Estrogen‐induced lysosomal proteases secreted by breast cancer cells: A role in carcinogenesis?

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

1985 • 1,360 citations

LYSOSOMAL ENZYMES AND THEIR RECEPTORS

1986 • 915 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

A secreted glycoprotein induced by estrogen in human breast cancer cell lines

1980 • 481 citations

Lysosomal Cathepsin B: Correlation with Metastatic Potential

1981 • 370 citations

Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions

1985 • 366 citations

Cloning and sequence analysis of cDNA for human cathepsin D.

1985 • 318 citations

Induction of Epidermal Growth Factor-Related Polypeptides by 17β-Estradiol in MCF-7 Human Breast Cancer Cells

1986 • 296 citations

Autocrine and paracrine growth regulation of human breast cancer

1986 • 293 citations

Autocrine Growth Stimulation of the MCF 7 Breast Cancer Cells by the Estrogen-Regulated 52 K Protein*

1986 • 273 citations

Cathepsin D. Purification of isoenzymes from human and chicken liver

1970 • 273 citations

Effect of estradiol on human breast cancer cells in culture.

1983 • 272 citations

Hormones and cell culture

1978 • 269 citations

Presence of transforming growth factors in human breast cancer cells.

1984 • 222 citations

Cancer cells. 3: Growth factors and transformation

1985 • 176 citations

ACTIVATION OF PLASMINOGEN: A GENERAL MECHANISM FOR PRODUCING LOCALIZED EXTRACELLULAR PROTEOLYSIS

1978 • 176 citations

Estrogens Stimulate Cell Proliferation and Induce Secretory Proteins in a Human Breast Cancer Cell Line (T₄₇D)*

1982 • 175 citations

Lysosomal Enzyme Precursors in Human Fibroblasts. Activation of Cathepsin D Precursor in vitro and Activity of beta-Hexosaminidase A Precursor towards Ganglioside GM2

1982 • 163 citations

Phosphorylation, glycosylation, and proteolytic activity of the 52-kD estrogen-induced protein secreted by MCF7 cells.

1987 • 147 citations

The major excreted protein of transformed fibroblasts is an activable acid-protease.

1986 • 147 citations

Effects of antiestrogens on the estrogen-regulated pS2 RNA and the 52- and 160-kilodalton proteins in MCF7 cells and two tamoxifen-resistant sublines.

1984 • 120 citations

17 beta-estradiol regulates and v-Ha-ras transfection constitutively enhances MCF7 breast cancer cell interactions with basement membrane.

1986 • 113 citations

The 52-kDa estrogen-induced protein secreted by MCF7 cells is a lysosomal acidic protease

1986 • 98 citations

The tumor promoter phorbol 12-myristate 13-acetate induces a program of altered gene expression similar to that induced by platelet-derived growth factor and transforming oncogenes.

1986 • 96 citations

Characterization of monoclonal antibodies to the estrogen-regulated Mr 52,000 glycoprotein and their use in MCF7 cells.

1985 • 89 citations

Processing and lysosomal localization of a glycoprotein whose secretion is transformation stimulated.

1985 • 89 citations

Estradiol induced proteins in the MCF7 human breast cancer cell line

1979 • 85 citations

Distribution of the Mr 52,000 estrogen-regulated protein in benign breast diseases and other tissues by immunohistochemistry.

1986 • 74 citations

Secretion of a thiol proteinase from mouse mammary carcinomas and its characterization.

1982 • 72 citations

The major excreted protein (MEP) of transformed mouse cells and cathepsin L have similar protease specificity

1986 • 66 citations

Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins.

1986 • 58 citations

Multiple forms of plasminogen activator in human breast tumors.

1985 • 56 citations

Processing and Estrogen Regulation of the 52-Kilodalton Protein inside MCF₇Breast Cancer Cells*

1986 • 55 citations

Immunological Approaches to the Diagnosis and Therapy of Breast Cancer

1987 • 53 citations

A guided tour of the living cell

1985 • 50 citations

Progesterone and estrogen control of rates of synthesis of uterine cathepsin D.

1980 • 48 citations

Banbury Report 8. Hormones and Breast Cancer

1982 • 47 citations

Proteolytic Enzymes in Tumor Invasion and Degradation of Host Extracellular Matrices

1986 • 42 citations

Autocrine stimulation by estradiol-regulated growth factors of rat hormone-responsive mammary cancer: interaction with the polyamine pathway.

1986 • 40 citations

Degradation of endothelial basement membrane by human breast cancer cell lines.

1986 • 35 citations

Estrogen-induced membrane alterations and growth associated with proteinase activity in endometrial cells.

1979 • 35 citations

Estradiol increases the production of α1-antichymotrypsin in MCF7 and T47D human breast cancer cell lines

1985 • 28 citations

Association of plasminogen activator activity and steroid receptors in human breast cancer

1982 • 27 citations

Purification and first characterization of the secreted and cellular 52-kDa proteins regulated by estrogens in human-breast cancer cells

1986 • 25 citations

Randomized clinical trial of tamoxifen plus sequential CMF chemotherapy versus tamoxifen alone in postmenopausal women with advanced breast cancer

1981 • 25 citations

Acid protease secreted from human pancreatic carcinoma cell line HPC-YT into serum-free, chemically defined medium.

1986 • 18 citations

Estrogen regulation of specific proteins as a mode of hormone action in human breast cancer.

1983 • 17 citations

Purification and properties of an acid protease from human ascitic fluid

1978 • 12 citations