Molecular and Regulatory Properties of Adrenergic Receptors

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

A STUDY OF THE ADRENOTROPIC RECEPTORS

1948 • 2,856 citations

Phosphorylation-Dephosphorylation of Enzymes

1979 • 2,205 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Molecular Genetics of Human Color Vision: The Genes Encoding Blue, Green, and Red Pigments

1986 • 1,702 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model

1985 • 732 citations

Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin

1983 • 689 citations

cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

1987 • 687 citations

Beta-adrenergic receptors: biochemical mechanisms of physiological regulation

1984 • 672 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

The structure of one of the eight or more distinct chromosomal genes for human interferon-α

1980 • 486 citations

ADENYLATE CYCLASE-COUPLED BETA-ADRENERGIC RECEPTORS: Structure and Mechanisms of Activation and Desensitization

1983 • 486 citations

Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains

1986 • 471 citations

Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase.

1983 • 441 citations

Nucleotide sequences of STE2 and STE3 , cell type-specific sterile genes from Saccharomyces cerevisiae

1985 • 351 citations

Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.

1985 • 332 citations

Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.

1985 • 312 citations

Purification of the catalyst of adenylate cyclase.

1986 • 259 citations

Mammalian .beta.2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system

1984 • 249 citations

Phorbol diesters promote β-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes

1984 • 238 citations

Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.

1987 • 235 citations

Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes.

1984 • 233 citations

Genes and spacers of cloned sea urchin histone DNA analyzed by sequencing

1978 • 233 citations

Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.

1985 • 213 citations

Mammalian .beta.2-adrenergic receptor: purification and characterization

1984 • 207 citations

Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.

1987 • 206 citations

Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase

1986 • 205 citations

Inhibitors of Na+/H+ exchange block epinephrine- and ADP-induced stimulation of human platelet phospholipase C by blockade of arachidonic acid release at a prior step.

1986 • 158 citations

Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity.

1984 • 154 citations

Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.

1986 • 154 citations

Reconstitution of catecholamine-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to the stimulatory GTP-binding protein of adenylate cyclase

1984 • 136 citations

A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for .beta.-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase

1986 • 125 citations

Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit.

1984 • 120 citations

The beta 1-adrenergic receptor of the turkey erythrocyte. Molecular heterogeneity revealed by purification and photoaffinity labeling.

1982 • 117 citations

Chapter 1 Rhodopsin chemistry, structure and topography

1982 • 115 citations

Pure β-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase

1983 • 114 citations

The partial primary structure of bovine rhodopsin and its topography in the retinal rod cell disc membrane

1980 • 106 citations

A role for Ni in the hormonal stimulation of adenylate cyclase

1985 • 99 citations

Purification and characterization of the human platelet alpha 2-adrenergic receptor.

1986 • 94 citations

Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit.

1986 • 81 citations

Photoaffinity labeling of mammalian alpha 1-adrenergic receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe.

1984 • 81 citations

The beta-adrenergic receptor: rapid purification and covalent labeling by photoaffinity crosslinking.

1982 • 76 citations

125I-labeled p-azidobenzylcarazolol, a photoaffinity label for the beta-adrenergic receptor. Characterization of the ligand and photoaffinity labeling of beta 1- and beta 2-adrenergic receptors.

1982 • 76 citations

Identification of the subunit-binding site of alpha 2-adrenergic receptors using [3H]phenoxybenzamine.

1984 • 29 citations

Affinity chromatography of human platelet α ₂ -adrenergic receptors

1982 • 27 citations

Photoaffinity labeling of turkey erythrocyte beta-adrenergic receptors: Degradation of the Mr = 49,000 protein explains apparent heterogeneity

1984 • 18 citations