Improved Secondary Structure Predictions for a Nicotinic Receptor Subunit: Incorporation of Solvent Accessibility and Experimental Data into a Two-Dimensional Representation

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

1997 • 38,984 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

The Structure of the Potassium Channel: Molecular Basis of K ⁺ Conduction and Selectivity

1998 • 6,595 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Prediction of Protein Secondary Structure at Better than 70% Accuracy

1993 • 2,958 citations

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

1979 • 2,930 citations

A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure

1991 • 2,629 citations

The relation between the divergence of sequence and structure in proteins.

1986 • 2,373 citations

Tmbase-A database of membrane spanning protein segments

1993 • 2,294 citations

GABA_A Receptor Channels

1994 • 1,948 citations

SOSUI: classification and secondary structure prediction system for membrane proteins.

1998 • 1,907 citations

Membrane protein structure prediction

1992 • 1,680 citations

Database of homology‐derived protein structures and the structural meaning of sequence alignment

1991 • 1,641 citations

Combining evolutionary information and neural networks to predict protein secondary structure

1994 • 1,471 citations

Prediction of transmembrane alpha-helices in prokaryotic membrane proteins: the dense alignment surface method

1997 • 1,043 citations

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Structural homology of Torpedo californica acetylcholine receptor subunits

1983 • 798 citations

Transmembrane helices predicted at 95% accuracy

1995 • 669 citations

Conservation and prediction of solvent accessibility in protein families

1994 • 646 citations

Further developments of protein secondary structure prediction using information theory

1987 • 573 citations

Evolutionary history of the ligand-gated ion-channel superfamily of receptors

1995 • 535 citations

Improved prediction of protein secondary structure by use of sequence profiles and neural networks.

1993 • 525 citations

Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor.

1984 • 513 citations

Identification and application of the concepts important for accurate and reliable protein secondary structure prediction

1996 • 463 citations

Allosteric Receptors after 30 Years

1998 • 430 citations

Quaternary Structure of the Native GABA_A Receptor Determined by Electron Microscopic Image Analysis

1994 • 423 citations

Molecular evolution of the nicotinic acetylcholine receptor: An example of multigene family in excitable cells

1995 • 422 citations

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the α subunit

1994 • 418 citations

Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor gamma subunit.

1983 • 412 citations

Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities

1993 • 401 citations

Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.

1988 • 388 citations

Incorporation of non-local interactions in protein secondary structure prediction from the amino acid sequence

1996 • 378 citations

Seventy-five percent accuracy in protein secondary structure prediction

1997 • 377 citations

How good are predictions of protein secondary structure?

1983 • 375 citations

Nicotinic receptor of acetylcholine: structure of an oligomeric integral membrane protein

1984 • 373 citations

Complete mRNA coding sequence of the acetylcholine binding alpha-subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain.

1983 • 332 citations

Amino acids of the Torpedo marmorata acetylcholine receptor .alpha. subunit labeled by a photoaffinity ligand for the acetylcholine binding site

1988 • 314 citations

Prediction of Protein Secondary Structure by Combining Nearest-neighbor Algorithms and Multiple Sequence Alignments

1995 • 306 citations

An algorithm for secondary structure determination in proteins based on sequence similarity

1986 • 305 citations

Refined Structure of Escherichia coli Heat-labile Enterotoxin, a Close Relative of Cholera Toxin

1993 • 299 citations

Neurotransmitter action: Opening of ligand-gated ion channels

1993 • 267 citations

Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites.

1990 • 247 citations

Ion channel of acetylcholine receptor reconstructed from images of postsynaptic membranes

1988 • 247 citations

GABAc receptors

1995 • 243 citations

Genes expressed in the brain define three distinct neuronal nicotinic acetylcholine receptors.

1988 • 232 citations

Hybrid system for protein secondary structure prediction

1992 • 230 citations

Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata

1973 • 212 citations

Identifying the Lipid-Protein Interface of the Torpedo Nicotinic Acetylcholine Receptor: Secondary Structure Implications

1994 • 200 citations

Secondary structure prediction: combination of three different methods

1988 • 199 citations

The Emerging Three‐Dimensional Structure of a Receptor

1996 • 197 citations

Neurotransmitter-gated ion channels as unconventional allosteric proteins

1994 • 197 citations

Three-dimensional structure of the acetylcholine receptor by cryoelectron microscopy and helical image reconstruction.

1990 • 197 citations

The Location of the Gate in the Acetylcholine Receptor Channel

1998 • 196 citations

The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.

1990 • 186 citations

Identification of Acetylcholine Receptor Channel-Lining Residues in the M1 Segment of the .alpha.-Subunit

1995 • 179 citations

Agonist pharmacology of neonatal and adult glycine receptor alpha subunits: identification of amino acid residues involved in taurine activation.

1992 • 177 citations

Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor.

1996 • 173 citations

Comparison of conformational characteristics in structurally similar protein pairs

1993 • 171 citations

Determinants of competitive antagonist sensitivity on neuronal nicotinic receptor beta subunits.

1996 • 166 citations

Protein Secondary Structure Prediction Using Nearest-neighbor Methods

1993 • 165 citations

Molecular dissection of subunit interfaces in the acetylcholine receptor: Identification of determinants of α-Conotoxin M1 selectivity

1995 • 164 citations

Mutational Analysis of the Charge Selectivity Filter of the α7 Nicotinic Acetylcholine Receptor

1999 • 161 citations

Bridging the Protein Sequence-Structure Gap by Structure Predictions

1996 • 152 citations

Identification of a New Component of the Agonist Binding Site of the Nicotinic α7 Homooligomeric Receptor

1995 • 147 citations

Determinants of Competitive Antagonist Sensitivity on Neuronal Nicotinic Receptor β Subunits

1996 • 141 citations

Negatively charged amino acid residues in the nicotinic receptor delta subunit that contribute to the binding of acetylcholine.

1993 • 117 citations

Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor alpha subunit form the strychnine-binding site.

1992 • 111 citations

Assessment of secondary-structure prediction of proteins comparison of computerized chou-fasman method with others

1983 • 109 citations

Critical Elements Determining Diversity in Agonist Binding and Desensitization of Neuronal Nicotinic Acetylcholine Receptors

1998 • 104 citations

Projection Structure of the Nicotinic Acetylcholine Receptor: Distinct Conformations of the α Subunits

1996 • 102 citations

Identification of Amino Acids Contributing to High and Low Affinity d-Tubocurarine Sites in the TorpedoNicotinic Acetylcholine Receptor

1997 • 97 citations

Amino acid sequence homology applied to the prediction of protein secondary structures, and joint prediction with existing methods

1986 • 95 citations

NMR solution structure of an .alpha.-bungarotoxin/nicotinic receptor peptide complex

1993 • 94 citations

Three-dimensional location of the main immunogenic region of the acetylcholine receptor

1995 • 94 citations

Molecular Dissection of Subunit Interfaces in the Acetylcholine Receptor

1996 • 92 citations

The macro- and microarchitectures of the ligand-binding domain of glutamate receptors

1998 • 91 citations

Crystalline arrays of membrane-bound acetylcholine receptor.

1981 • 89 citations

A model of the nicotinic receptor extracellular domain based on sequence identity and residue location

1997 • 77 citations

The Limits of Protein Secondary Structure Prediction Accuracy from Multiple Sequence Alignment

1993 • 77 citations

On the conformation of the acetylcholine receptor protein from Torpedo nobiliana

1974 • 65 citations

Refining neural network predictions for helical transmembrane proteins by dynamic programming.

1996 • 61 citations

Ligand-gated ion channels

1990 • 59 citations

The inhibitory neuronal glycine receptor

1994 • 58 citations

The Handedness of the Subunit Arrangement of the Nicotinic Acetylcholine Receptor from Torpedo californica

1995 • 56 citations

A sequence in the main cytoplasmic loop of the α subunit is required for assembly of mouse muscle nicotinic acetylcholine receptor

1994 • 47 citations

Secondary Structure of the Nicotinic Acetylcholine Receptor:Implications for Structural Models of a Ligand-Gated Ion Channel

1994 • 43 citations

Water-soluble Nicotinic Acetylcholine Receptor Formed by α7 Subunit Extracellular Domains

1998 • 42 citations

A mixed helix—beta-sheet model of the transmembrane region of the nicotinic acetylcholine receptor

1996 • 42 citations

Main Immunogenic Region of Torpedo Electroplax and Human Muscle Acetylcholine Receptor: Localization and Microheterogeneity Revealed by the Use of Synthetic Peptides

1990 • 39 citations

FTIR analysis of nicotinic acetylcholine receptor secondary structure in reconstituted membranes

1993 • 38 citations

Atomic force microscopy of cloned nicotinic acetylcholine receptor expressed in Xenopus oocytes.

1993 • 38 citations

The Secondary Structure of Acetylcholine Receptor Reconstituted in a Single Lipid Component as Determined by Raman Spectroscopy

1984 • 37 citations

Expression and Circular Dichroism Studies of the Extracellular Domain of the α Subunit of the Nicotinic Acetylcholine Receptor

1997 • 37 citations

Predicted structure of the extracellular region of ligand‐gated ion‐channel receptors shows SH2‐like and SH3‐like domains forming the ligand‐binding site

1997 • 31 citations

A retrospective analysis of CASP2 threading predictions

1997 • 29 citations

Better 1D predictions by experts with machines

1997 • 26 citations

Better 1D predictions by experts with machines

1997 • 18 citations

Prediction of secondary structure

1996 • 12 citations

Prediction of the secondary structure of the nicotinic acetylcholine receptor nontransmembrane regions

1997 • 8 citations

The accessible surface of the nicotinic acetylcholine receptor

1998 • 4 citations

Protein structure prediction—principles and approaches

1996 • 2 citations