Occupancy of adenosine receptors raises cyclic AMP alone and in synergy with occupancy of chemoattractant receptors and inhibits membrane depolarization

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Subclasses of external adenosine receptors.

1980 • 1,087 citations

Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.

1975 • 749 citations

Adenosine receptors in the central nervous system: Relationship to the central actions of methylxanthines

1981 • 535 citations

Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.

1983 • 467 citations

Measurement of Serum Vitamin B12 Level Using Radioisotope Dilution and Coated Charcoal

1965 • 386 citations

MECHANISMS OF LYSOSOMAL ENZYME RELEASE FROM HUMAN LEUKOCYTES

1973 • 346 citations

Adenosine; a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils.

1985 • 345 citations

STUDIES ON LYSOSOMES

1968 • 238 citations

Induction of a transient elevation in intracellular levels of adenosine-3',5'-cyclic monophosphate by chemotactic factors: an early event in human neutrophil activation.

1980 • 221 citations

Use of lipophilic probes of membrane potential to assess human neutrophil activation. Abnormality in chronic granulomatous disease.

1980 • 203 citations

Increased levels of cyclic adenosine-3',5'-monophosphate in human polymorphonuclear leukocytes after surface stimulation.

1980 • 193 citations

Inhibition by adenosine of reactive oxygen metabolite production by human polymorphonuclear leucocytes

1985 • 111 citations

Receptor-specific threshold effects of cyclic AMP are involved in the regulation of enzyme release and superoxide production from human neutrophils

1985 • 56 citations

Cytoplasmic pH regulation in activated human neutrophils: Effects of adenosine and pertussis toxin on Na+H+ exchange and metabolic acidification

1986 • 33 citations

Adenosine Inhibits Polymorphonuclear Leukocyte in Vitro Activation: A Possible Role as an Endogenous Calcium Entry Blocker

1985 • 21 citations

Synergistic action of adenosine and fmet-leu-phe in raising camp content of purified human monocytes

1986 • 16 citations