Potent Activation of Phosphatidylinositol 3'-Kinase by Simple Phosphotyrosine Peptides Derived from Insulin Receptor Substrate 1 Containing Two YMXM Motifs for binding SH2 Domains

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Evidence for the involvement of vicinal sulfhydryl groups in insulin-activated hexose transport by 3T3-L1 adipocytes.

1985 • 512 citations

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.

1993 • 452 citations

Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit

1993 • 395 citations

Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo.

1992 • 317 citations

YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase.

1992 • 170 citations

Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach.

1993 • 154 citations

Inhibition of SH2 domain/phosphoprotein association by a nonhydrolyzable phosphonopeptide

1992 • 138 citations

Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate.

1991 • 123 citations

Phosphatidyl-inositol 3-kinase: a key enzyme in diverse signalling processes

1992 • 99 citations

Mutational analysis of insulin receptor function

1993 • 79 citations

Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro.

1992 • 79 citations

Insulin signalling: the role of insulin receptor substrate 1

1994 • 76 citations

A biosensor approach to probe the structure and function of the p85 alpha subunit of the phosphatidylinositol 3-kinase complex

1993 • 52 citations

Synthesis of O‐phosphonotyrosyl peptides

1989 • 42 citations

Dot-blot hybridization: quantitative analysis with direct beta counting.

1991 • 31 citations