Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

1998 • 1,460 citations

Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67‐GFP knock‐in mouse

2003 • 1,239 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia

2007 • 833 citations

A CENTRAL ROLE FOR CENTRAL TOLERANCE

2006 • 730 citations

Central tolerance: learning self-control in the thymus

2005 • 641 citations

The Cellular Mechanism of Aire Control of T Cell Tolerance

2005 • 622 citations

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

2005 • 540 citations

A Novel ES Cell Line, TT2, with High Germline-Differentiating Potency

1993 • 475 citations

Real-time PCR

2009 • 473 citations

RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

2007 • 463 citations

Tolerance and Autoimmunity

2001 • 453 citations

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

2007 • 367 citations

Autoimmune Regulator Is Expressed in the Cells Regulating Immune Tolerance in Thymus Medulla

1999 • 293 citations

Gene Dosage–limiting Role ofAirein Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity

2004 • 291 citations

Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice

2005 • 287 citations

Spontaneous autoimmunity prevented by thymic expression of a single self-antigen

2006 • 271 citations

MafB Is Essential for Renal Development and F4/80 Expression in Macrophages

2006 • 208 citations

Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin

2007 • 207 citations

NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner

2004 • 207 citations

Localization of the APECED protein in distinct nuclear structures

1999 • 154 citations

Gene defect behind APECED: a new clue to autoimmunity

1998 • 154 citations

Autoimmune regulator: from loss of function to autoimmunity

2003 • 137 citations

Aire-Dependent Alterations in Medullary Thymic Epithelium Indicate a Role for Aire in Thymic Epithelial Differentiation

2007 • 126 citations

An Efficient Gene-Trap Method Using Poly A Trap Vectors and Characterization of Gene-Trap Events1

1993 • 118 citations

Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice

2006 • 117 citations

Epidermal differentiation

1990 • 101 citations

Features of Medullary Thymic Epithelium Implicate Postnatal Development in Maintaining Epithelial Heterogeneity and Tissue-Restricted Antigen Expression

2006 • 79 citations

Subcellular Expression of Autoimmune Regulator Is Organized in a Spatiotemporal Manner

2004 • 71 citations

Contrasting models of promiscuous gene expression by thymic epithelium

2005 • 67 citations

A unified theory of central tolerance in the thymus

2006 • 63 citations

Characterization of human thymic epithelial cell surface antigens: Phenotypic similarity of thymic epithelial cells to epidermal keratinocytes

1995 • 63 citations

Corticosteroids Regulate Epithelial Cell Differentiation and Hassall Body Formation in the Human Thymus

2004 • 58 citations

Simultaneous Detection of EGFP and Cell Surface Markers by Fluorescence Microscopy in Lymphoid Tissues

2003 • 54 citations

ang is a novel gene expressed in early neuroectoderm, but its null mutant exhibits no obvious phenotype

2004 • 48 citations

Transcriptional regulation in thymic epithelial cells for the establishment of self tolerance

2007 • 13 citations

Antigen‐presenting cells expressing glutamate decarboxylase 67 were identified as epithelial cells in glutamate decarboxylase 67‐GFP knock‐in mouse thymus

2006 • 7 citations