Transgenic mice carrying the mouse mammary tumor virus ras fusion gene: distinct effects in various tissues.

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

THE MOLECULAR GENETICS OF CELLULAR ONCOGENES

1984 • 765 citations

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

1983 • 553 citations

Mutational Activation of the K-rasOncogene

1987 • 542 citations

Microinjection of the oncogene form of the human H-ras (t-24) protein results in rapid proliferation of quiescent cells

1984 • 401 citations

Malignant Activation of a K- ras Oncogene in Lung Carcinoma But Not in Normal Tissue of the Same Patient

1984 • 395 citations

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1

1983 • 377 citations

Glucocorticoid regulation of the Ha-MuSV p21 gene conferred by sequences from mouse mammary tumor virus

1981 • 303 citations

Biology of the Laboratory Mouse

1967 • 296 citations

RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes.

1987 • 231 citations

A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome

1987 • 231 citations

Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice.

1987 • 228 citations

Loss of a c-H-ras-1 allele and aggressive human primary breast carcinomas.

1986 • 214 citations

Characterization of a human colon/lung carcinoma oncogene

1983 • 208 citations

A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient.

1984 • 207 citations

Altered gene products are associated with activation of cellular rasK genes in human lung and colon carcinomas

1983 • 175 citations

Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype.

1983 • 172 citations

Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.

1984 • 132 citations

Prognostic significance of the expression of a ras protein with a molecular weight of 21,000 by human breast cancer.

1987 • 130 citations

The human c-Kirstenrasgene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231

1987 • 130 citations

Driven by the same Ig enhancer and SV40 T promoter ras induced lung adenomatous tumors, myc induced pre-B cell lymphomas and SV40 large T gene a variety of tumors in transgenic mice.

1987 • 129 citations

Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors.

1986 • 116 citations

Genetic predisposition to human lung cancer

1986 • 104 citations

The mouse mammary tumor virus long terminal repeat directs expression in epithelial and lymphoid cells of different tissues in transgenic mice

1987 • 100 citations

Three different activated ras genes in mouse tumours; evidence for oncogene activation during progression of a mouse lymphoma.

1984 • 97 citations

High Frequency of Rare Alleles of the Human c-Ha-ras-1 Proto-oncogene in Breast Cancer Patients2

1986 • 96 citations

KRAS2 as a genetic marker for lung tumor susceptibility in inbred mice

1989 • 95 citations

Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells.

1984 • 88 citations

Multiple regulatory domains in the mouse mammary tumor virus long terminal repeat revealed by analysis of fusion genes in transgenic mice.

1988 • 70 citations

The Molecular Genetics of Cellular Oncogenes

1984 • 51 citations

Quantitation of Harvey <italic>ras</italic> p21 Enhanced Expression in Human Breast and Colon Carcinomas

1987 • 51 citations

Mitogenic effects of the proto-oncogene and oncogene forms of c-H-ras DNA in human diploid fibroblasts.

1986 • 38 citations

Separation of hemopoietic cells from adult mouse marrow by use of monoclonal antibodies

1983 • 27 citations

Spleen specific expression of an MMTV related transcript associated with the Mtv-6 locus in BALB/c mice

1986 • 15 citations

Two adjacent mutations at position 12 activate the K-ras2 oncogene of a human mammary tumor cell line.

1987 • 14 citations

Multiple Regulatory Domains in the Mouse Mammary Tumor Virus Long Terminal Repeat Revealed by Analysis of Fusion Genes in Transgenic Mice

1988 • 7 citations