

Protein kinase C and non-functional EGF receptor in K-ras transformed cells

1986 • 7 citations

Polypeptide Growth Factors and the Growth of Mammary Epithelial Cells

1986 • 7 citations