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1970 • 253,849 citations

Molecular portraits of human breast tumours

2000 • 15,445 citations

Evaluation of Factors Related to Late Recurrence - Later than 10 Years after the Initial Treatment - in Primary Breast Cancer

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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Ki67 expression in breast cancer

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Cellular survival: a play in three Akts

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Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

1998 • 2,096 citations

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1997 • 2,063 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

Caspase structure, proteolytic substrates, and function during apoptotic cell death

1999 • 1,540 citations

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

1992 • 1,496 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

2000 • 1,365 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

PIK3CA is implicated as an oncogene in ovarian cancer

1999 • 1,170 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1999 • 1,102 citations

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1998 • 1,097 citations

Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

1999 • 1,084 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

The biology of erbB-2/nue/HER-2 and its role in cancer

1994 • 975 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

1991 • 900 citations

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

2000 • 885 citations

Induction of NF-κB by the Akt/PKB kinase

1999 • 847 citations

Phosphorylation and Activation of p70 ^s6k by PDK1

1998 • 835 citations

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1995 • 831 citations

Induction of Mammary Tumors by Expression of Polyomavirus Middle T Oncogene: A Transgenic Mouse Model for Metastatic Disease

1992 • 812 citations

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

1999 • 787 citations

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

1996 • 785 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1997 • 740 citations

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

1992 • 732 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.

1997 • 698 citations

Generation of Coherent X-rays in the Water Window Using 5-Femtosecond Laser Pulses

1997 • 694 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.

1997 • 689 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

1995 • 673 citations

Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

1998 • 652 citations

Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

1999 • 650 citations

Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB

2000 • 637 citations

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 • 636 citations

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1998 • 579 citations

Regulation of G₁progression by thePTENtumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

1999 • 572 citations

Targeted disruption ofSHIPleads to hemopoietic perturbations, lung pathology, and a shortened life span

1998 • 566 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

1997 • 549 citations

The modular phosphorylation and activation of p70^s6k

1997 • 539 citations

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.

1991 • 537 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

Somatic mutations of PTEN in glioblastoma multiforme.

1997 • 526 citations

Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site

2000 • 524 citations

PTEN/MMAC1 mutations in endometrial cancers.

1997 • 517 citations

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

1995 • 492 citations

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

2000 • 487 citations

Molecular cloning and characterisation of a novel putative protein‐serine kinase related to the cAMP‐dependent and protein kinase C families

1991 • 485 citations

A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain

1997 • 481 citations

The Drosophila Gene hid Is a Direct Molecular Target of Ras-Dependent Survival Signaling

1998 • 477 citations

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

1994 • 476 citations

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.

1997 • 464 citations

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2

1999 • 440 citations

Activation of Phosphatidylinositol-3′ Kinase by Src-Family Kinase SH3 Binding to the p85 Subunit

1994 • 437 citations

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1997 • 436 citations

Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

2000 • 430 citations

p110δ, a novel phosphoinositide 3-kinase in leukocytes

1997 • 417 citations

Transformation of Chicken Cells by the Gene Encoding the Catalytic Subunit of PI 3-Kinase

1997 • 414 citations

NF-κB as a primary regulator of the stress response

1999 • 407 citations

Regulation of Bad Phosphorylation and Association with Bcl-xL by the MAPK/Erk Kinase

1999 • 385 citations

PTEN gene mutations are seen in high-grade but not in low-grade gliomas.

1997 • 383 citations

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB

1999 • 368 citations

The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

1998 • 360 citations

p70s6k function is essential for G1 progression

1993 • 348 citations

An 81 kd protein complexed with middle T antigen and pp60c-src: A possible phosphatidylinositol kinase

1987 • 346 citations

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1991 • 344 citations

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

1999 • 344 citations

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

2000 • 339 citations

Tumor Suppressor PTEN Inhibits Integrin- and Growth Factor–mediated Mitogen-activated Protein (MAP) Kinase Signaling Pathways

1998 • 336 citations

PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development

1999 • 316 citations

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: Involvement of MEK upstream of Bad phosphorylation

1998 • 308 citations

BAD Ser-155 Phosphorylation Regulates BAD/Bcl-XL Interaction and Cell Survival

2000 • 304 citations

An inositol tetrakisphosphate-containing phospholipid in activated neutrophils

1988 • 292 citations

Rsk1 mediates a MEK–MAP kinase cell survival signal

2000 • 290 citations

Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity

1998 • 279 citations

PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics.

1998 • 270 citations

Crystal structure at 2.2 Å resolution of the pleckstrin homology domain from human dynamin

1994 • 268 citations

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.

1993 • 259 citations

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

1999 • 258 citations

The Principal Rapamycin-Sensitive p70^s6k Phosphorylation Sites, T-229 and T-389, Are Differentially Regulated by Rapamycin-Insensitive Kinase Kinases

1996 • 245 citations

Structure of the pleckstrin homology domain from β-spectrin

1994 • 233 citations

Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase.

1995 • 229 citations

Cell–substrate interactions and signaling through ILK

2000 • 228 citations

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

1999 • 216 citations

Activation of p70/p85 S6 kinase by a pathway independent of p21fi ras

1994 • 207 citations

Requirement for Both Shc and Phosphatidylinositol 3′ Kinase Signaling Pathways in Polyomavirus Middle T-Mediated Mammary Tumorigenesis

1998 • 200 citations

Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q.

1998 • 199 citations

PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.

1997 • 199 citations

The conserved PI3′K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila

2000 • 193 citations

The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo

1999 • 192 citations

Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications.

1993 • 173 citations

Germline PTEN mutations in Cowden syndrome-like families.

1998 • 160 citations

Proteolytic fragments of phosphoinositide-specific phospholipase C-delta 1. Catalytic and membrane binding properties

1993 • 160 citations

A Dual Role for Src Homology 2 Domain–Containing Inositol-5-Phosphatase (Ship) in Immunity

2000 • 154 citations

GSK3: a SHAGGY frog story

1996 • 150 citations

Phosphoinositide 3-OH Kinase (PI3K) and PKB/Akt Delay the Onset of p53-mediated, Transcriptionally Dependent Apoptosis

1999 • 141 citations

Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3-Kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3

1995 • 141 citations

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinase in Vivoat Thr-412 as well as Thr-252

1999 • 138 citations

Genetic analysis of protein kinase B (AKT) in Drosophila

1998 • 138 citations

Growth factor-dependent survival of rodent fibroblasts requires phosphatidylinositol 3-kinase but is independent of pp70S6K activity.

1996 • 120 citations

The Pleckstrin Homology Domain in Insulin Receptor Substrate-1 Sensitizes Insulin Signaling

1995 • 113 citations

Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B

1998 • 111 citations

Regulation of mouse mammary gland development and tumorigenesis by the ERBB signaling network.

2001 • 110 citations

Pleckstrin homology domains: a fact file

1995 • 101 citations

Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3-Kinase

1995 • 100 citations

Signal transduction in mammary tumorigenesis: a transgenic perspective

2000 • 97 citations

Phosphatidylinositol 3-kinase binds to α-actinin through the p85 subunit

1994 • 92 citations

Oxidative Stress and Vanadate Induce Tyrosine Phosphorylation of Phosphoinositide-Dependent Kinase 1 (PDK1)

2000 • 83 citations

Cloning of a Novel, Ubiquitously Expressed Human Phosphatidylinositol 3-Kinase and Identification of Its Binding Site on p85

1993 • 66 citations

Evidence of a Role for Phosphatidylinositol 3-Kinase Activation in the Blocking of Apoptosis by Polyomavirus Middle T Antigen

1998 • 62 citations

14 Ribosomal Protein S6 Phosphorylation and Signal Transduction

1996 • 59 citations

Signal transduction pathways induced by heregulin in MDA-MB-453 breast cancer cells.

1996 • 54 citations

Protein kinases: Six degrees of separation?

2000 • 52 citations

Potent Activation of Phosphatidylinositol 3'-Kinase by Simple Phosphotyrosine Peptides Derived from Insulin Receptor Substrate 1 Containing Two YMXM Motifs for binding SH2 Domains

1994 • 48 citations

Phosphorylation of cbl after Stimulation of Nb2 Cells with Prolactin and Its Association with Phosphatidylinositol 3-Kinase

1997 • 48 citations

Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-β1 stimulation

2000 • 32 citations

Caspase Phosphorylation, Cell Death, and Species Variability

2000 • 27 citations

Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity.

1994 • 26 citations

Role of p70 S6 kinase in cytokine-regulated hemopoietic cell survival

1996 • 19 citations

Genetic Analysis of a Phosphatidylinositol 3-Kinase SH2 Domain Reveals Determinants of Specificity

1994 • 11 citations