Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

ras GENES

1987 • 3,818 citations

Silver staining of proteins in polyacrylamide gels

1981 • 3,565 citations

A rapid, sensitive, and specific method for the determination of protein in dilute solution

1973 • 2,518 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

A ras-like protein is required for a post-Golgi event in yeast secretion

1987 • 894 citations

Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1982 • 836 citations

Diphtheria Toxin

1977 • 780 citations

ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase.

1978 • 732 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

The origin, structure, and pharmacological activity of botulinum toxin.

1981 • 637 citations

ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.

1982 • 600 citations

Identification of the predominant substrate for ADP-ribosylation by islet activating protein.

1983 • 583 citations

The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding.

1982 • 542 citations

Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.

1985 • 509 citations

Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.

1984 • 498 citations

Purification of the regulatory component of adenylate cyclase.

1980 • 497 citations

Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin.

1984 • 410 citations

Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins.

1986 • 380 citations

Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain.

1986 • 341 citations

Two roles for guanine nucleotides in the stimulus-secretion sequence of neutrophils

1986 • 339 citations

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum.

1988 • 299 citations

Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21.

1986 • 291 citations

Inhibition by islet-activating protein of a chemotactic peptide-induced early breakdown of inositol phospholipids and Ca2+ mobilization in guinea pig neutrophils.

1985 • 250 citations

Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells.

1987 • 244 citations

Clostridium botulinum type C produces a novel ADP‐ribosyltransferase distinct from botulinum C2 toxin

1987 • 238 citations

Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo

1978 • 229 citations

Two G-proteins act in series to control stimulus-secretion coupling in mast cells: use of neomycin to distinguish between G-proteins controlling polyphosphoinositide phosphodiesterase and exocytosis.

1987 • 197 citations

Purification of the major GTP-binding proteins from human placental membranes.

1986 • 190 citations

Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride. Evidence for participation of a pertussis and cholera toxin-insensitive G protein.

1987 • 188 citations

Expression of p21ras in normal and malignant human tissues: lack of association with proliferation and malignancy.

1987 • 159 citations

Chromatographic resolution and immunologic identification of the alpha 40 and alpha 41 subunits of guanine nucleotide-binding regulatory proteins from bovine brain.

1988 • 144 citations

ADP-ribosylation of transducin by islet-activation protein. Identification of asparagine as the site of ADP-ribosylation.

1984 • 137 citations

Purification and immunochemical characterization of the major pertussis‐toxin‐sensitive guanine‐nucleotide‐binding protein of bovine‐neutrophil membranes

1987 • 110 citations

ADP-ribosylation of a Mr 21,000 membrane protein by type D botulinum toxin.

1987 • 104 citations

Control of exocytosis

1987 • 98 citations

Inhibition of exocytosis in bovine adrenal medullary cells by botulinum toxin type D

1985 • 96 citations

Subcellular localization and quantitation of the major neutrophil pertussis toxin substrate, Gn.

1988 • 94 citations

Intracellular localization of N-formyl chemotactic receptor and Mg2+ dependent ATPase in human granulocytes☆

1982 • 91 citations

The presence of free G protein beta/gamma subunits in human neutrophils results in suppression of adenylate cyclase activity.

1987 • 66 citations

Identification of novel GTP-binding proteins in the human neutrophil

1988 • 59 citations

Botulinum ADP‐ribosyltransferase C3 but not botulinum neurotoxins C1 and D ADP‐ribosylates low molecular mass GTP‐binding proteins

1987 • 57 citations

Botulinum toxin types A, B and D inhibit catecholamine secretion from bovine adrenal medullary cells

1986 • 53 citations

ADP‐ribosylation of specific membrane proteins in pheochromocytoma and primary‐cultured brain cells by botulinum neurotoxins type C and D

1987 • 42 citations

Effect of botulinum D toxin on neutrophils

1988 • 9 citations