Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Integrins and other cell adhesion molecules

1990 • 1,990 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

FIBRONECTIN AND ITS RECEPTORS

1988 • 1,336 citations

Fibronectins: multifunctional modular glycoproteins.

1982 • 1,334 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

1996 • 1,106 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

Cadherins in cancer: implications for invasion and metastasis

1993 • 939 citations

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

1995 • 763 citations

Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

1990 • 746 citations

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta.

1987 • 736 citations

Embryonic mesodermal defects in α5 integrin-deficient mice

1993 • 694 citations

Integrin cytoplasmic domains mediate inside-out signal transduction

1994 • 682 citations

Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization.

1989 • 627 citations

The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression.

1995 • 627 citations

Changes in integrin receptors on oncogenically transformed cells

1989 • 548 citations

Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway

1997 • 501 citations

Cell adhesion protein receptors as targets for transforming growth factor-$beta; action

1987 • 498 citations

The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily

1991 • 455 citations

Inside-out integrin signalling

1992 • 439 citations

Transformations between epithelium and mesenchyme: Normal, pathological, and experimentally induced

1995 • 428 citations

Integrin Activation by R-ras

1996 • 414 citations

Integrin cytoplasmic interactions and bidirectional transmembrane signalling

1996 • 396 citations

Activation of protein kinase C precedes alpha 5 beta 1 integrin-mediated cell spreading on fibronectin.

1993 • 358 citations

Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix

1995 • 349 citations

Cadherins and catenins in development

1996 • 344 citations

Interaction of the 70,000-mol-wt amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblasts.

1985 • 335 citations

Molecular nature of the calcium-dependent cell-cell adhesion system in mouse teratocarcinoma and embryonic cells studied with a monoclonal antibody

1984 • 318 citations

Cell surface receptors for extracellular matrix components

1990 • 297 citations

Beta 1 integrin-dependent and -independent polymerization of fibronectin.

1996 • 292 citations

Binding of plasma fibronectin to cell layers of human skin fibroblasts.

1983 • 289 citations

Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin.

1985 • 286 citations

Adhesion molecules in cancer: the role of integrins

1993 • 264 citations

Overexpression of the Integrin-linked Kinase Promotes Anchorage-independent Cell Cycle Progression

1997 • 259 citations

Fibronectin's cell-adhesive domain and an amino-terminal matrix assembly domain participate in its assembly into fibroblast pericellular matrix.

1987 • 255 citations

Extracellular Matrix Assembly

1988 • 250 citations

Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin.

1995 • 247 citations

Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin.

1993 • 240 citations

Inhibition of binding of fibronectin to matrix assembly sites by anti-integrin (alpha 5 beta 1) antibodies.

1990 • 231 citations

Identification of the fibronectin sequences required for assembly of a fibrillar matrix.

1991 • 213 citations

The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak

1993 • 209 citations

The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin

1993 • 188 citations

E‐cadherin as a tumor (invasion) suppressor gene

1995 • 179 citations

Phorbol ester modulation of integrin-mediated cell adhesion: a postreceptor event.

1989 • 164 citations

The alpha 5 beta 1 integrin fibronectin receptor, but not the alpha 5 cytoplasmic domain, functions in an early and essential step in fibronectin matrix assembly.

1993 • 160 citations

Assembly of extracellular matrix

1992 • 159 citations

Altered rate of fibronectin matrix assembly by deletion of the first type III repeats.

1996 • 154 citations

The fibronectin receptor is organized by extracellular matrix fibronectin: implications for oncogenic transformation and for cell recognition of fibronectin matrices.

1989 • 150 citations

Integrin Signaling and Matrix Assembly

1996 • 144 citations

Fibronectin self-association is mediated by complementary sites within the amino-terminal one-third of the molecule.

1994 • 143 citations

Isolation and characterization of Chinese hamster ovary cell variants deficient in the expression of fibronectin receptor.

1989 • 135 citations

Increased tumorigenicity of fibronectin receptor deficient Chinese hamster ovary cell variants.

1991 • 133 citations

In vivo analyses of integrin beta 1 subunit function in fibronectin matrix assembly.

1990 • 127 citations

Integrins and tumor invasion

1990 • 119 citations

Fibronectins: structure, functions and receptors

1989 • 113 citations

Fibronectin's amino-terminal matrix assembly site is located within the 29-kDa amino-terminal domain containing five type I repeats.

1988 • 108 citations

Identification of a New Biological Function for the Integrin α_vβ₃: Initiation of Fibronectin Matrix Assembly

1996 • 106 citations

Expression of β1 integrins changes during transformation of avian lens epithelium to mesenchyme in collagen gels

1994 • 99 citations

Invasion promoter versus invasion suppressor molecules: the paradigm of E-cadherin

1994 • 87 citations

the role of α4β1 integrin in cell motility and fibronectin matrix assembly

1995 • 83 citations

The bone marrow fibrosis of hairy-cell leukemia is caused by the synthesis and assembly of a fibronectin matrix by the hairy cells

1994 • 76 citations

Integrins and Adhesive Receptors in Normal and Leukemic CD34+ Progenitor Cells: Potential Regulatory Checkpoints for Cellular Traffic

1994 • 68 citations

The role of beta 1 integrins in tumors.

1993 • 55 citations

Enhanced fibronectin receptor expression in Rous sarcoma virus-induced tumors.

1988 • 52 citations

Cell surface molecules that bind fibronectin's matrix assembly domain

1991 • 46 citations

Distinct regions of human fibronectin are essential for fibril assembly in an in vivo developing system

1992 • 41 citations

Fibronectin Fibrils and Growth Factors Stimulate Anchorage-Independent Growth of a Murine Mammary Carcinoma

1996 • 35 citations

Integrins and Metastases: An Overview

1991 • 29 citations

Fibronectin and its alpha 5 beta 1 integrin receptor in malignancy.

1994 • 28 citations