Activation of p70/p85 S6 kinase by a pathway independent of p21fi ras

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

The pathway to signal achievement

1993 • 563 citations

[35] Epitope tagging and protein surveillance

1991 • 526 citations

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1988 • 470 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

Involvement of p21ras in activation of extracellular signal-regulated kinase 2

1992 • 403 citations

p70s6k function is essential for G1 progression

1993 • 348 citations

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

1994 • 303 citations

GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.

1992 • 228 citations

MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways

1991 • 208 citations

Nuclear localization of p85s6k: functional requirement for entry into S phase.

1994 • 202 citations

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.

1993 • 189 citations

The Many Roads That Lead to Ras

1993 • 185 citations

B-type receptor for platelet-derived growth factor mediates a chemotactic response by means of ligand-induced activation of the receptor protein-tyrosine kinase.

1990 • 169 citations

A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras.

1993 • 161 citations

Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk.

1992 • 156 citations

The immunosuppressant rapamycin induces inactivation of p70s6k through dephosphorylation of a novel set of sites

1993 • 112 citations

Networking with protein kinases

1993 • 62 citations

Phosphorylation of the ribosomal protein S6 is elevated in cells transformed by a variety of tumor viruses

1984 • 58 citations

Identification and early activation of a Xenopus laevis p70s6k following progesterone-induced meiotic maturation.

1992 • 53 citations