Acetylcholinesterase: How is structure related to function?

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

The α/β hydrolase fold

1992 • 2,024 citations

Crystal Structure of Human Butyrylcholinesterase and of Its Complexes with Substrate and Products

2003 • 768 citations

Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium.

1988 • 706 citations

Sulfonyl Fluorides as Inhibitors of Esterases. I. Rates of Reaction with Acetylcholinesterase, α-Chymotrypsin, and Trypsin

1963 • 646 citations

Acetylcholine Binding by a Synthetic Receptor: Implications for Biological Recognition

1990 • 608 citations

Relationship between sequence conservation and three‐dimensional structure in a large family of esterases, lipases, and related proteins

1993 • 570 citations

Dichlorophenyl phosphoramidates as substrates for avian and mammalian liver phosphotriesterases: activity levels, calcium dependence and stereospecificity

1999 • 547 citations

Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidum

1991 • 534 citations

The X-ray Structure of a Transition State Analog Complex Reveals the Molecular Origins of the Catalytic Power and Substrate Specificity of Acetylcholinesterase

1996 • 360 citations

Structure of acetylcholinesterase complexed with the nootropic alkaloid, (–)-huperzine A

1997 • 360 citations

Acetylcholinesterase inhibition by fasciculin: Crystal structure of the complex

1995 • 347 citations

On the Self-Diffusion of Ions in a Polyelectrolyte Solution

1962 • 316 citations

Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine^,

2002 • 305 citations

Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

2000 • 302 citations

Three‐dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors

2000 • 290 citations

Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis.

1992 • 286 citations

Structure of acetylcholinesterase complexed with (−)‐galanthamine at 2.3 Å resolution

1999 • 284 citations

Crystal Structures of Aged Phosphonylated Acetylcholinesterase: Nerve Agent Reaction Products at the Atomic Level^,

1999 • 268 citations

Open "Back Door" in a Molecular Dynamics Simulation of Acetylcholinesterase

1994 • 259 citations

CHOLINESTERASES IN THE BLOOD OF MAN

1940 • 256 citations

An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase.

1993 • 253 citations

Structural insights into substrate traffic and inhibition in acetylcholinesterase

2006 • 178 citations

Energetic origins of specificity of ligand binding in an interior nonpolar cavity of T4 lysozyme

1995 • 176 citations

Structure and dynamics of the active site gorge of acetylcholinesterase: Synergistic use of molecular dynamics simulation and X‐ray crystallography

1994 • 170 citations

Molecular Dynamics of Acetylcholinesterase Dimer Complexed with Tacrine

1997 • 151 citations

Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica 1 1Edited by R. Huber

2000 • 141 citations

Substrate and Product Trafficking through the Active Center Gorge of Acetylcholinesterase Analyzed by Crystallography and Equilibrium Binding

2006 • 130 citations

Anionic subsites of the acetylcholinesterase from Torpedo californica: affinity labelling with the cationic reagent N,N-dimethyl-2-phenyl-aziridinium.

1990 • 111 citations

Is myosin a "back door" enzyme?

1995 • 111 citations

Metabolism and function of the nerve cell.

1953 • 110 citations

Access of ligands to cavities within the core of a protein is rapid

1996 • 105 citations

The Role of the Peripheral Anionic Site and Cation−π Interactions in the Ligand Penetration of the Human AChE Gorge

2005 • 96 citations

Flexibility and Ligand Exchange in a Buried Cavity Mutant of T4 Lysozyme Studied by Multinuclear NMR

2000 • 93 citations

Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase.

1994 • 91 citations

How Does Huperzine A Enter and Leave the Binding Gorge of Acetylcholinesterase? Steered Molecular Dynamics Simulations

2003 • 90 citations

Allosteric Control of Acetylcholinesterase Catalysis by Fasciculin

1995 • 79 citations

The action of phenylmethylsulfonyl fluoride on human acetylcholinesterase, chymotyrpsin and trypsin.

1969 • 78 citations

External and internal electrostatic potentials of cholinesterase models

1997 • 72 citations

Does “Butyrylization” of Acetylcholinesterase through Substitution of the Six Divergent Aromatic Amino Acids in the Active Center Gorge Generate an Enzyme Mimic of Butyrylcholinesterase?

2001 • 71 citations

Pharmacological evaluation of phenyl-carbamates as CNS-selective acetylcholinesterase inhibitors.

1994 • 65 citations

Site‐directed mutants designed to test back‐door hypotheses of acetylcholinesterase function

1996 • 63 citations

A Modular Treatment of Molecular Traffic Through the Active Site of Cholinesterase

1999 • 59 citations

Dynamic Mechanism of E2020 Binding to Acetylcholinesterase: A Steered Molecular Dynamics Simulation

2005 • 58 citations

The “back door” hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis.

1994 • 56 citations

Molecular Dynamics Analysis of Structural Factors Influencing Back Door Pi Release in Myosin

2004 • 53 citations

Use of a `caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography

2007 • 45 citations

Kinetic analysis of differences in brain acetylcholinesterase from fish or mammalian sources

1978 • 45 citations

The Hydration of the Neurotransmitter Acetylcholine in Aqueous Solution

2006 • 44 citations

Selective Adsorption of Poly(ethylene oxide) onto a Charged Surface Mediated by Alkali Metal Ions

2007 • 43 citations

Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate

2004 • 42 citations

Reversibly Bound and Covalently Attached Ligands Induce Conformational Changes in the Omega Loop, Cys69–Cys96, of Mouse Acetylcholinesterase

2001 • 40 citations

The Dynamics of Ligand Barrier Crossing inside the Acetylcholinesterase Gorge

2003 • 40 citations

Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl fluoride.

2000 • 38 citations

Induced Fit in Mouse Acetylcholinesterase upon Binding a Femtomolar Inhibitor: A Molecular Dynamics Study

2005 • 19 citations

Efficient product clearance through exit channels in substrate hydrolysis by acetylcholinesterase

1994 • 15 citations

(21) Measuring carbamoylation and decarbamoylation rate constants by continuous assay of AChE

2005 • 11 citations

Preface

2005 • 4 citations