Ligand-Receptor Dynamics and Signal Amplification in the Neutrophil
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Abstract
References (187)
The role of protein kinase C in cell surface signal transduction and tumour promotion
1984 • 7,521 citations
Inositol trisphosphate and diacylglycerol as second messengers
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Ionic Channels of Excitable Membranes
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Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C
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Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate
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N-formylmethionyl peptides as chemoattractants for leucocytes.
1975 • 871 citations
The structure-activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal secretion for neutrophils.
1976 • 734 citations
Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte
1980 • 645 citations
A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca 2+ -Dependent Protein Kinase
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Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor.
1982 • 615 citations
Identification of the predominant substrate for ADP-ribosylation by islet activating protein.
1983 • 583 citations
myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.
1984 • 567 citations
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1984 • 567 citations
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1974 • 567 citations
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1982 • 541 citations
Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes.
1977 • 541 citations
Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli.
1984 • 520 citations
Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes.
1978 • 512 citations
Is Cytosolic Ionized Calcium Regulating Neutrophil Activation?
1983 • 471 citations
A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters
1985 • 446 citations
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin
1984 • 418 citations
Human neutrophils increase expression of C3bi as well as C3b receptors upon activation.
1984 • 391 citations
Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.
1985 • 358 citations
Demonstration of a receptor on rabbit neutrophils for chemotactic peptides
1977 • 345 citations
Adenosine; a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils.
1985 • 345 citations
Protein kinase C activation of physiological processes in human neutrophils at vanishingly small cytosolic Ca2+ levels
1984 • 334 citations
Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme.
1985 • 300 citations
A saturable receptor for 32P-inositol-l,4,5-trisphosphate in hepatocytes and neutrophils
1986 • 296 citations
Evidence for distinct intracellular pools of receptors for C3b and C3bi in human neutrophils.
1985 • 291 citations
Stimulated neutrophils from patients with autosomal recessive chronic granulomatous disease fail to phosphorylate a Mr-44,000 protein
1985 • 286 citations
Coupling of the guanine nucleotide regulatory protein to chemotactic peptide receptors in neutrophil membranes and its uncoupling by islet-activating protein, pertussis toxin. A possible role of the toxin substrate in Ca2+-mobilizing receptor-mediated signal transduction.
1985 • 281 citations
Stimulus response coupling in the human neutrophil. II. Temporal analysis of changes in cytosolic calcium and calcium efflux.
1984 • 272 citations
Inositol 1,4,5-trisphosphate releases Ca2+ from a Ca2+-transporting membrane vesicle fraction derived from human platelets.
1985 • 268 citations
Ca2+ homeostasis in permeabilized human neutrophils. Characterization of Ca2+-sequestering pools and the action of inositol 1,4,5-triphosphate.
1984 • 266 citations
Specific binding of leukotriene B4 to receptors on human polymorphonuclear leukocytes.
1982 • 263 citations
Modulation of cytosolic-free calcium transients by changes in intracellular calcium-buffering capacity: correlation with exocytosis and O2-production in human neutrophils.
1984 • 262 citations
Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion.
1984 • 249 citations
Receptor-mediated uptake and degradation of 125I-chemotactic peptide by human neutrophils.
1979 • 243 citations
Affinity labeling of the protein kinase associated with the epidermal growth factor receptor in membrane vesicles from A431 cells.
1982 • 232 citations
Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes
1985 • 229 citations
Further studies on the structural requirements for synthetic peptide chemoattractants
1980 • 226 citations
Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes.
1983 • 223 citations
The NADPH oxidase of human polymorphonuclear leukocytes. Evidence for regulation by multiple signals.
1984 • 222 citations
Effect of phorbol 12-myristate 13-acetate and its analogue 4 alpha-phorbol 12,13-didecanoate on protein phosphorylation and lysosomal enzyme release in rabbit neutrophils.
1984 • 221 citations
Induction of a transient elevation in intracellular levels of adenosine-3',5'-cyclic monophosphate by chemotactic factors: an early event in human neutrophil activation.
1980 • 221 citations
Heterogeneity of human polymorphonuclear leukocyte receptors for leukotriene B4. Identification of a subset of high affinity receptors that transduce the chemotactic response.
1984 • 218 citations
Intracellular Free Calcium Localization in Neutrophils During Phagocytosis
1985 • 217 citations
Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor.
1986 • 215 citations
Ca2+-dependent and Ca2+-independent phagocytosis in human neutrophils
1985 • 211 citations
Phospholipid-sensitive Ca2+-dependent protein phosphorylation system in various types of leukemic cells from human patients and in human leukemic cell lines HL60 and K562, and its inhibition by alkyl-lysophospholipid.
1983 • 207 citations
Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells.
1985 • 197 citations
Phorbol myristate acetate stimulates ATP-dependent calcium transport by the plasma membrane of neutrophils.
1984 • 193 citations
Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes.
1985 • 192 citations
Sensory adaptation of leukocytes to chemotactic peptides.
1979 • 190 citations
Chemotactic factor causes rapid decreases in phosphatidylinositol,4,5-bisphosphate and phosphatidylinositol 4-monophosphate in rabbit neutrophils
1983 • 188 citations
Chemotactic peptide activation of human neutrophils and HL-60 cells. Pertussis toxin reveals correlation between inositol trisphosphate generation, calcium ion transients, and cellular activation.
1985 • 182 citations
Pertussis toxin inhibits the rise in the intracellular concentration of free calcium that is induced by chemotactic factors in rabbit neutrophils: Possible role of the “G proteins” in calcium mobilization
1984 • 180 citations
Relationship of actin polymerization and depolymerization to light scattering in human neutrophils: dependence on receptor occupancy and intracellular Ca++.
1985 • 178 citations
The dynamics of ligand-receptor interactions. Real-time analyses of association, dissociation, and internalization of an N-formyl peptide and its receptors on the human neutrophil.
1984 • 178 citations
Stimulus response coupling in the human neutrophil. I. Kinetic analysis of changes in calcium permeability.
1984 • 177 citations
Cyclic 3′,5′-adenosine monophosphate in the human leukocyte: synthesis, degradation, and effects on neutrophil candidacidal activity
1971 • 176 citations
Formyl peptide chemoattractants: a model of the receptor on rabbit neutrophils
1982 • 174 citations
Modulation of human neutrophil chemotactic responses by cyclic 3′,5′-guanosine monophosphate and cyclic 3′,5′-adenosine monophosphate
1975 • 171 citations
Production of phosphoinositide-derived messengers
1984 • 163 citations
Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils with a GTP-binding protein sensitive to pertussis toxin.
1985 • 159 citations
Intracellular pH modulates the generation of superoxide radicals by human neutrophils.
1985 • 156 citations
The inhibition of neutrophil granule enzyme secretion and chemotaxis by pertussis toxin.
1985 • 155 citations
Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects.
1985 • 154 citations
Correlation of human neutrophil secretion, chemoattractant receptor mobilization, and enhanced functional capacity.
1982 • 154 citations
Changes in cytoskeletal proteins of polymorphonuclear leukocytes induced by chemotactic peptides
1983 • 153 citations
Secretagogue-induced phosphoinositide metabolism in human leucocytes
1984 • 152 citations
Ca2+-dependent conversion of phosphatidylinositol to phosphatidate in neutrophils stimulated with fMet-Leu-Phe or ionophore A23187
1984 • 152 citations
The Influence of Histamine on Immune and Inflammatory Responses
1984 • 149 citations
Rapid modulation of N-formyl chemotactic peptide receptors on the surface of human granulocytes: formation of high-affinity ligand-receptor complexes in transient association with cytoskeleton.
1984 • 145 citations
Effects of leukotrienes and f-Met-Leu-Phe on oxidative metabolism of neutrophils and eosinophils.
1984 • 143 citations
GTPase activity of the stimulatory GTP-binding regulatory protein of adenylate cyclase, Gs. Accumulation and turnover of enzyme-nucleotide intermediates.
1985 • 143 citations
Specific binding of leukotriene B4 to a receptor on human polymorphonuclear leukocytes.
1983 • 142 citations
Chemoattractant receptor functions in human polymorphonuclear leukocytes are divergently altered by membrane fluidizers.
1982 • 140 citations
Kinetic analysis of chemotactic peptide receptor modulation
1982 • 137 citations
Reconstitution of catecholamine-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to the stimulatory GTP-binding protein of adenylate cyclase
1984 • 136 citations
Surface‐reactive stimuli selectively increase protein phosphorylation in human neutrophils
1981 • 134 citations
Human C5a and C5a analogs as probes of the neutrophil C5a receptor
1980 • 134 citations
Superoxide release by neutrophils: Synergistic effects of a phorbol ester and a calcium ionophore
1984 • 129 citations
Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase.
1985 • 124 citations
Stimulus specificity of prostaglandin inhibition of rabbit polymorphonuclear leukocyte lysosomal enzyme release and superoxide anion production.
1984 • 122 citations
Phosphorylation and dephosphorylation of the insulin receptor: evidence against an intrinsic phosphatase activity
1984 • 122 citations
Signal transduction and ligand-receptor dynamics in the human neutrophil. Transient responses and occupancy-response relations at the formyl peptide receptor.
1985 • 120 citations
Phospholipid-sensitive Ca2+-dependent protein kinase and its substrates in human neutrophils
1983 • 112 citations
Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4
1985 • 110 citations
Characterization of a C5a receptor on human polymorphonuclear leukocytes (PMN).
1985 • 109 citations
A continuous, spectroscopic analysis of the kinetics of elastase secretion by neutrophils. The dependence of secretion upon receptor occupancy.
1982 • 108 citations
Consequences of chemotactic peptide receptor modulation for leukocyte orientation.
1981 • 107 citations
Thrombin-induced platelet responses differ in requirement for receptor occupancy. Evidence for tight coupling of occupancy and compartmentalized phosphatidic acid formation.
1981 • 101 citations
Chemotactic factor-induced activation of Na+/H+ exchange in human neutrophils. II. Intracellular pH changes.
1985 • 101 citations
The Effects of Extracellular K+, Na+ and Ca++ on Lysosomal Enzyme Secretion from Polymorphonuclear Leukocytes
1977 • 100 citations
Stimulus–secretion coupling in rabbit neutrophils is not mediated by phosphatidylinositol breakdown
1980 • 97 citations
Role of Ca2+ in phosphatidylinositol response and arachidonic acid release in formylated tripeptide- or Ca2+ ionophore A23187-stimulated guinea pig neutrophils.
1983 • 96 citations
The protein kinase C inhibitors H-7 and H-9 fail to inhibit human neutrophil activation
1986 • 95 citations
Macrophage membrane potential changes associated with gamma 2b/gamma 1 Fc receptor-ligand binding.
1983 • 93 citations
Studies of leukotriene B4-specific binding and function in rat polymorphonuclear leukocytes: absence of a chemotactic response.
1985 • 92 citations
Pertussis but not cholera toxin inhibits the stimulated increase in actin association with the cytoskeleton in rabbit neutrophils: Role of the “G proteins” in stimulus-response coupling
1985 • 92 citations
GTP hydrolysis by pure Ni, the inhibitory regulatory component of adenylyl cyclases.
1984 • 89 citations
Covalent affinity labeling of the formyl peptide chemotactic receptor.
1980 • 87 citations
Leukotriene B4 mobilizes calcium without the breakdown of polyphosphoinositides and the production of phosphatidic acid in rabbit neutrophils.
1984 • 86 citations
The Ca2+-activated polyphosphoinositide phosphodiesterase of human and rabbit neutrophil membranes
1984 • 85 citations
Membrane‐cytoskeleton interactions and the regulation of chemotactic peptide‐induced activation of human granulocytes: The effects of dihydrocytochalasin B
1985 • 84 citations
Release of superoxide and change in morphology by neutrophils in response to phorbol esters: antagonism by inhibitors of calcium-binding proteins.
1985 • 83 citations
A pertussis toxin-sensitive GTP-binding protein in the human neutrophil regulates multiple receptors, calcium mobilization, and lectin-induced capping.
1985 • 83 citations
The formylpeptide chemotactic receptor on rabbit peritoneal neutrophils. I. Evidence for two binding sites with different affinities.
1982 • 82 citations
Characterization of formylmethionyl-leucyl-phenylalanine stimulation of inositol trisphosphate accumulation in rabbit neutrophils.
1985 • 82 citations
Subcellular localization of H2O2 production in human neutrophils stimulated with particles and an effect of cytochalasin-B on the cells
1982 • 80 citations
The fatty acid composition of phosphatidylinositol, phosphatidate and 1,2-diacylglycerol in stimulated human neutrophils
1984 • 80 citations
Receptor-mediated Modulation of Human Monocyte, Neutrophil, Lymphocyte, and Platelet Function by Phorbol Diesters
1982 • 80 citations
Transducin: an amplifier protein in vision
1981 • 79 citations
Calcium requirements for increased complement receptor expression during neutrophil activation.
1985 • 77 citations
Signal transduction and ligand-receptor dynamics in the neutrophil. Ca2+ modulation and restoration.
1985 • 76 citations
Calmodulin-dependents stimulation of the NADPH oxidase of human neutrophils
1982 • 75 citations
The kinetics of neutrophil activation. The response to chemotactic peptides depends upon whether ligand-receptor interaction is rate-limiting.
1981 • 74 citations
Multiple forms of phosphoinositide-specific phospholipase C of different relative molecular masses in animal tissues. Evidence for modification of the platelet enzyme by Ca2+-dependent proteinase
1984 • 74 citations
Analysis of ligand-receptor interactions with the fluorescence activated cell sorter
1982 • 73 citations
Fluoresceinated chemotactic peptide and high-affinity antifluorescein antibody as a probe of the temporal characteristics of neutrophil stimulation.
1981 • 71 citations
Protein kinase C phosphorylates a component of NADPH oxidase of neutrophils
1985 • 71 citations
Stimulus-specific deactivation of chemotactic factor-induced cyclic AMP response and superoxide generation by human neutrophils.
1980 • 69 citations
Amphotericin B alters the affinity and functional activity of the oligopeptide chemotactic factor receptor on human polymorphonuclear leukocytes.
1982 • 68 citations
Anti-inflammatory effects of prostaglandin E1: in vivo modulation of the formyl peptide chemotactic receptor on the rat neutrophil.
1983 • 68 citations
Stimulus response coupling in the human neutrophil. Differential requirements for receptor occupancy in neutrophil responses to a chemoattractant.
1984 • 68 citations
Transduction by leukotriene B4 receptors of increases in cytosolic calcium in human polymorphonuclear leukocytes.
1985 • 67 citations
Identification of the polymorphonuclear leukocyte C5a receptor.
1985 • 67 citations
Isoproterenol inhibition of isolated human neutrophil function
1984 • 65 citations
Human neutrophils permeabilized with digitonin respond with lysosomal enzyme release when exposed to micromolar levels of free calcium
1986 • 64 citations
Activation of nadph oxidase of human neutrophils. Potentiation of chemotactic peptide by a diacylglycerol
1984 • 63 citations
Formation of a receptor state from which insulin dissociates slowly in hepatic cells and plasma membranes.
1980 • 62 citations
A New View of Receptor Action
1984 • 62 citations
Inositol 1,4,5‐trisphosphate may be a signal for f‐Met‐Leu‐Phe‐induced intracellular Ca mobilisation in human leucocytes (HL‐60 cells)
1984 • 60 citations
Photoaffinity labeling of the N-formyl peptide receptor binding site of intact human polymorphonuclear leukocytes. A label suitable for following the fate of the receptor-ligand complex.
1983 • 58 citations
Specific binding of synthetic chemotactic peptides to rabbit peritoneal neutrophils: Effects on dissociability of bound peptide, receptor activity and subsequent biologic responsiveness (deactivation)
1980 • 58 citations
Structural heterogeneity of the C3b/C4b receptor (Cr 1) on human peripheral blood cells.
1983 • 57 citations
Chemotactic factor-induced activation of Na+/H+ exchange in human neutrophils. I. Sodium fluxes.
1985 • 56 citations
Receptor-specific threshold effects of cyclic AMP are involved in the regulation of enzyme release and superoxide production from human neutrophils
1985 • 56 citations
Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin
1985 • 54 citations
Response of adenosine cyclic 3',5'-monophosphate level in rabbit neutrophils to the chemotactic peptide formyl-methionyl-leucyl-phenylalanine.
1979 • 53 citations
Evidence for N‐formyl chemotactic peptide‐stimulated GTPase activity in human neutrophil homogenates
1984 • 53 citations
Oxidation of leukotrienes at the omega end: demonstration of a receptor for the 20-hydroxy derivative of leukotriene B4 on human neutrophils and implications for the analysis of leukotriene receptors.
1984 • 51 citations
Con-A-stimulated superoxide production by granulocytes: reversible activation of NADPH oxidase
1982 • 51 citations
Detergent solubilization of the formyl peptide chemotactic receptor. Strategy based on covalent affinity labeling.
1981 • 50 citations
Adenosine triphosphate-dependent calcium pump in the plasma membrane of guinea pig and human neutrophils.
1984 • 50 citations
Chemotactic factors induced vimentin phosphorylation in rabbit peritoneal neutrophil.
1984 • 46 citations
Labeling the granulocyte C5a receptor with a unique photoreactive probe.
1985 • 45 citations
Subcellular localization of hydrogen peroxide production in human polymorphonuclear leukocytes stimulated with lectins, phorbol myristate acetate, and digitonin: an electron microscopic study using CeCl3
1982 • 44 citations
Ligand/receptor internalization: A kinetic, flow cytometric analysis of the internalization of N‐formyl peptides by human neutrophils
1983 • 44 citations
Micromolar concentrations of free calcium provoke secretion of lysozyme from human neutrophils permeabilized with saponin.
1985 • 43 citations
Formyl peptide chemotactic receptor. Evidence for an active proteolytic fragment.
1983 • 42 citations
Human Leukocyte Fc (IgG) Receptors: Quantitation and Affinity with Radiolabeled Affinity Cross-Linked Rabbit IgG
1979 • 39 citations
Diglyceride Kinase Activity of Microtubules
1976 • 39 citations
Ligand/receptor internalization: a spectroscopic analysis and a comparison of ligand binding, cellular response, and internalization by human neutrophils
1982 • 36 citations
Retinoids stimulate the release of superoxide by neutrophils and change their morphology
1986 • 35 citations
Competitive binding kinetics in ligand-receptor-competitor systems. Rate parameters for unlabeled ligands for the formyl peptide receptor.
1985 • 35 citations
Mechanism of action of leukotriene B4: Intracellular calcium redistribution in rabbit neutrophils
1984 • 33 citations
Characterization of the rat neutrophil formyl peptide chemotaxis receptor.
1983 • 33 citations
ATP-dependent calcium transport in plasma membrane vesicles from neutrophil leukocytes.
1983 • 31 citations
Photoaffinity labeling of the N‐formyl peptide receptor of human polymorphonuclear leukocytes
1982 • 30 citations
Kinetics of insulin binding to rat white fat cells at 15 degrees C.
1986 • 26 citations
Cytosolic free Calcium and Intracellular Calcium Stores in Neutrophils from Hypertensive Subjects
1985 • 25 citations
Isolation and reconstitution of the N‐formylpeptide receptor from HL‐60 derived neutrophils
1984 • 24 citations
Prostaglandin E2 Receptors on Human Peripheral Blood Monocytes
1985 • 23 citations
Effects of sodium on chemotactic peptide binding to polymorphonuclear leukocytes.
1985 • 22 citations
Lymphoblastoid cell supernatants increase expression of C3b receptors on human polymorphonuclear leucocytes: direct binding studies with 125I-C3b.
1984 • 22 citations
Desensitization, two-state receptors and pharmacological parameters
1983 • 21 citations
Relationship between the binding of N-formylmethionylleucylphenylalanine and the respiratory responses in human neutrophils
1983 • 20 citations
Mechanism of desensitization of neutrophil response to N-formylmethionylleucylphenylalanine by slow rate of receptor occupancy. Studies on changes in Ca2+ concentration and phosphatidylinositol turnover
1985 • 19 citations
Leukotriene B4 is an incomplete agonist for the activation of human neutrophils
1984 • 19 citations
Covalent affinity labeling, detergent solubilization, and fluid-phase characterization of the rabbit neutrophil formyl peptide chemotaxis receptor
1985 • 19 citations
Dissociation between aggregation and superoxide production in human granulocytes.
1985 • 18 citations
Transmembrane signaling: an ion-flux-independent model for signal transduction by complexed Fc receptors.
1984 • 17 citations
Intensity and kinetics of the respiratory burst of human neutrophils in relation to receptor occupancy and rate of occupation by formylmethionylleucylphenylalanine
1985 • 17 citations
Processing of the formyl peptide receptor by HL-60 cells.
1984 • 16 citations
The choice of erroneous models of hormone-receptor interactions: A consequence of illegitimate utilization of scatchard graphs
1984 • 15 citations
Autacoid andβ-adrenergic agonist modulation of N-formylmethionyl-leucyl-phenylalanine evoked lysosomal enzyme release from human neutrophils
1984 • 14 citations
Formyl peptide chemotaxis receptors on the rat neutrophil: Experimental evidence for negative cooperativity
1985 • 14 citations
Expression of beta-adrenergic receptors in synchronous and asynchronous S49 lymphoma cells. II. Relationship between receptor number and response.
1986 • 12 citations
Uncoupling of the beta-adrenergic receptor as a mechanism of in vitro neutrophil desensitization.
1984 • 11 citations
Complement-derived Chemotactic Factors
1981 • 5 citations