The covalent modification of eukaryotic proteins with lipid.

Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins

1984 • 471 citations

A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation.

1984 • 447 citations

Glycosyl-sn-1,2-dimyristylphosphatidylinositol is covalently linked to Trypanosoma brucei variant surface glycoprotein.

1985 • 422 citations

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

1984 • 403 citations

n-Tetradecanoyl is the NH2-terminal blocking group of the catalytic subunit of cyclic AMP-dependent protein kinase from bovine cardiac muscle.

1982 • 395 citations

Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformation.

1985 • 386 citations

The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipid

1982 • 357 citations

Phosphatidylinositol is the membrane-anchoring domain of the Thy-1 glycoprotein

1985 • 355 citations

Fatty acid binding to vesicular stomatitis virus glycoprotein: a new type of post-translational modification of the viral glycoprotein

1979 • 330 citations

Biosynthesis of the human transferrin receptor in cultured cells.

1981 • 316 citations

Identification of the NH₂‐terminal blocking group of calcineurin B as myristic acid

1982 • 312 citations

A Glycophospholipid Tail at the Carboxyl Terminus of the Thy-1 Glycoprotein of Neurons and Thymocytes

1985 • 306 citations

Myristylation site in Pr65gag is essential for virus particle formation by Moloney murine leukemia virus.

1986 • 300 citations

Developmental regulation of a dictyostelium gene encoding a protein homologous to mammalian ras protein

1984 • 267 citations

Amino Terminal Myristylation of the Protein Kinase p60 src , a Retroviral Transforming Protein

1985 • 264 citations

The ral gene: a new ras related gene isolated by the use of a synthetic probe.

1986 • 264 citations

Myristyl amino-terminal acylation of murine retrovirus proteins: An unusual post-translational protein modification

1983 • 263 citations

Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae.

1987 • 259 citations

Role of phosphatidylinositol in attachment of alkaline phosphatase to membranes

1980 • 256 citations

Covalent binding of fatty acid to the transferrin receptor in cultured human cells.

1981 • 246 citations

Evidence for covalent attachment of fatty acids to Sindbis virus glycoproteins.

1979 • 244 citations

Phosphatidylinositol is involved in the membrane attachment of NCAM-120, the smallest component of the neural cell adhesion molecule.

1986 • 232 citations

Relation of fatty acid attachment to the translation and maturation of vesicular stomatitis and Sindbis virus membrane glycoproteins.

1980 • 225 citations

Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog

1985 • 223 citations

Rous sarcoma virus transforming protein lacking myristic acid phosphorylates known polypeptide substrates without inducing transformation

1986 • 223 citations

Amino-terminal processing of proteins by N-myristoylation. Substrate specificity of N-myristoyl transferase.

1987 • 220 citations

An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins

1985 • 201 citations

Acylation of bovine rhodopsin by [3H]palmitic acid.

1984 • 200 citations

Identification of the intermolecular disulfide bonds of the human transferrin receptor and its lipid-attachment site.

1987 • 198 citations

Rapid processing of the carboxyl terminus of a trypanosome variant surface glycoprotein.

1985 • 198 citations

Specific release of plasma membrane enzymes by a phosphatidylinositol-specific phospholipase C

1978 • 196 citations

Two classes of fatty acid acylated proteins exist in eukaryotic cells.

1985 • 196 citations

Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds.

1984 • 189 citations

The absence of myristic acid decreases membrane binding of p60src but does not affect tyrosine protein kinase activity

1986 • 174 citations

The presence of cysteine in the cytoplasmic domain of the vesicular stomatitis virus glycoprotein is required for palmitate addition.

1984 • 174 citations

Myristic acid is attached to the transforming protein of Rous sarcoma virus during or immediately after synthesis and is present in both soluble and membrane-bound forms of the protein.

1984 • 173 citations

Acylation of virol. spike glycoproteins: A feature of enveloped RNA viruses

1982 • 169 citations

Direct identification of palmitic acid as the lipid attached to p21ras.

1986 • 157 citations

A Short Sequence in the p60^src N Terminus Is Required for p60^src Myristylation and Membrane Association and for Cell Transformation

1984 • 149 citations

Identification of the NH2-terminal blocking group of NADH-cytochrome b5 reductase as myristic acid and the complete amino acid sequence of the membrane-binding domain.

1984 • 145 citations

Acylation of a Plasmodium falciparum merozoite surface antigen via sn-1,2-diacyl glycerol.

1985 • 142 citations

Physicochemical behaviour and structural characteristics of membrane-bound acetylcholinesterase from Torpedo electric organ. Effect of phosphatidylinositol-specific phospholipase C

1985 • 135 citations

Protein fatty acid acylation: enzymatic synthesis of an N-myristoylglycyl peptide.

1986 • 123 citations

Characterization of the protein apparently responsible for the elevated tyrosine protein kinase activity in LSTRA cells.

1984 • 121 citations

Covalently bound myristate in a lymphoma tyrosine protein kinase.

1984 • 120 citations

Fatty acylation of cellular proteins. Temporal and subcellular differences between palmitate and myristate acylation.

1986 • 120 citations

Posttranslational processing of p21 ras proteins involves palmitylation of the C-terminal tetrapeptide containing cysteine-186

1985 • 120 citations

Structural characterization of the TAP molecule: A phosphatidylinositol-linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1

1986 • 111 citations

Myristylation of gag-onc fusion proteins in mammalian transforming retroviruses

1984 • 107 citations

Carbohydrate is linked through ethanolamine to the C-terminal amino acid of Trypanosoma brucei variant surface glycoprotein

1983 • 102 citations

Identification of the parasite transferrin receptor of Plasmodium falciparum-infected erythrocytes and its acylation via 1,2-diacyl-sn-glycerol.

1986 • 98 citations

Ankyrin is fatty acid acylated in erythrocytes.

1986 • 90 citations

Cell-free fatty acid acylation of Semliki Forest viral polypeptides with microsomal membranes from eukaryotic cells.

1984 • 89 citations

Acylated simian virus 40 large T-antigen: a new subclass associated with a detergent-resistant lamina of the plasma membrane.

1983 • 85 citations

Human apolipoprotein A-I. Post-translational modification by fatty acid acylation.

1986 • 83 citations

Myristic Acid Is Attached to the Transforming Protein of Rous Sarcoma Virus During or Immediately After Synthesis and Is Present in Both Soluble and Membrane-Bound Forms of the Protein

1984 • 73 citations

Structural organization of the rat thy-1 gene

1985 • 66 citations

Complete nucleotide sequence of complementary DNA coding for a variant surface glycoprotein from Trypanosoma brucei

1982 • 56 citations

Direct Identification of Palmitic Acid as the Lipid Attached to p21^ras

1986 • 42 citations

Characterization of the Protein Apparently Responsible for the Elevated Tyrosine Protein Kinase Activity in LSTRA Cells

1984 • 36 citations