Allosteric Receptors: From Electric Organ to Cognition

A Neural Substrate of Prediction and Reward

1997 • 8,991 citations

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

A cognitive theory of consciousness

1988 • 3,565 citations

Neuronlike adaptive elements that can solve difficult learning control problems

1983 • 3,122 citations

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits^*

1966 • 2,956 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Allosteric proteins and cellular control systems

1963 • 2,187 citations

A framework for mesencephalic dopamine systems based on predictive Hebbian learning

1996 • 2,003 citations

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 • 1,736 citations

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.

1996 • 1,516 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Selective stabilisation of developing synapses as a mechanism for the specification of neuronal networks

1976 • 1,444 citations

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

1998 • 1,304 citations

Structure and gating mechanism of the acetylcholine receptor pore

2003 • 1,261 citations

A neuronal model of a global workspace in effortful cognitive tasks

1998 • 1,231 citations

A missense mutation in the neuronal nicotinic acetylcholine receptor α4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy

1995 • 1,112 citations

General Conclusions: Teleonomic Mechanisms in Cellular Metabolism, Growth, and Differentiation

1961 • 1,043 citations

Recognition Dynamics Up to Microseconds Revealed from an RDC-Derived Ubiquitin Ensemble in Solution

2008 • 1,025 citations

International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric Acid_AReceptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update

2008 • 1,008 citations

The Enzymology of Control by Feedback Inhibition

1962 • 1,003 citations

A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

1990 • 923 citations

Brain nicotinic acetylcholine receptors: native subtypes and their relevance

2006 • 838 citations

A neuronal network model linking subjective reports and objective physiological data during conscious perception

2003 • 812 citations

AXON RETRACTION AND DEGENERATION IN DEVELOPMENT AND DISEASE

2005 • 808 citations

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

Nicotinic Receptors at the Amino Acid Level

2000 • 795 citations

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1993 • 769 citations

Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

1982 • 730 citations

Brain Dynamics Underlying the Nonlinear Threshold for Access to Consciousness

2007 • 711 citations

Neuromuscular transmission in new‐born rats

1970 • 701 citations

EXTENT OF RECOVERY FROM THE EFFECTS OF VISUAL DEPRIVATION IN KITTENS

1965 • 691 citations

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

2008 • 667 citations

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

1995 • 659 citations

ISOLATION OF THE LAC REPRESSOR

1966 • 657 citations

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

2008 • 657 citations

Neural signature of the conscious processing of auditory regularities

2009 • 656 citations

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

2009 • 654 citations

Allostery and cooperativity revisited

2008 • 653 citations

Stereospecific Interaction Between Narcotic Analgesics and a Synaptic Plasma Membrane Fraction of Rat Cerebral Cortex

1973 • 650 citations

Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei.

2001 • 640 citations

Of dreaming and wakefulness

1991 • 631 citations

Receptor clustering as a cellular mechanism to control sensitivity

1998 • 617 citations

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

2005 • 617 citations

Mechanisms of cooperativity and allosteric regulation in proteins

1989 • 615 citations

Acetylcholine Receptor: Complex of Homologous Subunits

1980 • 594 citations

On the reaction of cells and of nerve‐endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari

1905 • 581 citations

Use of a Snake Venom Toxin to Characterize the Cholinergic Receptor Protein

1970 • 575 citations

Molecular and Physiological Diversity of Nicotinic Acetylcholine Receptors in the Midbrain Dopaminergic Nuclei

2001 • 574 citations

Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

1999 • 546 citations

Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors

2005 • 544 citations

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

2008 • 520 citations

Nicotinic systems and cognitive function

1992 • 519 citations

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1991 • 515 citations

Mechanisms of cooperativity and allosteric regulation in proteins

1990 • 514 citations

Subunit Composition of Functional Nicotinic Receptors in Dopaminergic Neurons Investigated with Knock-Out Mice

2003 • 504 citations

Effects of chronic nicotine infusion on tolerance development and nicotinic receptors.

1983 • 455 citations

ON THE COOPERATIVITY OF BIOLOGICAL MEMBRANES

1967 • 439 citations

Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic

1992 • 420 citations

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.

1984 • 408 citations

Biological Sciences: Isolation of the Cholinergic Receptor Protein of Torpedo Electric Tissue

1971 • 407 citations

Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities

1993 • 401 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

Large‐Scale Purification of the Acetylcholine‐Receptor Protein in Its Membrane‐Bound and Detergent‐Extracted Forms from Torpedo marmorata Electric Organ

1977 • 375 citations

Synapse Elimination and Indelible Memory

2000 • 373 citations

Reduced number of [3H]nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains

1986 • 360 citations

The Wisconsin Card Sorting Test: Theoretical Analysis and Modeling in a Neuronal Network

1991 • 346 citations

Concentration of acetylcholine receptor mRNA in synaptic regions of adult muscle fibres

1985 • 344 citations

Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems

1995 • 338 citations

On the nature of allosteric transitions: Implications of non-exclusive ligand binding

1966 • 336 citations

Complete mRNA coding sequence of the acetylcholine binding alpha-subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain.

1983 • 332 citations

Some Reflections on Visual Awareness

1990 • 329 citations

The Oxygen Equilibrium of Hemoglobin and Its Structural Interpretation

1935 • 328 citations

Ongoing Spontaneous Activity Controls Access to Consciousness: A Neuronal Model for Inattentional Blindness

2005 • 319 citations

Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel

1986 • 315 citations

Amino acids of the Torpedo marmorata acetylcholine receptor .alpha. subunit labeled by a photoaffinity ligand for the acetylcholine binding site

1988 • 314 citations

Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes

1986 • 312 citations

Crucial Role of α4 and α6 Nicotinic Acetylcholine Receptor Subunits from Ventral Tegmental Area in Systemic Nicotine Self-Administration

2008 • 309 citations

Responses of acetylcholinesterase from Torpedo marmorata to salts and curarizing drugs.

1966 • 308 citations

Ivermectin: A Positive Allosteric Effector of the α7 Neuronal Nicotinic Acetylcholine Receptor

1998 • 308 citations

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

2006 • 302 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine.

1986 • 296 citations

Identification of a GABA_AReceptor Anesthetic Binding Site at Subunit Interfaces by Photolabeling with an Etomidate Analog

2006 • 284 citations

In Vivo Regulation of [³H]Acetylcholine Recognition Sites in Brain by Nicotinic Cholinergic Drugs

1985 • 283 citations

Glycine receptors: recent insights into their structural organization and functional diversity

2006 • 283 citations

Quaternary structure of the acetylcholine receptor

1985 • 281 citations

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

2009 • 280 citations

Neural networks that learn temporal sequences by selection.

1987 • 278 citations

Hierarchical Control of Dopamine Neuron-Firing Patterns by Nicotinic Receptors

2006 • 277 citations

Ontogenesis of olivocerebellar relationships. I. Studies by intracellular recordings of the multiple innervation of Purkinje cells by climbing fibers in the developing rat cerebellum

1981 • 266 citations

Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca ²⁺ -binding sites

2002 • 262 citations

Two adjacent MyoD1-binding sites regulate expression of the acetylcholine receptor α-subunit gene

1990 • 261 citations

Value-dependent selection in the brain: Simulation in a synthetic neural model

1994 • 260 citations

Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site

2008 • 258 citations

The acetylcholine receptor: an "allosteric" membrane protein.

1979 • 256 citations

Synaptic transmission and neuronal interaction

1975 • 256 citations

A Theory of the Epigenesis of Neuronal Networks by Selective Stabilization of Synapses

1973 • 255 citations

Nicotine Upregulates Its Own Receptors through Enhanced Intracellular Maturation

2005 • 255 citations

Evidence for "preterminal" nicotinic receptors on GABAergic axons in the rat interpeduncular nucleus

1993 • 255 citations

In Vitro excitation of purified membrane fragments by cholinergic agonists

1971 • 250 citations

Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites.

1990 • 247 citations

Requirement of the nicotinic acetylcholine receptor β2 subunit for the anatomical and functional development of the visual system

2001 • 246 citations

The Acetylcholine Receptor

1973 • 245 citations

Nicotinic and muscarinic modulations of excitatory synaptic transmission in the rat prefrontal cortexin vitro

1993 • 244 citations

Allosteric modulation of nicotinic acetylcholine receptors

2007 • 243 citations

The Feedback Control Mechanism of Biosynthetic L-Threonine Deaminase by L-Isoleucine

1961 • 243 citations

Affinity-labeling of purified acetylcholine receptor from Torpedo californica

1974 • 243 citations

Purification and Properties of the Cholinergic Receptor Protein from Electrophorus electricus Electric Tissue

1974 • 238 citations

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.

1992 • 238 citations

The 5-HT3 receptor – the relationship between structure and function

2008 • 238 citations

Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels.

2004 • 237 citations

Effects of blocking sulfhydryl groups and of reducing disulfide bonds on the acetylcholine-activated permeability system of the electroplax

1966 • 237 citations

Acetylcholinesterase: How is structure related to function?

2008 • 229 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the .beta. and .delta. chains

1987 • 228 citations

Working memory, response selection, and effortful processing in rats with medial prefrontal lesions.

1994 • 227 citations

Allosteric interactions in aspartate transcarbamylase. I. Binding of specific ligands to the native enzyme and its isolated subunits

1968 • 219 citations

Detection of the nicotinic acetylcholine receptor alpha-subunit mRNA by in situ hybridization at neuromuscular junctions of 15-day-old chick striated muscles.

1988 • 217 citations

Translation of exogenous messenger RNA coding for nicotinic acetylcholine receptors produces functional receptors in Xenopus oocytes

1982 • 217 citations

Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata

1973 • 212 citations

Calcitonin gene-related peptide enhances the rate of desensitization of the nicotinic acetylcholine receptor in cultured mouse muscle cells.

1988 • 208 citations

Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors

1999 • 207 citations

Abnormal Functional Organization in the Dorsal Lateral Geniculate Nucleus of Mice Lacking the β2 Subunit of the Nicotinic Acetylcholine Receptor

2003 • 204 citations

Ligand-gated ion channels: mechanisms underlying ion selectivity

2003 • 196 citations

Existence of different subtypes of nicotinic acetylcholine receptors in the rat habenulo-interpeduncular system

1991 • 193 citations

Alpha 5, alpha 3, and non-alpha 3. Three clustered avian genes encoding neuronal nicotinic acetylcholine receptor-related subunits.

1990 • 191 citations

Potentiation of nicotinic receptor response by external calcium in rat central neurons

1992 • 191 citations

Working memory, response selection, and effortful processing in rats with medial prefrontal lesions.

1994 • 190 citations

Normal Mode Analysis Suggests a Quaternary Twist Model for the Nicotinic Receptor Gating Mechanism

2005 • 187 citations

The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.

1990 • 186 citations

Progress in the purification of the cholinergic receptor protein from Electrophorus electricus by affinity chromatography

1972 • 186 citations

Consequences of tenotomy on the evolution of multiineervation in developing rat soleus muscle

1975 • 183 citations

Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica

1977 • 183 citations

Fast Kinetic Studies on the Interaction of a Fluorescent Agonist with the Membrane‐Bound Acetylcholine Receptor from Torpedo marmorata

1979 • 183 citations

Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons

1999 • 181 citations

A hierarchical neuronal network for planning behavior

1997 • 178 citations

Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?

2007 • 173 citations

Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor.

1996 • 173 citations

Regulation of binding properties of the nicotinic receptor protein by cholinergic ligands in membrane fragments from Torpedo marmorata.

1975 • 169 citations

Nicotinic control of axon excitability regulates thalamocortical transmission

2007 • 166 citations

Spontaneous openings of the acetylcholine receptor channel.

1984 • 162 citations

Mutational Analysis of the Charge Selectivity Filter of the α7 Nicotinic Acetylcholine Receptor

1999 • 161 citations

An isolated single electroplax preparation I. New data on the effect of acetylcholine and related compounds

1957 • 160 citations

Purification fromTorpedo marmorata electric tissue of membrane fragments particularly rich in cholinergic receptor protein

1972 • 160 citations

Executive and social behaviors under nicotinic receptor regulation

2003 • 160 citations

On the excitability and cooperativity of the electroplax membrane.

1968 • 159 citations

Presynaptic ionotropic receptors

1996 • 159 citations

Reduction and specific alkylation of the receptor for acetylcholine.

1968 • 158 citations

Isolation of the nicotinic acetylcholine receptor by biospecific chromatography on insolubilized Naja naja neurotoxin

1972 • 156 citations

Implication of a multisubunit Ets-related transcription factor in synaptic expression of the nicotinic acetylcholine receptor

1998 • 153 citations

Binding of Naja nigricollis (3H)alpha-toxin to membrane fragments from Electrophorus and Torpedo electric organs. II. Effect of cholinergic agonists and antagonists on the binding of the tritiated alpha-neurotoxin.

1974 • 148 citations

Localization of nicotinic acetylcholine receptor alpha-subunit transcripts during myogenesis and motor endplate development in the chick.

1989 • 146 citations

Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin

2008 • 145 citations

Kinetics of agonist-mediated transitions in state of the cholinergic receptor.

1977 • 143 citations

Allosteric Interactions in Aspartate Transcarbamylase. III. Interpretation of Experimental Data in Terms of the Model of Monod, Wyman, and Changeux

1968 • 143 citations

Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia

2008 • 141 citations

Golgi apparatus in chick skeletal muscle: changes in its distribution during end plate development and after denervation.

1989 • 140 citations

Nicotinic and muscarinic receptors in the rat prefrontal cortex: Differential roles in working memory, response selection and effortful processing

1995 • 140 citations

Fractionation and partial characterization of membrane particles from Torpedo californica electroplax

1973 • 134 citations

A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions

1996 • 134 citations

The neuron-restrictive silencer element: A dual enhancer/silencer crucial for patterned expression of a nicotinic receptor gene in the brain

1997 • 134 citations

Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function

2005 • 134 citations

Membranes Rich in Acetylcholine Receptor: Characterization and Reconstitution to Excitable Membranes from Exogenous Lipids

1978 • 132 citations

Conversion of the Ion Selectivity of the 5-HT3AReceptor from Cationic to Anionic Reveals a Conserved Feature of the Ligand-gated Ion Channel Superfamily

2001 • 127 citations

A Neuronal Model of a Global Workspace in Effortful Cognitive Tasks

2001 • 125 citations

A Simple Model of Prefrontal Cortex Function in Delayed-Response Tasks

1989 • 124 citations

Molecular genetics and animal models in autistic disorder

2002 • 122 citations

In vitro phosphorylation of the acetylcholine receptor

1977 • 122 citations

Experimentally based model of a complex between a snake toxin and the α7 nicotinic receptor

2002 • 119 citations

Nicotine activates immature “silent” connections in the developing hippocampus

2003 • 115 citations

Effects of inhibitors of the binding of iodinated alpha-bungarotoxin to acetylcholine receptors in rat muscle.

1976 • 115 citations

Ultraviolet light-induced labeling by noncompetitive blockers of the acetylcholine receptor from Torpedo marmorata.

1981 • 113 citations

Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ

1976 • 113 citations

Evolution of allosteric models for hemoglobin

2007 • 110 citations

Interaction of the Acetylcholine (Nicotinic) Receptor Protein from Torpedo marmorata Electric Organ with Monolayers of Pure Lipids

1978 • 109 citations

Effects of local anesthetics and calcium on the interaction of cholinergic ligands with the nicotinic receptor protein from Torpedo marmorata.

1974 • 108 citations

Rapid kinetics of agonist binding and permeability response analyzed in parallel on acetylcholine receptor rich membranes from Torpedo marmorata

1983 • 108 citations

Channel Opening Motion of α7 Nicotinic Acetylcholine Receptor as Suggested by Normal Mode Analysis

2005 • 108 citations

A novel type of nicotinic receptor in the rat central nervous system characterized by patch-clamp techniques

1990 • 107 citations

Nicotinic receptors, allosteric proteins and medicine

2008 • 106 citations

Structural Mechanisms Underlying Benzodiazepine Modulation of the GABA_AReceptor

2008 • 105 citations

The Croonian Lecture 2000. Nicotinic acetylcholine receptor and the structural basis of fast synaptic transmission,Lecture delivered 5 October 2000 at University College London

2000 • 105 citations

The reaction site of a non-competitive antagonist in the delta-subunit of the nicotinic acetylcholine receptor.

1986 • 104 citations

Critical Elements Determining Diversity in Agonist Binding and Desensitization of Neuronal Nicotinic Acetylcholine Receptors

1998 • 104 citations

Molecular cloning of cDNA coding for the gamma subunit of Torpedo acetylcholine receptor.

1982 • 102 citations

Long-term effects of chronic nicotine exposure on brain nicotinic receptors

2007 • 102 citations

Fast Kinetic Studies on the Allosteric Interactions between Acetylcholine Receptor and Local Anesthetic Binding Sites

1979 • 102 citations

Identification of a DNA element determining synaptic expression of the mouse acetylcholine receptor delta-subunit gene.

1995 • 101 citations

Improved Secondary Structure Predictions for a Nicotinic Receptor Subunit: Incorporation of Solvent Accessibility and Experimental Data into a Two-Dimensional Representation

1999 • 100 citations

Consequences of blocking the nerve with a local anaesthetic on the evolution of multiinnervation at the regenerating neuromuscular junction of the rat

1978 • 100 citations

Positive Allosteric Modulation of the α7 Nicotinic Acetylcholine Receptor: Ligand Interactions with Distinct Binding Sites and Evidence for a Prominent Role of the M2-M3 Segment

2008 • 100 citations

Nicotinic Acetylcholine Receptors: From Molecular Biology to Cognition

2005 • 97 citations

Unliganded gating of acetylcholine receptor channels

2008 • 97 citations

Modes of actions of purified toxins from elapid venoms on neuromuscular transmission.

1966 • 97 citations

T and R states in the crystals of bacterial L–lactate dehydrogenase reveal the mechanism for allosteric control

1994 • 96 citations

A solution NMR study showing that active site ligands and nucleotides directly perturb the allosteric equilibrium in aspartate transcarbamoylase

2007 • 95 citations

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors

2006 • 94 citations

Molecular weight and quaternary structure of the cholinergic receptor protein extracted by detergents from Electrophorus electricus electric tissue

1973 • 92 citations

Interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from Torpedomarmorata in the millisecond time range: Resolution of an “intermediate” conformational transition and evidence for positive cooperative effects

1980 • 90 citations

Localization of the cholinergic receptor protein inElectrophoruselectroplax by high resolution autoradiography

1972 • 89 citations

Affinity labeling of the acetylcholine-receptor.

1967 • 87 citations

Use of affinity chromatography for acetylcholine receptor purification

1972 • 87 citations

Compartmentalization of cold-stable and acetylated microtubules in the subsynaptic domain of chick skeletal muscle fibre

1990 • 87 citations

Smoking impacts on prefrontal attentional network function in young adult brains

2006 • 86 citations

Time-resolved photolabeling by the noncompetitive blocker chlorpromazine of the acetylcholine receptor in its transiently open and closed ion channel conformations.

1984 • 83 citations

β2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered breathing after nicotine exposure

2002 • 83 citations

A Study on the Motion Of Protenis in Excitable Membrane Fragment by Nanosecond Fluorescence Polarization Spectroscopy

1971 • 82 citations

A neurocomputational hypothesis for nicotine addiction

2006 • 81 citations

Ontogenesis of olivocerebellar relationships. II. Spontaneous activity of inferior olivary neurons and climbing fibermediated activity of cerebellar Purkinje cells in developing rats

1981 • 79 citations

An Extracellular Protein Microdomain Controls Up-regulation of Neuronal Nicotinic Acetylcholine Receptors by Nicotine

2004 • 79 citations

Crosslinking of α‐bungarotoxin to the acetylcholine receptor from Torpedo marmorata by ultraviolet light irradiation

1982 • 79 citations

In vivo and in vitro analysis of electricalactivity-dependent expression of muscle acetylcholine receptor genes usingadenovirus.

1994 • 78 citations

Cholinergic Binding Capacity of Proteolipids from Isolated Nerve-Ending Membranes

1967 • 77 citations

Differential nicotinic regulation of the nigrostriatal and mesolimbic dopaminergic pathways: Implications for drug development

2006 • 77 citations

Fast Kinetic Studies on the Interaction of Cholinergic Agonists with the Membrane-Bound Acetylcholine Receptor from Torpedo marmorata as Revealed by Quinacrine Fluorescence

1977 • 76 citations

Interplay of β2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion

2008 • 75 citations

Pharmacological profile of nicotinic acetylcholine receptors in the rat prefrontal cortex: An electrophysiological study in a slice preparation

1989 • 75 citations

Pore conformations and gating mechanism of a Cys-loop receptor

2005 • 71 citations

Interaction of a fluorescent ligand with membrane-bound cholinergic receptor from Torpedo marmorata

1973 • 71 citations

Skeletal muscle acetylcholine receptor. Purification, characterization, and turnover in muscle cell cultures.

1978 • 67 citations

Fishing for allosteric sites on GABAA receptors

2004 • 66 citations

Binding of Naja nigricollis (3H)alpha-toxin to membrane fragments from Electrophorus and Torpedo electric organs. 3. Effects of local anaesthetics on the binding of the tritiated alpha-neurotoxin.

1974 • 65 citations

Congenital Myasthenic Syndromes

2005 • 61 citations

The Mode of Action of Acetylcholine: A Theory Extended to a Hypothesis on the Mode of Action of other Biologically Active Substances.

1953 • 60 citations

Selective labeling of the .delta. subunit of the acetylcholine receptor by a covalent local anesthetic

1981 • 60 citations

The amino‐terminal sequence of the 40 000 molecular weight subunit of the acetylcholine receptor protein from Torpedo marmorata

1979 • 58 citations

Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ

1976 • 57 citations

Identification of a cDNA clone coding for the acetylcholine binding subunit of Torpedo marmorata acetylcholine receptor.

1982 • 56 citations

Characterization of the transient agonist-triggered state of the acetylcholine receptor rapidly labeled by the noncompetitive blocker [3H]chlorpromazine: additional evidence for the open channel conformation

1986 • 56 citations

In vitro interaction of 1-anilino 8-naphtalene sulfonate with excitable membranes isolated from the electric organ of Electrophorus electricus

1969 • 55 citations

Opiate receptors and beyond: 30 years of neural signaling research

2004 • 50 citations

Synthesis of acetylcholine receptor during differentiation of cultured embryonic muscle cells.

1975 • 47 citations

Changes in extrinsic fluorescence intensity of the electroplax membrane during electrical excitation

1971 • 45 citations

Interaction of Curare and Related Substances with Acetylcholine Receptor-Like Protein

1959 • 42 citations

Quantitative studies on the localization of the cholinergic receptor protein in the normal and denervated electroplaque from Electrophorus electricus.

1978 • 40 citations

Negative regulatory elements upstream of a novel exon of the neuronal nicotinic acetylcholine receptor α2 subunit gene

1993 • 39 citations

The Neuronal Workspace Model: Conscious Processing and Learning

2008 • 38 citations

STUDIES ON THE MECHANISM OF CURARIZATION*

1959 • 38 citations

Isolation and Purification of the Nicotinic Acetylcholine Receptor and Its Functional Reconstitution into a Membrane Environment

1977 • 37 citations

X‐ray diffraction study of membrane fragments rich in acetylcholine receptor protein prepared from the electric organ of Torpedo Marmorata

1974 • 37 citations

Acetylcholine and Nerve Activity

1964 • 34 citations

Inhibition Mechanism of the Acetylcholine Receptor by α-Neurotoxins as Revealed by Normal-Mode Dynamics

2008 • 33 citations

Evidence for degradation of the acetylcholine (nicotinic) receptor in skeletal muscle during the development of the chick embryo

1977 • 31 citations

Stability of multiple innervation of Purkinje cells by climbing fibers in the agranular cerebellum of old rats X-irradiated at birth

1984 • 31 citations

Mechanism of Cl- Selection by a Glutamate-gated Chloride (GluCl) Receptor Revealed through Mutations in the Selectivity Filter

2006 • 31 citations

The Ferrier Lecture 1998 The molecular biology of consciousness investigated with genetically modified mice

2006 • 30 citations

[Extraction from electric tissue of gymnotus of a protein presenting several typical properties characteristic of the physiological receptor of acetylcholine].

1970 • 25 citations

Distinction between the active sites of acetylcholine-receptor and acetylcholinesterase.

1967 • 21 citations

Interaction of a spin-labeled long chain acylcholine with the cholinergic receptor protein in its membrane environment.

1975 • 20 citations

Charge Scan Reveals an Extended Region at the Intracellular End of the GABA Receptor Pore that Can Influence Ion Selectivity

2007 • 19 citations

Myasthenic nicotinic receptor mutant interpreted in terms of the allosteric model

1997 • 17 citations

Sevoflurane Anesthesia Alters Exploratory and Anxiety-like Behavior in Mice Lacking the β2Nicotinic Acetylcholine Receptor Subunit

2008 • 17 citations

[Separation of excitable membranes from the electric organ of Electrophorus electricus].

1969 • 15 citations

[Molecular model of the regulation of chemical synapse efficiency at the postsynaptic level].

1982 • 15 citations

Le cerveau et l'événement

1972 • 11 citations

[Separation of the receptor protein of acetylcholine and acetylcholinesterase].

1971 • 11 citations

[ON THE ALLOSTERIC PROPERTIES OF L-THREONINE DEAMINASE. I. METHODS OF STUDYING BIOSYNTHETIC L-THREONINE DEAMINASE].

1964 • 8 citations

[Effects of chronic paralysis of chick embryo by flaxedil on the development of the neuromuscular junction].

1978 • 5 citations

[The high affinity binding site for chlorpromazine is present only as a single copy per cholinergic receptor molecule and is shared by four polypeptide chains].

1982 • 5 citations

[Selective stabilization of neuronal representations by resonance between spontaneous prerepresentations of the cerebral network and percepts evoked by interaction with the outside world].

1984 • 3 citations

[Structural transitions of the Torpedo cholinergic receptor in its membrane state as demonstrated by a fluorescent local anesthetic: quinacrine].

1975 • 1 citations

[Electrophysiology of the cerebellar cortex in the staggerer mutant mouse].

1974 • 1 citations

[Perfecting an apparatus allowing to measure changes of extrinsic fluorescence intensit y associated with electric excitation of electroplaque isolated from gymnotus].

1970 • 1 citations