An Extracellular Protein Microdomain Controls Up-regulation of Neuronal Nicotinic Acetylcholine Receptors by Nicotine

Comparative Protein Modelling by Satisfaction of Spatial Restraints

1993 • 12,640 citations

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

1997 • 10,943 citations

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

1998 • 10,251 citations

RASMOL: biomolecular graphics for all

1995 • 2,601 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 • 1,736 citations

Mortality from tobacco in developed countries: indirect estimation from national vital statistics

1992 • 1,416 citations

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

1998 • 1,304 citations

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.

1992 • 858 citations

Long-Term Potentiation of Excitatory Inputs to Brain Reward Areas by Nicotine

2000 • 715 citations

Molecular and Cellular Aspects of Nicotine Abuse

1996 • 605 citations

Evidence that Tobacco Smoking Increases the Density of (−)‐[³H]Nicotine Binding Sites in Human Brain

1988 • 554 citations

Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment

1992 • 540 citations

Allosteric Receptors after 30 Years

1998 • 430 citations

Alternate Stoichiometries of α4β2 Nicotinic Acetylcholine Receptors

2003 • 406 citations

Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover.

1994 • 381 citations

Chronic Exposure to Nicotine Upregulates the Human α4β2 Nicotinic Acetylcholine Receptor Function

2001 • 355 citations

Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies.

1999 • 353 citations

Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca ²⁺ -binding sites

2002 • 262 citations

Nicotine addiction: the possible role of functional upregulation

2002 • 247 citations

Upregulation of surface alpha4beta2 nicotinic receptors is initiated by receptor desensitization after chronic exposure to nicotine.

1999 • 238 citations

Upregulation of Surface α4β2 Nicotinic Receptors Is Initiated by Receptor Desensitization after Chronic Exposure to Nicotine

1999 • 194 citations

Tobacco—the growing epidemic

1999 • 188 citations

Chronic Nicotine Treatment Up-regulates Human α3β2 but Not α3β4 Acetylcholine Receptors Stably Transfected in Human Embryonic Kidney Cells

1998 • 184 citations

Chronic Nicotine Treatment Up-Regulates α3 and α7 Acetylcholine Receptor Subtypes Expressed by the Human Neuroblastoma Cell Line SH-SY5Y

1997 • 184 citations

Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor.

1996 • 172 citations

Neuronal nicotinic receptor beta2 and beta4 subunits confer large differences in agonist binding affinity.

1998 • 166 citations

Neuronal Nicotinic Receptor β2 and β4 Subunits Confer Large Differences in Agonist Binding Affinity

1998 • 153 citations

Subtype-Selective Up-Regulation by Chronic Nicotine of High-Affinity Nicotinic Receptors in Rat Brain Demonstrated by Receptor Autoradiography

2003 • 151 citations

Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition.

1998 • 150 citations

Regulation of Human α4β2 Neuronal Nicotinic Acetylcholine Receptors by Cholinergic Channel Ligands and Second Messenger Pathways

1997 • 131 citations

Molecular determinants of glycine receptor subunit assembly

1999 • 127 citations

Effects of chronic nicotine treatment on expression of diverse nicotinic acetylcholine receptor subtypes. I. Dose- and time-dependent effects of nicotine treatment.

1998 • 126 citations

Dose‐Response Relationship for Nicotine‐Induced Up‐Regulation of Rat Brain Nicotinic Receptors

1997 • 120 citations

Critical Elements Determining Diversity in Agonist Binding and Desensitization of Neuronal Nicotinic Acetylcholine Receptors

1998 • 104 citations

Identification of Amino Acids Contributing to High and Low Affinity d-Tubocurarine Sites in the TorpedoNicotinic Acetylcholine Receptor

1997 • 97 citations

Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor

1995 • 95 citations

The Role of the Cystine Loop in Acetylcholine Receptor Assembly

1997 • 87 citations

Evidence for Functional Activity of Up‐Regulated Nicotine Binding Sites in Rat Striatal Synaptosomes

1990 • 85 citations

Imidacloprid, Thiacloprid, and Their Imine Derivatives Up-Regulate the α4β2 Nicotinic Acetylcholine Receptor in M10 Cells

2000 • 85 citations

Sustained Nicotine Exposure Differentially Affects α3β2 and α4β2 Neuronal Nicotinic Receptors Expressed in Xenopus Oocytes

1996 • 84 citations

Up-regulation of human α7 nicotinic receptors by chronic treatment with activator and antagonist ligands

1998 • 77 citations

Alternate Use of Distinct Intersubunit Contacts Controls GABA_AReceptor Assembly and Stoichiometry

2001 • 75 citations

Identification of two amino acid residues in the ϵ subunit that promote mammalian muscle acetylcholine receptor assembly in COS cells

1991 • 75 citations

Changes in Conformation and Subcellular Distribution of α4β2 Nicotinic Acetylcholine Receptors Revealed by Chronic Nicotine Treatment and Expression of Subunit Chimeras

2002 • 74 citations

Regulation of Brain Nicotinic Receptors by Chronic Agonist Infusion

1991 • 59 citations

Identification of tryptophan 55 as the primary site of [³H]nicotine photoincorporation in the γ‐subunit of the Torpedo nicotinic acetylcholine receptor

1998 • 53 citations

Regulation of Nicotinic Receptor Subtypes Following Chronic Nicotinic Agonist Exposure in M10 and SH‐SY5Y Neuroblastoma Cells

1998 • 46 citations

Desensitization of Neuronal Nicotinic Acetylcholine Receptors Conferred by N-Terminal Segments of the β2 Subunit

2001 • 42 citations

Acetylcholine receptor extracellular domain determines sensitivity to nicotine-induced inactivation

2000 • 40 citations

Regulation of α4β2 nicotinic acetylcholine receptors in M10 cells following treatment with nicotinic agents

1995 • 35 citations

Altered Glycosylation Sites of the δ Subunit of the Acetylcholine Receptor (AChR) Reduce αδ Association and Receptor Assembly

1999 • 29 citations