Chapter 4 Signal Transduction by GTP Binding Proteins during Leukocyte Activation: Phagocytic Cells

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

ras GENES

1987 • 3,818 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

1980 • 1,579 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

A ras-like protein is required for a post-Golgi event in yeast secretion

1987 • 894 citations

Roles of G protein subunits in transmembrane signalling

1988 • 794 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery

1988 • 699 citations

Regulation of transmembrane signaling by receptor phosphorylation

1987 • 678 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

Structure of the GDP Domain of EF-Tu and Location of the Amino Acids Homologous to ras Oncogene Proteins

1985 • 626 citations

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1989 • 585 citations

Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.

1984 • 585 citations

Biological and biochemical properties of human rasH genes mutated at codon 61

1986 • 538 citations

The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein.

1986 • 533 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21

1988 • 532 citations

Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

1987 • 524 citations

Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits.

1983 • 492 citations

The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein

1989 • 491 citations

A novel ras-related gene family

1985 • 487 citations

Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase.

1983 • 441 citations

G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2

1989 • 438 citations

Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin

1984 • 418 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein.

1984 • 411 citations

Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin.

1984 • 410 citations

Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library.

1987 • 403 citations

Two Cytosolic Neutrophil Oxidase Components Absent in Autosomal Chronic Granulomatous Disease

1988 • 401 citations

ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.

1984 • 389 citations

Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins.

1986 • 380 citations

Light dependent phosphorylation of rhodopsin by ATP

1972 • 370 citations

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.

1985 • 358 citations

Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

1987 • 356 citations

MECHANISMS OF LYSOSOMAL ENZYME RELEASE FROM HUMAN LEUKOCYTES

1973 • 346 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition.

1984 • 345 citations

Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.

1987 • 344 citations

Two roles for guanine nucleotides in the stimulus-secretion sequence of neutrophils

1986 • 339 citations

Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.

1988 • 334 citations

Receptor-Coupled Activation of Phosphoinositide-Specific Phospholipase C by an N Protein

1986 • 324 citations

The covalent modification of eukaryotic proteins with lipid.

1987 • 319 citations

Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities.

1986 • 315 citations

Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins.

1985 • 314 citations

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum.

1988 • 299 citations

Signal transduction and cytoskeletal activation in the neutrophil.

1987 • 282 citations

Coupling of the guanine nucleotide regulatory protein to chemotactic peptide receptors in neutrophil membranes and its uncoupling by islet-activating protein, pertussis toxin. A possible role of the toxin substrate in Ca2+-mobilizing receptor-mediated signal transduction.

1985 • 281 citations

The ras-related YPT1 gene product in yeast: A GTP-binding protein that might be involved in microtubule organization

1986 • 281 citations

Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins.

1987 • 276 citations

Direct evidence for involvement of a guanine nucleotide-binding protein in chemotactic peptide-stimulated formation of inositol bisphosphate and trisphosphate in differentiated human leukemic (HL-60) cells. Reconstitution with Gi or Go of the plasma membranes ADP-ribosylated by pertussis toxin.

1986 • 276 citations

The role of cyclic AMP in the chemotactic responsiveness and spontaneous motility of rabbit peritoneal neutrophils. The inhibition of neutrophil movement and the elevation of cyclic AMP levels by catecholamines, prostaglandins, theophylline and cholera toxin.

1975 • 271 citations

G protein multiplicity in eukaryotic signal transduction systems

1988 • 267 citations

The ral gene: a new ras related gene isolated by the use of a synthetic probe.

1986 • 264 citations

Purification of ras GTPase activating protein from bovine brain.

1988 • 255 citations

The purified alpha subunits of Go and Gi from bovine brain require beta gamma for association with phospholipid vesicles.

1986 • 253 citations

Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin.

1988 • 251 citations

Association of a Ras-related protein with cytochrome b of human neutrophils

1989 • 248 citations

Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin.

1986 • 233 citations

Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes.

1983 • 223 citations

Induction of a transient elevation in intracellular levels of adenosine-3',5'-cyclic monophosphate by chemotactic factors: an early event in human neutrophil activation.

1980 • 221 citations

Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes

1987 • 216 citations

Purification and characterization of a novel GTP-binding protein with a molecular weight of 24,000 from bovine brain membranes.

1988 • 207 citations

Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins.

1988 • 204 citations

Epidermal growth factor stimulates guanine nucleotide binding activity and phosphorylation of ras oncogene proteins

1984 • 203 citations

Two G-proteins act in series to control stimulus-secretion coupling in mast cells: use of neomycin to distinguish between G-proteins controlling polyphosphoinositide phosphodiesterase and exocytosis.

1987 • 197 citations

Family of G protein α chains: amphipathic analysis and predicted structure of functional domains

1986 • 197 citations

Increased levels of cyclic adenosine-3',5'-monophosphate in human polymorphonuclear leukocytes after surface stimulation.

1980 • 193 citations

The Role of Cyclic AMP in the Chemotactic Responsiveness and Spontaneous Motility of Rabbit Peritoneal Neutrophils

1975 • 193 citations

Purification of the major GTP-binding proteins from human placental membranes.

1986 • 190 citations

A new GTP‐binding protein in brain tissues serving as the specific substrate of islet‐activating protein, pertussis toxin

1987 • 189 citations

Essential synergy between Ca2+ and guanine nucleotides in exocytotic secretion from permeabilized rat mast cells.

1987 • 188 citations

Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride. Evidence for participation of a pertussis and cholera toxin-insensitive G protein.

1987 • 188 citations

A novel small molecular weight GTP-binding protein with the same putative effector domain as the ras proteins in bovine brain membranes. Purification, determination of primary structure, and characterization.

1988 • 185 citations

Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters.

1987 • 184 citations

Model for Leukocyte Regulation by Chemoattractant Receptors: Roles of a Guanine Nucleotide Regulatory Protein and Polyphosphoinositide Metabolism

1986 • 181 citations

Pertussis toxin inhibits the rise in the intracellular concentration of free calcium that is induced by chemotactic factors in rabbit neutrophils: Possible role of the “G proteins” in calcium mobilization

1984 • 180 citations

Substrate for botulinum ADP-ribosyltransferase, Gb, has an amino acid sequence homologous to a putative rho gene product.

1988 • 178 citations

The dynamics of ligand-receptor interactions. Real-time analyses of association, dissociation, and internalization of an N-formyl peptide and its receptors on the human neutrophil.

1984 • 178 citations

Chapter 5 Interactions between photoexcited rhodopsin and light-activated enzymes in rods

1984 • 174 citations

Modulation of human neutrophil chemotactic responses by cyclic 3′,5′-guanosine monophosphate and cyclic 3′,5′-adenosine monophosphate

1975 • 171 citations

Detection of 23-27 kDa GTP-binding proteins in platelets and other cells

1987 • 166 citations

Functional interaction of purified muscarinic receptors with purified inhibitory guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.

1986 • 161 citations

Degranulating stimuli increase the availability of receptors on human neutrophils for the chemoattractant f-met-leu-phe.

1980 • 161 citations

Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils with a GTP-binding protein sensitive to pertussis toxin.

1985 • 159 citations

Reconstitution of the muscarinic acetylcholine receptor. Guanine nucleotide-sensitive high affinity binding of agonists to purified muscarinic receptors reconstituted with GTP-binding proteins (Gi and Go).

1986 • 150 citations

Activation of the Neutrophil (Part 1 of 4)

1988 • 149 citations

Immunochemical evidence for a novel pertussis toxin substrate in human neutrophils.

1986 • 148 citations

Rapid modulation of N-formyl chemotactic peptide receptors on the surface of human granulocytes: formation of high-affinity ligand-receptor complexes in transient association with cytoskeleton.

1984 • 145 citations

Chromatographic resolution and immunologic identification of the alpha 40 and alpha 41 subunits of guanine nucleotide-binding regulatory proteins from bovine brain.

1988 • 144 citations

Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel.

1988 • 141 citations

3′-End formation of transcripts from the yeast rRNA operon.

1986 • 136 citations

Activation of the superoxide radical generating oxidase in plasma membrane from bovine polymorphonuclear neutrophils by arachidonic acid, a cytosolic factor of protein nature, and nonhydrolyzable analogs of GTP

1988 • 127 citations

ADP-ribosylation of the bovine brain rho protein by botulinum toxin type C1.

1988 • 126 citations

HORMONAL CONTROL OF LYSOSOMAL ENZYME RELEASE FROM HUMAN NEUTROPHILS

1974 • 124 citations

Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase.

1985 • 124 citations

Stimulus specificity of prostaglandin inhibition of rabbit polymorphonuclear leukocyte lysosomal enzyme release and superoxide anion production.

1984 • 122 citations

Guanine nucleotides stimulate polyphosphoinositide phosphodiesterase and exocytotic secretion from HL60 cells permeabilized with streptolysin O

1988 • 121 citations

Mutations in a gene encoding the alpha subunit of a Saccharomyces cerevisiae G protein indicate a role in mating pheromone signaling.

1988 • 121 citations

Purification and immunochemical characterization of the major pertussis‐toxin‐sensitive guanine‐nucleotide‐binding protein of bovine‐neutrophil membranes

1987 • 110 citations

The dynamics of exocytosis in human neutrophils.

1988 • 109 citations

Effect of tumor necrosis factor on GTP binding and GTPase activity in HL-60 and L929 cells.

1988 • 101 citations

Lateral segregation of neutrophil chemotactic receptors into actin- and fodrin-rich plasma membrane microdomains depleted in guanyl nucleotide regulatory proteins.

1988 • 99 citations

Control of exocytosis

1987 • 98 citations

Calcium shares the limelight in stimulus-secretion coupling

1986 • 97 citations

Receptor‐mediated ADP‐ribosylation of a phospholipase C‐stimulating G protein

1987 • 96 citations

Subcellular localization and quantitation of the major neutrophil pertussis toxin substrate, Gn.

1988 • 94 citations

A new GTP-binding protein in differentiated human leukemic (HL-60) cells serving as the specific substrate of islet-activating protein, pertussis toxin.

1987 • 93 citations

Purification and characterization of a GTP-binding protein with a molecular weight of 20,000 in bovine brain membranes. Identification as the rho gene product.

1988 • 93 citations

Guanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils

1986 • 92 citations

Regulation of ligand-receptor dynamics by guanine nucleotides. Real-time analysis of interconverting states for the neutrophil formyl peptide receptor.

1987 • 89 citations

Bacterial lipopolysaccharides, phorbol myristate acetate, and zymosan induce the myristoylation of specific macrophage proteins.

1986 • 88 citations

Detection of multiple forms of G_iαin HL60 cells

1987 • 88 citations

Human G_i protein α‐subunit: deduction of amino acid structure from a cloned cDNA

1987 • 85 citations

Subcellular localization of Gi alpha in human neutrophils.

1988 • 85 citations

Occupancy of adenosine receptors raises cyclic AMP alone and in synergy with occupancy of chemoattractant receptors and inhibits membrane depolarization

1988 • 85 citations

Membrane‐cytoskeleton interactions and the regulation of chemotactic peptide‐induced activation of human granulocytes: The effects of dihydrocytochalasin B

1985 • 84 citations

The formylpeptide chemotactic receptor on rabbit peritoneal neutrophils. I. Evidence for two binding sites with different affinities.

1982 • 82 citations

A chemoattractant receptor on macrophages exists in two affinity states regulated by guanine nucleotides.

1984 • 82 citations

The formylpeptide chemoattractant receptor copurifies with a GTP-binding protein containing a distinct 40-kDa pertussis toxin substrate.

1988 • 80 citations

Subunit dissociation is the mechanism for hormonal activation of the Gs protein in native membranes.

1988 • 74 citations

A pertussis/choleratoxin-sensitive N protein may mediate chemoattractant receptor signal transduction

1986 • 74 citations

Mechanisms of guanine nucleotide-mediated regulation of adenylate cyclase activity.

1984 • 72 citations

Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K.

1988 • 72 citations

Molecular cloning of a new human G protein Evidence for two G_iα‐like protein families

1987 • 70 citations

Colony-stimulating factor 1-induced Na+ influx into human monocytes involves activation of a pertussis toxin-sensitive GTP-binding protein.

1988 • 69 citations

Ligand-Receptor Dynamics and Signal Amplification in the Neutrophil

1986 • 69 citations

Adaptation of human neutrophil responsiveness to the chemoattractant N-formylmethionylleucylphenylalanine. Heterogeneity and/or negative cooperative interaction of receptors.

1982 • 68 citations

The presence of free G protein beta/gamma subunits in human neutrophils results in suppression of adenylate cyclase activity.

1987 • 66 citations

Modes of inhibitory action of protein kinase C in the chemotactic peptide-induced formation of inositol phosphates in differentiated human leukemic (HL-60) cells.

1987 • 60 citations

Identification of novel GTP-binding proteins in the human neutrophil

1988 • 59 citations

Botulinum ADP‐ribosyltransferase C3 but not botulinum neurotoxins C1 and D ADP‐ribosylates low molecular mass GTP‐binding proteins

1987 • 57 citations

Identification of a new GTP-binding protein. A Mr = 43,000 substrate for pertussis toxin.

1987 • 57 citations

Reversible activation of NADPH oxidase in membranes of HL-60 human leukemic cells

1987 • 56 citations

The inhibition of neutrophil responsiveness caused by phorbol esters is blocked by the protein kinase C inhibitor H7

1986 • 54 citations

Response of adenosine cyclic 3',5'-monophosphate level in rabbit neutrophils to the chemotactic peptide formyl-methionyl-leucyl-phenylalanine.

1979 • 53 citations

Evidence for N‐formyl chemotactic peptide‐stimulated GTPase activity in human neutrophil homogenates

1984 • 53 citations

Adenylate cyclase inhibition and GTPase stimulation by somatostatin in S49 lymphoma cyc⁻ variants are prevented by islet‐activating protein

1983 • 53 citations

Regulation of the affinity state of the N-formylated peptide receptor of neutrophils: role of guanine nucleotide-binding proteins and the cytoskeleton.

1987 • 48 citations

Fluoride can activate the respiratory burst independently of Ca 2+ , stimulation of phosphoinositide turnover and protein kinase C translocation in primed human neutrophils

1988 • 46 citations

Activation of bovine neutrophil oxidase in a cell free system. GTP-dependent formation of a complex between a cytosolic factor and a membrane protein

1988 • 45 citations

Major pertussis‐toxin‐sensitive GTP‐binding protein of bovine lung

1988 • 43 citations

Transient Catecholamine Modulation of Neutrophil Activation: Kinetic and Intracellular Aspects of Isoproterenol Action

1986 • 43 citations

Activation of the Neutrophil1

2015 • 43 citations

Purification and characterization of c-Ki-ras p21 from bovine brain crude membranes.

1988 • 42 citations

Inhibition of interleukin 3 and colony-stimulating factor 1-stimulated marrow cell proliferation by pertussis toxin

1988 • 42 citations

Three States for the Formyl Peptide Receptor on Intact Cells

1989 • 42 citations

Identification of rho as a substrate for botulinum toxin C₃‐catalyzed ADP‐ribosylation

1989 • 41 citations

G-Protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe

1987 • 41 citations

The potency and kinetics of the beta-adrenergic receptors on human neutrophils.

1988 • 39 citations

Molecular and Regulatory Properties of Adrenergic Receptors

1987 • 38 citations

GTP analogues promote release of the α subunit of the guanine nucleotide binding protein, Gi2, from membranes of rat glioma C6 BU1 cells

1988 • 38 citations

Glucagon receptor-mediated activation of Gs is accompanied by subunit dissociation.

1988 • 37 citations

Guanine nucleotides reduce the free calcium requirement for secretion of granule constituents from permeabilized human neutrophils

1986 • 34 citations

Adenosine Modulates the Generation of Superoxide Anion by Stimulated Human Neutrophils via Interaction with a Specific Cell Surface Receptora

1985 • 33 citations

Stimulation of exocytotic degranulation by microinjection of the ras oncogene protein into rat mast cells.

1988 • 31 citations

Coupling of antagonistic signalling pathways in modulation of neutrophil function

1989 • 30 citations

Intracellular stimulation of mast cells with guanine nucleotides mimic antigenic stimulation

1987 • 29 citations

Identification and purification of a novel G protein from neutrophils

1987 • 24 citations

Nature and functioning of the pertussis toxin-sensitive G protein of neutrophils.

1987 • 23 citations

Pertussis toxin does not affect the time course of exocytosis in mast cells stimulated by intracellular application of GTP‐γ‐S

1987 • 23 citations

Solubilization and reconstitution of the formylmethionylleucylphenylalanine receptor coupled to guanine nucleotide regulatory protein

1988 • 20 citations

Role of the β-Adrenergic Receptor in the Regulation of Adenylate Cyclase

1984 • 20 citations

Botulinum toxin D ADP-ribosylates A 22–24 KDa membrane protein in platelets and HL-60 cells that is distinct from p21N-RAS

1988 • 19 citations

Effect of botulinum D toxin on neutrophils

1988 • 9 citations

Dynamics of Interaction Among Ligand, Receptor, and G Protein

1989 • 6 citations

Guanine nucleotide regulatory proteins as transducers of receptor-stimulated neutrophil activation.

1987 • 5 citations