Signal transduction in mammary tumorigenesis: a transgenic perspective

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

The multistep nature of cancer

1993 • 1,872 citations

Risk Factors for Breast Cancer in Women with Proliferative Breast Disease

1985 • 1,817 citations

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

1992 • 1,496 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

1992 • 1,190 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

Increasing complexity of Ras signaling

1998 • 1,069 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

The biology of erbB-2/nue/HER-2 and its role in cancer

1994 • 975 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

1994 • 886 citations

Induction of Mammary Tumors by Expression of Polyomavirus Middle T Oncogene: A Transgenic Mouse Model for Metastatic Disease

1992 • 812 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1990 • 753 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.

1994 • 520 citations

Cyclin D1 protein expression and function in human breast cancer

1994 • 515 citations

CDC25 Phosphatases as Potential Human Oncogenes

1995 • 498 citations

Polyoma virus transforming protein associates with the product of the c-src cellular gene

1983 • 497 citations

A Noncatalytic Domain Conserved among Cytoplasmic Protein-Tyrosine Kinases Modifies the Kinase Function and Transforming Activity of Fujinami Sarcoma Virus P130^gag-fps

1986 • 478 citations

Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice

1990 • 447 citations

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

1999 • 445 citations

The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway

1998 • 440 citations

neu/erbB-2 amplification identifies a poor-prognosis group of women with node-negative breast cancer. Toronto Breast Cancer Study Group.

1998 • 435 citations

Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancer

1992 • 415 citations

Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3.

1995 • 407 citations

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

1989 • 395 citations

Mammalian Grb2 Regulates Multiple Steps in Embryonic Development and Malignant Transformation

1998 • 377 citations

Identification of c-erbB-3 binding sites for phosphatidylinositol 3′-kinase and SHC using an EGF receptor/c-erbB-3 chimera.

1994 • 354 citations

Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers.

1995 • 329 citations

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps.

1986 • 317 citations

Signal transduction from multiple Ras effectors

1997 • 308 citations

Involvement of pp60c-src with two major signaling pathways in human breast cancer.

1994 • 273 citations

Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.

1992 • 271 citations

The c-erbB-2 proto-oncogene as a prognostic and predictive marker in breast cancer: A paradigm for the development of other macromolecular markers-A review

1995 • 260 citations

Heterogeneity of intraductai carcinoma of the breast

1989 • 250 citations

The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer.

1994 • 246 citations

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity.

1994 • 233 citations

From Src Homology domains to other signaling modules: proposal of the `protein recognition code'

1998 • 232 citations

Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice.

1987 • 228 citations

Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice.

1994 • 203 citations

Requirement for Both Shc and Phosphatidylinositol 3′ Kinase Signaling Pathways in Polyomavirus Middle T-Mediated Mammary Tumorigenesis

1998 • 200 citations

Prognostic factors in early breast carcinoma

1994 • 199 citations

A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway.

1994 • 198 citations

The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands

1998 • 196 citations

Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc

1994 • 193 citations

Novel Activating Mutations in the neu Proto-oncogene Involved in Induction of Mammary Tumors

1994 • 188 citations

A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides

1995 • 174 citations

Association of the polyomavirus middle-T antigen with c-yes protein

1987 • 172 citations

The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites.

1993 • 165 citations

Incidence of activating ras oncogene mutations associated with primary and metastatic human breast cancer.

1989 • 158 citations

Tyrosine Phosphorylation Sites at Amino Acids 239 and 240 of Shc Are Involved in Epidermal Growth Factor-Induced Mitogenic Signaling That Is Distinct from Ras/Mitogen-Activated Protein Kinase Activation

1997 • 156 citations

Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.

1994 • 153 citations

Augmented Mitogenic Responsiveness to Epidermal Growth Factor in Murine Fibroblasts That Overexpress pp60^c-src

1988 • 147 citations

Synergistic Interaction of the Neu Proto-Oncogene Product and Transforming Growth Factor α in the Mammary Epithelium of Transgenic Mice

1996 • 146 citations

Identification and characterization of p59fyn (a src-like protein tyrosine kinase) in normal and polyoma virus transformed cells.

1988 • 145 citations

Distinct Tyrosine Autophosphorylation Sites Negatively and Positively Modulate Neu-Mediated Transformation

1997 • 143 citations

Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3-Kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3

1995 • 141 citations

Activated neu Induces Rapid Tumor Progression

1996 • 141 citations

Early and multifocal tumors in breast, salivary, Harderian and epididymal tissues developed in MMTY-Neu transgenic mice

1992 • 123 citations

Characterization of a growth factor that binds exclusively to the erbB-2 receptor and induces cellular responses.

1992 • 117 citations

Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirus.

1988 • 113 citations

Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts.

1995 • 97 citations

Ligand and p185c-neu density govern receptorinteractions and tyrosine kinase activation.

1994 • 92 citations

Regulated coupling of the Neu receptor to phosphatidylinositol 3'-kinase and its release by oncogenic activation.

1992 • 91 citations

An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice

1993 • 89 citations

p185HER2 signal transduction in breast cancer cells

1991 • 88 citations

Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src.

1988 • 87 citations

The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency.

1991 • 86 citations

Transgenic mouse models of mammary tumorigenesis.

1993 • 83 citations

Transformation by polyoma virus is drastically reduced by substitution of phenylalanine for tyrosine at residue 315 of middle-sized tumor antigen.

1984 • 83 citations

Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene.

1995 • 78 citations

Epidermal growth factor receptor status of histological sub-types of breast cancer

1988 • 72 citations

Characterization of a neu/c-erbB-2 protein-specific activating factor.

1991 • 66 citations

Tyrosine phosphatase inhibition permits analysis of signal transduction complexes in p185HER2/neu-overexpressing human tumor cells.

1992 • 58 citations

Mechanisms of transformation by polyoma virus middle T antigen

1989 • 58 citations

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity

1994 • 56 citations

Transgenic mouse models of breast cancer

1996 • 54 citations

Value of epidermal growth factor receptor status compared with growth fraction and other factors for prognosis in early breast cancer

1992 • 47 citations

Mutants of polyomavirus middle-T antigen

1987 • 46 citations

Interrupting the early region of polyoma virus DNA enhances tumorigenicity.

1979 • 45 citations

The Product of the EMS1 Gene, Amplified and Overexpressed in Human Carcinomas, is Homologous to a v-src Substrate and is Located in Cell-Substratum Contact Sites

1993 • 38 citations

Site-directed mutagenesis of polyomavirus middle-T antigen sequences encoding tyrosine 315 and tyrosine 250

1986 • 37 citations

Transport in solid oxide porous electrodes: Effect of gas diffusion

1995 • 30 citations

Polyomavirus middle T-antigen NPTY mutants

1992 • 28 citations

Mammary Tumor Cell Cycle, Differentiation, and Metastasis

1996 • 27 citations

Alterations of the c-erbB2 gene in human breast cancer

1992 • 22 citations

The erbB-2 Mitogenic Signaling Pathway: Tyrosine Phosphorylation of Phospholipase C-γ and GTPase-Activating Protein Does Not Correlate with erbB-2 Mitogenic Potency

1991 • 21 citations

Stygocyclopia Balearica, a new genus and species of calanoid copepod (Pseudocyclopiidae) from anchihaline caves in the Balearic Islands (Mediterranean)

1995 • 18 citations

Carboxyl-terminal deletion and point mutations decrease the transforming potential of the activated rat neu oncogene product.

1992 • 11 citations

Association of Signaling Proteins with a Nonmitogenic Heterodimeric Complex Composed of Epidermal Growth Factor Receptor and Kinase-Inactive p185^c-neu"

1996 • 11 citations

The Genetics of Breast Cancer

1994 • 6 citations

A nursing intervention for early detection of spinal cord compressions in patients with cancer

1993 • 4 citations

Numerical simulations of flows in centrifugal turbomachinery

1995 • 4 citations

Expression profiling of BRCA1 associated breast tumors

2000 • 2 citations